106 results about "Chalcone" patented technology

The invention discloses application of licochalcone as a drug sensitizer and an anti-tumor drug composition. The application comprises an application of the acanthochalcone in preparation of an anti-tumor drug sensitizer and an application of the acanthochalcone in improvement of the anti-tumor efficacy of platinum chemotherapeutic drugs, and the invention further provides an anti-tumor composition capable of efficiently inhibiting platinum drug-resistant gastric cancer cells based on the application. Through a gastric cancer organ model and an in-vitro cytology experiment, it is found that the acanthochalcone has an inhibiting effect on proliferation of gastric cancer cells, and the sensitivity of the gastric cancer cells to platinum drugs can be remarkably enhanced. The invention also finds that IC50 of gastric cancer cells to cis-platinum and oxaliplatin, especially platinum acquired drug-resistant gastric cancer cells, can be significantly reduced by combined use of the acanthochalcone and platinum drugs. Therefore, the invention provides a new medication basis and choice for overcoming acquired platinum drug resistance of gastric cancer by utilizing the acanthochalcone.

The invention discloses a gingko GbDRF2 gene as well as an expression protein and application thereof, and belongs to the field of plant molecular biology. The GbDFR2 gene is obtained by analyzing and screening based on data of a ginkgo transcriptome in the earlier stage of a research group, the nucleotide sequence of the GbDFR2 gene is shown as SEQ ID NO.1, and the amino acid sequence of expression protein of the GbDFR2 gene is shown as SEQ ID NO.2. A GbDFR2 overexpression vector is constructed and nicotiana benthamiana is transformed, so that the synthesis of flavonoid substances in a transgenic plant is obviously changed, the contents of 9 flavonoid substances such as sakuranetin and 3, 7-dimethyl quercetin are increased, and the contents of 10 metabolites such as naringin and chalcone are decreased. The invention discloses a regulation effect of the ginkgo GbDFR2 gene in synthesis of flavonoid compounds, and provides a theoretical basis and a molecular tool for improving plant secondary metabolites through genetic engineering.

The present application relates to a kind of catalyst composition and its application in catalytic preparation optically active secondary alcohol, the catalyst composition includes chiral ionic bridged aryloxyalkane rare earth complex and additive, the additive is selected from one or more of pyrimidine, N,N-dicyclohexylmethylamine, 4,4'-dipyridyl.The above-mentioned catalyst composition can be used for synergistically catalyzing asymmetric borohydration of chalcone and its derivatives with pinacol borane, and show high catalytic activity and high enantioselectivity, product yield is as high as 99%, ee value can reach 84%, provide a reliable new way for the efficient, high selective synthesis of optically active secondary alcohol.

The invention relates to a surface-imprinted combined modified electrode and its production method, comprising a novel chalcone-substituted cyclotriphosphazene (CBRG-Fe) and multi-walled carbon nanotube (MWCNT) composite, intended to be used as an electrochemically active sensor for the sensitive determination of ractopamine.

This invention discloses a novel chalcone gypsum glycoside compound with the structure shown in Formula I. The chalcone gypsum glycoside compound of this invention has a novel and unique structure, and for the first time, it is disclosed that this compound possesses significant hepatoprotective activity and can be used in the preparation of hepatoprotective drugs. This invention also discloses the use of the aforementioned novel chalcone gypsum glycoside compound in the preparation of hepatoprotective drugs.

The present invention relates to the use of a compound of formula (I) or a mixture of two or more compounds of formula (I) for providing sweetness and / or modulating the sweetness of one or more sweet substances, and to a method for producing such a compound. Furthermore, the present invention relates to a compound of formula (I), a composition comprising such a compound, and a method for modulating the sweetness of one or more sweet substances.

