17 results about "Iron absorption" patented technology

The invention relates to the technical field of microorganisms, in particular to a strain of Senotrophomonas sepilia DB3 with disease-resistant, iron-dissolving and growth-promoting functions and application thereof, and the strain is separated from calcareous soil pear tree rhizosphere and has good capabilities of producing IAA (Indoleacetic Acid), quickly growing, dissolving insoluble iron, producing iron carriers and effectively antagonizing various pathogenic bacteria. Pot experiments show that the DB3 microbial inoculum can significantly promote growth of peanut and pyrus betulaefolia seedlings, improve root development and iron nutrient content, enhance leaf SPAD value and iron absorption and relieve iron-deficiency yellows, can be used for preparing biological bacterial fertilizers and reducing chemical iron fertilizer investment, and has good development and application prospects.

The application relates to the technical field of sialic acid application, in particular to application of sialic acid in promoting iron absorption of iron supplement agents. It is found for the first time that sialic acid with a daily intake of 0.8-3.5 mg / kg and ferrous iron with a daily intake of 0.2-0.5 mg / kg can promote the absorption of ferrous iron by human bodies. More specifically, the application claims an iron supplement agent containing ferrous iron drugs and sialic acid. The iron supplement agent provided by the application promotes iron supplement by compounding sialic acid and ferrous iron drugs, thereby improving the bioavailability of iron, regulating immunity, promoting intestinal health and achieving various biological activities while supplementing iron.

The present application relates to the field of microorganisms, in particular to a mucinophilic Akkermansia strain and application thereof, the mucinophilic Akkermansia has a preservation number of CCTCC NO: M 20241304.The mucinophilic Akkermansia AKK-86 of the present application has good effects of promoting iron absorption, improving iron metabolism, and relieving intestinal inflammation.In addition, the mucinophilic Akkermansia of the present application can also promote the production of GLP-1, and has potential application in reducing blood sugar and weight loss products.

The invention provides burkholderia cepacia S66, a complex microbial inoculant and application of the burkholderia cepacia S66, and belongs to the technical field of agricultural microorganisms. The preservation number of the Burkholderia cepacia S66 is GDMCC (China General Microbiological Culture Collection Center) No: 67740. The composite microbial agent is prepared from bacillus velezensis and burkholderia cepacia S66. The complex microbial inoculant can generate a synergistic effect through interaction, forms a stable biological membrane structure at rhizosphere, dissolves phosphorus which is difficult to utilize, enhances the absorption capacity of plants to iron, promotes plant growth, and is especially suitable for alkaline and / or iron-deficient soil environments. Results of the embodiment show that the complex microbial inoculant has efficient phosphate solubilizing and siderophore producing capacities, and can significantly promote the growth of arabidopsis thaliana and cucumbers in iron-deficient alkaline soil. The complex microbial inoculant can form a stable biological membrane through a metabolism complementation and siderophore sharing mechanism and promote the growth of plants in an iron-deficient environment, and has important theoretical value and application prospect.

The invention discloses a chlamydomonas reinhardtii source organism iron steady state regulator and application thereof, and belongs to the technical field of biology. The chlamydomonas reinhardtii hydroxyproline-rich glycoprotein or the protein component thereof disclosed by the invention can activate low-oxygen inducible factor signal channels of intestinal tracts, livers and kidneys, and up-regulate the expression of iron absorption transporters such as a divalent metal ion carrier 1, duodenum cytochrome b, membrane iron transporters and ferrous oxidase in intestinal epithelial cells; according to the present invention, the liver hepcidin overexpression caused by inflammation can be inhibited, the generation of erythropoietin in the liver and the kidney can be promoted so as to stimulate the absorption of the body on the iron nutrient, and the compound can be used in the anemia improving health food and the anemia improving drug. The organism iron homeostasis regulator adopted by the invention is derived from microalgae food, so that compared with a conventional artificially synthesized organism iron homeostasis regulator drug, the organism iron homeostasis regulator has the advantage of no toxic or side effect.

