120 results about "Tosylhydrazone" patented technology

The present invention relates to the field of the preparation of polyurethane elastic fibers, and relates to a preparation method for a bio-based polyurethane elastic fiber, comprising: preparing polyether polyol from sucrose, glycerol, dimethylamine and propylene oxide; adding a solvent, i.e., N,N-dimethylacetamide, and polyether polyol and polyisocyanate into a reaction tank, and adding p-Toluenesulfonyl semicarbazide and aluminum methylenebis(2,4-di-tert-butylphenoxy) phosphate to prepare a spinning solution; and subjecting the spinning solution to spinning and oil application by means of dry spinning technology to obtain the bio-based polyurethane elastic fiber. The present invention ensures that the properties of polyurethane elastic fibers do not deteriorate or are partially enhanced, while the cost and performance advantages are achieved.

A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi wherein the at least one fungicide is a fungicidal sterol biosynthesis-inhibitor.

The invention is applicable to the technical field of fuel cells, and provides a blending modified polybenzimidazole proton exchange membrane and a preparation method thereof, and the preparation method comprises the following steps: S1, preparing 4-methyl-N-toluenesulfonyl benzene sulfonamide; s2, preparing 4, 4 '-[imino bis (sulfonyl)] dibenzoic acid; s3, preparation of PSI: dissolving CBSI and a proper amount of anhydrous lithium chloride in a proper amount of a mixed solution of pyridine, triphenyl phosphite and pyrrolidone, adding diamino molecules after complete dissolution, heating and stirring the solution for 12 h, pouring the solution into methanol, filtering and collecting a product, washing with water, and drying to obtain the product PSI; and S4, preparing the PSI / OPBI blended membrane. The blended membrane prepared by the invention has excellent proton conductivity and good mechanical properties, and meets the performance requirements of the proton exchange membrane of the fuel cell; moreover, the raw materials are low in cost and easy to obtain, the synthesis conditions are mature, the yield is high, the feasibility is high, and the application prospect is wide.

The invention discloses a low-damping PVC-U electrical conduit and a processing technology thereof, and belongs to the technical field of conduit preparation. The low-damping PVC-U electrical conduit is prepared from the following components in parts by weight: 70 to 80 parts of PVC resin, 30 to 42 parts of light calcium carbonate, 8 to 15 parts of ethylene-vinyl acetate copolymer, 0.5 to 1 part of ethylene bis stearamide, 3 to 6 parts of epoxy compound and 4 to 7 parts of compound stabilizer, the preparation method comprises the following steps: preparing an epoxy compound from ethyl benzoylacetate, 2-(trimethylsilyl) phenyl trifluoromethane sulfonate, p-toluenesulfonyl azide, p-aminophenol, p-toluenesulfonyl chloride, iodobenzene diacetic acid and rhodium diacetate as raw materials, and preparing the compound stabilizer from 2-(2-aminoethoxy) ethanol, 4-fluorophenol and xylene alkane diisocyanate as raw materials. The PVC-U electrical conduit prepared from the substances has the advantages of low damping, excellent stability, excellent mechanical property and excellent aging resistance.

The invention relates to a production method of quizalofop-p-ethyl, which comprises the following steps: reacting 2-(4-hydroxyphenoxy) propionic acid with absolute ethyl alcohol to obtain ethyl 2-(4-hydroxyphenoxy) propionate, and replacing the original process of reacting p-toluenesulfonyl chloride with L-ethyl lactate to obtain an intermediate, namely ethyl p-toluenesulfonyl lactate, with a process of reacting 2-(4-hydroxyphenoxy) propionic acid with absolute ethyl alcohol to obtain ethyl 2-(4-hydroxyphenoxy) propionate; meanwhile, in the post-treatment method, centrifugal separation replaces plate-and-frame pressure filtration, closed-circuit flash drying replaces original rake drying, racemization of quizalofop-p-ethyl is effectively avoided, the optical purity and yield of quizalofop-p-ethyl are improved, and the environmental protection benefits of the process are improved. Experiments show that the optical purity of the quizalofop-p-ethyl produced by the method provided by the invention is 99% or above, the yield is 98% or above, and the method is suitable for industrial production.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi wherein the at least one fungicide is a multi-site inhibitor or a strobilurin inhibitor.

