48 results about "Iron transport" patented technology

Positional cloning has been carried out to identify the gene responsible for the hypochromic anemia of the zebrafish mutant weissherbst. The gene, ferroportin1, encodes a novel multiple-transmembrane domain protein, expressed in the yolk sac. Zebrafish ferroportin1 is required for the transport of iron from maternally-derived yolk stores to the circulation, and functions as an iron exporter when expressed in Xenopus oocytes. Human and mouse homologs of the ferroportin1 gene have been identified. The invention includes isolated polynucleotides, vectors and host cells comprising nucleotide sequences encoding Ferroportin1 proteins and variants thereof, including those having iron transport function. The invention also includes polypeptides encoded by ferroportin1 genes and variants of such polypeptides, and fusion polypeptides comprising a Ferroportin1 or a portion thereof. Methods to produce a Ferroportin1, methods to produce antibodies to a Ferroportin1 and methods to identify agents binding to a Ferroportin1, which can be inhibitors or enhancers of Ferroportin1 iron transport activity, are also described. Inhibitors of Ferroportin1 activity can be used in a therapy for hemochromatosis.

The invention provides an intelligent molten iron conveying system. The system comprises a haulage motor body, a molten iron conveying vehicle body, a vehicle-mounted control system and a ground control system, wherein the vehicle-mounted control system is used for controlling motions of the haulage motor body and the molten iron conveying vehicle body according to a control instruction, the ground control system is used for collecting external environment information and controlling a ground advancing line of the haulage motor body and the molten iron conveying vehicle body according to the control instruction, and a centralized control platform is used for sending the control instruction to the vehicle-mounted control system and the ground control system. Automatic interaction of information and the control instruction is performed through the centralized control platform, a molten iron transporting vehicle achieves unmanned and organization scheduling intelligence in the whole molten iron transporting working process from a blast furnace casting field to a steel making transit station, the haulage motor operation efficiency is improved, the iron molten temperature drop is lowered, the road and haulage motor operation safety is improved, equipment damage and accidents caused by faults such as worker operation and judgment are completely eradicated, the operation risk is lowered, and personal safety of workers is ensured.

The invention discloses a molten iron transportation online molten iron tank heat preservation device. Two ladle covering and uncovering mechanisms are arranged on molten iron transport carts (5) and symmetrically distributed at the two sides of a molten iron tank (4) with the axis of the molten iron tank (4) serving as the center. By the adoption of the technical scheme, the molten iron tank is transported in a covered mode in the whole molten iron transport cart operation process, the molten iron tank is covered for heat preservation, and therefore energy loss caused by molten iron temperature drop is reduced; a four-bar mechanism is adopted, covering and uncovering operation conducted on a molten iron pouring station with narrow space is achieved; normal operation of the two carts is not affected; each molten iron tank heat preservation device is only provided with one power execution device and a point of action is near the center of symmetry of the mechanisms, so that overall stable operation of covering and uncovering operation of the mechanisms is guaranteed; the structure is compact, operation is simple, use is convenient, and the device is safe, reliable and long in service life.

The invention discloses a molten iron transport system, which comprises a first transport path of molten iron in a blast furnace, a second transport path of molten iron between adjacent blast furnaces, and a third transport path for transporting molten iron to a steel-making plant, wherein the first transport path is linearly arranged between the blast furnace and the second transport path ; the second transport path is linearly arranged between two adjacent blast furnaces; the third transport path is linearly arranged between the second transport path and the steel-making shop; a first transport vehicle is arranged at the transition position of the first transport path and the second transport path; a second transport vehicle is arranged at the transition position of the second transport path and the third transport path; a desulfurizing station is also arranged at the transition position of the second transport path and the third transport path ; a first ground molten iron tank car, a second ground molten iron tank car and a third ground molten iron tank car are respectively arranged on the first transport path, the second transport path and the transport path third. The molten iron transport system has high transport continuity, and can maximally shorten the transport cycle and eliminate the influence of centrifugal force on the production safety in the transport process, thus improving the transport speed and reducing temperature drop of the molten iron.