The invention provides a preparation process of a feed additive organic trace humic acid iron (complex) chelate, the specific flow comprises coal (peat, lignite and weathered coal) mineral separation, coal mine crushing and oxidation chain scission, coal water slurry preparation, fine selection and impurity removal, biological acidification reaction, enzymatic hydrolysis reaction, chelation reaction and drying granulation, and the complex (complex) rate of the prepared complex (complex) is greater than 95%. The invention solves the technical problems that the existing humic acid iron product is prepared by physical modes such as mixing, roasting, washing, concentration crystallization and the like or chemical reaction and is low in utilization rate, and solves the technical problems that in the prior art, the pH value of gastrointestinal tracts is regulated only by utilizing acidity of ferric sulfate or humic acid is utilized to promote feed activation and absorption, regulate intestinal health and the like; and the problem that the iron absorption rate is improved by an iron combination form is not fundamentally solved.

Methods and compositions increase iron absorption, for example by increasing iron absorbability and / or increasing iron bioavailability. A method for increasing iron absorption, preferably naturally present in plant-based food, meal or diet, includes administering to an individual in need thereof a milk-based composition galactooligosaccharide (GOS), preferably a low sugar low lactose milk composition comprising galactooligosaccharide (GOS). The individual, to whom the milk-based composition is administered, may be chosen from adults; older adults; pregnant or lactating women; menopausal or perimenopausal women, infants; children; and subjects consuming a vegetarian diet, a flexitarian diet, a vegan diet or any type of plant-based diet.

This invention relates to the field of microbial technology, specifically disclosing a strain of *Lactobacillus paracasei* BL23 that promotes iron absorption and its applications. The preservation number of *Lactobacillus paracasei* BL23 is CGMCC No. 32468. Experimental verification shows that this strain has the ability to reduce ferric iron to ferrous iron, and that specific reducing epitopes exist on the cell surface, enabling it to secrete siderophores. This strain utilizes siderophore secretion and Fe... 3＋ It reduces iron absorption through a dual mechanism and has strong strain specificity, enabling it to independently improve iron deficiency anemia without relying on exogenous iron supplements, thus providing a novel probiotic resource for the prevention and treatment of iron deficiency anemia.

The invention relates to novel compounds of the general formula (I-A) as defined in the application and pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and / or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders leading to increased iron levels or increased iron absorption, and / or iron overload.

The application belongs to the technical field of microorganisms and particularly relates to a strain of DB3 with disease-resistant iron-dissolving and growth-promoting functions Stenotrophomonas sepilia The strain DB3 is isolated from the rhizosphere of pear trees in calcareous soil, has good abilities of IAA production, rapid growth, dissolution of insoluble iron, iron carrier production and antagonism to various pathogenic bacteria. Through potting tests, it is shown that the DB3 bacterial agent can significantly promote the growth of peanut and pear seedlings, improve the root development and iron nutrient content, enhance the SPAD value and iron absorption of leaves, and relieve the iron deficiency chlorosis, and can be used for preparing a biological bacterial fertilizer, reducing the input of chemical iron fertilizer, and has a good development and application prospect.

The invention belongs to the technical field of plant growth-promoting bacteria, and particularly relates to a microbacterium T2 for decomposing trichothecin and application of the microbacterium T2. The invention provides a strain of microbacterium trichiothenolytica T2, and the preservation number of the strain is GDMCC (China General Microbiological Culture Collection Center) No. 64981. The strain of microbacterium trichiothenolytica T2 has the advantages that the preservation number is GDMCC No. 64981; the microbacterium T2 for decomposing the trichothecin provided by the invention has the capabilities of producing IAA (Indoleacetic Acid), producing siderophores, producing ammonia, fixing nitrogen and dissolving iron, and can promote the growth of plants. The result of the embodiment shows that the microbacterium T2 for decomposing the trichothecin can obviously promote iron absorption and growth of arabidopsis thaliana under the iron limiting condition; potting experiments also show that the microbacterium unilaterosporum T2 can improve iron deficiency yellowing of different plants and promote plant growth, and has a good effect.

