166 results about "Tosylhydrazone" patented technology

The present invention relates to the field of the preparation of polyurethane elastic fibers, and relates to a preparation method for a bio-based polyurethane elastic fiber, comprising: preparing polyether polyol from sucrose, glycerol, dimethylamine and propylene oxide; adding a solvent, i.e., N,N-dimethylacetamide, and polyether polyol and polyisocyanate into a reaction tank, and adding p-Toluenesulfonyl semicarbazide and aluminum methylenebis(2,4-di-tert-butylphenoxy) phosphate to prepare a spinning solution; and subjecting the spinning solution to spinning and oil application by means of dry spinning technology to obtain the bio-based polyurethane elastic fiber. The present invention ensures that the properties of polyurethane elastic fibers do not deteriorate or are partially enhanced, while the cost and performance advantages are achieved.

A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi, wherein the at least one fungicide is a succinate dehydrogenase-inhibitor.

A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi wherein the at least one fungicide is a fungicidal sterol biosynthesis-inhibitor.

The invention is applicable to the technical field of fuel cells, and provides a blending modified polybenzimidazole proton exchange membrane and a preparation method thereof, and the preparation method comprises the following steps: S1, preparing 4-methyl-N-toluenesulfonyl benzene sulfonamide; s2, preparing 4, 4 '-[imino bis (sulfonyl)] dibenzoic acid; s3, preparation of PSI: dissolving CBSI and a proper amount of anhydrous lithium chloride in a proper amount of a mixed solution of pyridine, triphenyl phosphite and pyrrolidone, adding diamino molecules after complete dissolution, heating and stirring the solution for 12 h, pouring the solution into methanol, filtering and collecting a product, washing with water, and drying to obtain the product PSI; and S4, preparing the PSI / OPBI blended membrane. The blended membrane prepared by the invention has excellent proton conductivity and good mechanical properties, and meets the performance requirements of the proton exchange membrane of the fuel cell; moreover, the raw materials are low in cost and easy to obtain, the synthesis conditions are mature, the yield is high, the feasibility is high, and the application prospect is wide.

The invention discloses a polyurethane sealant primer as well as a preparation method and application thereof, and relates to a primer as well as a preparation method and application thereof. The invention aims to solve the problems that the existing single-component polyurethane sealant has low bonding strength on aviation organic glass and cannot meet the bonding sealing of helicopter cabin organic glass and crack arrest of cabin cover organic glass. The primer is prepared from a T100 prepolymer, an MDI and TPTI mixed isocyanate prepolymer, 4-toluenesulfonyl isocyanate, a catalyst, butanone, carbon black and methanesulfonic acid. The method comprises the following steps: 1, preparing a mixed isocyanate prepolymer of MDI and TPTI; and 2, preparing the polyurethane sealant primer. According to the application, the adhesive is applied to bonding sealing of helicopter cabin organic glass and crack arrest of cabin cover organic glass. The invention provides the polyurethane sealant primer as well as the preparation and the application thereof.

The invention discloses a low-damping PVC-U electrical conduit and a processing technology thereof, and belongs to the technical field of conduit preparation. The low-damping PVC-U electrical conduit is prepared from the following components in parts by weight: 70 to 80 parts of PVC resin, 30 to 42 parts of light calcium carbonate, 8 to 15 parts of ethylene-vinyl acetate copolymer, 0.5 to 1 part of ethylene bis stearamide, 3 to 6 parts of epoxy compound and 4 to 7 parts of compound stabilizer, the preparation method comprises the following steps: preparing an epoxy compound from ethyl benzoylacetate, 2-(trimethylsilyl) phenyl trifluoromethane sulfonate, p-toluenesulfonyl azide, p-aminophenol, p-toluenesulfonyl chloride, iodobenzene diacetic acid and rhodium diacetate as raw materials, and preparing the compound stabilizer from 2-(2-aminoethoxy) ethanol, 4-fluorophenol and xylene alkane diisocyanate as raw materials. The PVC-U electrical conduit prepared from the substances has the advantages of low damping, excellent stability, excellent mechanical property and excellent aging resistance.

