70 results about "Iron deficient" patented technology

The invention relates to methods and compositions for delivering iron to an iron-deficient patient, more particularly, to methods whereby an iron complex comprising divalent or trivalent ionic iron complexed with one or more low molecular weight anions is administered to a patient by transfer from dialysate. A complex selected according to the invention is non-polymeric; soluble in an aqueous medium; chemically stable, thereby preventing the dissociation of iron ions from the anions under conditions according to the invention; and can be well absorbed into blood and the living body. Also provided are dialysate compositions including therein an iron complex selected according to the invention, and dialysate concentrates which may be diluted to yield an inventive dialysate composition.

The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to iron deficient growth conditions. The methods use molecular genetic markers to identify, select and / or construct disease-tolerant plants or identify and counterselect disease-susceptible plants. Soybean plants that display tolerance or improved tolerance to Phytophthora root rot infection that are generated by the methods of the invention are also a feature of the invention.

In a process for producing an iron-dextran compound for use in parenteral treatment of iron-deficiency in humans or animals a stable compound of desired relatively low molecular weight is obtained by using first hydrogenation and then oxidation to convert reducing terminal groups on the dextran molecules before reaction with the iron. By varying the ratio of hydrogenated groups to oxygenated groups the average molecular weight of the resulting iron-dextran compound can be varied.

The invention discloses a high-power yttrium-gadolinium garnet ferrite having the composition chemical formula specifically expressed as Sm[x]Y[3-x-y-2z-p-q-q']Gd[y]Ca[2z+p+q+q']V[z]Ge[p]Sn[q]Ti[q']In[q'']Al[w]Mn[w']Fe[5-z-p-q-q'-q''-w-w'-[delta]]O[12], wherein 0<=x<=0.20, 0<=y<=3.0, 0<=z<=1.3, 0<=p<=0.9, 0<=q<=0.7, 0<=q'<=0.7, 0<=q''<=0.70, 0<=w<=1.3, 0<=w'<=0.10, 0<=delta<=0.8, and delta represents iron deficient quantity. The high-power garnet ferrite material having high spin wave line width [delta]Hk, low ferromagnetic resonance line width [delta]H and high dielectric constant epsilon' can be obtained.

New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSf1 defined by the formula of (MCV×MRV)1 / 2, or RSf2 defined by the formula of (MCV×MRV) / 100, a volume-hemoglobin factor (VHf) defined by the formula of (MCV×Hgb) / 100, and a volume-hemoglobin / distribution factor (VHDWf) defined by the formula of (MCV×Hgb) / (RDW×10). Further disclosed are the methods of using these parameters for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency. Also disclosed is a method of using RSf for detection of hemochromatosis.

The invention discloses a composite ferrum preparation for correcting iron-deficient chlorosis of fruit trees and increasing ferrum contents in fruit. The composite ferrum preparation comprises the following contents in mass percent: 60 % of commercially available composite amino acid powder, 2 % of citric acid, 16 % of ferrous sulfate, 18 % of zinc sulfate, and 4 % of surface active agent of sodium dodecyl sulfate. The composite ferrum has obvious effects on correcting iron-deficient chlorosis of fruit trees and increasing ferrum contents in fruit.

The invention discloses a nutrient solution for preventing and treating chlorosis of a camphor tree. The nutrient solution comprises the following components in concentration by mass: 0.1-2 percent ofwater-soluble iron-contained compound, 0.01-0.1 percent of ethyoxyl modified polytrisiloxane and the balance of water. The invention also discloses a method for preventing and treating chlorosis of the camphor tree by the nutrient solution. The nutrient solution is applied to the camphor tree by a leaf surface spray method. The invention can effectively solve the phenomenon of the iron deficiencychlorosis of the camphor tree.

The invention relates to a coding gene for enhancing iron deficiency tolerance and accumulation of a plant and application of the coding gene. The sequence of the coding gene for enhancing iron deficiency tolerance and accumulation of the plant is as shown in the sequence table SEQ ID No: 1. The coding gene for enhancing iron deficiency tolerance and accumulation of the plant is transferred into the plant, the coding gene for enhancing iron deficiency tolerance and accumulation of the plant is over-expressed in the plant, so that the tolerance of the plant to iron deficiency is displayed in vivo. The coding gene for enhancing iron deficiency tolerance and accumulation of the plant can provide gene resources and technical support for breeding crops under iron deficiency stress tolerance.

The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakary-ocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.

