58 results about "Chemical purity" patented technology

The invention belongs to the field of medical isotope separation and preparation, and particularly relates to a method for separating and purifying < 212 > Pb from a thorium solution, which comprises the following steps: 1) leacheate is introduced into a Pb selective adsorption column to pretreat the Pb selective adsorption column, and then < 232 > Th salt solution and leacheate are introduced in sequence; 2) continuously introducing a desorption solution into the Pb selective adsorption column, enabling the desorption solution passing through the Pb selective adsorption column to flow into the Th selective adsorption column, and collecting the outflowing desorption solution; a desorption solution only containing 212Pb is obtained; according to the method, the 212Pb in the high-concentration thorium solution can be separated and purified at the same time. While < 232 > Th impurity entrainment and pollution in a < 212 > Pb product are remarkably reduced, compared with a single-column process, the separation time is basically not increased. The separated 212Pb product has high radionuclide purity and chemical purity at the same time, and can meet related pharmaceutical requirements.

The present invention relates to tungsten(VI) oxytetrachloride, which is notable for its particular chemical purity, and also to a method for its production.

The invention provides a fluorination method of a PSMA radiopharmaceutical intermediate, and further provides a preparation method of an Al18F-labeled PSMA radiopharmaceutical preparation based on the fluorination method, and the fluorination method and the preparation method have the advantages that through adjustment of a reaction system, the purity of the PSMA radiopharmaceutical intermediate is improved, and the purity of the PSMA radiopharmaceutical preparation is improved. The preparation method of the PSMA radiopharmaceutical preparation marked by the Al18F has the advantages that marking time efficiency, radiochemical purity of a final product, radiochemical conversion rate and product yield are guaranteed, requirements on fluorination reaction temperature in a marking process are effectively lowered, and the preparation method of the PSMA radiopharmaceutical preparation marked by the Al18F based on the fluorination method is good in applicability, thorough in reaction and high in yield. New impurities are not introduced into the final product due to reduction of the reaction temperature or adjustment of a reaction system, and the preparation method can further reduce and control the variety and content of the impurities in the final product, so that the medication safety of patients is further ensured. In addition, the final product preparation product obtained by the fluorination method or the preparation method provided by the invention has good inter-batch uniformity, and has good stability under the storage conditions of 30 DEG C + / -2 DEG C and 40 DEG C + / -2 DEG C.

The application discloses a kind of radionuclide 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds 18 The present application discloses a method for detecting the radiochemical purity of F-labeled FAPI compounds, which comprises using thin layer chromatography to detect the radiochemical purity of F-labeled FAPI compounds

This invention belongs to the field of baicalin crystallization technology, and relates to a leaf-shaped baicalin crystal, its preparation method, and its application. The crystal has a leaf-like microstructure with a length ranging from 1 μm to 17 μm; the bulk density of the crystal is 0.1-0.2 g / mL, and the compactness is 0.2-0.4 g / mL. The leaf-shaped baicalin crystals provided by this invention are easy to compress into tablets and have a high surface area / volume ratio, which is beneficial for its adsorption and dissolution in vivo. The preparation process is simple to operate and can directionally prepare leaf-shaped baicalin crystals. The purity of the obtained leaf-shaped baicalin crystals can reach 93% or higher, significantly improving the chemical purity and forming a unique low bulk density physical property.

This invention relates to a method for preparing the fenelone intermediate 2-cyanoethyl(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxylic acid ester, and also relates to diastereomeric salts (Va), (Vb), (Vc), and / or (Vd). This method is simple to operate, and the diastereomeric salts can be obtained with very high chemical and enantiomeric purity (tartrate ester content <0.05%) through a single dissociation, avoiding the raw material loss and waste problems caused by multiple dissociations. It also has low production costs and meets the requirements of green production.

