7 results about "Toltrazuril" patented technology

The invention discloses a composition for improving disease resistance of bred animals and a preparation method thereof, the composition comprises 5-15 parts by weight of toltrazuril, 0.5-1.5 parts by weight of a suspending aid, 1.5-2 parts by weight of a surfactant, 0.1-0.5 part by weight of an antioxidant, 5-10 parts by weight of plant polysaccharide, 20-35 parts by weight of dandelion, 10-25 parts by weight of purslane and 10-15 parts by weight of radix stemonae. The health-care food is prepared from, by weight, 10-20 parts of honeysuckle flowers, 1-2 parts of multivitamins, 1-2 parts of mineral substances and 1-5 parts of amino acid. The traditional Chinese medicine composition is prepared by scientific compatibility and reasonable collocation of various components. The toltrazuril component can effectively prevent the harm of coccidiosis to feed animals, not only can enhance the immunity of the fed animals, but also can promote the growth of the fed animals, saves resources, is easy to control, and is suitable for mass production.

The invention discloses a toltrazuril nano suspension and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The suspension contains toltrazuril, an iron compound, a bacteriostatic agent, a suspending aid, a stabilizer and the balance of water. According to the invention, an ultrahigh-pressure nano homogenizer technology is adopted, the medicine is prepared into a nano-scale particle size, and the medicine is uniformly dispersed in the preparation, so that the medicine has good stability and dispersibility. The preparation not only can be used for effectively preventing and treating animal coccidiosis, but also can improve animal anemia, and has a wide clinical application prospect.

The invention belongs to the technical field of toltrazuril suspension, and discloses toltrazuril suspension as well as a preparation method and application thereof, the toltrazuril suspension comprises the following components: toltrazuril, an emulsifier, a wetting agent, a suspending aid, a defoaming agent and a dispersion medium, the defoaming agent contains dimeticone and silicon dioxide, and has the following beneficial effects that the silicon dioxide of the defoaming agent has relatively large specific surface area and adsorbability and can be adsorbed on the surfaces of toltrazuril particles, so that the repulsive force among the particles is increased, the particles are not agglomerated, the particle size is relatively uniform, and the defoaming agent has a good defoaming effect on the toltrazuril particles. The toltrazuril suspension is excellent in stability in the storage, transportation and use processes; and the defoaming agent contains dimeticone and silicon dioxide, so that the emulsifier can form a complete water phase-oil phase interfacial film, the interfacial film is high in strength, high in toughness and compact in structure, and the obtained toltrazuril suspension has good water-oil amphiphilic characteristics.

A method for synthesizing a stable isotope-labeled toltrazuril-D3 belongs to the field of organic synthesis technology. This method uses methylamine hydrochloride-D3 as the stable isotope labeling source, reacting it with p-trifluoromethylthiophenol and 1-chloro-2-methyl-5-nitrobenzene as starting materials, undergoing sequential condensation and reduction to obtain an aminodiphenyl ether intermediate. Simultaneously, methylamine hydrochloride-D3 reacts with sodium cyanate to generate methylurea-D3, which then reacts with carbonyl diimidazole to obtain an activated intermediate. Finally, the aminodiphenyl ether intermediate condenses with the activated intermediate, followed by base-catalyzed cyclization to obtain the target product, toltrazuril-D3. This invention features a rationally designed synthetic route, readily available raw materials, mild reaction conditions, simple operation, and easy product separation and purification. The obtained product achieves a chemical purity and isotope abundance of over 99%.

The utility model provides an efficient detection kit for toltrazuril in pork, which relates to the technical field of pork quality inspection, and comprises a kit main body and a moisture-proof chassis, detection round bins are distributed on the top surface of the kit main body in a linear array manner, one side of the top surface of each detection round bin is hinged with an observation window, a reagent pipeline is connected between adjacent liquid injection pipelines, and the reagent pipelines are connected with the moisture-proof chassis. By designing a plurality of detection round bins and corresponding sample injection ports, simultaneous detection of multiple samples is realized, the parallel detection mode greatly improves the detection efficiency, reduces the time consumption of one-by-one detection of single samples in a traditional detection method, and simplifies the operation process; according to the invention, a plurality of samples can be subjected to reagent injection and reaction through the same system, the operation process is simplified, manual operation steps are reduced, and the detection fluency and efficiency are improved.

The application provides a synthesis method of tolfenpyrad, and belongs to the technical field of medicine synthesis. Methylamine aqueous solution is used for synthesizing methylaminoformic acid ethyl ester with diethyl carbonate. N-[3-methyl-4-(4-trifluoromethylsulfanyl-phenoxy)-phenyl]-urea (arylurea) is used as a starting material to react with the obtained methylaminoformic acid ethyl ester under the action of a catalyst to synthesize biuret. The biuret is subjected to ring closing with diethyl carbonate to generate tolfenpyrad. The synthesis method does not need to use phosgene, is simple to operate, raw materials are easy to obtain, cost is low, and the yield is high.

This invention provides a water-soluble toltrazuril solid powder, its preparation method, and its application. The water-soluble toltrazuril solid powder is a solid adsorption complex formed by toltrazuril and an adsorption ligand under alkaline conditions. The adsorption ligand is any one of tris(hydroxymethyl)aminomethane, tetrabutylammonium bisulfate, dodecyltrimethylammonium chloride, and N-ethylpiperazine. The molar ratio of toltrazuril to the adsorption ligand in the solid powder is 1:(1.1-1.3). It can dissolve rapidly without stirring under still drinking water conditions, and no drug precipitation occurs after long-term storage after dilution, thus meeting the needs of the aquaculture and pet breeding industries for convenient, stable, and efficient anticoccidial administration programs.