12 results about "Myocardial imaging" patented technology

A deep learning model for the detection of obstructive coronary artery disease (CAD) can take a set of polar maps and patient information as input, then output obstructive CAD scoring data, such as probabilities of obstructive CAD associated with various cardiac territories, as well as an attention map and a CAD scoring map. The model can operate agnostic of camera type used to capture the set of polar maps. The attention map indicates regions of the polar maps important to the deep learning process for that particular set of polar maps. The attention map and obstructive CAD scoring data can be used to generate a CAD scoring map showing CAD probability by segment on a standard 17-segment model of a left ventricle. The attention map and / or CAD scoring map can act as easily explainable tools for interpreting the results of a myocardial perfusion imaging study.

The invention relates to a coronary microcirculation disturbance examination technology in non-occlusive coronary diseases, and aims to objectively evaluate the myocardial ischemia degree of angina pectoris patients without occlusive coronary diseases and quantify the myocardial ischemia range caused by microcirculation disturbance through a load dynamic myocardial perfusion imaging (MPI) technology. Siemens third-generation double-source CT is adopted, a coarse pitch scanning mode is utilized, a one-stop CCTA combined MPI technology is achieved, the problem that the radiation dosage is too high is solved, and meanwhile the detection rate of myocardial ischemia is increased. Indexes such as myocardial blood flow (MBF), myocardial blood volume (MBV), time of arrival (TTP), coronary artery blood flow reserve (CFR) and the like of angina pectoris patients and healthy volunteers are compared, and changes of myocardial ischemia areas are objectively evaluated. The degree and range of microcirculation disturbance are quantitatively evaluated, and an infarction region and an ischemic region are identified. Quantitative evaluation is carried out on coronary artery microcirculation of the angina pectoris patient in clinical work, and a basis is provided for early intervention.

The present application provides a preparation method and use of a myocardial perfusion imaging agent precursor. The method of the present application avoids the use of explosive sodium azide by redesigning the synthesis route of the myocardial perfusion imaging agent precursor, thereby increasing production safety. At the same time, all materials involved in the route are commercialized products, which are cheap and easy to obtain, thereby reducing production costs.

A method for performing magnetic resonance (MR) imaging includes receiving imaging data associated with a region of interest of a subject prior to an injection of a contrast agent into the region of interest, after the injection of the contrast agent into the region of interest, or both; obtaining a plurality of initial contrast-sensitive images of the region of interest of the subject, each of the plurality of initial contrast-sensitive images being indicative of a state of the region of interest at a plurality of times within an initial period of time; and generating, based on the plurality of initial contrast-sensitive images, a subsequent contrast-sensitive image that is indicative of the state of the region of interest at a subsequent time after the initial period of time ends.

The utility model relates to a load myocardial perfusion imaging injection suite which comprises a first extension tube, a first three-way connector, a second extension tube, a second three-way connector and a third extension tube which are sequentially connected, the inlet end of the first extension tube is connected with a high-pressure injector, the first three-way connector is used for injecting radionuclide, and the third three-way connector is used for injecting radionuclide. The second three-way connector is used for injecting load medicine, the second extension tube is arranged in a winding mode, the whole section of the second extension tube is arranged in the anti-radiation box, the volume of the second extension tube is larger than the total injection dosage of radionuclide, and a connector used for being connected with an indwelling needle is arranged at the tail end of the third extension tube. According to the utility model, two medicaments needing to be injected can be injected into the injection suite together for later use, so that the whole set of injection scheme can be completed by only one high-pressure injector, the infection risk is reduced, and the waste of medicaments is prevented. Enough radionuclides are directly pushed into the anti-radiation box during medicine preparation and then pushed out of the lead box during formal injection, so that the radiation exposure time of patients, nurses and technicians is effectively shortened.

The utility model provides an operating table and myocardial imaging equipment, the operating table comprises a shell, a control unit, a light source, an optical fiber coupler, a data acquisition unit and a display unit, the control unit, the light source, the optical fiber coupler and the data acquisition unit are arranged in the shell, and the display unit is arranged on the surface of the shell; the light source, the optical fiber coupler, the data acquisition unit and the display unit are sequentially connected, the control unit is respectively connected with the light source, the optical fiber coupler, the data acquisition unit and the display unit, and the optical fiber coupler is also respectively connected with a reference mirror and an optical fiber probe for scanning cardiac muscle. And medical staff can observe different structures of the cardiac muscle and even the distribution of different cells in real time according to the image displayed by the display unit.