The group of inventions relates to the field of medicine, pharmacology and the chemical and pharmaceutical industry and includes an improved method for producing (10S, 13S, 16R, 17R)-17-hydroxy-10,13,16-trimethyl-17-propanoyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3-one (compound of formula (I)) and the use thereof for industrial batch, semi-continuous and continuous chemical production. Also described is a method for producing an intermediate compound, Vamorolone Acetate. The method for producing the compound of formula (I) is carried out according to the schema depicted. The production method makes it possible to produce the compound of formula (I) with a purity suitable for the use thereof in a finished dosage form for subjects requiring treatment for Duchenne muscular dystrophy. Thus, the technical results of the present invention consist in an improved production method which results in: a high yield and chemical purity, including stereoisomeric purity, of the compound of formula (I) and intermediate products in the synthesis of the compound of formula (I), which are suitable for use in a finished dosage form for subjects requiring treatment for Duchenne muscular dystrophy; the adaptability of the synthesis of the compound of formula (I) to industrial production; environmentally-friendly production; and a decrease in the formation of undesirable by-products.

The application belongs to the field of analytical chemistry detection, and particularly relates to a method for detecting radiochemical purity of an actinium 225 Ac] conjugate. The method adopts high performance liquid chromatography combined with a gamma counter, a mobile phase includes mobile phase A and mobile phase B, the mobile phase A is a mixed solution of buffer salt and cationic pair reagent, and the mobile phase B is acetonitrile. 225 The detection method can accurately detect the radiochemical purity of the actinium 225 Ac] conjugate, is stable and reliable, has high sensitivity, and is of great significance for quality control and research of the actinium [Ac] conjugate product.

The invention relates to the technical field of rice stress-resistant cultivation, and discloses a rice root system salt tolerance adjusting method based on exogenous spermidine, which comprises the following core steps: in the critical period of rice root system development, directionally applying a spermidine solution subjected to purity verification to a rice root system area, by accurately regulating and controlling the application concentration, frequency, duration and application environment conditions of spermidine, the osmotic regulation capability and the anti-oxidation system function of a rice root system in a high-salt environment with the soil conductivity larger than or equal to 2 dS / m are improved, the salt tolerance of the root system is remarkably improved, and then growth and development of rice are guaranteed. The spermidine is a straight-chain polyamine compound with good biocompatibility, the chemical purity is not lower than 98%, no heavy metal is left, and the contents of lead, cadmium and mercury are all smaller than or equal to 0.1 mg / kg. According to the invention, precise targeted regulation and control of the salt tolerance of the rice root system are realized, and the regulation effect is stable and remarkable.

This application discloses a method for preparing Bosein. The method includes the following steps: mixing 1-C-(β-D-xylanosyl)-acetone, an alcohol solvent, an inorganic acid / base, and a reducing agent; reacting the mixture; filtering; desalting; decolorizing; and distilling to obtain Bosein with a purity of over 98%. The isomer ratio of the Bosein is in the range of (β, S) / (β, R) of 99:1 to 30:70. The isomer ratio is controllable, the operation is simple, and the obtained Bosein has a wide range of isomer ratios and good chemical purity.

The application discloses a preparation method of high-purity Fmoc-S-trityl-L-penicillamine and belongs to the field of synthetic chemistry. The method is characterized in that L-penicillamine is used as a starting material, dehydrated with methyl boronic acid to generate a cyclic protective structure, then a thiol group is selectively protected by trityl, and an acid is used to open a ring to obtain an S-trityl-L-penicillamine intermediate; then, in a sodium bicarbonate buffered water / dioxane weak alkaline system, Fmoc-OSu (9-fluorenylmethoxycarbonyl succinimidyl ester) is used to react with the S-trityl-L-penicillamine intermediate to protect an amino group, and racemization is effectively inhibited; finally, the product is refined by recrystallization in an ethyl acetate / n-heptane system to obtain a high-purity end product. The process route is simple and efficient, the conditions are mild, the purification method is unique and effective, the obtained product has high chemical purity and optical purity, good stability, is suitable for large-scale production, and can meet the needs of high-end polypeptide drug synthesis.