The invention discloses an application of a cyclochalcone cationic compound as a fluorescent dye in the field of pressing discoloration and detection of trace water or protonic solvents in solvents, the structural formula of the cyclochalcone cationic compound is shown in formula I. The monitoring of the trace water or protonic solvents in the solvents can be realized in the'opening 'process of a fluorescent signal of the dye; the dye fluorescence signal'closing 'phenomenon can be observed through grinding, and the process can be applied to the fields of stress detection, ink-free writing, anti-counterfeiting and the like. The dye can be prepared into test paper, developing powder and other test carriers for portable application, has the advantages of simplicity in operation, low cost, real-time detection and the like, and has the potential of large-scale popularization and application.

This invention provides a chalcone isopentenyltransferase gene. GiPT16 This invention relates to the GiPT16 protein, amplification primer set, and applications, belonging to the field of biogenetics technology. It is based on *Glycyrrhiza inflata* (GiPT16 protein, amplification primer set, and applications). Glycyrrhiza inflata Using whole-genome sequencing data and a reverse genetics strategy, the key aromatic isopentenyltransferase GiPT16, involved in the isopentenylation modification of chalcone active ingredients, was successfully identified and functionally characterized. This enzyme was confirmed to specifically catalyze the biosynthesis of psoralen and glycyrrhizin C using DMAPP as a donor. It is the first chalcone isopentenyltransferase characterized in *Glycyrrhiza inflata*, filling a gap in the study of key enzymes in the chalcone isopentenylation metabolic pathway of this species and providing important evidence for further elucidating the molecular mechanisms of quality formation in *Glycyrrhiza inflata* medicinal materials.

The present invention provides an isopsoralen chalcone-curcumin derivative, its preparation method and application, and an antibacterial pharmaceutical preparation, belonging to the field of pharmaceutical chemistry technology. The isopsoralen chalcone-curcumin derivative of the present invention is based on the isopsoralen chalcone and curcumin structural framework. In vitro antibacterial experiments have shown that it has excellent broad-spectrum antibacterial activity, especially against drug-resistant Staphylococcus aureus (MRSA), with antibacterial activity that is more than 1,000 times that of the positive drug ofloxacin. At the same time, the isopsoralen chalcone-curcumin derivative has high biosafety.

The application provides a synthesis method of 2,3-disubstituted benzofuran compounds and application thereof. The application takes o-hydroxy chalcone and gamma-bromobutyric acid ester as reaction raw materials, and obtains a series of 2,3-disubstituted benzofuran compounds through one-pot multi-step tandem reaction under the promotion of alkali. Advantages of the application include: the reaction reagent is cheap and easy to obtain, the reaction is efficient, the reaction step is short, the application is economical and practical, and the application is environment-friendly; the reaction is easy to enlarge, and has practical value. The compounds have certain inhibitory activity on alpha-glucosidase, and can be used for treating diabetes.

The invention discloses an application of a cyclic chalcone cationic compound as a fluorescent probe in detection of amine molecules, the structural formula of the cyclic chalcone cationic compound is as shown in formula I. The probe can realize quantitative detection of the amine molecules through fluorescence intensity. Qualitative detection of amine molecules is realized through fluorescence color difference after response with different amines, and difference visual detection of different amine molecules is realized. Detection carriers such as filter paper developed by using the probe have the advantages of simplicity in operation, low cost, real-time detection and the like, and have the potential of large-scale popularization and application.

The invention discloses an indole pyridine chalcone compound and application thereof in medicine for treating colitis, and belongs to the technical field of biological medicine. The compound has a structure as shown in a formula I, wherein R1 is selected from C1-C8 alkyl, C1-C8 alkoxy, halogen, cyano, nitryl and morpholinyl, and R2 is selected from nitryl. According to the invention, multiple excellent pharmacophores such as indole, pyridine, chalcone, sulfonamide and the like are fused in the same molecule for the first time, the preparation method does not need pre-activation of a substrate, does not need a metal catalyst or an additive, and has the advantages of mild reaction conditions, high yield, good selectivity, low cost and environmental friendliness. The compound has strong inhibitory activity on hexokinase 2 (HK2), can significantly inhibit inflammatory response and regulate macrophage polarization, shows an excellent colitis treatment effect in in-vivo and in-vitro experiments, provides a new choice for developing novel colitis treatment drugs, and has a wide medical application prospect.