The invention relates to the technical field of synthesis of organic compounds, and discloses a preparation method of N-Boc-cis-4-hydroxy-L-proline methyl ester, which comprises the following steps: step 1, synthesis of (2S, 4R)-4-p-toluenesulfonyloxy-1, 2-pyrroline dicarboxylic acid-1-tert-butyl ester-2-methyl ester (2): (2S, 4R)-4-hydroxy-1, 2, 4-triazole-2-methyl ester (3) is prepared from (2S, 4R)-4-hydroxy-1, 2, 4-triazole-2-methyl ester and (2S, 4R)-4-p-toluenesulfonyloxy-1, 2-pyrroline dicarboxylic acid-1- The preparation method comprises the following steps: dissolving 1-tert-butyl-2-methyl 2-pyrroline dicarboxylic acid-1-tert-butyl ester-2-methyl ester in dichloromethane; according to the method, (2S, 4R)-4-hydroxy-1, 2-pyrroline dicarboxylic acid-1-tert-butyl-2-methyl ester which is cheap and easy to obtain in the market is adopted as a raw material, after p-benzoylation and acetylation are performed, hydroxyl of the raw material is converted from trans form to cis form, chiral conversion is performed, and finally the target product is synthesized. The used acetate replaces benzoate, the raw materials are cheaper, and the generated by-product acetic acid is more environment-friendly than benzoic acid, so that the method is suitable for large-scale production.

The invention relates to a production method of quizalofop-p-ethyl, which comprises the following steps: reacting 2-(4-hydroxyphenoxy) propionic acid with absolute ethyl alcohol to obtain ethyl 2-(4-hydroxyphenoxy) propionate, and replacing the original process of reacting p-toluenesulfonyl chloride with L-ethyl lactate to obtain an intermediate, namely ethyl p-toluenesulfonyl lactate, with a process of reacting 2-(4-hydroxyphenoxy) propionic acid with absolute ethyl alcohol to obtain ethyl 2-(4-hydroxyphenoxy) propionate; meanwhile, in the post-treatment method, centrifugal separation replaces plate-and-frame pressure filtration, closed-circuit flash drying replaces original rake drying, racemization of quizalofop-p-ethyl is effectively avoided, the optical purity and yield of quizalofop-p-ethyl are improved, and the environmental protection benefits of the process are improved. Experiments show that the optical purity of the quizalofop-p-ethyl produced by the method provided by the invention is 99% or above, the yield is 98% or above, and the method is suitable for industrial production.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi wherein the at least one fungicide is a multi-site inhibitor or a strobilurin inhibitor.

The present application belongs to the technical field of water treatment, and relates to a heat-sensitive color developing agent F-103 production wastewater treatment method. The present application performs multistage treatment on the wastewater. First, an alkaline chemical separation reaction is performed on the wastewater to remove part of the acidic polar organic matter 3-p-tolylsulfonylureido phenol, p-toluenesulfonic acid and the like in the water. Then, an acid chemical separation reaction is performed to further remove the alkaline polar organic matter intermediate MAPOTs and the like in the water. Subsequently, an adsorption reaction is performed using activated carbon to further remove the organic matter and inorganic impurities in the water. Finally, evaporation and concentration are performed to recover the salt sodium chloride. The wastewater treatment of the present application recovers the salt sodium chloride in the wastewater as a resource under the premise of solving the toxicity problem of the organic matter in the wastewater, and realizes the harmless treatment and the reduction of hazardous waste of the wastewater.

The present invention provides a heat-sensitive recording material which has improved thermal responsiveness and improved stability of the print part and the background in comparison to conventional heat-sensitive recording materials that contain a non-phenolic compound as a color developer. The present invention provides a heat-sensitive recording composition which contains a color former, a color developer and a stabilizer, wherein: N-[2-(3-phenylureido)phenyl]benzenesulfonamide or N-(p-toluenesulfonyl)-N′-(3-p-toluenesulfonyloxyphenyl) urea is contained as the color developer, and 1,3-diphenyl urea is contained as the stabilizer.

The invention relates to the field of skin care products, and discloses an unsaturated silanol composition and application thereof in skin care, the composition comprises organosilanol, plant essential oil microcapsules, glycerin, hyaluronic acid, caprylic / capric polyethylene glycol glyceride and purified water; the general formula of the organosilanol is X-Si (OH) 2-Y; wherein: X is a vinyl group, an allyl group, a linear or branched C1-C4 alkyl group; y is a vinyl group, an allyl group,-OCH3,-OCH2CH3,-OCH2OH,-OCH2CH2OH, a linear or branched C1-C4 alkyl group; the plant essential oil microcapsule is prepared by using modified agar prepared by reacting octenyl succinic anhydride with agar, modified beta-cyclodextrin prepared by grafting mono-6-p-toluenesulfonyl-beta-cyclodextrin with chitosan and sodium alginate as wall materials, plant essential oil as a core material and calcium chloride as a cross-linking agent through an extrusion method and a freeze-drying method. And the composition with good antibacterial and antiseptic capabilities, skin barrier reparability and moisturizing and water locking effects is prepared.

The invention provides a method for synergistically preparing 3, 4-dihydro-2H-benzo [b] [1, 4] thiazine through monopersulfate, and belongs to the technical field of heterocyclic compounds. In the presence of a mixed solvent, a 2-N-benzenesulfonyl substituted phenylmethyl sulfide derivative and a halide MX are used as raw materials, and the (E)-2-(halogenated methylene)-4-p-toluenesulfonyl-3, 4-dihydro-2H-benzo [b] [1, 4] thiazine is prepared through catalysis of a catalyst monopersulfate at the reaction temperature of not more than 80 DEG C. The preparation method comprises the following steps of: preparing the (E)-2-(halogenated methylene)-4-p-toluenesulfonyl-3, 4-dihydro-2H-benzo [b] [1, 4] thiazine, the method has the advantages of simple preparation steps, mild reaction conditions, environmental protection, high product yield, high stereoselectivity, simple composition of raw materials and auxiliary materials participating in the reaction, low price, and easy obtaining, and reduces the synthesis cost.

The invention particularly relates to a preparation method of paratoluensulfonylurea. The preparation method comprises the following steps: jointly adding paratoluensulfonyl chloride and urea into a solvent containing an acid-binding agent, and sufficiently and uniformly mixing; adding p-toluene sulfonamide and 4-dimethylaminopyridine, sealing the reaction system, heating to 100-130 DEG C, and reacting for 2-4 hours; and adding alkali liquor into the cooled reaction system to adjust the pH value to be neutral, continuously stirring for a period of time, and filtering to obtain a solid, namely p-toluenesulfonylurea. According to the method, p-toluene sulfonamide and 4-dimethylaminopyridine are adopted as the composite catalyst, the reaction activity of urea is remarkably improved, the reaction yield is increased, in addition, the acid-binding agent can be regenerated after being treated by alkali liquor, recycling of waste filtrate and the composite catalyst in production is achieved, wastewater discharge is remarkably reduced, and the production cost is reduced.

Provided is a heat-sensitive recording body which is environmentally friendly and has excellent water resistance and oil resistance as well as excellent color developing performance.　The heat-sensitive recording body has a heat-sensitive recording layer containing a colorless or light-colored electron-donating leuco dye and an electron-accepting developer on a support, wherein the electron-accepting developer is an isolated lignin, and the heat-sensitive recording layer contains toluenesulfonamide as a sensitizer.

This invention provides a naphthopyrimidine-fused-acid sugar derivative, its synthesis method, and its application, belonging to the field of pharmaceutical technology. The naphthopyrimidine-fused-acid sugar derivative has the structures shown in formulas (I) to (IV). These compounds are obtained by one-step cyclization via a condensation reaction with 1,8-diaminonaphthalene in an organic solvent under the catalysis of a trifluoromethanesulfonate catalyst, using a propionyl-protected and p-toluenesulfonated sugar as the starting material. The preparation method is efficient and simple. The compounds of this invention exhibit good anti-proliferative activity against colon cancer tumor cells.

