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Adprin granule and preparation method thereof

A technology of granules and furoline, applied in the field of adefuroline granules and the preparation thereof, can solve the problems of difficulty, inability to use, influence absorption and convenience of adefuroline, and achieve the effect of good water solubility

Inactive Publication Date: 2017-01-04
朱隆娅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Adefurin is insoluble in water and cannot be used after being dissolved in water, which will affect its absorption and convenience after use, and limit its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Adfurfural 5g, sodium dodecylbenzene sulfonate 1g, microcrystalline cellulose 10g, lactose supplement. Prepare as follows:

[0020] In the first step, use a jet mill to micronize the raw material adfuroline and sodium dodecylbenzenesulfonate to obtain a co-micronized material, the particle size D90 after micronization is between 5 and 10 μm, and set aside;

[0021] The second step is to weigh the prescribed amount of microcrystalline cellulose and add it to an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0022] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inlet speed,...

Embodiment 2

[0024] Adefurin 5g, sodium dodecylbenzene sulfonate 10g, sodium carboxymethylcellulose 1g, soluble starch to make up. Prepare as follows:

[0025] In the first step, use a jet mill to micronize the raw material adfuroline and sodium dodecylbenzenesulfonate to obtain a co-micronized material, the particle size D90 after micronization is between 5 and 10 μm, and set aside;

[0026] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0027] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inlet ...

Embodiment 3

[0029] Adefurin 5g, sodium dodecylbenzene sulfonate 8g, polyvinyl alcohol 5g, lactose supplement. Prepare as follows:

[0030] In the first step, use a jet mill to micronize the raw material adfuroline and sodium dodecylbenzenesulfonate to obtain a co-micronized material, the particle size D90 after micronization is between 5 and 10 μm, and set aside;

[0031] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0032] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inlet speed, atomization p...

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PUM

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Abstract

The invention discloses an adprin granule and a preparation method thereof, and belongs to the field of veterinary preparations. According to a technical scheme provided by the invention, the adprin granule is composed of adprin, surfactant and adhesive. The adprin preparation with favorable stability and water solubility is prepared by performing co-micronization technical treatment and adopting the reasonable formula.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to adfuroline granules and a preparation method thereof. Background technique [0002] Adefurin is a new generation of chemically synthesized anticoccidial drugs. Its main structure is different from other anticoccidial drugs, and it has no cross-resistance with other anticoccidial drugs. Laboratory studies have confirmed that adefurin has broad-spectrum anticoccidial activity, and has inhibitory and killing effects on various small intestinal coccidia. It is a highly efficient, broad-spectrum, and low-toxic anticoccidial drug. [0003] Adefurin is insoluble in water and cannot be used after being dissolved in water, which affects its absorption and convenience after use and limits its application. Contents of the invention [0004] In order to overcome the deficiencies of the prior art, the invention provides a defurfural granule. [0005] To achieve the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/52A61K47/20A61P33/02
CPCA61K9/1617A61K9/0095A61K9/1635A61K31/52
Inventor 朱隆娅
Owner 朱隆娅
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