The invention relates to a flocculant used for purifying the water quality, and in particular relates to a preparation method of solid polymeric ferric chloride silicate flocculant. The preparation method comprises the following steps of: selecting concentrated hydrochloric acid and injecting the selected concentrated hydrochloric acid into water to prepare diluted hydrochloric acid; taking liquid state sodium silicate and putting the liquid state sodium silicate into water to obtain sodium silicate water solution; adding the diluted hydrochloric acid into a reaction tank, slowing injecting the sodium silicate water solution into the reaction tank, and putting ferric trichloride into the reaction tank for a plurality of times for dissolving; standing still to form polymeric iron silicate; and micro-heating to obtain the solid polymeric ferric chloride silicate flocculant. The flocculant only contains two raw materials including Fe and Si, wherein Fe is non-toxic and is essential trace element of the human body, and iron-deficiency anemia can be caused when the human body is lack of the Fe; Si has the function of promoting development and growth; and when the metasilicic acid content in drinking water is more than 25mg / L, the drinking water belongs to mineral water and can be used for preventing diseases after being drunk for a long time, thus having the health care function of prolonging the life. The flocculant not only has excellent turbidity removal function, but also can remove harmful substances such as heavy metal, thus being beneficial to the health of human body.

The invention discloses a complementary deoxyribonucleic acid (cDNA) sequence related to iron deficiency of a plant and an encoded protein and application thereof. A full-length cDNA of a ZmFDR gene is cloned from an iron-deficient induced corn root and the structural characteristic of the full-length cDNA and the functional complementation of the full-length cDNA in yeast are analyzed. The analysis of the structural characteristic indicates that the full length of the ZmFDR gene is 3.3 kb, the gene comprises two open reading frames which are 1,068 bp and 648 bp respectively and the latter is named as ZmFDR4 (SEQ ID NO:1). The encoded protein (SEQ ID NO:2) has four transmembrane domains and has a signal peptide which belongs to a secretory protein and has a similar structure domain to a Flip protein in an III type secretory system. Extensive homology comparison indicates that no homology sequence is found in a higher plant. A yeast functional complementation experiment proves that the expression of the cDNA sequence in the yeast can transfer iron ions effectively.

To relieve symptoms caused by mineral deficiency such as taste abnormality and skin damage due to zinc deficiency, anemia due to iron deficiency and decreased bone mineral content due to calcium deficiency to thereby improve quality of life (QOL). Namely, foods such as foods for specific health uses and foods with nutrient function claims containing 0.1% or marc, based on gram of a dry natural plant material comprising a papaya powder etc., of zinc which are prepared by nonproliferatively stirring and / or shaking the natural plant material in a state of being suspended in a solution containing 100 ppm or greater of zinc.

The invention relates to the technical field of soil fertilizer and in particular provides a compound iron-supplementing agent applicable to a saline and alkaline land as well as preparation and application methods thereof. By combining inorganic iron salt and a fermentation technology, inorganic iron participates in a metabolism process of microorganisms and is converted into an organic chelatingform; the iron with the organic state has relatively good permeability and dissolubility so that the absorption rate and the utilization rate of plants in the saline and alkaline land on an iron element can be improved, and physiological diseases, caused by iron deficiency, on the plants are prevented and alleviated.

The present invention generally relates to iron-polysaccharide (polydextrose) complexes and methods for the preparation thereof. In particular, the present invention relates to iron-polydextrose complexes and methods for the preparation thereof. The inventive complexes are suitable for use in various compositions, including particulate compositions that may be incorporated in various forms of administration, including tablets, capsules, and intravenous formulations. The complexes and compositions of the present invention are suitable for use in the treatment of iron deficient anemia. Advantageously, in addition to providing iron supplementation the complexes and compositions of the present invention provide certain advantages based on the presence of polydextrose (e.g., its low glycemic index and high fiber content).

The invention discloses a Zea mays zinc iron-regulated transporter ZmITR1 gene and its applications. The Zea mays zinc iron-regulated transporter ZmITR1 gene is separated from Zea mays, and the cDNA sequence of the gene is represented by SEQ ID No.1. Subcellular localization shows that the zinc iron-regulated transporter is localized in the plasma membrane and endoplasmic reticulum of a cell, has zinc and iron absorption, transportation and storage effects in plant cells, and particles in detoxification of zinc and iron ions. Quantitative real-time RT-PCR expression analysis shows expression the expression of the ZmITR1 in zinc or iron deficient root and overground parts rises, the expression in the later stage of embryo growth obviously rises, and the ZmITR1 plays an important role in the regulation of the embryo growth. Yeast complementation experiments show that the ZmITR1 gene has a zinc and iron complementation ability. The separated ZmITR1 gene has important application prospects in the regulation of zinc and iron absorption, transportation and storage of plants, promotion of the embryo growth and increase of the content of zinc and iron in grains of food crops.

Provided are a pharmaceutical composition including iron oxide nanoparticles for preventing or treating iron deficiency and iron deficiency anemia accompanied thereby, and a preparation method thereof.