The invention belongs to the technical field of pharmacy, and particularly relates to application of polycyclic alkaloid in preparation of an anti-breast cancer drug, and the polycyclic alkaloid is 1, 2a, 7-trimethyl-5-tosyl-1, 2, 2a, 3, 4, 5-hexahydropyrrolo [4, 3, 2-de] quinoline. The polycyclic alkaloid compound is applied to preparation of anti-breast cancer drugs, the effect of inhibiting growth of breast cancer cells is remarkable, and the efficacy of the polycyclic alkaloid compound is far better than that of a positive drug ML162 aiming at EC50 (mu M) + / -S.D = 9.04 + / -0.37 of HCC1937 human breast cancer cells.

The invention discloses a preparation method of a fluorine-containing ester-containing triazole compound, which comprises the following steps of: reacting fluorine-containing ester-containing p-toluenesulfonylhydrazone prepared from cheap and easily available starting raw materials (ketone containing trifluoromethyl or difluoromethyl functional groups) with an aromatic amine compound in tert-butyl hydroperoxide and acetonitrile under the promotion condition of iodine to obtain the fluorine-containing ester-containing triazole compound. And the fluorine-containing ester-containing triazole compound is obtained by a cyclization reaction and a'one-pot method '. In the preparation process, an expensive metal catalyst or ligand does not need to be used, so that the problem of toxicity or use safety caused by metal residues or azide compounds in a pharmaceutical process does not exist; in addition, the raw materials used in the process are bulk, cheap and easily available, the reaction system is green and environment-friendly, and the method has the advantages of simple operation steps and post-treatment process and high yield; the subsequent conversion research of the process can be applied to the synthesis of medical intermediates or related similar compounds.

The invention provides a method for synergistically preparing 3, 4-dihydro-2H-benzo [b] [1, 4] thiazine-1-oxide through monopersulfate, and belongs to the technical field of heterocyclic compounds. In the presence of an alcohol solvent, a 2-N-benzenesulfonyl substituted phenylmethyl sulfide derivative and a halide MX are used as raw materials, and the (R, E)-2-(halogenated methylene)-4-p-toluenesulfonyl-3, 4-dihydro-2H-benzo [b] [1, 4] thiazine-1-oxide with a determined spatial configuration is prepared through a catalytic reaction of a catalyst monopersulfate. The method has the advantages of simple preparation steps, mild reaction conditions, environmental protection, high product yield, high stereoselectivity, simple composition of raw materials and auxiliary materials participating in the reaction, low price, and easy obtaining, and reduces the synthesis cost.

The invention discloses benzaldehyde p-toluenesulfonyl hydrazone and a synthesis method thereof, and belongs to the technical field of organic compounds. The preparation method comprises the following steps: mixing benzaldehyde, p-toluenesulfonyl hydrazide and water, and carrying out condensation reaction to obtain benzaldehyde p-toluenesulfonyl hydrazone. According to the method, green and environment-friendly water is adopted as a solvent, the reaction temperature is mild, purification is easy, the requirement for equipment is low, the purity of the obtained benzaldehyde p-toluenesulfonyl hydrazone is larger than 99.5%, and the yield reaches up to 99.9% or above.

The invention relates to the technical field of high polymer materials, in particular to a high-toughness nylon material and a synthesis method thereof. The preparation method adopts a three-step strategy of'protection-polycondensation-hydrolytic conversion ', and comprises the following steps: firstly, reacting a 4-p-toluenesulfonyl aminophenol protective agent with a polyether amine prepolymer with an ester bond side chain to protect an ester bond; secondly, the protected prepolymer and dicarboxylic acid are subjected to efficient polycondensation at the temperature of 160-230 DEG C, and a high-molecular-weight nylon polymer is obtained; and finally, by controlling acid hydrolysis conditions, removing a protecting group, and converting an ester bond side chain into an active carboxylic acid side chain at the same time. The method breaks through the traditional synthesis bottleneck, and the prepared nylon material has excellent mechanical properties brought by high molecular weight and functionality endowed by carboxylic acid side chains, and has important industrial application value.

The invention discloses a method for constructing a C (sp3)-C (sp3) bond in a light-mediated non-catalytic manner, and belongs to the technical field of organic photosynthesis. The method comprises the following steps: under the protection of inert gas, irradiating a reaction tube under a 427 nm light source for 4-20 hours by taking a p-toluenesulfonyl hydrazone derivative 1 and non-activated alkane or ether 2 as raw materials in the presence of alkali and an organic solvent, and separating and purifying to obtain a C (sp3)-C (sp3) bond coupling compound 3; the key of the reaction is that a singlet carbene intermediate is generated through photolysis by slowly releasing a donor / donor heavy nitrogen compound, and then the singlet carbene intermediate is selectively inserted into a C-H bond of alkane or ether through a transition state of a three-membered ring; the reaction system has the advantages of cheap and easily available raw materials, simple operation, greenness and environmental protection, and provides a green, efficient and easily operated synthesis strategy for realizing the construction of the C (sp3)-C (sp3) bond. Meanwhile, the method can also be applied to gram-level synthesis and later modification of drug molecules, and shows good practicability.

The utility model belongs to the technical field of o-toluene sulfonamide production, and particularly relates to a crystal centrifugal leaching device for synthesizing o-toluene sulfonamide, which comprises a tank body, the top of the tank body is rotatably connected with a rotating shaft through a bearing, the bottom end of the rotating shaft extends into the tank body and is fixedly provided with a rotating plate, and the rotating plate is fixedly connected with the rotating shaft. Centrifugal hoppers are fixed in four through holes formed in the top of the rotating plate, a guide disc is fixed in the tank body, and the bottom ends of the centrifugal hoppers are tightly attached to the guide disc. Through the arrangement of the tank body, the rotating shaft, the rotating plate, the centrifugal hoppers, the guide disc, the baffle plate, the driving mechanism and the spraying assembly, ortho-toluene sulfonamide crystals can be respectively placed in the four centrifugal hoppers in the process of using the crystal centrifugal leaching device for synthesizing ortho-toluene sulfonamide; the o-toluene sulfonamide crystals can be cleaned by utilizing the arranged spraying assembly, and the o-toluene sulfonamide crystals and cleaning liquid can be thrown off by driving the rotating plate to rotate through the rotating shaft after cleaning is completed.

The invention discloses ultra-corrosion-resistant ultraviolet light-moisture curing conformal coating, which is prepared from the following raw materials in parts by weight: 30 to 60 parts of light-cured resin; 1-3 parts of a reactive leveling agent; 30 to 60 parts of an acrylate active monomer; 0.5 to 3 parts of a defoaming agent; 1-5 parts of a coupling agent; 0.3-2 parts of a dehydrating agent; 2-8 parts of a photoinitiator; the light-cured resin is prepared according to the following steps: (a) polycarbonate diol, hexamethylene diisocyanate and dibutyltin dilaurate are subjected to a reaction at 70-90 DEG C, and a polymerization mixture is obtained; and (b) sequentially adding a hydroxyethyl acrylate mixed solution and p-toluenesulfonyl isocyanate into the polymerization mixture to enable the molar ratio of the isocyanate group to the hydroxyl group to be 1: (0.3-0.7), and reacting at 50-70 DEG C, thereby obtaining the polyurethane adhesive. Light / moisture dual curing can be achieved, and the advantages of being good in yellowing resistance, high and low temperature resistance, salt fog resistance and the like are achieved.