The invention belongs to the technical field of oriented silicon steel, and particularly relates to silicon steel grade magnesium oxide and a preparation method and application thereof. The chemical purity of the silicon steel grade magnesium oxide provided by the invention is 98.8-99.2%, the citric acid activity of 40% CAA is 60-70s, the crystal structure is in a hexagonal sheet shape, the viscosity is 60-80cp, the hydration rate is less than or equal to 2.50%, the D50 particle size is 2.8-3.2 mu m, and the D90 particle size is 11-15 mu m. The silicon steel grade magnesium oxide provided by the invention has excellent activity, crystal structure and viscosity, can effectively promote the oriented silicon steel to form a uniform high-quality bottom layer with strong adhesive force, meanwhile, obviously reduces or even eliminates a roll throwing phenomenon during rolling after a high-temperature annealing process, improves the coating uniformity and cohesiveness of a coating, and improves the service life of the coating. The yield and quality stability of oriented silicon steel products are improved, and the method is particularly suitable for manufacturing low-temperature high-magnetic-induction oriented silicon steel (HiB steel) products with higher grades and harsh requirements for bottom layers.

This invention discloses a method and apparatus for detecting the purity of OLED intermediate materials, relating to the field of materials testing. The method includes: performing multi-dimensional detection on the material to be tested to obtain multiple detection spectra; emitting a purity numerical signal when the multiple spectra meet predetermined confirmation constraints; obtaining the chemical purity value of the material to be tested using chromatography; obtaining predetermined functional targets for the OLED device and matching the target functional requirements of the material to be tested within the targets; retrieving corresponding predetermined functional indicators to detect the material to be tested to obtain functional indicator parameters; and performing quality assessment on the material to be tested in conjunction with the chemical purity value. This application solves the problems of existing intermediate material quality testing that focus only on chemical purity while neglecting functional performance, have insufficient accuracy in structural confirmation, and fail to match test results with actual application needs. It achieves the effect of balancing chemical purity and functional performance testing, improving the accuracy of structural confirmation, and ensuring that test results are accurately matched with actual application needs.

A process for treating a lactide feed to form a lactide stream having a high configuration purity and a high chemical purity, comprising the steps of:-subjecting a feed comprising L-lactide, meso-lactide, water, lactic acid and optionally other components to a first separation step, thereby obtaining a stream comprising lactic acid and water and one or more crude lactide streams; -subjecting the crude lactide stream comprising L-lactide and meso-lactide resulting from the first separation step to a first crystallization step, thereby obtaining a purified L-lactide stream and a residual stream comprising L-lactide and meso-lactide; -subjecting the residue stream comprising L-lactide and meso-lactide resulting from the first crystallization step to a second separation step, thereby obtaining at least a second L-lactide stream and a meso-lactide stream; -subjecting the meso-lactide stream resulting from the second separation step to a second crystallization step, thereby obtaining a purified meso-lactide stream and a further residue stream.

The invention discloses a preparation method of a high-reliability tantalum alloy sealing ring with a composite coating. The preparation method comprises the following steps that a tantalum alloy sealing ring base body is manufactured; the tantalum alloy sealing ring base body is cleaned; the surface of the tantalum alloy sealing ring base body is activated; depositing gold, silver or copper on the tantalum alloy sealing ring base body through physical vapor deposition to form a base layer; depositing gold, silver or copper on the base layer through chemical vapor deposition to form a functional layer; the tantalum alloy sealing ring base body with the deposited functional layer is cleaned under the sealing ring phase; and after cleaning, performing heat treatment in a low-temperature inert atmosphere. The tantalum alloy sealing ring is manufactured in the mode that physical vapor deposition and chemical vapor deposition are combined, the ultrahigh binding force of a plating layer and an inert tantalum base body is ensured through the physical vapor deposition, a functional layer which is extremely compact, free of holes, controllable in thickness and high in chemical purity grows through the chemical vapor deposition, and the defects of a single plating layer technology are perfectly overcome.

This invention provides a fluorination method for a PSMA radiopharmaceutical intermediate, and further provides an Al based on this fluorination method. 18 A method for preparing F-labeled PSMA radiopharmaceutical formulations, through adjustments to the reaction system, effectively reduces the temperature requirements of the fluorination reaction during the labeling process while ensuring labeling aging, radiochemical purity of the final product, radiochemical conversion rate, and product yield. This invention is based on the Al provided by this fluorination method. 18 The preparation method for F-labeled PSMA radiopharmaceutical formulations exhibits good applicability, complete reaction, and no new impurities are introduced into the final product due to lower reaction temperature or adjustments to the reaction system. Furthermore, this preparation method can further reduce and control the types and amounts of impurities in the final product, further ensuring patient safety. In addition, the final product formulations obtained using the fluorination method or preparation method provided by this invention show good batch-to-batch homogeneity and good stability under storage conditions of 30℃±2℃ and 40℃±2℃.

