Enramycin granules and preparation method thereof

A technology of enramycin and granules, which is applied in the field of enramycin granules and its preparation, can solve the problems of enramycin difficulty, application limitation, influence on absorption and convenience, etc., and achieve the effect of good water solubility

Inactive Publication Date: 2017-02-08
朱隆娅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Enramycin is insoluble in water and cannot be used after being dissolved in water, which affects its absorption and convenience after use, and limits its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Enramycin 4g, sodium dodecylbenzene sulfonate 1g, microcrystalline cellulose 10g, lactose 85g. Prepare as follows:

[0021] In the first step, use a jet mill to micronize the raw material drug enramycin and sodium dodecylbenzenesulfonate to obtain co-micronized materials, the particle size D90 after micronization is between 5 and 10 μm, and set aside;

[0022] The second step is to weigh the prescribed amount of microcrystalline cellulose and add it to an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0023] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inlet speed, atom...

Embodiment 2

[0025] Enramycin 4g, sodium dodecylbenzenesulfonate 10g, sodium carboxymethylcellulose 1g, soluble starch 85g. Prepare as follows:

[0026] In the first step, use a jet mill to micronize the raw material drug enramycin and sodium dodecylbenzenesulfonate to obtain co-micronized materials, the particle size D90 after micronization is between 5 and 10 μm, and set aside;

[0027] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0028] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inlet spee...

Embodiment 3

[0030] Enramycin 4g, sodium dodecylbenzene sulfonate 8g, polyvinyl alcohol 2g, lactose 86g. Prepare as follows:

[0031] In the first step, use a jet mill to micronize the raw material drug enramycin and sodium dodecylbenzenesulfonate to obtain co-micronized materials, the particle size D90 after micronization is between 5 and 10 μm, and set aside;

[0032] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0033] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inlet speed, atomization pres...

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Abstract

The invention discloses enramycin granules and a preparation method thereof, belonging to the field of veterinary medicine preparations. The technical scheme is as follows: the enramycin granules are composed of enramycin, a surfactant and an adhesive; and the enramycin granules are a stable high-water-solubility enramycin preparation obtained by a co-micronization technique according to the reasonable formula.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to an enramycin granule and a preparation method thereof. Background technique [0002] Enramycin (enramycin) is fermented by actinomyces (Streptomyces fungicidicus). It is a polypeptide antibiotic combined with unsaturated fatty acids and more than a dozen amino acids. The main components are enramycin A and B. It is white or Slightly yellowish white powder (the crude product is gray or taupe powder with special odor). Decompose at 234~238℃, easily soluble in dilute hydrochloric acid, slightly soluble in water, methanol, ethanol, etc. [0003] Enramycin has strong activity against Gram-positive bacteria, especially against harmful Clostridium in the intestine. It is not easy to produce drug resistance after long-term use, and has the effect of changing the bacterial population in the intestinal tract. Long-term use of livestock and poultry can promote weigh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/20A61K38/10A61P31/04
CPCA61K38/10A61K9/1617A61K9/1694
Inventor 朱隆娅
Owner 朱隆娅
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