The invention discloses an aryl-substituted chalcones compound, a preparation method and an application. The aryl-substituted chalcones compound has a structure shown as a formula(I) or a formula(II), wherein, R1, R2, R3, R4, R5 are aromatic groups or aromatic groups with a substituent, the aromatic groups are phenyl, furan, thienyl, pyridyl, pyrimidyl, thiazolyl or pyrrolyl, the substituent is one or more selected from hydroxyl, methoxyl, ethoxyl, methyl, ethyl, trifluoromethyl, halogen, amino, methylamino or dimethylamino; R3 is selected from hydrogen, amino or-NHCOCH3. The aryl-substituted chalcones compound introduces the aromatic groups based on a phenyl skeleton to form a structure with steric hindrance, the molecule presents a V-shaped spatial conformation, compared with the current chalcone compounds, and the aryl-substituted chalcones compound has higher inhibitory activity to cancer cells and can be used for preparing the antitumor drugs.