The present invention relates to the technical field of biomedicine, and in particular to a preparation method for 18F-DOPA and an F-18-labeled precursor thereof. The structural formula of an F-18-labeled phenolic precursor compound is as shown in formula I, wherein R1 and R2 are hydroxyl protecting groups; R3 is a leaving group; R4 and R5 are each independently hydrogen or an amino protecting group; and R6 is a carboxyl protecting group. The present invention provides a simple and efficient preparation method for 18F-DOPA, specifically by constructing a key phenolic precursor compound and by means of a simple and efficient photocatalytic aromatic hydrocarbon deoxyfluorination reaction to implement the preparation of 18F-DOPA. The method has fewer steps, high yield, simple and convenient operation, good reproducibility, and good automated production potential. The radiotracer 18F-DOPA synthesized by means of the method has high specific activity and high chemical purity and radiochemical purity, and has significant value for the clinical promotion of 18F-DOPA.

The application discloses benzamide phenylpiperazine radioactive compounds and a preparation method and application thereof, and belongs to the field of radioactive drugs. 18 The F-labeled compound is simple in preparation method. The benzamide phenylpiperazine radioactive compound can be used as a dopamine D3 receptor targeted radioactive probe, and has the characteristics of excellent biological performance, high chemical purity and high specific activity.

The invention relates to the field of anion exchange polymer membrane preparation, and discloses an alkali-resistant and high-temperature-resistant anion exchange polymer easy to prepare and a preparation method thereof.The preparation method comprises the steps that a non-aromatic precursor polymer with a latent functional group is constructed, and the non-aromatic precursor polymer is prepared into a gradient porous membrane through a phase inversion technology; in the unified treatment step, aromatization of the main chain of the precursor and activation of the functional group are synchronously realized, so that the porous structure is chemically fixed; according to the method, the construction of a high-performance main chain and the introduction of a high-activity functional group are thoroughly separated in time sequence, so that the problem of associated degradation in a traditional synthesis path is avoided, and the final structural defect removal step is combined; and the finally obtained polymer film has relatively high structural integrity and chemical purity on the molecular scale.

The invention discloses a synthetic method of 5-aminolevulinic acid and derivatives thereof, 5-aminolevulinic acid and derivatives thereof and application, and relates to the technical field of chemical synthesis, and the synthetic method comprises the following steps: mixing monoalkyl succinate, an inert solvent and an activating reagent, and carrying out acylation activating reaction to obtain a first intermediate; mixing the first intermediate, nitromethane, an alkaline agent, a molecular sieve and an organic solvent, and carrying out nitro condensation reaction to obtain a second intermediate; and mixing the second intermediate, a solvent and a catalyst, and carrying out catalytic hydrogenation reaction to obtain the 5-aminolevulinic acid and the derivative thereof. By adopting the steps, only three-step reaction is needed from the initial raw material to the target product, the reaction conditions are mild and efficient, the 5-aminolevulinic acid and the derivative thereof prepared by the process are white solids, the chemical purity of the 5-aminolevulinic acid and the derivative thereof can reach more than 96.0% and the yield can reach more than 70% through HPLC (High Performance Liquid Chromatography) analysis, and the requirements of industrial large-scale production are completely met.

The invention relates to a nalfurafine hydrochloride crystal form and a preparation method thereof.The X-ray powder diffraction pattern of the nalfurafine hydrochloride crystal form has characteristic peaks at the 2 theta angles of 6.9 degrees, 10.5 degrees, 15.3 degrees, 16.7 degrees and 20.2 degrees, the preparation method comprises the following steps that nalfurafine free alkali is dissolved in absolute ethyl alcohol, hydrochloric acid is dropwise added while stirring is conducted at the room temperature, after the hydrochloric acid is dropwise added, stirring is conducted at the room temperature, and then the nalfurafine hydrochloride crystal form is obtained; continuously stirring to separate out crystals, and filtering, washing and drying to obtain a nalfurafine hydrochloride crystal form; the nalfurafine hydrochloride crystal form provided by the invention has a unique X-ray powder diffraction pattern different from the existing known crystal form, has good physical and chemical stability, is beneficial to long-term storage of drugs, and has the advantages of simple process, convenience in operation, room-temperature reaction, mild conditions, no need of special equipment, low production cost and environmental friendliness; and the product has high crystal form purity and chemical purity and good reproducibility, and is suitable for industrial large-scale production.