The present application belongs to the field of medicinal chemistry and pharmacotherapy, and particularly relates to a chalcone mannich base compound, a pharmaceutical composition and a preparation method and application thereof. The present application takes paeonol as a raw material, and obtains corresponding 3-substituted and 5-amino-methyl-substituted paeonol mannich base through mannich reaction of paeonol, polyoxymethylene and different organic amines. After the 3-substituted and 5-substituted paeonol mannich base is separated through column chromatography, the chalcone mannich base compound is obtained through Claisen-Schmidt reaction of the 3-substituted and 5-substituted paeonol mannich base and benzaldehyde containing different substituents. Experiments prove that the chalcone mannich base compound improves the physical and chemical properties of the chalcone mannich base and improves the drug efficacy, can solve the problem of poor water solubility, and has good anti-tumor cell proliferation activity.

The present invention discloses a pterostilbene chalcone compound represented by general formula (I) or a pharmaceutically acceptable salt thereof. The compound has a strong inhibitory effect on LPS-induced NO production in RAW264.7 cells, significantly superior to indomethacin, and can be developed into a new anti-inflammatory drug. The preparation method of the compound of the present invention is characterized by readily available raw materials, simple operation, and high yield.

The application discloses a hydroxyl chalcone carboxyl derivative and a preparation method thereof, and provides use of the compound, a pharmaceutically acceptable salt thereof or a mixture thereof in preparation of a medicine for preventing and / or treating diabetes and complications thereof. The compound is used as an aldose reductase selective inhibitor, an alpha-glucosidase inhibitor, a hypoglycemic agent, an antioxidant and a lipid metabolism improver, and has the effects of preventing and / or treating diabetes and complications thereof. The application further provides a pharmaceutical composition containing the compound and having the effects of preventing and / or treating diabetes and complications thereof. In the application, R1 is a hydroxyl group or an alkoxy group, the alkoxy group is preferably a methoxy group or an ethoxy group; R2, R3, R4, R5 and R6 are independently selected from hydrogen, halogen, a hydroxyl group, a methoxy group or a trifluoromethyl group, and at least one of R2, R3, R4, R5 and R6 is a hydroxyl group; and the halogen is preferably fluorine.

The invention specifically discloses a novel chalcone compound as well as a preparation method, a pharmaceutical composition and application thereof. Experimental results show that the compound shows remarkable anti-inflammatory activity in a lipopolysaccharide stimulated RAW 264.7 cell model, and the anti-inflammatory activity is obviously superior to that of a positive drug dexamethasone; the compound shows a remarkable lipid accumulation inhibition effect in a HepG2 cell model treated by free fatty acid, is obviously superior to a positive drug obeticholic acid, and can be used for developing drugs for treating the non-alcoholic fatty liver disease, including but not limited to simple fatty liver, non-alcoholic steatohepatitis and related liver cirrhosis.

To provide a chalcone dye compound that can be produced from living cells of Escherichia coli and has high industrial utility, and means and methods for the production of the same.SOLUTION: The present invention provides a composition for producing a chalcone dye compound which is a glycoside of isoliquiritigenin with a methylated hydroxy group at 2' position, the composition comprising cells of Escherichia coli expressing 4-coumarate-CoA ligase (4CL), chalcone synthase (CHS), chalcone reductase (CHR), isoliquiritigenin 2'-O-methyltransferase (I2'MT), and UDP glycosyltransferase (UGT). There are also provided a chalcone dye compound and a method for producing the same.SELECTED DRAWING: Figure 3

The invention discloses a chalcone substituted compound, a preparation method thereof and application of the chalcone substituted compound in preparation of anti-inflammatory drugs, and relates to the field of medicinal chemistry. In particular relates to chalcone substituted compounds, a preparation method thereof, a pharmaceutical composition containing the compounds and medical application thereof, and particularly, the chalcone substituted compounds can remarkably inhibit generation of inflammatory mediators and have important application potential and clinical value in treatment of inflammation-related diseases. Based on the molecular hybridization principle, the chalcone substituted compound is prepared through a chemical synthesis method, and experiments show that the compound has remarkable advantages in the aspect of inhibiting generation of inflammatory mediators (such as NO) and has the application potential of developing novel anti-inflammatory drugs.

