87 results about "Diclazuril" patented technology

The invention relates to a chick starter which is made from the following raw materials in parts by mass: 56.7-57.6 parts of corn, 25.1-25.8 parts of bean pulp, 1.5-1.6 part of mountain flour, 0.04-0.06 part of ethoxy quinoline, 0.6-0.7 part of traditional Chinese medicine premix, 0.04-0.06 part of bacillus subtilis preparation, 0.04-0.06 part of rice bran powder carrier zymin, 0.02-0.03 part of bacitracin zinc preparation, 0.01-0.02 part of diclazuril, 0.1 part of trace mineral premix, 0.04 part of vitamin premix, as well as a binder, wheat middling and bentonite; and the granularity of the prepared product granules is 1.5-2.5mm. Fed with the chick starter, egg chicks can grow favorably and can show best production performance favorably in the future. The chick starter is mainly suitable for the Jinghong Number 1 egg chicks which are 15-40 days old.

The invention relates to nano suspension containing Diclazuril, Maduramycin ammonium and sulfachloropyrazine sodium and preparation method thereof. The nano suspension of the invention is taken with drinking water, and after being diluted, the primary suspension can dissolve in water uniformly to form clear and stable solution; besides the sulfachloropyrazine sodium, the Diclazuril and Maduramycin ammonium, which are difficult to dissolve, can dissolve in the drinking water completely to form a clear, uniform and stable solution system. The suspension has the characteristics of allowing for convenient administration, reducing waste, ensuring dose, improving medicine availability, avoiding blocking a drinker and the like. The Diclazuril, Maduramycin ammonium and sulfachloropyrazine sodium cooperate to produce a synergistic effect in treating coccidiosis in chicken, so that the suspension has a scores of times higher anticoccidiosis effect than common anticoccidiosis medicines.

The invention relates to the preparation method of a diclazuril micro-emulsion. The preparation procedure of the diclazuril micro-emulsion is as follows: (1) florfenicol is weighed, added with tween-80 and is mixed uniformly; (2) propanediol is added and mixed uniformly; (3) DMF dimethylformamide is added and mixed uniformly; (4) water is added and mixed, and then florfenicol micro-emulsion is prepared. The invention adopts advanced microemulsion technology, and florfenicol which is slightly soluble in water is prepared into florfenicol micro-emulsion solution in any proportion. The preparation method effectively improves the bioavailability of the product, the property of the quality is stationary and the absorption is complete. The drug is released by targeting drug release and the product has the characteristics of rapid, durable and high effects. The half-life is long and the effective plasma concentration is maintained in bodies for a long time. The diclazuril micro-emulsion of the invention has low toxicity, high effects, sound safety, is capable of curing bacterial diseases, is drinkable with water and the use is convenient.

The invention relates to a method for preparing coccidium-resistant suspension containing Diclazuril and maduramicin ammonium. A user can take the suspension with water; and diluted stock solution can be uniformly dispersed in water and keep the stable suspension state, and has the characteristics of convenient administration, waste reduction, dosage guarantee, high dissolution rate of medicaments, high saturated solubility of the medicaments, long detention time of the medicaments in vivo, high bioavailability, no blockage of drinkers and the like. The coccidium-resistant suspension containing the Diclazuril and the maduramicin ammonium can fully exert the medical effect when treating chicken coccidiosis.

The invention discloses a preparation method of an anticoccidial drug Diclazuril. The method takes 3,4,5-trichloronitrobenzene as a raw material and the 3,4,5-trichloronitrobenzene and 4-chlorobenzylcyanide are subjected to condensation reaction to generate 2,6-dichloro-alpha-(4-chlorobenzyl)-4-nitrophenylacetonitrile; enabling a condensate and hydrazine hydrate to be subjected to reduction to generate 2,6-dichloro-alpha-(4-chlorobenzyl)-4-aminophenylacetonitrile, enabling a reduzate and malonyl ethyl dicarbamate to be subjected to diazo, coupling, cyclization, hydrolysis and decarboxylationone-pot reaction to generate the Diclazuril. The method disclosed by the invention has a simple technology and is easy to operate; the environment protection problem caused by the fact that the odor of thioglycolic acid is great in a decarboxylation process of the Diclazuril is solved; meanwhile, the yield is improved and the total yield of the Diclazuril synthesized by taking 2,6-dichloro p-nitroaniline as the raw material is 43.8 percent, so that the preparation method is suitable for industrial production.

