A chalcone lignan glycoside compound isolated from sea buckthorn and its hepatoprotective uses.
By extracting and purifying neochalcone lignan glycosides from sea buckthorn, the problem of the ineffective utilization of the hepatoprotective active ingredients of sea buckthorn in existing technologies has been solved, achieving significant hepatoprotective effects, especially in the treatment and prevention of drug-induced liver injury.
Patent Information
- Application Number
- CN202411759011.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-03
- Publication Date
- 2025-10-28
- Estimated Expiration
- 2044-12-03
AI Technical Summary
Existing technologies have failed to effectively utilize the hepatoprotective active ingredients of sea buckthorn, and there is a lack of significant hepatoprotective drug development, especially in the treatment and prevention of drug-induced liver injury.
A novel chalcone lignan glycoside compound was extracted and purified from sea buckthorn using a bioactivity-guided separation method. The compound, exhibiting significant hepatoprotective activity, was obtained through multi-step chromatography and resin column separation and was prepared into a pharmaceutically acceptable dosage form for the treatment and prevention of liver injury.
We have successfully isolated novel chalcone lignan glycosides from sea buckthorn, which exhibit significant hepatoprotective activity and can effectively protect hepatocytes. These compounds can be used to prepare hepatoprotective drugs, particularly for the treatment and prevention of drug-induced liver injury.