The invention relates to the technical field of pharmaceutical chemical engineering and chiral compound purification, in particular to (R)-2-allylpyrrolidine-2-carboxylic acid and a chiral purification method thereof, and the method comprises the following steps: dissolving a raw material hydrochloride in a free solvent, and dropwise adding free alkali for reaction to obtain a free body; dissolving the free body in a refining solvent I, dropwise adding a refining solvent II after refluxing and dissolving, inducing a product to separate out by utilizing gradient solubility difference, cooling, aging, filtering and drying to obtain a high-purity product. According to the present invention, the synergistic effect of the specific free alkali and the solvent system can be utilized, the racemization problem of allyl side chain induction is solved through chemical resolution and physical recrystallization, the chiral purity is increased from about 95% to 99.0% or more, and the chemical purity reaches 98.5% or more. The method is mild in process, high in yield and environment-friendly, and has a good industrial application prospect.

The invention relates to a preparation method of electronic grade hypoxanthine, which comprises the following steps: taking a hypoxanthine crude product synthesized by an enzymic method as a raw material, mixing the hypoxanthine crude product with high-purity water at the temperature of 30-60 DEG C, adjusting the pH value to 7-9, adding 0.1%-2% of neutral or alkaline protease to hydrolyze protein to react for 0.5-3 hours, cooling to 5-30 DEG C, and performing suction filtration to obtain the electronic grade hypoxanthine. Dissolving the wet product with an alkaline aqueous solution at 50-80 DEG C, removing impurities with activated carbon, performing hot filtration, adjusting the pH value of the filtrate to 6.5-7.5 with electronic-grade acid, cooling to 5-30 DEG C, crystallizing, performing suction filtration, washing the wet product with purified water for 3-5 times, and drying to obtain the product. Organic impurities, metal ions and environmental particles are systematically removed, and finally the ultra-high-purity electronic-grade hypoxanthine is prepared. The chemical purity of the prepared product is larger than or equal to 99.99%, the total metal ion content is smaller than or equal to 100 ppb, the moisture content is smaller than or equal to 0.1%, and the product has the advantages of being concentrated in particle size distribution and uniform in crystal form and completely meets the harsh requirements of OLED and other high-end photoelectric devices for key organic materials.

The invention discloses a thin-layer chromatographic analysis method for detecting radiochemical purity of a gallium chloride [68Ga] solution, and belongs to the field of chemical analysis. According to the method, iTLC-SG thin-layer chromatographic paper is used as a stationary phase, sodium acetate solution-methanol is used as a mobile phase, the radiochemical purity of a gallium chloride [68Ga] solution, a system adaptive solution and a gallium chloride [68Ga] and system adaptive solution is detected by thin-layer chromatography, and the influence of different mobile phases on detection results is investigated. According to the method provided by the invention, the radioactive chemical purity of the gallium chloride [68Ga] solution can be accurately and quickly detected by optimizing the conditions of the stationary phase and the mobile phase, the gallium chloride [68Ga] solution can present symmetrical and sharp chromatographic peaks, the accuracy and reliability of the detection result are ensured, the whole analysis process only needs several minutes from sample application to scanning completion, and the detection result is accurate and reliable. And the high requirement of the transient half-life period of the gallium-68 nuclide on the analysis speed is met.

A new crystal form of a tetrahydrobenzyl isoquinoline compound, a preparation method and uses thereof, the new crystal form of the tetrahydrobenzyl isoquinoline compound is a crystal form of a compound of formula (I), characterized in that, using Cu-K alpha radiation, the X-ray powder diffraction of the crystal form A has characteristic peaks at diffraction angles 2 theta of 13.4+0.2, 14.1+0.2, 18.0+0.2, 21.0+0.2, 26.8+0.2 degrees. The crystal form of the application has high chemical purity and optical purity, good stability, is easy to store, is suitable for industrial production, in addition, can be used for preparing mivacurium, and is favorable for improving the purity of mivacurium.

