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Decoquinate granules and preparation method thereof

A technology of decoquinate and granules, which is applied in the field of decoquinate granules and its preparation, can solve the problems of insufficient stability and solubility, and achieve good water solubility

Inactive Publication Date: 2018-04-24
朱隆娅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of them have the defects of insufficient solubility or insufficient stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Decyloxyquinate 6g, sodium dodecylbenzenesulfonate 1g, microcrystalline cellulose 10g, lactose supplement. Prepare as follows:

[0019] In the first step, use a jet mill to micronize the raw material decoquinate and sodium dodecylbenzenesulfonate to obtain a co-micronized material, the particle size D90 of which is between 5 and 10 μm after micronization, and set aside for use;

[0020] The second step is to weigh the prescribed amount of microcrystalline cellulose and add it to an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0021] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust t...

Embodiment 2

[0023] Decoxyquinate 6g, sodium dodecylbenzene sulfonate 10g, sodium carboxymethylcellulose 1g, soluble starch to make up. Prepare as follows:

[0024] In the first step, use a jet mill to micronize the raw material decoquinate and sodium dodecylbenzenesulfonate to obtain a co-micronized material, the particle size D90 of which is between 5 and 10 μm after micronization, and set aside for use;

[0025] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0026] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, a...

Embodiment 3

[0028] Decoxyquinate 6g, sodium dodecylbenzenesulfonate 8g, polyvinyl alcohol 6g, lactose supplement. Prepare as follows:

[0029] In the first step, use a jet mill to micronize the raw material decoquinate and sodium dodecylbenzenesulfonate to obtain a co-micronized material, the particle size D90 of which is between 5 and 10 μm after micronization, and set aside for use;

[0030] In the second step, weigh the prescription amount of sodium carboxymethyl cellulose and add an appropriate amount of purified water, stir and dissolve until the mixture is uniform, and set aside;

[0031] The third step is to weigh other excipients according to the prescription amount, put the other excipients and the co-micronized material prepared in the first step into the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in the fluidized state, and turn on the spray button , spray the adhesive solution prepared in the second step, adjust the liquid inle...

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Abstract

The invention discloses decoquinate granules and a preparation method thereof, and belongs to the field of veterinary preparations. According to the technical scheme, the decoquinate granules and thepreparation method thereof are provided, wherein the decoquinate granules consist of decoquinate, a surfactant and a binding agent. A decoquinate preparation, which is stable and good in water solubility, is prepared by conducting processing by virtue of a co-micronization technique and on the basis of a reasonable formula.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a decoquinate granule and a preparation method thereof. Background technique [0002] Decoxyquinate is a white or off-white crystalline powder, slightly soluble in ethanol, insoluble in water, and can play a role in the asexual reproduction stage of coccidia. After entering the coccidia spore cells, it prevents its development by interfering with DNA synthesis. It works early in the worm's life cycle to avoid damage to the poultry gut. However, decoquinate is expensive, insoluble in water, and very inconvenient to use; moreover, the drug effect also has a great relationship with the particle size of the additive. Today, as the feed industry is becoming more and more meager, it is difficult to promote its use in feed. Although several factories in China have synthesized decoquinate API, its price still prevents it from being widely added in feed. At prese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/47A61K47/20A61P33/02
CPCA61K31/47A61K9/1617
Inventor 朱隆娅
Owner 朱隆娅
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