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Iron transport. the process whereby iron is carried from the intestinal mucosa to sites of use and storage. Iron binds with transferrin and shuttles to storage and utilization sites. Transferrin becomes attached to exogenous iron that enters through the intestinal villi or that reenters the plasma from the sinusoids of the spleen.
Uses and compositions of iron transporter inhibitors (VIT-2763)
The invention relates to the technical field of antitumor drugs, and particularly discloses application and a composition of an iron transporter inhibitor (VIT-2763). The invention provides an application of an iron transporter inhibitor VIT-2763 in preparation of a medicine for preventing and treating tumor metastasis. The iron transporter inhibitor VIT-2763 can obviously inhibit liver metastasis of colorectal cancer and has the potential of being used as a medicine for resisting liver metastasis of colorectal cancer. Meanwhile, the invention further provides a composition for resisting colorectal cancer liver metastasis, the composition comprises the iron transporter inhibitor VIT-2763 and oxaliplatin, and when the iron transporter inhibitor VIT-2763 and the oxaliplatin are combined for use, the drug resistance of colorectal cancer cells to the oxaliplatin can be improved, the sensitivity of liver metastatic colorectal cancer cells to the oxaliplatin is remarkably improved, and the curative effect is good. The treatment effect of resisting colorectal cancer liver metastasis is synergistically enhanced, and the technical problem that an existing treatment means lacks a specific intervention means for colorectal cancer liver metastasis is solved.
Owner:THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV