70 results about "Tosylhydrazone" patented technology

The present invention relates to the field of the preparation of polyurethane elastic fibers, and relates to a preparation method for a bio-based polyurethane elastic fiber, comprising: preparing polyether polyol from sucrose, glycerol, dimethylamine and propylene oxide; adding a solvent, i.e., N,N-dimethylacetamide, and polyether polyol and polyisocyanate into a reaction tank, and adding p-Toluenesulfonyl semicarbazide and aluminum methylenebis(2,4-di-tert-butylphenoxy) phosphate to prepare a spinning solution; and subjecting the spinning solution to spinning and oil application by means of dry spinning technology to obtain the bio-based polyurethane elastic fiber. The present invention ensures that the properties of polyurethane elastic fibers do not deteriorate or are partially enhanced, while the cost and performance advantages are achieved.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

The present application belongs to the technical field of water treatment, and relates to a heat-sensitive color developing agent F-103 production wastewater treatment method. The present application performs multistage treatment on the wastewater. First, an alkaline chemical separation reaction is performed on the wastewater to remove part of the acidic polar organic matter 3-p-tolylsulfonylureido phenol, p-toluenesulfonic acid and the like in the water. Then, an acid chemical separation reaction is performed to further remove the alkaline polar organic matter intermediate MAPOTs and the like in the water. Subsequently, an adsorption reaction is performed using activated carbon to further remove the organic matter and inorganic impurities in the water. Finally, evaporation and concentration are performed to recover the salt sodium chloride. The wastewater treatment of the present application recovers the salt sodium chloride in the wastewater as a resource under the premise of solving the toxicity problem of the organic matter in the wastewater, and realizes the harmless treatment and the reduction of hazardous waste of the wastewater.

The invention relates to the field of skin care products, and discloses an unsaturated silanol composition and application thereof in skin care, the composition comprises organosilanol, plant essential oil microcapsules, glycerin, hyaluronic acid, caprylic / capric polyethylene glycol glyceride and purified water; the general formula of the organosilanol is X-Si (OH) 2-Y; wherein: X is a vinyl group, an allyl group, a linear or branched C1-C4 alkyl group; y is a vinyl group, an allyl group,-OCH3,-OCH2CH3,-OCH2OH,-OCH2CH2OH, a linear or branched C1-C4 alkyl group; the plant essential oil microcapsule is prepared by using modified agar prepared by reacting octenyl succinic anhydride with agar, modified beta-cyclodextrin prepared by grafting mono-6-p-toluenesulfonyl-beta-cyclodextrin with chitosan and sodium alginate as wall materials, plant essential oil as a core material and calcium chloride as a cross-linking agent through an extrusion method and a freeze-drying method. And the composition with good antibacterial and antiseptic capabilities, skin barrier reparability and moisturizing and water locking effects is prepared.

Provided is a heat-sensitive recording body which is environmentally friendly and has excellent water resistance and oil resistance as well as excellent color developing performance.　The heat-sensitive recording body has a heat-sensitive recording layer containing a colorless or light-colored electron-donating leuco dye and an electron-accepting developer on a support, wherein the electron-accepting developer is an isolated lignin, and the heat-sensitive recording layer contains toluenesulfonamide as a sensitizer.

This invention provides a naphthopyrimidine-fused-acid sugar derivative, its synthesis method, and its application, belonging to the field of pharmaceutical technology. The naphthopyrimidine-fused-acid sugar derivative has the structures shown in formulas (I) to (IV). These compounds are obtained by one-step cyclization via a condensation reaction with 1,8-diaminonaphthalene in an organic solvent under the catalysis of a trifluoromethanesulfonate catalyst, using a propionyl-protected and p-toluenesulfonated sugar as the starting material. The preparation method is efficient and simple. The compounds of this invention exhibit good anti-proliferative activity against colon cancer tumor cells.