A method for synthesizing a stable isotope-labeled toltrazuril-D3 belongs to the field of organic synthesis technology. This method uses methylamine hydrochloride-D3 as the stable isotope labeling source, reacting it with p-trifluoromethylthiophenol and 1-chloro-2-methyl-5-nitrobenzene as starting materials, undergoing sequential condensation and reduction to obtain an aminodiphenyl ether intermediate. Simultaneously, methylamine hydrochloride-D3 reacts with sodium cyanate to generate methylurea-D3, which then reacts with carbonyl diimidazole to obtain an activated intermediate. Finally, the aminodiphenyl ether intermediate condenses with the activated intermediate, followed by base-catalyzed cyclization to obtain the target product, toltrazuril-D3. This invention features a rationally designed synthetic route, readily available raw materials, mild reaction conditions, simple operation, and easy product separation and purification. The obtained product achieves a chemical purity and isotope abundance of over 99%.

The invention discloses a method for preparing high-purity zinc based on a zinc sulfate system and the high-purity zinc, aiming at the problem of high impurity content of a new electrolytic solution in the process of preparing the high-purity zinc through electrolysis of the zinc sulfate system, the method comprises the following steps: taking concentrated sulfuric acid with the chemical purity of 98%, water with the conductivity of less than 10 [mu] S / cm, hydrogen peroxide meeting the 27.5% superior product standard of GB / T 1616-2014 and metal zinc with the impurity content meeting the Zn99.995 standard in GB / T 470-2008 as raw materials; the preparation method comprises the following steps: preparing a solution with the zinc ion concentration of 120-140g / L by controlling from an impurity source, then adding sulfuric acid into the obtained solution to control the pH value to be 2-5.5, and finally adding a bone glue solution to prepare the low-impurity electrolyte with low impurity content. The low-impurity electrolyte prepared by the method can be used for electrolytically preparing high-purity zinc of 5N or above.

The application belongs to the technical field of pharmaceutical crystal, and relates to a crystalline form of nervonic acid and a preparation method thereof. In the X-ray powder diffraction pattern of the crystalline form, Cu-Kalpha radiation has characteristic peaks at diffraction angles 2theta of 5.2+ / -0.2, 8.8+ / -0.2, 12.4+ / -0.2, 16.0+ / -0.2, 19.2+ / -0.2, 23.9+ / -0.2 and 25.2+ / -0.2. The crystalline form provided by the application has good chemical purity and crystal stability, and exhibits excellent physical stability, which is beneficial to the development, production and storage of pharmaceutical preparations. In addition, research shows that the crystalline form also has suitable solubility characteristics, which is beneficial to improving the bioavailability and more beneficial to the related research and development of drugs.

This invention belongs to the field of specialized equipment for building material production, and discloses a smelting device for recycling and reprocessing periclase from magnesium ore waste. The device includes a waste pretreatment unit, a multi-channel centrifugal sedimentation density distribution acquisition unit, an intelligent sorting decision unit, a sorting execution mechanism, a smelting reactor, and a process feedback control module connected in sequence. The density distribution acquisition unit obtains the equivalent density of particles through centrifugal sedimentation; the intelligent sorting decision unit extracts a five-dimensional density difference feature vector, adaptively adjusts the classification boundary using a support vector machine, and combines improved hierarchical clustering to achieve dynamic particle grouping and screen for high-purity components; the process simulation interface embeds a thermodynamic-kinetic coupled model to pre-simulate the smelting quality, and inversely optimizes the feature weights when a batch is determined to be a challenging recycling batch. This invention solves the problem of insufficient sorting accuracy caused by the nonlinear mapping between density and chemical purity, and improves the purity stability of periclase products.

The application provides a preparation method of a pyrrolidone intermediate. The method uses a continuous flow technology to obtain a target molecule through a substitution and a cyclization reaction of a cheap and readily available glutamic acid derivative and a halogenated ethylamine. The substitution reaction is directly used for the next step of the cyclization reaction without post-treatment. The total yield is greater than 80%, the chemical purity is greater than 99.1%, the optical purity is greater than 99.5% ee, the reaction safety factor is high, the cost is low, the efficiency is high, and the product yield and purity are high.