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Anticoccidiosis nano suspension and preparation method thereof

A nano-suspension, anti-coccidial technology, applied in the directions of medical preparations, pharmaceutical formulations, anti-infectives, etc. containing active ingredients, to achieve the effects of improving bioavailability, prolonging residence time, and simple process

Inactive Publication Date: 2011-04-06
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The object of the present invention is to provide a kind of nanosuspension containing diclazuril, maduramycin ammonium, sulfachlorpyrazine sodium and preparation method thereof, to solve its convenient administration, reduce waste and ensure dosage

Method used

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  • Anticoccidiosis nano suspension and preparation method thereof
  • Anticoccidiosis nano suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The prescription of diclazuril, maduramycin ammonium, sulfachlorpyrazine sodium nanosuspension:

[0037] components

Dosage

Diclazuril

0.5% (W / V)

Ammonium Maduramycin

2.0% (W / V)

Sodium sulfachlorpyrazine

5.0% (W / V)

Polysorbate-80

1.0% (V / V)

polyethylene glycol-400

0.5% (V / V)

Sodium carboxymethyl cellulose

0.5% (W / V)

Anhydrous sodium sulfite

0.1% (W / V)

sodium bicitrate

0.05% (W / V)

Dimethylacetamide

5% (V / V)

purified water

30% (V / V)

ethanol

Add to 100.0%

[0038] The preparation method of diclazuril, maduramycin ammonium, sulfachlorpyrazine sodium composite nanosuspension:

[0039] (1) First dissolve sodium bicitrate and anhydrous sodium sulfite into a small amount of purified water, stir and dissolve to obtain solution A.

[0040] (2) Diclazuril was added into dimethylacetamide to fully dissolve, then ammonium maduramycin w...

Embodiment 2

[0047] The prescription of diclazuril, maduramycin ammonium, sulfachlorpyrazine sodium nanosuspension:

[0048] components

Dosage

Diclazuril

0.5% (W / V)

Ammonium Maduramycin

2.0% (W / V)

Sodium sulfachlorpyrazine

5.0% (W / V)

Glycerol formal

10.0% (V / V)

Sodium carboxymethyl cellulose

0.5% (W / V)

Anhydrous sodium sulfite

0.1% (W / V)

sodium bicitrate

2.0% (W / V)

Dimethylacetamide

5% (V / V)

purified water

30% (V / V)

Propylene Glycol

Add to 100.0%

[0049] The preparation method of diclazuril, maduramycin ammonium, sulfachlorpyrazine sodium composite nanosuspension:

[0050] (1) First dissolve sodium bicitrate and anhydrous sodium sulfite into a small amount of purified water, stir and dissolve to obtain solution A.

[0051] (2) Diclazuril was added into dimethylacetamide to fully dissolve, then ammonium maduramycin was added to completely dissolve and stirred ev...

Embodiment 3

[0057] Example 3, clinical efficacy test of diclazuril, maduramycin ammonium, and sulfachlorpyrazine sodium composite nanosuspension

[0058] In order to verify the efficacy of the compound nanosuspension of diclazuril, maduramycin ammonium and sulfachlorpyrazine sodium, a laboratory efficacy verification test was carried out. Using AA broiler chickens, when they were raised to 11 days old, they were inoculated with 100,000 sporulated oocysts of Eimeria tenella by artificial crop infection, and the anti-coccidia effect of the compound nanosuspension was determined, and Group A: diclazuril solution (5mg / ml); group B: diclazuril, maduramycin ammonium solution (containing diclazuril diclazuril: 5mg / ml; maduramycin ammonium: 30mg / ml); C group: 10% sulfachlorpyrazine sodium soluble powder is used as contrast drug. The test results are as follows:

[0059] Table 1: Experimental results of diclazuril, maduramycin ammonium, and sulfachlorpyrazine sodium nanosuspensions

[0060] ...

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Abstract

The invention relates to nano suspension containing Diclazuril, Maduramycin ammonium and sulfachloropyrazine sodium and preparation method thereof. The nano suspension of the invention is taken with drinking water, and after being diluted, the primary suspension can dissolve in water uniformly to form clear and stable solution; besides the sulfachloropyrazine sodium, the Diclazuril and Maduramycin ammonium, which are difficult to dissolve, can dissolve in the drinking water completely to form a clear, uniform and stable solution system. The suspension has the characteristics of allowing for convenient administration, reducing waste, ensuring dose, improving medicine availability, avoiding blocking a drinker and the like. The Diclazuril, Maduramycin ammonium and sulfachloropyrazine sodium cooperate to produce a synergistic effect in treating coccidiosis in chicken, so that the suspension has a scores of times higher anticoccidiosis effect than common anticoccidiosis medicines.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to an anticoccidial nano-suspension containing diclazuril, maduramycin and sodium sulfachlorpyrazine and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a chicken parasitic disease caused by Eimeria coccidiosis, and the morbidity rate of chicks aged 5-30 days is as high as more than 80%, and the mortality rate is as high as 30%. It is currently the most harmful parasitic disease to the poultry industry. One of the immune characteristics of parasites is "immunity with worms". After the coccidia sneak into the body, the growth period is 2 days of asexual reproduction and 5 days of sexual reproduction. Within 7 days, an invading oocyst can multiply into 250,000 oocysts, which is harmful to the body. The disease mostly occurred in spring and autumn in the past. With the development of chicken industry, hatching has changed fr...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/53A61K31/635A61K9/10A61J3/00A61P33/00
Inventor 聂丽娜
Owner TIANJIN RINGPU BIO TECH
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