Preparation method for radioactive 68Ge solution

A radioactive and solution-based technology, applied to the improvement of process efficiency, photographic technology, instruments, etc., can solve the problems of high technical difficulty of Ni alloy target, weak copper target support, easy to generate aerosol, etc. The method is convenient and fast , The target is firm and easy to operate

Active Publication Date: 2012-03-21
HTA CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] Currently, bulk 68 The production method of Ge mainly utilizes Ga prepared by accelerator irradiation melting method. 4 Ni alloy target or Nb-Ga liquid gallium target through CCl 4 Separation and production by liquid-liquid extraction 68 Ge solution, the disadvantage of which is the preparation of Ga by melting 4 The Ni alloy target is technically difficult, the combination with the copper target holder is not firm, and the radiation beam that can withstand is small; use CCl 4 Separation and production by liquid-liquid extraction 68 Ge solution, cumbersome to operate, easy to generate aerosol, causing radioactive pollution

Method used

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  • Preparation method for radioactive 68Ge solution
  • Preparation method for radioactive 68Ge solution
  • Preparation method for radioactive 68Ge solution

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preparation example Construction

[0033] Radioactive 68 The preparation method of Ge solution is: dissolving gallium salt and nickel salt in hydrochloric acid solution, using the principle of electrodeposition, co-depositing two metals of gallium and nickel on the copper target holder to prepare gallium and nickel alloy targets; alloy targets After being irradiated by CYCLONE30, 68 Ge alloy target, place the target after cooling and irradiated, electrolyze the irradiated target, and separate, purify, desorb the electrolyte on a silica gel column, evaporate the desorbed liquid, dissolve the solid after evaporation, collect and dissolve Liquid, prepared for preparation 68 Ge- 68 Radioactivity of Ga generator 68 Ge solution, it contains the following steps:

[0034] 1) Prepare Ga by electrodeposition 4 Ni alloy target

[0035] Preparation of Ga by Electrodeposition 4 The electroplating tank of the Ni alloy target is a constant temperature water bath vertical plating tank with stirring function, the anode and cathode s...

Embodiment 1

[0051] Radioactive 68 The preparation method of Ge solution is: dissolving gallium salt and nickel salt in hydrochloric acid solution, using the principle of electrodeposition, co-depositing two metals of gallium and nickel on the copper target holder to prepare gallium and nickel alloy targets; alloy targets After being irradiated by CYCLONE30, 68 The Ge alloy target is left to cool the target for one month, and then the target is electrolyzed. Electrolysis is the reverse process of electroplating; then the electrolyte is separated, purified, and desorbed on a silica gel column, and the desorbed solution is evaporated to dissolve the remaining Solid matter, realize the conversion of desorption liquid medium, and prepare it for preparation 68 Ge- 68 Radioactivity of Ga generator 68 Ge solution, it contains the following steps:

[0052] 1) Prepare Ga by electrodeposition 4 Ni alloy target

[0053] Dissolve 1.0mol / L gallium trichloride and 0.25mol / L nickel dichloride in 0.1mol / L hydr...

Embodiment 2

[0068] Radioactive prepared according to the preparation method and operation steps described in Example 1 of the present invention 68 The technical indicators of Ge solution are as follows: nuclear purity is greater than 99.995%, chemical purity is greater than 98%, and sulfate ion concentration is less than 14.9×10 -4 moL / L (as shown in Table 1, 2, 3, 4).

[0069] Table 1 68 Nuclear purity of Ge solution

[0070]

[0071] Table 2 68 The desorption efficiency of Ge solution,

[0072]

[0073] table 3 68 Chemical purity of Ge solution

[0074]

[0075] Table 4 68 Concentration of sulfate in Ge solution

[0076]

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Abstract

The invention belongs to the field of preparation of radioactive nuclide, and discloses a preparation method for a radioactive 68Ge solution. The preparation method comprises the following steps of: preparing a solid Ga4Ni alloy target containing gallium and nickel by using an electro-deposition method; performing CYCLONE 30 irradiation on the alloy target to prepare an alloy target containing radioactive 68Ge; cooling; electrolyzing the target; separating and purifying electrolyte on a silica gel column; desorbing 68Ge by using a nitric acid solution; evaporating a desorption solution to dryness; and dissolving solid-state 68Ge to prepare the radioactive 68Ge solution for a 68Ge-68Ga generator. The method has the advantages of simple equipment for preparing the Ga4Ni alloy target, quickness in method, high repeatability, stable process, firm target, high quality and easiness in target shooting. The 68Ge has the advantages of stable purification process, completeness in separation from impurity ions, nuclear purity of more than 99.995 percent, chemical purity of more than 98 percent, desorption efficiency of more than 98 percent, easiness in operation, no pollution and contribution to conventional and large-scale production.

Description

Technical field [0001] The present invention relates to the preparation of radionuclides, in particular to a method for 68 Ge- 68 Radionuclide of Ga generator 68 Preparation method of Ge solution. Background technique [0002] 68 Ge is one of the important medical radionuclides, and it is mainly used to prepare positron emission tomography (PET) calibration radioactive source and 68 Ge- 68 Ga generator. 68 The half-life of Ge is 288 days. After electron capture, 68 Ga(68.3m, 88%β + ) Can be prepared for PET imaging 68 Ga-labeled drugs; with the development of PET, 68 The application of Ga in radionuclide imaging is becoming more and more extensive, creating social and economic benefits continuously. There are so many things in the world about 68 The report on the preparation method of Ge solution, but 68 The actual production of Ge is mainly concentrated in the National Laboratory in the United States and Accelerator Co., Ltd. in Obninsk, Russia. As early as 1974, R. Caletka and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22B41/00C22B3/24C25C1/24
CPCY02P10/20
Inventor 傅红宇罗文博沈亦佳王刚李超李贵群李江航王春林李锦富
Owner HTA CO LTD
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