4 results about "Decoquinate" patented technology

The invention relates to the technical field of anticoccidial drugs, in particular to a decoquinate-embedded composite preparation and a preparation method thereof. The decoquinate-embedded composite preparation is prepared from the following raw materials in parts by mass: 15 to 35 parts of decoquinate, 5 to 15 parts of organic carrier, 5 to 10 parts of maltodextrin, 0.01 to 0.1 part of beta-CGTase enzyme preparation, 0.01 to 0.1 part of lanthanum chloride, 1 to 3 parts of branched polylysine, 0.01 to 0.1 part of ammonium persulfate, 1 to 3 parts of sodium trimetaphosphate, 20 to 60 parts of glucose and 1 to 8 parts of surfactant, wherein the enzyme activity of the beta-CGTase enzyme preparation is 3000 to 8000 U / g. After decoquinate is loaded twice, the utilization rate of effective components in the medicine is effectively increased, the medicine stability is extremely high, the anti-coccidiosis effect is better than that of a common preparation, meanwhile, the preparation technology is simple and easy to implement, and large-scale production is easy to achieve.

The invention discloses a decoquinate hapten as well as synthesis and application thereof. The structure of the decoquinate hapten is shown as a formula I. Compared with 3-6 carbon chains, the synthetic method of the decoquinate hapten provided by the invention has the characteristics of mild reaction conditions, high yield, few reaction steps and capability of reducing the cost of raw materials. The decoquinate colloidal gold detection product prepared from the decoquinate complete antigen provided by the invention has the characteristics of strong specificity, high sensitivity and the like, can realize accurate detection of decoquinate in a sample, and has no cross reaction with other drugs. # imgabs0 #

The invention relates to a suspension type nano decoquinate premixing agent which is mainly prepared from the following raw materials in parts by weight: 5-15 parts of decoquinate, 15-25 parts of an antioxidant, 5-10 parts of a plasticizer, 2-8 parts of a nucleation inhibitor and 45-70 parts of a carrier material. The defects that decoquinate is difficult to take, poor in palatability, poor in mixing uniformity, difficult to absorb during oral administration, poor in bioavailability and the like are effectively overcome. The suspension type nano decoquinate preparation is prepared through a solid dispersion technology, the taste is masked, the dissolution rate of decoquinate is also possibly improved, the problem that the administration mode is single is solved, nano-scale molecules are prepared through the technology, the oral absorption rate is increased, the effect is quickly achieved, and the bioavailability is improved. And the method has obvious practical value.

This invention provides a water-soluble toltrazuril solid powder, its preparation method, and its application. The water-soluble toltrazuril solid powder is a solid adsorption complex formed by toltrazuril and an adsorption ligand under alkaline conditions. The adsorption ligand is any one of tris(hydroxymethyl)aminomethane, tetrabutylammonium bisulfate, dodecyltrimethylammonium chloride, and N-ethylpiperazine. The molar ratio of toltrazuril to the adsorption ligand in the solid powder is 1:(1.1-1.3). It can dissolve rapidly without stirring under still drinking water conditions, and no drug precipitation occurs after long-term storage after dilution, thus meeting the needs of the aquaculture and pet breeding industries for convenient, stable, and efficient anticoccidial administration programs.