The invention discloses a concentrated feed for chickens, which comprises the constituents (by weight percent)of maize 52-60%, short flour 4-6%, feed oil 1-1.5%, soybean waste 25-28%, cotton seed waste 3-5%, DDGS 2-4%, stone powder 1-1.5%, calcium hydrogen phosphate 1-2%, table salt 0.1-0.4%, sodium sulfate 0.1-0.3%, lypressin 0.3-0.5%, methionine 0.1-0.2%, threonine 0.03-0.07%, choline 0.06-0.15%, concentrated enzyme 0.01-0.03%, antibiotics 0.01-0.02%, Flavomycin 0.01-0.02%, Diclazuril 0.03-0.05%, multivitamins 0.01-0.03%, multi-minerals 0.01-0.03%.

The invention discloses diclazuril granules and a preparation method thereof and belongs to the field of veterinary preparations. According to the diclazuril granules and the preparation method thereof, provided by the technical scheme of the invention, the diclazuril granules are prepared from diclazuril, a surfactant and a bonding agent; a diclazuril preparation which is stable and has good water solubility is obtained through treatment of a common micronization technology and a reasonable formula.

The invention discloses a young rabbit feed capable of preventing coccidiosis. The young rabbit feed capable of preventing coccidiosis is characterized by comprising the following raw materials in parts by weight: 300-350 parts of high-quality corns, 100-160 parts of wheat bran, 50-82 parts of bean pulp, 30-52 parts of fish meal, 20-28 parts of bone meal, 8-12 parts of calcium hydrophosphate, 8-11 parts of salt, 55-68 parts of grass meal, 6-9 parts of allicin and 0.5-1 part of diclazuril. The young rabbit feed disclosed by the invention is capable of greatly preventing coccidiosis while providing scientific nutrition for young rabbits.

The invention discloses an ELISA (enzyme linked immunosorbent assay) kit for detecting diclazuril, which comprises a kit body, wherein a diclazuril specific antibody, a conjugate and a conjugate reagent of diclazuril and carrier protein, an ELISA plate coated with a diclazuril antigen or specific antibody, a diclazuril standard solution, a substrate developing solution, a cleaning solution and a stop solution are arranged in the kit body; the diclazuril specific antibody is a diclazuril monoclonal antibody. In the diclazuril ELISA kit, main reagents are provided in the form of working solution, the use is convenient and the price is low; during the assay, the pretreatment requirement on a sample is low, the treatment process is simple, and a large batch of samples can be rapidly screened at the same time by the ELISA kit; compared with instrumental analysis techniques, the ELISA kit has the characteristics of high speed, great convenience, high accuracy, high sensitivity and the like.

The invention discloses a chemiluminescent enzyme-linked immunoassay detection kit for diclazuril. The kit comprises a kit body, an enzyme labeled plate arranged in the kit body and a reagent arranged in the kit body. The kit is characterized in that each hole in the enzyme labeled plate is coated with coating antigen, i.e., diclazuril mother nucleus, and a conjugate of carrier protein. The reagent comprises a diclazuril monoclonal antibody, a horseradish peroxidase-labeled goat anti-mouse antibody, a diclazuril-series standard solution, a concentrated phosphate buffer solution, a concentrated washing solution and a chemiluminescent solution. The chemiluminescent enzyme-linked immunoassay detection kit has the characteristics of high sensitivity, simplicity, rapidness, high accuracy and capacity of detecting a variety of medicines. Compared with traditional colorimetric ELISA methods, the kit provided by the invention enables operation time to be greatly reduced. The kit can be used for detecting residual diclazuril in aquatic products (e.g., fish flesh and shrimp flesh).

The invention discloses a concentrated feed for egg-laying hens which comprises the following constituents (by weight percent): soybean oil 0.8-1.2%, soybean waste powder 8-12%, short flour 8-9%, stone powder 25-30%, calcium hydrogen phosphate 30-34%, table salt 4-6%, lypressin 1.4-1.8%, methionine 2-4%, 50% choline chloride 1.5-2%, anti-oxidizing agent 0.1-0.2%, zinc bacitracin 0.3-0.6%, antibiotics 0.1-0.2%, Diclazuril 0.3-0.6%, sodium sulfate 4-6%, multivitamins 0.2-0.6%, multi-minerals 3-5%.

The invention discloses a Diclazuril effervescent tablet prepared with Diclazuril soluble power. The Diclazuril soluble power contains 1 to 5 portion of Diclazuril and 9 to 20 portion of polyvinylpyrrolidone by weight. The Diclazuril is diffused in the polyvinylpyrrolidone in form of molecules. The Diclazuril soluble power is mixed evenly with pharmaceutically acceptable disintegrant, pharmaceutically acceptable disintegrant and dispersant, and then is wetted by adhesive to produce granules, which are arranged and tabletted. Then the Diclazuril effervescent tablet is prepared. The Diclazuril soluble power of the invention has the advantages of high dissolution and high bioavailability. The effervescent tablet prepared in the method further improves the treating effects, and the effervescent tablet has the advantages of convenient transport and storage, no need of weighing and direct use, etc, thereby suitable for prevention of coccidiosis in peasant houses and livestock farms. So the invention has wide marketing prospects.