The invention provides an image processing method to assess quantitative myocardial blood flow and / or myocardial flow reserve, comprising the steps of: (a) pre-processing of images comprises: (i) reconstructing dynamic cine 3D tomographic myocardial perfusion imaging (MPI) data, (ii) optionally, denoising to improve the quality of image, (iii) extracting blood input function from a region of interest (ROI) of the left ventricle blood cavity, (iv) estimating the distribution volume (DV), given by the ratio of uptake and washout rates (K1 / k2) to stabilize and improve estimation of K1, k2 and total blood volume (TBV) and subsequent myocardial blood flow measures, and (v) data normalization by dividing by the maximum of the blood input function; (b) assessing the individual signals pre-processed in step (a) to generate K1 and TBV parametric maps using artificial neural network; (c) post-processing of K1, k2 and TBV parametric maps; and of rest and stress myocardial blood flow to estimate myocardial flow reserve (MFR) and / or coronary flow reserve (CFR).

A method for performing magnetic resonance (MR) imaging includes receiving imaging data associated with a region of interest of a subject prior to an injection of a contrast agent into the region of interest, after the injection of the contrast agent into the region of interest, or both; obtaining a plurality of initial contrast-sensitive images of the region of interest of the subject, each of the plurality of initial contrast-sensitive images being indicative of a state of the region of interest at a plurality of times within an initial period of time; and generating, based on the plurality of initial contrast-sensitive images, a subsequent contrast-sensitive image that is indicative of the state of the region of interest at a subsequent time after the initial period of time ends.

Systems and methods are disclosed for automatically performing motion correction in dynamic positron emission tomography scans, such as dynamic positron emission tomography myocardial perfusion imaging studies. An automated algorithm can be used. The algorithm can use simplex iterative optimization of a count-based cost-function customized to different dynamic phases for performing frame-by-frame motion correction.

The application provides a myocardial imaging method and an ultrasonic imaging device. The method comprises: acquiring a plurality of ultrasonic images of a heart of a target object during a myocardial perfusion process; acquiring an electrocardiogram signal of the target object during the myocardial perfusion process; identifying a position of a heart phase in the electrocardiogram signal; taking an ultrasonic image corresponding to the heart phase as a key frame image of the heart phase; generating an electrocardiogram pattern representing the electrocardiogram signal; marking the position of the first heart phase in the electrocardiogram signal on the electrocardiogram pattern; detecting whether a reset operation of the first heart phase is received by a user; if the reset operation is received, setting the position of the first heart phase in the electrocardiogram signal, re-determining the key frame image; and if the reset operation is not received, keeping the key frame image unchanged. The myocardial imaging method and the ultrasonic imaging device allow the user to manually adjust the position of the heart phase, so that a heart phase more in line with the user's expectation can be obtained.

The present invention provides an image processing method to assess quantitative myocardial blood flow and / or myocardial flow reserve, comprising the steps of: (a) pre-processing of images comprises: (i) reconstructing dynamic cine 3D tomographic myocardial perfusion imaging (MPI) data, (ii) optionally, denoising to improve the quality of image, (iii) extracting blood input function from a region of interest (ROI) of the left ventricle blood cavity, (iv) estimating the distribution volume (DV), given by the ratio of uptake and washout rates (K1 / k2) to stabilize and improve estimation of K1, k2 and total blood volume (TBV) and subsequent myocardial blood flow measures, and (v) data normalization by dividing by the maximum of the blood input function; (b) assessing the individual signals pre-processed in step (a) in order to generate K1 and TBV parametric maps using artificial neural network;(c) post-processing of K1, k2 and TBV parametric maps; and of rest and stress myocardial blood flow to estimate myocardial flow reserve (MFR) and / or coronary flow reserve (CFR).

Embodiments of the present disclosure relate to compositions and methods for performing positron emission tomography (PET), and more particularly, to compositions and methods for use in selected imaging techniques (e.g., studying myocardial physiology). 18 Provided are compositions and methods for the development and use of F-based PET tracers. In particular, as disclosed herein, at the tracer level, [ 18 [F]F-AraG has the potential to be used in many emerging PET methodologies, including those designed for cardiac and / or mitochondrial activity imaging. 18 The use of [F]F-AraG has demonstrated significant benefits over conventional methods in many distinct applications, including the observation of selected physiological phenomena (e.g., myocardial perfusion, myocardial viability, and cardiac inflammation). 18 The method of the present invention provides significant advantages over F-labeled tracers. 18 F]F-AraG, including those designed to monitor patients.