The invention discloses a naphthalene type chalcone compound and a preparation method and application thereof, and relates to the technical field of medicinal chemistry, and the structural formula of the naphthalene type chalcone compound is shown in the specification. Wherein part of the compounds have a good inhibition effect on HDAC6 protein, can obviously inhibit proliferation of tumor cells, and can be used for developing tumor treatment drugs related to abnormal expression of HDAC6 activity.

Various embodiments of the invention utilize chalcones to treat blood, bleeding, and / or bleeding disorders. As described herein, chalcones significantly reduce blood clotting time in normal / hemophilic blood and normal / hemophilic animal models. As also described herein, chalcones reduce blood clotting time and increase blood clotting efficiency without any apparent risk of immunogenicity or unwanted blood clots. As also described herein, chalcones reduce the inhibitory activity of antithrombin on thrombin-driven blood clotting, thereby increasing the effectiveness of the thrombin mechanism in clotting blood.

A flavor composition is provided. The composition includes a dihydrochalcone selected from the group consisting of hesperetin dihydrochalcone, hesperetin dihydrochalcone 4"-beta-D-glucoside, and combinations thereof, and an aromatic ingredient selected from the group consisting of 4-hydroxy-2H-furan-5-one, ethyl furanone, maltol, furfural, 5-methylfurfural, vanillin, benzaldehyde, and combinations thereof.

The invention discloses a photosensitive resin composition containing an anthryl chalcone photosensitizer and application of the photosensitive resin composition. The photosensitive resin composition comprises an anthryl chalcone photosensitizer, and the anthryl chalcone photosensitizer at least comprises an anthracene derivative as shown in a general formula (III). Wherein R1 is one of straight chain or branched chain alkyl of C1 to C5, N-methylpyrrole-2-yl, furan-2-yl, benzofuran-2-yl, thiophene-2-yl, naphthalene-2-yl, phenyl and substituted aryl, and R2 is one of C1-C5 alkyl, N-methylpyrrole-2-yl, furan-2-yl, benzofuran-2-yl, thiophene-2-yl, naphthalene-2-yl, phenyl and substituted aryl; the anthryl chalcone is adopted as the photosensitizer of the photosensitive resin composition, the photosensitizer cannot migrate into a polyethylene (PE) film, and in the electroplating process after exposure and development, small molecular fragments cannot be separated out to pollute electroplating liquid, so that the undesirable phenomena of short circuit, open circuit and the like of a corrosion-resistant pattern are avoided, and the yield of a product is remarkably improved.

The application relates to the technical field of medicines, in particular to application of glycyrrhiza chalcone A in preparation of medicines for treating depression. The application experiment shows that the glycyrrhiza chalcone A can significantly improve the CUMS-induced depression-like behavior of mice, reduce the hippocampal neuron damage, inhibit the neuroinflammatory reaction, and restore the 5-HT level, and the anti-depression mechanism may be closely related to multiple mechanisms such as down-regulation of MAPK / JNK path activity, inhibition of inflammatory factor expression and neurotransmitter regulation.

Provided herein are compounds, compositions, and methods useful for the treatment of breast cancer, particularly triple negative breast cancers. In certain aspects, provided herein are compounds of formula (I):or a pharmaceutically acceptable salt or solvate thereof. In certain aspects, provided herein are compositions comprising any of the compounds provided herein. In certain aspects, provided herein are methods for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of any of the compounds or compositions provided herein.