The present invention discloses an application of Rangoon creeper fruit in the preparation of medicine for remedying the coccidiosis in chicken. Compared with western medicines, the Rangoon creeper fruit has obvious effect for remedying the coccidiosis in chicken; the Western medicines of flavianic medicine, Diclazuril etc. have very good effect in the beginning of remedying the coccidiosis in chicken, but after a period of time, the chicken can have drug resistance, the dosage is required to be increased again and again; if the medicine dosage is not increased by degrees, the state of illness can repeat. In the treatment process, the Rangoon creeper fruit can remedy the coccidiosis in chicken effectively just by collocating the same dosage and concentration; at the same time, after the Rangoon creeper fruit is used for the prevention for chicklings, the chickens can not fall ill until being slaughtered to be sold, so that the application is proved to have good effect for preventing the coccidiosis in chicken.

The invention relates to a coccidiostat composition and making method in medicinal composition field, which comprises the following parts: 5-15% diclazuril, 0. 1-1% vitamin K3, 0. 5-2% mequindox and 35-45% findings to add purified water to 100%. The invention is characterized by the following: adopting modern micro emulsion technology to produce; improving bioavailability of diclazuril to a great extent; extending releasing drug time with good dispersity and stable thermodynamic property and facilitating to absorb because of low viscosity; solving faults of strong irritation and conspicuously bad medicinal crop of overusing organic solvent drug of traditional agent; improving body's resisting power to achieve expecting treating effect. The invention can be used for diseases raised through all kinds of coccidian because of low toxicity and high efficient, which can be water-based drinking and used conveniently.

The invention discloses a dissolving agent capable of dissolving diclazuril and ethopabate simultaneously and an anticoccidial medicinal composition. The dissolving agent consists of tetrahydrofuran and dimethylfomamide, and can be used for well dissolving diclazuril and ethopabate; and the production problem that diclazuril and ethopabate are dissoluble in water while an ordinary anticoccidial premixing agent is difficult to mix uniformly in a feed is solved. The anticoccidial medicinal composition prepared by using the dissolving agent contains high concentration diclazuril and ethopabate, and has low toxicity; a solution is stable in an environment of which the temperature is over 4 DEG C; crystal substances are precipitated out in a low-temperature environment; and crystal substances can be dissolved by heating to 65 DEG C and preserving heat for 15 minutes or heating to 25 DEG C and preserving heat for 80 minutes, and the solution becomes clear. Due to the adoption of the dissolving agent, diclazuril and ethopabate can be administrated effectively by drinking water; and the dissolving agent is simple, convenient and effective, and has a wide market prospect and high economic benefit.

The invention provides a high-stability diclazuril suspension and a preparation method thereof. The high-stability diclazuril suspension is prepared from, by weight, 10-20 parts of diclazuril slow-release particles, 3-5 parts of suspending agent, 1-3 parts of dispersing agent, 1-2 parts of defoamer, 1-3 parts of sodium chloride, 0.8-1.2 parts of antioxidant and 66.8-82.7 parts of water. The preparation method of the diclazuril slow-release particles includes the following steps that chitosan is dissolved in a 3wt% acetic acid water solution, a solution A is prepared, diclazuril is added into the solution A, and after the materials are stirred and mixed to be uniform, the diclazuril slow-release particles are prepared through spray drying. The high-stability diclazuril suspension has good low-temperature stability, is stable in performance after being stored for a year, and is conveniently put into use; the slow release effect is achieved, and irritation of medicine to animal stomachs and intestines is reduced.

The invention relates to a method for detecting the content of six anticoccidial drugs, namely clopidol, dinitolmide, nicarbazin, sulfaquinoxaline, chlorcucurbita hydrochloride and diclazuril in chicken feed, premix and feed additives. The method mainly comprises the following steps that: extraction isperformed with using 0.1% trichloroacetic acid acetonitrile; purification is performed with 50mg of PSA; redissolving is performed with methanol and a 5mmol/L ammonium acetate aqueous solution in a volume ratio of 8: 2 as a redissolving solution; and an Agilent Extend-C18 (250 mm * 4.6 mm i. D., 5 [mu] m) chromatographic column is used as an analytical column, 270 nm and 340 nm wavelengths are selected, the sample size is 20 [mu] L, the column temperature is 25 DEG C, and an Agilent 1260 high performance liquid chromatography system (Agilent, DAD) is used for analysis. The invention aims to establish a novel, simple and convenient analysis method for rapidly determining various anticoccidial drugs in chicken feed, premix and feed additive by a high performance liquid chromatography detection method with good repeatability. The method is simple and convenient to operate and good in repeatability, and saves time and cost.

