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Diclazuril derivative and application thereof and fungicide containing derivative

A derivative, clazuril technology, applied in the field of pesticides, can solve the problem of unclear action mechanism of diclazuril, etc.

Active Publication Date: 2019-08-30
HUAZHONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The current mechanism of action of diclazuril is not yet clear, and the current research on its mechanism of action is only based on the cellular and subcellular levels

Method used

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  • Diclazuril derivative and application thereof and fungicide containing derivative
  • Diclazuril derivative and application thereof and fungicide containing derivative
  • Diclazuril derivative and application thereof and fungicide containing derivative

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0050] Specific embodiment 1: In formula (1) and formula (2),

[0051] R 11 And R 12 Respectively selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, methoxy, ethoxy, n-propoxy, isopropoxy, n Butoxy, isobutoxy, tert-butoxy, fluorine, chlorine, bromine, nitro, cyano, monobromomethyl, monochloromethyl, monofluoromethyl, trifluoromethyl and trifluoromethyl Fluoromethoxy;

[0052] R 21 , R 22 , R 23 And R 24 Respectively selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, methoxy, ethoxy, n-propoxy, isopropoxy, n Butoxy, isobutoxy, tert-butoxy, fluorine, chlorine and bromine;

[0053] R 3 Selected from H, C 1-4 The alkyl group, C 1-4 The halogenated alkyl group, C 1-4 的alkoxy, C 1-4 The halogenated alkoxy group, C 1-4 的alkylthio, C 1-4 At least one of halogenated alkylthio, nitro, cyano and halogen; and when R 11 , R 21 And R 24 For H, R 22 And R 23 When Cl and W is O; R 3 Not 4-Cl or 4-OCH 3 .

specific Embodiment approach 2

[0054] Embodiment 2: In formula (1) and formula (2),

[0055] R 11 And R 12 Respectively selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, methoxy, ethoxy, n-propoxy, isopropoxy, n Butoxy, isobutoxy, tert-butoxy, fluorine, chlorine, bromine, trifluoromethyl and trifluoromethoxy;

[0056] R 21 , R 22 , R 23 And R 24 Respectively selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl and chlorine;

[0057] R 3 Selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butyl Oxy, isobutoxy, tert-butoxy, methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, isobutylthio, tert-butylthio, nitro, cyano At least one of radical and halogen; and

[0058] When R 11 , R 21 And R 24 For H, R 22 And R 23 When Cl and W is O; R 3 Not 4-Cl or 4-OCH 3 .

specific Embodiment approach 3

[0059] Specific embodiment 3: In formula (1) and formula (2),

[0060] R 11 And R 12 Respectively selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl and trifluoromethyl;

[0061] R 21 , R 22 , R 23 And R 24 Respectively selected from H, methyl, ethyl, n-propyl, isopropyl and chlorine;

[0062] R 3 Selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butyl Oxy, isobutoxy, tert-butoxy, methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, isobutylthio, tert-butylthio, nitro, cyano At least one of radical and halogen; and

[0063] When R 11 , R 21 And R 24 For H, R 22 And R 23 When Cl and W is O; R 3 Not 4-Cl or 4-OCH 3 .

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Abstract

The invention relates to the field of pesticides, and discloses a diclazuril derivative and an application thereof and a fungicide containing the derivative. The derivative has a structure representedby a formula (1) or formula (2). The provided diclazuril derivative can be applied as a mitochondrial succinate dehydrogenase inhibitor, and has an action against plant fungal diseases, and more specifically, the diclazuril derivative can be used for prevention and treatment of rice sheath blight, cucumber gray mold, cucumber downy mildew, cucumber powdery mildew and the like.

Description

[0001] This application is a divisional application of the Chinese invention patent application with the filing date of June 2, 2016, the application number of 201610387500.4, and the title of "Diclazuril derivatives and their applications and fungicides containing the derivatives". Technical field [0002] The present invention relates to the field of pesticides, in particular, to a diclazuril derivative, the application of diclazuril derivative as a mitochondrial succinate dehydrogenase inhibitor, and the use of diclazuril derivative in anti-fungal diseases of plants Application and a fungicide used to fight plant fungal diseases. Background technique [0003] In 2012, global sales of fungicides accounted for 26.3% of global pesticide sales, reaching 14.01 billion US dollars. Among them, the growth rate of fungicides targeting succinate dehydrogenase reached 20% in 2012, which was the fastest growth rate. The first category of fungicides accounted for 5.4% of the total market sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/54C07D239/553A01N43/54A01P3/00
CPCA01N43/54C07D239/54C07D239/553
Inventor 杨光富熊力
Owner HUAZHONG NORMAL UNIV
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