The invention provides a benzophenone carbazole chalcone photoinitiator and application of the benzophenone carbazole chalcone photoinitiator. The benzophenone carbazole chalcone photoinitiator comprises a compound with a structural formula as shown in a formula (I). The benzophenone carbazolyl chalcone provided by the invention can be used as a single-component photoinitiator or can be compounded with other substances to initiate a photopolymerization reaction under visible light, and particularly has a good photoinitiation effect under long-wavelength (preferably 405-470 nm) LED light.

The invention discloses a benzimidazole modified chalcone compound, a preparation method and an anti-cancer effect of the benzimidazole modified chalcone compound. According to the invention, a chalcone structure and a benzimidazole structure are combined, a compound with relatively good anti-tumor activity is expected to be obtained, the range of the existing anti-cancer compound is widened, and the compound can be continuously optimized as a lead compound. The anti-cancer capsule has a good anti-cancer effect and meets the requirements of the field of medicines.

The invention relates to a carbon-methyltransferase (RdCMT) and an application of the carbon-methyltransferase (RdCMT) in synthesis of farrerol. RdCMT is cloned and is subjected to heterologous expression in Escherichia coli BL21 (DE3) by mining transcriptome information of Rhododendron dauricum, the generated fusion protein of which the N terminal or / and the C terminal are / is connected with tags can specifically and efficiently catalyze C-3 'and C-5' methylation of chalcone compounds naringenin chalcone to generate a double-carbon-methylation product, and the double-carbon-methylation product is spontaneously dehydrated to generate the farrerol. The invention also relates to the application of the RdCMT in a model plant Nicotiana benthamiana, and the production of the farrerol through the construction of a total synthesis path of the Nicotiana benthamiana.

The invention discloses a citric acid and licochalcone B repairing composition and application, and belongs to the technical field of medicine. According to the invention, the repair promoting potential of citric acid and the anti-inflammatory and anti-oxidation activity of licochalcone B are known, and the two natural active components with different action mechanisms are creatively compounded according to a specific proportion; therefore, the citric acid and licochalcone B repairing composition which has a synergistic effect on repairing gastric mucosa epithelial cell injury caused by HP infection is provided, the effect is better than that of a single component, safety and compliance are better, and a new technical approach is provided for solving the repairing problem of clinical gastric mucosa injury.

The invention discloses a modification method of polytetrafluoroethylene, and belongs to the technical field of modification. The invention relates to a modification method of polytetrafluoroethylene, which comprises the following steps: mixing materials containing polytetrafluoroethylene, a modifier, a metal A, a metal salt and a solvent to obtain modified polytetrafluoroethylene, the modifier is a ketone compound; the ketone compound comprises a benzophenone compound and / or a chalcone compound. The method is simple to operate and high in feasibility, and polytetrafluoroethylene can be uniformly modified only by mixing the benzophenone compound (chalcone compound), the metal A, the metal salt and polytetrafluoroethylene; according to the method, the modification efficiency is high, polytetrafluoroethylene, a benzophenone compound (chalcone compound), metal A and metal salt are mixed according to the molar ratio of 0.5: 1: 1: 1, and the modification rate within 30 min can reach 100%; the modification method is novel, and the obtained polytetrafluoroethylene is uniform in modification effect.

The invention discloses a chalcone emulsion in water, application of the chalcone emulsion in water in resisting cotton verticillium wilt and a prevention and treatment method. The chalcone emulsion in water comprises the following components in percentage by mass: 25% of chalcone, 30% of solvent oil 150, 7-8% of pesticide emulsifier 600 and 0.1% of xanthan gum. The preferable formula of the 25% chalcone emulsion in water is obtained through screening, and indoor and field bacteriostasis tests prove that the 25% chalcone emulsion in water can inhibit the growth of verticillium dahliae, reduce the disease index of cotton wilt and verticillium wilt, reduce the influence of cotton wilt and verticillium wilt on the agronomic traits of cotton plants in the boll period, and improve the cotton boll period. The composition is used for preventing and treating cotton verticillium wilt or cotton blight and verticillium wilt, and the prevention and treatment method is simple and effective.