The present application belongs to the technical field of water treatment, and relates to a heat-sensitive color developing agent F-103 production wastewater treatment method. The present application performs multistage treatment on the wastewater. First, an alkaline chemical separation reaction is performed on the wastewater to remove part of the acidic polar organic matter 3-p-tolylsulfonylureido phenol, p-toluenesulfonic acid and the like in the water. Then, an acid chemical separation reaction is performed to further remove the alkaline polar organic matter intermediate MAPOTs and the like in the water. Subsequently, an adsorption reaction is performed using activated carbon to further remove the organic matter and inorganic impurities in the water. Finally, evaporation and concentration are performed to recover the salt sodium chloride. The wastewater treatment of the present application recovers the salt sodium chloride in the wastewater as a resource under the premise of solving the toxicity problem of the organic matter in the wastewater, and realizes the harmless treatment and the reduction of hazardous waste of the wastewater.

The invention relates to the field of skin care products, and discloses an unsaturated silanol composition and application thereof in skin care, the composition comprises organosilanol, plant essential oil microcapsules, glycerin, hyaluronic acid, caprylic / capric polyethylene glycol glyceride and purified water; the general formula of the organosilanol is X-Si (OH) 2-Y; wherein: X is a vinyl group, an allyl group, a linear or branched C1-C4 alkyl group; y is a vinyl group, an allyl group,-OCH3,-OCH2CH3,-OCH2OH,-OCH2CH2OH, a linear or branched C1-C4 alkyl group; the plant essential oil microcapsule is prepared by using modified agar prepared by reacting octenyl succinic anhydride with agar, modified beta-cyclodextrin prepared by grafting mono-6-p-toluenesulfonyl-beta-cyclodextrin with chitosan and sodium alginate as wall materials, plant essential oil as a core material and calcium chloride as a cross-linking agent through an extrusion method and a freeze-drying method. And the composition with good antibacterial and antiseptic capabilities, skin barrier reparability and moisturizing and water locking effects is prepared.

The invention particularly relates to a preparation method of paratoluensulfonylurea. The preparation method comprises the following steps: jointly adding paratoluensulfonyl chloride and urea into a solvent containing an acid-binding agent, and sufficiently and uniformly mixing; adding p-toluene sulfonamide and 4-dimethylaminopyridine, sealing the reaction system, heating to 100-130 DEG C, and reacting for 2-4 hours; and adding alkali liquor into the cooled reaction system to adjust the pH value to be neutral, continuously stirring for a period of time, and filtering to obtain a solid, namely p-toluenesulfonylurea. According to the method, p-toluene sulfonamide and 4-dimethylaminopyridine are adopted as the composite catalyst, the reaction activity of urea is remarkably improved, the reaction yield is increased, in addition, the acid-binding agent can be regenerated after being treated by alkali liquor, recycling of waste filtrate and the composite catalyst in production is achieved, wastewater discharge is remarkably reduced, and the production cost is reduced.

Provided is a heat-sensitive recording body which is environmentally friendly and has excellent water resistance and oil resistance as well as excellent color developing performance.　The heat-sensitive recording body has a heat-sensitive recording layer containing a colorless or light-colored electron-donating leuco dye and an electron-accepting developer on a support, wherein the electron-accepting developer is an isolated lignin, and the heat-sensitive recording layer contains toluenesulfonamide as a sensitizer.