The present invention discloses the signaling pathway involved erythroid repression by iron deficiency. Further disclosed is anon-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.

A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing plants, in particular, grass plants highly tolerant to iron deficiency. A nicotianamine synthase involved in the mugineic acid biosynthesis pathway; the amino acid sequence thereof; a gene encoding the same; a vector containing this gene; cells transformed by the vector; a process for producing nicotianamine by using the same; plants transformed by the gene encoding the nicotianamine synthase; and an antibody against the nicotianamine syntase.

There is provided polymorphs of ferric maltol. Such forms may be useful in the treatment of iron deficiency with or without anaemia, such as iron deficiency anaemia.

The invention discloses an oral nano iron supplement and a preparation method thereof, and effect of the oral nano iron supplement on intestinal flora of rats. The oral nano iron supplement is formedby wrapping iron oxide crystals with a pharmaceutical excipient cellulose. The cellulose comprises sodium carboxymethylcellulose, calcium carboxymethylcellulose, croscarmellose sodium, hydroxy propylcellulose, hydroxypropyl methyl cellulose or cellulose acetate. The iron supplement is used in a rat model with iron-deficiency anemia, can supplement hemoglobin to complete treatment of anemia in 3 weeks, and has higher curative effect and lower side effect than a traditional oral chalybeate ferrous sulfate. Through high-throughput sequencing for intestinal flora of rats, the anaylysis of 16S rRNA shows that the oral iron supplement of the invention can significantly increase abundance and diversity of intestinal flora of rats, promote to restore a steady state of the intestinal flora, facilitate normal growth of the rats and has great application potential in a human body compared to an iron-deficient group and an iron-supplementing group with ferrous sulfate.

The invention provides a food for infantile iron deficiency and a preparation method thereof. The food comprises the following raw materials in part by mass: 40-60 parts of walnut kernel, 10-30 parts of lilium brownii, 10-30 parts of semen nelumbinis and 5-20 parts of peanut kernel. The invention provides the food for infantile iron deficiency and the preparation method thereof, wherein the supplementary food is reasonable in formula, simple in production process, unique in flavor, good in sensory quality and rich in nutrition; the selected raw materials are rich in iron and are supplemented with other natural raw materials for promoting iron absorption, so that infants can absorb iron in supplementary food more quickly and effectively. The food is pollution-free, free of additives, and is a natural infant food which is easy to absorb, high in quality and inexpensive, and healthy.

The present invention relates to an iron-based composition, for use in conditions of total or relative iron deficiency. In particular, the present invention relates to a solid composition, preferablyin the form of powder or granules, for use in the treatment of disorders or diseases related to or derived from an iron deficiency. The composition of the present invention is suitable for pediatric subjects, adolescents, athletes, men, women, pregnant women and elderly. Finally, the present invention relates to a process for preparing said solid composition.

The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and / or prophylaxis of iron deficiency symptoms and iron deficiency anemias.

The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.

Provided are methods of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter using a small molecule. For example, the method may increase transepithelial iron transport, or it may increase iron release. Additionally, the small molecule may be hinokitiol, or it may be selected from the group consisting of amphotericin B, calcimycin, nonactin, deferiprone, purpurogallin, and maltol. Also provided is a method of identifying a compound capable of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter.

The present invention provides methods and compositions for identifying soybean plants that are tolerant or have improved tolerance, or those that are susceptible to, iron deficient growth conditions. The methods use molecular markers to identify, select, and / or introgress genetic loci modulating phenotypic expression of an iron deficiency tolerance trait in soybean plant breeding. Methods are provided for screening germplasm entries for the performance and expression of this trait.

The invention discloses a vitamin and mineral tablet for pregnant women. The vitamin and mineral tablet includes a tablet core and a film coating layer, and the tablet core includes the following rawmaterials in parts by mass: 200-300 parts of calcium carbonate, 50-100 parts of tricalcium phosphate, 100-150 parts of magnesium carbonate, 4-8 parts of ferrous fumarate, 6-12 parts of polypeptide chelated iron, 15-30 parts of polysaccharide chelated iron, 0.1-0.2 part of vitamin D3, 0.3-0.5 part of folic acid, 3-5 parts of L-ascorbic acid, 0.5-1 part of tocopherol, 100-150 parts of inulin, and 300-400 parts of auxiliary materials. The vitamin and mineral tablet for the pregnant women provided by the invention can comprehensively supplement various vitamins and minerals required during pregnancy, and in particular the vitamin and mineral tablet can promote absorption of iron elements by a body, thereby effectively preventing the occurrence of iron deficiency during the pregnancy.

The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use in the treatment and / or prophylaxis of iron deficiency symptoms and iron deficiency anemias.