The invention discloses a molten iron vehicle scheduling system and scheduling method, and the method comprises the steps: enabling a vehicle-mounted mobile terminal to be connected with a local areanetwork through a factory WIFI base station, and enabling the vehicle-mounted mobile terminal to keep communication with a command monitoring device through a server; connecting avehicle-mounted wireless positioning module with the local area network through the factory area WIFI base station, and enabling the vehicle-mounted wireless positioning module to transmit information to a command monitoring device through the server; arranging a vehicle-mounted RFID tag on the molten iron transport vehicle, wherein an RFID read-write device is connected with the local area network through the RFID base station and the factory WIFI base station, the RFID read-write device transmits information to the command monitoring device through the server, and the RFID read-write device reads the vehicle-mounted RFID tag and obtains molten iron transport vehicle information; and connecting the command monitoring equipment to a monitoring large screen through the server. According to the invention, the technology of combining Beidou/GPS dual-mode positioning and stop point RFID identification is adopted, so that accurate positioning of the stop point can be realized even if the stop point is shielded,and the problems that the traditional molten iron vehicle scheduling depends on manpower, the position information feedback is not timely, the positioning is inaccurate and the like are well solved.

The invention discloses a molten iron transport system. The molten iron transport system comprises casting houses (1) of ironmaking blast furnaces and a steel-making workshop (7), parallel track lines (3) are arranged between the casting houses (1) of the ironmaking blast furnaces and the steel-making workshops (7), the casting houses (1) of a plurality of ironmaking blast furnaces are symmetrically and compactly arranged at two sides of the parallel track lines (3), each casting houses (1) of each ironmaking blast furnace is connected to adjacent track line (3) via a molten iron pot storing line (4) of each casting houses, and a molten iron pot (2) of each casting houses (1) of each ironmaking blast furnace can be transported to the track lines (3) along each molten iron pot storing line (4). The steel-making workshop (7) is arranged at one end of the parallel track lines (3), the molten iron pots (2) can be transported to the steel-making workshop (7) along the track lines (3). The molten iron transport system is compact in arrangement, less in land occupation without a transition across workshop and a crane, so the investment can be saved.

The invention discloses lactobacillus casei for prevention and auxiliary treatment of type II diabetes and application of the lactobacillus casei. The lactobacillus casei LCZ has a remarkable functionof preventing type II diabetes and the process of the type II diabetes can be well prevented after the lactobacillus casei intervenes for two weeks; the weight increase of a high-fat diet mice can beintervened and delayed, and the oral glucose tolerance increase induced by high-fat diet is prevented; expression of intestinal tract iron-related protein (transferrin and iron transport carrier protein) can be improved, chronic inflammation caused by endotoxin entering tissue is reduced, and then the effect of lowering the hyperglycemia level is achieved. Due to the remarkable functional characteristics of the lactobacillus casei, the lactobacillus casei has wide application value in various forms of probiotic foods, such as probiotic tabletting candies and probiotic solid beverages.

The invention provides applications of a primary astrocyte/primary midbrain ventral neuron co-culture system in iron metabolism, especially in iron transport, and belongs to the field of cytobiology.The technical schemes detect a co-culture system by designing test methods, the sources of iron in neurons, the mutual influence between interstellar astrocyte and the directionality problems of irontransport can be cleared at the cellular level. The established primary astrocyte and primary midbrain ventral neuron co-culture system is a novel cell model for studying Parkinson diseases, and can be used for studying the related research of high iron in the brain of neurodegenerative diseases such as the Parkinson diseases.

The invention discloses a pressure die-casting production line for iron pans and relates to the field of mechanical manufacturing. The pressure die-casting production line for iron pans comprises a molten iron melting device, a molten iron transfer device and a pressure die-casting device, wherein the molten iron transfer device is provided with a receiving container for receiving molten iron transported from a molten iron outlet; the pressure die-casting device comprises a rotary table, a plurality of lower pressure die-casting dies arranged on the rotary table and an upper pressure die-casting die arranged on the rotary table; the multiple lower pressure die-casting dies are arranged to rotate around the axis of the rotary table; and the molten iron transfer device is arranged to drive the receiving container to move back and forth between the pressure die-casting device and the molten iron outlet, so that molten iron in the receiving container is transported to the lower pressure die-casting dies. The pressure die-casting production line for iron pans can manufacture iron pans efficiently.

The invention discloses a molten iron quantitative loading system and a molten iron quantitative loading method, and relates to a weighing device. Since the existing molten iron transport vehicle is composed of two groups of wheels in front and back, a molten iron tank for holding the molten iron is arranged between two groups of wheels, a group weighing modules arranged below the transport wheelsare used for weighing the transport vehicle so as to judge whether the molten iron is in quantitative loading, and the weighing module has a use condition for guaranteeing the normal use thereof, sothat the weighing module is prone to failure once the condition dissatisfies a use environment range of the weighing module in normal use (such as the molten iron overflows to the weighing module); and the problem that the weighing module is prone to failure is solved through the molten iron quantitative loading system disclosed by the invention. The technical scheme key point is that a control terminal computes the difference between weighing data MA of a first weighing device and weighing data MB of a second weighing device, and takes an absolute value of the difference, the absolute value is compared with the preset maximum error data, so that a worker can timely acquire whether the weighing of the molten iron is exactly correct; and the system is in favor of accurately and quantitatively loading the molten iron.

