The invention discloses a tenofovir alafenamide fumarate raw material medicine and a production process thereof. The tenofovir alafenamide fumarate raw material medicine includes anhydrous tenofovir,triphenyl phosphite, 4-dimethylaminopyridine, triethylamine, acetonitrile, ethyl acetate, methanol, concentrated hydrochloric acid, thionyl chloride, toluene, dichloromethane, L-alanine isopropyl ester hydrochloride, potassium hydrogencarbonate, fumaric acid and isopropanol. Production raw material excipients for the tenofovir alafenamide fumarate raw material medicine include lactose monohydrate,microcrystalline cellulose, croscarmellose sodium and magnesium stearate. The new manufacturing raw materials and the production raw material excipients are selected, so that the anti-hepatitis B effect of the medicine is more excellent, mass production can be performed through the novel production method, and the anti-hepatitis B effect is strengthened to some extent.