Diclazuril granules and preparation method thereof

A technology of diclazuril and granules, applied in the directions of pharmaceutical formulations, inactive medical preparations, anti-infectives, etc., can solve the problems of difficulty in diclazuril, application limitation, influence on absorption and convenience, etc. achieve good water solubility

Inactive Publication Date: 2017-02-08
朱隆娅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing diclazuril preparations have the following defects. Since diclazuril is insoluble in water, it cannot be used after water dissolution, which affects its absorption and convenience after use, and limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Diclazuril 2g, sodium dodecylbenzene sulfonate 1g, microcrystalline cellulose 10g, lactose supplement. Prepare as follows:

[0022] In the first step, the raw material diclazuril and sodium dodecylbenzenesulfonate are micronized by a jet mill to obtain a co-micronized material, and the particle size D90 after micronization is between 5 and 10 μm, which is then used for later use;

[0023] The second step is to weigh the prescribed amount of microcrystalline cellulose and add it to an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0024] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust...

Embodiment 2

[0026] Diclazuril 2g, sodium dodecylbenzene sulfonate 10g, sodium carboxymethyl cellulose 1g, soluble starch to make up. Prepare as follows:

[0027] In the first step, the raw material diclazuril and sodium dodecylbenzenesulfonate are micronized by a jet mill to obtain a co-micronized material, and the particle size D90 after micronization is between 5 and 10 μm, which is then used for later use;

[0028] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0029] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second ste...

Embodiment 3

[0031] Diclazuril 2g, sodium dodecylbenzene sulfonate 8g, polyvinyl alcohol 2g, lactose supplement. Prepare as follows:

[0032] In the first step, the raw material diclazuril and sodium dodecylbenzenesulfonate are micronized by a jet mill to obtain a co-micronized material, and the particle size D90 after micronization is between 5 and 10 μm, which is then used for later use;

[0033] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0034] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid ...

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Abstract

The invention discloses diclazuril granules and a preparation method thereof and belongs to the field of veterinary preparations. According to the diclazuril granules and the preparation method thereof, provided by the technical scheme of the invention, the diclazuril granules are prepared from diclazuril, a surfactant and a bonding agent; a diclazuril preparation which is stable and has good water solubility is obtained through treatment of a common micronization technology and a reasonable formula.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a diclazuril granule and a preparation method thereof. Background technique [0002] Diclazuril is a triazine benzyl nitrile compound, which is a new type, high efficiency and low toxicity anticoccidial drug, widely used in chicken coccidiosis. The mechanism of action of diclazuril against coccidia is still unclear. The peak period of the main action on coccidia varies with different species of coccidia, such as the main action point on Eimeria tenella is in the sexual cycle of the second generation schizont coccidia. However, it is not effective against giant Eimeria brucei schizonts. The point of action on Eimeria maxima is at the zygote stage of Eimeria brucei; it is highly effective on the microgametophyte stage of Eimeria brucei. Diclozolid also inhibited the formation of sporulated oocysts. [0003] Diclazuril has an excellent effect on chicken tenderness, he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/53A61K47/38A61K47/26A61K47/20A61K47/36A61K47/32A61P33/02
CPCA61K31/53A61K9/1617A61K9/1635A61K9/1652A61K9/1694
Inventor 朱隆娅
Owner 朱隆娅
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