This invention provides a naphthopyrimidine-fused-acid sugar derivative, its synthesis method, and its application, belonging to the field of pharmaceutical technology. The naphthopyrimidine-fused-acid sugar derivative has the structures shown in formulas (I) to (IV). These compounds are obtained by one-step cyclization via a condensation reaction with 1,8-diaminonaphthalene in an organic solvent under the catalysis of a trifluoromethanesulfonate catalyst, using a propionyl-protected and p-toluenesulfonated sugar as the starting material. The preparation method is efficient and simple. The compounds of this invention exhibit good anti-proliferative activity against colon cancer tumor cells.

The invention belongs to the technical field of pharmacy, and particularly relates to application of polycyclic alkaloid in preparation of an anti-breast cancer drug, and the polycyclic alkaloid is 1, 2a, 7-trimethyl-5-tosyl-1, 2, 2a, 3, 4, 5-hexahydropyrrolo [4, 3, 2-de] quinoline. The polycyclic alkaloid compound is applied to preparation of anti-breast cancer drugs, the effect of inhibiting growth of breast cancer cells is remarkable, and the efficacy of the polycyclic alkaloid compound is far better than that of a positive drug ML162 aiming at EC50 (mu M) + / -S.D = 9.04 + / -0.37 of HCC1937 human breast cancer cells.

The invention discloses a preparation method of a fluorine-containing ester-containing triazole compound, which comprises the following steps of: reacting fluorine-containing ester-containing p-toluenesulfonylhydrazone prepared from cheap and easily available starting raw materials (ketone containing trifluoromethyl or difluoromethyl functional groups) with an aromatic amine compound in tert-butyl hydroperoxide and acetonitrile under the promotion condition of iodine to obtain the fluorine-containing ester-containing triazole compound. And the fluorine-containing ester-containing triazole compound is obtained by a cyclization reaction and a'one-pot method '. In the preparation process, an expensive metal catalyst or ligand does not need to be used, so that the problem of toxicity or use safety caused by metal residues or azide compounds in a pharmaceutical process does not exist; in addition, the raw materials used in the process are bulk, cheap and easily available, the reaction system is green and environment-friendly, and the method has the advantages of simple operation steps and post-treatment process and high yield; the subsequent conversion research of the process can be applied to the synthesis of medical intermediates or related similar compounds.

The invention relates to the technical field of high polymer materials, in particular to a high-toughness nylon material and a synthesis method thereof. The preparation method adopts a three-step strategy of'protection-polycondensation-hydrolytic conversion ', and comprises the following steps: firstly, reacting a 4-p-toluenesulfonyl aminophenol protective agent with a polyether amine prepolymer with an ester bond side chain to protect an ester bond; secondly, the protected prepolymer and dicarboxylic acid are subjected to efficient polycondensation at the temperature of 160-230 DEG C, and a high-molecular-weight nylon polymer is obtained; and finally, by controlling acid hydrolysis conditions, removing a protecting group, and converting an ester bond side chain into an active carboxylic acid side chain at the same time. The method breaks through the traditional synthesis bottleneck, and the prepared nylon material has excellent mechanical properties brought by high molecular weight and functionality endowed by carboxylic acid side chains, and has important industrial application value.

The utility model belongs to the technical field of o-toluene sulfonamide production, and particularly relates to a crystal centrifugal leaching device for synthesizing o-toluene sulfonamide, which comprises a tank body, the top of the tank body is rotatably connected with a rotating shaft through a bearing, the bottom end of the rotating shaft extends into the tank body and is fixedly provided with a rotating plate, and the rotating plate is fixedly connected with the rotating shaft. Centrifugal hoppers are fixed in four through holes formed in the top of the rotating plate, a guide disc is fixed in the tank body, and the bottom ends of the centrifugal hoppers are tightly attached to the guide disc. Through the arrangement of the tank body, the rotating shaft, the rotating plate, the centrifugal hoppers, the guide disc, the baffle plate, the driving mechanism and the spraying assembly, ortho-toluene sulfonamide crystals can be respectively placed in the four centrifugal hoppers in the process of using the crystal centrifugal leaching device for synthesizing ortho-toluene sulfonamide; the o-toluene sulfonamide crystals can be cleaned by utilizing the arranged spraying assembly, and the o-toluene sulfonamide crystals and cleaning liquid can be thrown off by driving the rotating plate to rotate through the rotating shaft after cleaning is completed.