The invention relates to a pharmaceutical composition comprising iron (III) polymaltose complex and an active ingredient selected from calcium folinate pentahydrate, vitamin C or a combination of both, wherein the active ingredients are stored separately in a container consisting of a cylindrical bottle and a storage closure, wherein the iron (III) polymaltose is stored in the form of an oral solution in the bottle and the calcium folinate pentahydrate or vitamin C or a combination thereof are stored separately in a sealed manner in solid form in the storage closure. The container is properly configured to allow the two substances to be mixed just before use, forming a single-dose oral solution. The pharmaceutical composition helps to increase blood iron levels and treat anemia in pregnancy and lactation.

The present invention relates to a novel process for the preparation of compounds of formula (I) and pharmaceutically acceptable salts thereof, which are suitable for use as drugs for the prevention and / or treatment of diseases caused by hepcidin deficiency or iron metabolism disorders leading to increased iron levels or increased iron absorption, including iron overload, thalassemia, sickle cell disease and hemochromatosis.

This invention provides a glycosylated peptide chelated iron pyrophosphate supplement, its preparation method, and its application. The raw materials for preparing the glycosylated peptide chelated iron pyrophosphate supplement include glycosylated peptides, iron pyrophosphate, and a solubilizer. The glycosylated peptide is a β-glucan-grafted casein phosphopeptide, and the solubilizer is sodium pyrophosphate. The glycosylated peptide chelated iron pyrophosphate supplement of this invention exhibits good water solubility, color stability over a wide pH range, coexistence with nutrients such as vitamin C and oils, high iron loading capacity, good stability in gastric juice, sustained iron release in simulated intestinal fluid, and high iron absorption and utilization rate, significantly improving anemia in iron-deficiency anemia mice. The excellent absorption performance and superior physicochemical properties of the glycosylated peptide chelated iron pyrophosphate supplement of this invention make it a potential candidate for widespread application in the iron supplement market.

The invention discloses application of artesunate in preparation of medicines and health care products for preventing and treating iron-deficiency anemia caused by iron absorption disorder and / or iron transport dysfunction, in-vitro experiments find that artesunate can target divalent metal transport protein (DMT1), DMT1 is oxidized through free radicals to form disulfide bonds, the space structure of DMT1 is changed, and the iron-deficiency anemia caused by iron absorption disorder and / or iron transport dysfunction is prevented. The iron transport function of the DMT1 protein is enhanced, so that the uptake of divalent iron by cells is effectively increased; animal experiments further prove that the artesunate can remarkably improve anemia symptoms of mice with iron-deficiency anemia, anemia related indexes of the mice are effectively recovered, and the iron content in red blood cells and livers is recovered to the normal level. In-vitro and in-vivo experiments prove the treatment effect of artesunate on iron-deficiency anemia, a new treatment scheme is provided for treatment of iron-deficiency anemia patients, and the indication types of artemisinin drugs are expanded.

This invention discloses a calcium and iron-enhancing donkey-hide gelatin peptide prepared based on a gastrointestinal digestion model, its preparation method, and its applications, belonging to the field of biotechnology. By comparing different animal gelatin bases, this invention selects highly active donkey-hide gelatin as a raw material and simulates in vitro gastrointestinal dynamic digestion to prepare highly absorbable calcium and iron active peptides, effectively improving peptide bioavailability. The preparation method described in this invention can efficiently screen for calcium and iron-enhancing and highly permeable bioactive peptides. The method is simple and easy to implement, enabling high-throughput screening of hundreds of candidate peptides or formulations. The screened peptide products can be specifically applied in functional foods and pharmaceuticals, showing significant market potential and providing new ideas for related research.