The invention discloses a method for using microorganisms to control iron deficiency yellowing of cinnamomum camphora and belongs to the technical field of controlling iron deficiency yellowing diseases in trees. The method includes applying plant growth promoting rhizobacteria (PGPR), rahnella aquatilis JZ-G 1 ferritin fermentation broth into the root of a cinnamomum camphora tree to improve irondeficiency yellowing of the cinnamomum camphora. The PGPR, rahnella aquatilis JZ-GX1 ferrtin fermentation broth is applied to the control of iron deficiency yellowing of the cinnamomum camphora to promote iron transport, and multiple roles are played in improving plant iron nutrition; the PGPR, rahnella aquatilis JZ-GX1 ferrtin fermentation broth applied to alkaline or nutrient-poor soil as an important improvement measure to alleviate the symptoms of iron deficiency and chlorosis, and a broad application prospect is achieved.

The invention relates to a fusion protein, a production method thereof, and a production method of transgenic rice. The fusion protein is a plant seed endosperm expressed Ex-TF fusion protein. The gene sequence of the fusion protein comprises a plant endosperm specific expression promoter (pGluB-5); a plant endosperm storage protein signal peptide (sp), an exenatide polypeptide (Exendin-4), a connection polypeptide (GGGGS)x3linker that connects Exendin-4 and human iron transport protein (hTF), a human iron transport protein (hTF), a histone label (6xHis) for the purification of proteins, and a transcription terminator (GluB-5-3'-UTR) of a plant gene (GluB-5). By utilizing the GluB-5 promoter, the fusion protein can be massively expressed in the whole endosperm. At the same time, the advantages of paddy rice such as high yield, easy plantation and management, and the like, and the advantages of paddy rice seed such as long shelf life, easy extraction, and the like, are utilized to realize the continuous production of Ex4-TF fusion protein drugs; the waste and shortage are avoided, and the production cost is reduced at the same time.

The invention discloses a tobacco (Nicotianatabacumcv.SR-1) chloroplast iron transporter gene NtPIC1 and application of encoding protein of the tobacco (Nicotianatabacumcv.SR-1) chloroplast iron transporter gene NtPIC1 in chloroplast iron transport. A nucleotide sequence of the gene is shown in a sequence table SEQIDNO: 1; a corresponding amino acid sequence is shown in a sequence table SEQIDNO: 2; the gene comprises 849bp of open reading frames; 282 amino acids are encoded; the predicted molecular weight is 29.7kDa. The accession number of the nucleotide sequence of the open reading frames on GeneBank is KF640606. By virtue of positioning analysis of GFP fusion protein cells, NtPIC1 protein is positioned on a chloroplast membrane. Proven by a yeast function complementary experiment, expression of the gene in a yeast can be used for effectively transporting iron ions. According to the tobacco (Nicotianatabacumcv.SR-1) chloroplast iron transporter gene NtPIC1 disclosed by the invention, the gene NtPIC1 is introduced into tobaccos so as to obtain transgenic tobaccos with high iron content in the chloroplast; a research result shows that the NtPIC1 gene is involved in the chloroplast iron transport and the chloroplast development process.

The invention discloses research for the influence on the endocytosis of cell transferrins of UNC-51 kinase, wherein maintenance for the stable level of iron elements in cells and body is necessary to the health of life; cell absorption and iron transport are mainly performed via the endocytosis of cell transferrins; the molecular mechanism and the cell mechanism of the endocytosis of cell transferrins are not clear yet; and interpretation for the molecular mechanism and the cell mechanism of the endocytosis of cell transferrins has important significance for prevention and treatment for neurological diseases. The research shows that the COS-7 cells for over-expressing Myc-tagged UNC-51 kinase inhibit the endocytosis of cell transferrins due to that the over-expressed UNC-51 kinase in the COS-7 cells have the function of promoting the dynamic changes of cytoskeletons, thus blocking the recirculation of the complex particles of transferrins, and achieving the effect of preventing the endocytosis of cell transferrins. The research shows the first mode of participating in the endocytosis of cell transferrins of UNC-51 kinase.