The application belongs to the technical field of dielectric material monomer synthesis, and discloses a preparation method of 1-methylbenzocyclobutene. The application adopts 1-hydroxybenzocyclobutene as raw material, and reacts with p-toluenesulfonyl chloride (TsCl) to generate 1-p-toluenesulfonyloxybenzocyclobutene. Then, the 1-p-toluenesulfonyloxybenzocyclobutene reacts with methylmagnesium chloride under the action of a catalyst to obtain the target product 1-methylbenzocyclobutene. The target product is synthesized under relatively mild conditions mainly by controlling the reaction temperature, the feeding sequence and the feeding ratio. The process operation is simple, the experimental condition is mild, the product yield is high, and the method is suitable for industrial production.

Disclosed is a phenol-free heat-sensitive recording material comprising: (a) a base material; from one side close to the base material, the coating sequentially comprises: (b) a bottom coating; and (c) a heat-sensitive layer; wherein the heat-sensitive layer includes: a first developer containing a sulfonamide compound represented by the following formula (1): wherein R1 and R2 may be the same or different and each independently represents a hydrogen atom, an alkyl group having 1-4 carbons, an alkoxy group having 1-4 carbons, or a halogen atom; one or more second color developing agents containing at least one phenyl ureide compound represented by the following formula (2): wherein R3 and R4 may be the same or different; and each independently represents a hydrogen atom, a halogen atom, a nitro group, an amino group, an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkylcarbonylamino group, an arylcarbonylamino group, an alkylsulfonylamino group, an arsulfonylamino group, a toluenesulfonyl group, a toluenesulfonyloxy phenyl group, a monoalkylamino group, a dialkylamino group, or an arylamino group; and one or more stabilizers selected from the group consisting of compounds represented by formulae (3) and (4) and derivatives thereof.

The present invention provides a method of controlling UV degradation of a compound of formula (I) wherein R is alkyl or alkylaryl; each of X1, X2, X3, X4 and X5 is independently H, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylthio group, a haloalkylthio group, an amino group, an alkylamino group, a dialkylamino group, an alkoxycarbonyl group, an alkylcarbonyl group, a hydroxyalkyl group, an ester, a haloid acid,-SH,-OH,-NH2,-NO2,-CN or CF3; y is O or S; and Z is halogen, comprising protecting the compound of formula (I) from UV light.

A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi wherein the at least one fungicide is a multi-site inhibitor or a strobilurin inhibitor.

This invention discloses a method for synthesizing 2-benzamido-2-phenyl-3-vinyl-1-indanone, relating to the field of chemical synthesis technology of 2-benzamido-2-phenyl-3-vinyl-1-indanone. This invention comprises the following steps: S1: At room temperature, N-(aryl(p-toluenesulfonyl)methyl)amide (0.5 mmol), thiazolyl carbene precursor (40.5 mg, 0.15 mmol, 30 mol%), and o-alkynylbenzaldehyde (0.75 mmol) are added to a dry double-necked round-bottom flask. Under a high-purity nitrogen atmosphere, dry acetonitrile (5 mL) is added using a syringe. The reaction mixture is stirred under nitrogen purging. Et3N (126.3 mg, 1.25 mmol, 2.5 equiv.) is added using a microsyringe. S2: The reaction mixture is stirred under a nitrogen atmosphere to quench the reaction. After removing the solvent, the residue is separated by silica gel column chromatography (PE:EA = 4:1 to 3:1) to obtain the o-amidoketone intermediate. The synthetic method of this invention has high reaction efficiency, easily introduces chiral carbon, has high stereoselectivity, is novel in both method and product, and has a yield of 82%.

