The invention discloses a special organic and inorganic compound fertilizer for pear trees and a preparation method thereof. The fertilizer is prepared from the following raw materials in parts by weight: 20-30 parts of urea, 5-10 parts of monoammonium phosphate, 15-25 parts of calcium superphosphate, 10-15 parts of potassium chloride, 1-2 parts of borax, 0.5-1 part of ammonium molybdate, 1-2 parts of ferrous sulfate, 0.5-1 part of magnesium sulfate, 30-40 parts of poultry and livestock excrement, 10-15 parts of sugar residue, 8-12 parts of soybean curb residue, 5-10 parts of pulverized fuel ash, 3-6 parts of turf, 4-6 parts of peanut shell powder, 2-4 parts of saw dust, 4-8 parts of cushaw stem, 10-15 parts of wintergreen oil, 5-10 parts of eucalyptus oil, and 2-3 parts of soil conditioner. The fertilizer is comprehensive in nutrition, contains inorganic nutrition, including nitrogen, phosphor, potassium, sulfur, calcium, magnesium and trace elements, and organic substances, such as amino acid and humic acid, can meet the requirement of a pear tree for nutrition in the whole growth period, has the effects of maintaining moisture, sterilizing, fertilizing, improving soil and the like, can promote quick growth of pear trees, and can improve the yield and quality of pear tree fruits.