The application belongs to the technical field of dielectric material monomer synthesis, and discloses a preparation method of 1-methylbenzocyclobutene. The application adopts 1-hydroxybenzocyclobutene as raw material, and reacts with p-toluenesulfonyl chloride (TsCl) to generate 1-p-toluenesulfonyloxybenzocyclobutene. Then, the 1-p-toluenesulfonyloxybenzocyclobutene reacts with methylmagnesium chloride under the action of a catalyst to obtain the target product 1-methylbenzocyclobutene. The target product is synthesized under relatively mild conditions mainly by controlling the reaction temperature, the feeding sequence and the feeding ratio. The process operation is simple, the experimental condition is mild, the product yield is high, and the method is suitable for industrial production.

The invention provides a preparation method of a sulfone-containing 1, 3-eneyne derivative, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, alkali, alkyne and paratoluensulfonyl iodide into an organic solvent, reacting at 40 DEG C for 4-8 hours, and performing post-treatment to obtain the sulfone-containing 1, 3-enyne derivative. The preparation method is easy to operate, and post-treatment is simple and convenient; the method has the advantages of cheap and easily available reaction starting raw materials, wide tolerance range of substrate functional groups, high reaction efficiency, one-step efficient and rapid synthesis of the sulfone-containing 1, 3-eneyne derivative, and strong practicality.

Disclosed is a phenol-free heat-sensitive recording material comprising: (a) a base material; from one side close to the base material, the coating sequentially comprises: (b) a bottom coating; and (c) a heat-sensitive layer; wherein the heat-sensitive layer includes: a first developer containing a sulfonamide compound represented by the following formula (1): wherein R1 and R2 may be the same or different and each independently represents a hydrogen atom, an alkyl group having 1-4 carbons, an alkoxy group having 1-4 carbons, or a halogen atom; one or more second color developing agents containing at least one phenyl ureide compound represented by the following formula (2): wherein R3 and R4 may be the same or different; and each independently represents a hydrogen atom, a halogen atom, a nitro group, an amino group, an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkylcarbonylamino group, an arylcarbonylamino group, an alkylsulfonylamino group, an arsulfonylamino group, a toluenesulfonyl group, a toluenesulfonyloxy phenyl group, a monoalkylamino group, a dialkylamino group, or an arylamino group; and one or more stabilizers selected from the group consisting of compounds represented by formulae (3) and (4) and derivatives thereof.

The present invention provides a method of controlling UV degradation of a compound of formula (I) wherein R is alkyl or alkylaryl; each of X1, X2, X3, X4 and X5 is independently H, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylthio group, a haloalkylthio group, an amino group, an alkylamino group, a dialkylamino group, an alkoxycarbonyl group, an alkylcarbonyl group, a hydroxyalkyl group, an ester, a haloid acid,-SH,-OH,-NH2,-NO2,-CN or CF3; y is O or S; and Z is halogen, comprising protecting the compound of formula (I) from UV light.

The invention discloses a synthesis method and application of an electrophilic selenium deuterated methyl reagent. The method comprises the following steps: firstly, adding sodium p-toluenesulfinate and selenium powder into a drying container in a nitrogen environment, adding D3-methyl p-toluenesulfonyl ester and an organic solvent in a sealed state, carrying out stirring reaction at normal temperature, extracting a product, drying, filtering, carrying out rotary evaporation to remove the solvent, and carrying out silica gel column chromatography to obtain the selenium deuterated methyl reagent. The reagent is used for preparing trideuterated methyl selenide alkyl ether, trideuterated methyl selenide alkynyl ether or trideuterated methyl selenide aryl ether. According to the method disclosed by the invention, the selenium deuterated methyl reagent can be obtained under the conditions of normal temperature and no additional additive by taking the deuterated methanol which is cheap and easy to obtain as an initial substance, and the cost is low. The electrophilic selenium deuterated methyl reagent prepared by the method disclosed by the invention reacts with beta-ketone ester, a terminal alkyne derivative, arylboronic acid or an arylboronic acid pinacol ester substrate, so that the construction of C (sp2)-SeCD3 and C (sp3)-SeCD3 bonds is realized.