The invention relates to a method for preparing 1, 2-bis (4-vinylphenyl) ethane, and relates to the technical field of organic chemistry, the preparation method comprises the following steps: (1) mixing a compound 1, p-toluenesulfonhydrazide and an organic solvent 1, and reacting to obtain a compound 2; and (2) reacting the compound 2 in an organic solvent 2 under the action of alkali and a polymerization inhibitor to generate the 1, 2-bis (4-vinyl phenyl) ethane. The method is mild in reaction condition, simple and convenient to operate, high in product purity, high in yield and suitable for industrial production.

The reaction device comprises a reaction kettle, a circulating cylinder is arranged in the reaction kettle, the top of the circulating cylinder is closed, the bottom of the circulating cylinder is open, a cavity is formed in the cylinder wall, a plurality of supporting rods are arranged on the edge portion of the outer top face of the circulating cylinder, the top ends of the supporting rods are fixedly connected with material dispersing cones, and the top of the reaction kettle corresponding to the material dispersing cones is communicated with a feeding pipe. A material pump is arranged between the bulk material cone and the top of the circulating barrel, an inlet of the material pump is communicated with a circulating pipe, the bottom end of the circulating pipe penetrates through the top of the circulating barrel to the inner side of the circulating barrel, a plurality of groups of connecting rods are arranged on the outer side of the circulating barrel, the same group of connecting rods are fixedly connected with the same motor, and an output shaft of the motor is fixedly connected with a disc type turbine stirrer; a plurality of air inlet branch pipes are circumferentially distributed at the bottom of the circulating cylinder at intervals, the top ends of the air inlet branch pipes are communicated with the cavity, and the bottom ends of the air inlet branch pipes extend out of the reaction kettle and are communicated with a hollow air inlet disc. The device can effectively improve the efficiency and quality of dissolution and reaction, and is more practical.

A mild and general method for tosyl protecting group removal from a protected organic nitrogen compound that is additionally suitable for use at commercial scale. A method for the removal of a tosyl protecting group from a protected organic nitrogen compound to form an unprotected nitrogen compound, including azabicyclo[3.1.0]hexane-6-carboxamide derivatives.

The invention relates to the technical field of yoga mat production, in particular to a uniformly foamed yoga mat and a preparation method thereof, polyvinyl chloride resin is used as a main component, and polyformaldehyde resin and polymethyl methacrylate resin are added as reinforcing components; the wear resistance, the elasticity, the heat resistance, the cold resistance and the corrosion resistance of the traditional PVC yoga mat can be improved; moreover, aiming at the mixed raw material of the polyvinyl chloride resin, the polyformaldehyde resin and the polymethyl methacrylate resin, three foaming agents with different decomposition temperatures, namely toluenesulfonyl hydrazide, di (benzenesulfonyl hydrazide) ether and p-toluenesulfonyl semicarbazide, are added, and three stages are set in the foaming stage, so that the foaming performance of the polyvinyl chloride resin, the polyformaldehyde resin and the polymethyl methacrylate resin is improved. Different foaming temperatures and foaming time are controlled in each stage, so that the mixed raw materials can be foamed more sufficiently, the foaming of the foaming materials is ensured to be more uniform, and the quality of the yoga mat is improved.

The invention provides a preparation method of a 2-(4-toluene methyl)-3-toluene sulfonyl benzofuran derivative, and belongs to the technical field of heterocyclic compounds. Lewis acid, o-hydroxyphenyl propargyl amine and sodium sulfinate are added into an organic solvent, a reaction is carried out for 14 hours at the temperature of 80 DEG C, and the 2-(4-toluene methyl)-3-toluene sulfonyl benzofuran derivative is obtained through aftertreatment. The preparation method is simple and convenient to operate, the initial raw materials are cheap and easy to obtain, the reaction efficiency is high, the substrate compatibility is good, and the 2-(4-toluenemethyl)-3-toluenesulfonyl benzofuran derivative can be efficiently and rapidly synthesized in one step.