The invention discloses a preparation method and application of a triazine anticoccidial medicinal composite molecularly imprinted polymer, and belongs to the technical field of molecular imprinting. The method comprises following steps: preparing a DIC (Diclazuril)-TOL (Toltrazuril) composite molecularly imprinted polymer by taking DIC as a template molecule I, taking TOL as a template molecule II, taking tetrahydrofuran as a pore-foaming agent, taking methacrylic acid (MAA) as a functional monomer, taking pentaerythritol triacrylate (PETA) as a cross-linking agent and taking azodiisobutyronitrile (AIBN) as an initiator; and mixing the imprinted polymer with diatomaceous earth at equal mass to obtain solid-phase extraction column filler which has high recognition capability specific to the DIC and the TOL. Through adoption of the method, the technical problem that a conventional molecular imprinting technology can only be applied to solid-phase extraction column preparation of a single target compound but cannot be applied to separate solid-phase extraction column preparation of various compounds is solved.

The invention provides a diclazuril-resistant specific monoclonal antibody hybridoma cell strain and applications of the diclazuril-resistant specific monoclonal antibody hybridoma cell strain, and belongs to the technical field of food safety immunological detection. The diclazuril-resistant specific monoclonal antibody hybridoma cell strain SS0711 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and is assigned with the accession number of CGMCC No.14689. The diclazuril-resistant specific monoclonal antibody is secreted by the diclazuril-resistant specificmonoclonal antibody hybridoma cell strain SS0711 with the accession number of CGMCC No.14689. The diclazuril-resistant specific monoclonal antibody hybridoma cell strain is applied to the analysis and detection for diclazuril residue in food safety detection. The obtained diclazuril-resistant monoclonal antibody cell strain has the good detection sensitivity and affinity for diclazuril, for the monoclonal antibody provided by the invention, the IC50=0.49ng/mL, the detection linear range is 0.16-1.55 ng/mL, and the lowest detection limit value (LOD) is 0.08ng/mL.

A slowly-releasing medicine in the form of powder or injection for preventing and treating the coccidiosis and bacilly dysentery of piglet and rabbit is prepared from diclazuril, norfloxacin or cinrofloxacin, and beta-cyclodextrin through dissolving diclazuril in solvent, grinding beta-cylodextrin in distilled water, mixing them together, stirring, adding the solution of norfloxacin or cinrofloxacin, stirring, drying and pulverizing.

The invention discloses a preparation method of an edible feed for growing rex rabbits and belongs to the field of feeds. The product is prepared from raw materials of garlic, soybean meal, barley, corn, wheat bran, dry peanut vine, shell powder, salt, arginine, lysine, cysteine, oligosaccharide, diclazuril, an enzyme preparation and probiotics, has advantages of rich nutrients, good palatability and high feed utilization rate. After eating the product, rex rabbits grow rapidly and have good fur quality, high yield of meat and strong disease resistance. The feed provided by the invention is a feed special for growing rex rabbits.

The invention provides a weaned young rabbit breeding method. The weaned young rabbit breeding method comprises the following steps: adding 5% milk powder into feed for a weaned young rabbit segmentally; adding a rabbit vibrio eliminating medicine into water or the feed to prevent enteritis of the young rabbit; injecting rabbit plague vaccine to prevent rabbit plague of the young rabbit; and adding sulfamide coccidian and diclazuril into the feed or water to prevent and control coccidiosis of the young rabbit. According to the weaned young rabbit breeding method, through comprehensive utilization of determination on a young rabbit weaning standard, feed control and management, and segmental prevention of the enteritis, the rabbit plague and the coccidiosis, the normal growth and development of the weaned young rabbit can be ensured, the survival rate of the young rabbits is increased from 65% to 95%, the young rabbits grow rapidly and can be slaughtered earlier, and the meat quality and the fur quality are high; therefore, the weaned young rabbit breeding method is applicable to breeding rabbits.

The invention discloses a composition with the effects of repelling and killing parasites. According to the composition, the effective components comprise albendazole, ivermectin and diclazuril. The composition has the advantages that the parasites can be efficiently and comprehensively repelled; a slow release effect is achieved, chemicals can be enabled to be released only after reaching intestinal tracts, and therefore the use of the chemicals can be greatly reduced; the application range is wide, the composition can be mixed with water according to any ratio, the suspension effect is good,suspension for a long time can be realized, and herbivore such as horses, cows and sheep can be fed with the composition more conveniently and efficiently; and the uniformity is high, and the problemof non-uniform mixing can be basically solved.