The invention discloses a preparation method of 7-p-toluenesulfonyl hydrazone-3-cholesteryl acetate. The 7-p-toluenesulfonyl hydrazone-3-cholesteryl acetate The invention provides a preparation method of a compound shown in a formula I. The preparation method comprises the following step: in an aprotic solvent, in the presence of acid, anhydride and an adsorbent, a compound shown in a formula II and a compound shown in a formula III are subjected to a reaction shown in the specification to obtain the compound shown in the formula I. The method is mild in reaction condition, high in reaction speed, high in conversion rate and few in side reaction, and the compound shown in the formula I and with the purity larger than or equal to 98.5% can be obtained; the obtained crystal particles are large in particle size and high in filtering speed; the method has good process conditions and is suitable for large-scale industrial production.

The present invention discloses a thiazole orange organosilicon quaternary ammonium salt compound, a preparation method thereof and an application. The structure of the compound is shown in Formula I, wherein, X 1 and X 2 are independently selected from chlorine, bromine, iodine, p-toluenesulfonyloxy, benzenesulfonyloxy, methanesulfonyloxy, R 1 , R 2 , R 3 , R 4 are independently selected from methyl, ethyl, C3-C8 alkyl, phenyl, nitro, nitroso, sulfonyl, methanesulfonyl, fluorine, chlorine, bromine, iodine, trifluoromethyl, difluoromethyl, m = 0-30, n = 0-30. The present invention simultaneously has four structures of thiazole ring, quinoline ring, quaternary ammonium group and organosiloxane, has a broad antibacterial spectrum, and simultaneously has antibacterial activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger, has good wash resistance, compared with the existing preparation methods, the operation of the present invention is simple, the raw materials are convenient to obtain, is environmentally friendly, suitable for industrial production, and has good application prospects.

The invention relates to the technical field of PUR automobile roof glue, and discloses anti-skinning and anti-bubble dual-functional moisture-curing reaction type PUR automobile roof glue and a preparation method thereof. The raw materials comprise crystalline polyester polyol, amorphous polyester polyol, polycarbonate polyol, trimethylolpropane, diisocyanate, modified starch, p-toluenesulfonyl isocyanate, carbodiimide, a zinc-bismuth composite catalyst, an antioxidant and a polymerization inhibitor according to the weight, the modified starch is prepared from the following raw materials: starch, octenyl succinic anhydride, epoxidized soybean oil, a silane coupling agent KH-560, calcium stearate and nano montmorillonite. Through dual modification of octenyl succinic anhydride and a silane coupling agent KH-560, the modified starch obtains high hydrophobicity and interface reaction activity, and by virtue of the strong hydrophobicity and excellent compatibility with a PUR system and cooperation with carbodiimide, the adhesive strength of the PUR system is improved while the excellent bonding strength of the PUR system is maintained. The problem that the PUR is easy to crust and blister when being used as the automobile roof adhesive is solved.

This invention discloses a method for preparing high-performance tin-containing perovskite solar cells using bifunctional acylhydrazide small molecules. The method focuses on selecting bifunctional acylhydrazide small molecules such as p-toluenesulfonylhydrazide (PTSH) and oxaloyl dihydrazide (ODZ) as additives to enhance the performance of tin-containing perovskite (ASn) solar cells. x Pb 1‑x X3) Modification of the active layer of solar cells. Compared to traditional Sn 2+ The coordination strategy of the bifunctional hydrazide small molecule selected in this invention can, in addition to coordinating with Sn... 2+ In addition to providing an antioxidant environment through coordination, Sn can also achieve... 4+ To Sn 2+ The reduction of Sn in perovskite films can be minimized. 4+ This leads to the P-type self-doping effect and defect density. The photoelectric conversion efficiency and device stability of the tin-containing perovskite solar cells prepared based on this invention are effectively improved.