The invention belongs to the technical field of pharmacy, and particularly relates to application of polycyclic alkaloid in preparation of an anti-breast cancer drug, and the polycyclic alkaloid is 1, 2a, 7-trimethyl-5-tosyl-1, 2, 2a, 3, 4, 5-hexahydropyrrolo [4, 3, 2-de] quinoline. The polycyclic alkaloid compound is applied to preparation of anti-breast cancer drugs, the effect of inhibiting growth of breast cancer cells is remarkable, and the efficacy of the polycyclic alkaloid compound is far better than that of a positive drug ML162 aiming at EC50 (mu M) + / -S.D = 9.04 + / -0.37 of HCC1937 human breast cancer cells.

The invention discloses a preparation method of a fluorine-containing ester-containing triazole compound, which comprises the following steps of: reacting fluorine-containing ester-containing p-toluenesulfonylhydrazone prepared from cheap and easily available starting raw materials (ketone containing trifluoromethyl or difluoromethyl functional groups) with an aromatic amine compound in tert-butyl hydroperoxide and acetonitrile under the promotion condition of iodine to obtain the fluorine-containing ester-containing triazole compound. And the fluorine-containing ester-containing triazole compound is obtained by a cyclization reaction and a'one-pot method '. In the preparation process, an expensive metal catalyst or ligand does not need to be used, so that the problem of toxicity or use safety caused by metal residues or azide compounds in a pharmaceutical process does not exist; in addition, the raw materials used in the process are bulk, cheap and easily available, the reaction system is green and environment-friendly, and the method has the advantages of simple operation steps and post-treatment process and high yield; the subsequent conversion research of the process can be applied to the synthesis of medical intermediates or related similar compounds.

The invention relates to the technical field of high polymer materials, in particular to a high-toughness nylon material and a synthesis method thereof. The preparation method adopts a three-step strategy of'protection-polycondensation-hydrolytic conversion ', and comprises the following steps: firstly, reacting a 4-p-toluenesulfonyl aminophenol protective agent with a polyether amine prepolymer with an ester bond side chain to protect an ester bond; secondly, the protected prepolymer and dicarboxylic acid are subjected to efficient polycondensation at the temperature of 160-230 DEG C, and a high-molecular-weight nylon polymer is obtained; and finally, by controlling acid hydrolysis conditions, removing a protecting group, and converting an ester bond side chain into an active carboxylic acid side chain at the same time. The method breaks through the traditional synthesis bottleneck, and the prepared nylon material has excellent mechanical properties brought by high molecular weight and functionality endowed by carboxylic acid side chains, and has important industrial application value.

The utility model belongs to the technical field of o-toluene sulfonamide production, and particularly relates to a crystal centrifugal leaching device for synthesizing o-toluene sulfonamide, which comprises a tank body, the top of the tank body is rotatably connected with a rotating shaft through a bearing, the bottom end of the rotating shaft extends into the tank body and is fixedly provided with a rotating plate, and the rotating plate is fixedly connected with the rotating shaft. Centrifugal hoppers are fixed in four through holes formed in the top of the rotating plate, a guide disc is fixed in the tank body, and the bottom ends of the centrifugal hoppers are tightly attached to the guide disc. Through the arrangement of the tank body, the rotating shaft, the rotating plate, the centrifugal hoppers, the guide disc, the baffle plate, the driving mechanism and the spraying assembly, ortho-toluene sulfonamide crystals can be respectively placed in the four centrifugal hoppers in the process of using the crystal centrifugal leaching device for synthesizing ortho-toluene sulfonamide; the o-toluene sulfonamide crystals can be cleaned by utilizing the arranged spraying assembly, and the o-toluene sulfonamide crystals and cleaning liquid can be thrown off by driving the rotating plate to rotate through the rotating shaft after cleaning is completed.

Disclosed is a phenol-free heat-sensitive recording material comprising: (a) a base material; from one side close to the base material, the coating sequentially comprises: (b) a bottom coating; and (c) a heat-sensitive layer; wherein the heat-sensitive layer includes: a first developer containing a sulfonamide compound represented by the following formula (1): wherein R1 and R2 may be the same or different and each independently represents a hydrogen atom, an alkyl group having 1-4 carbons, an alkoxy group having 1-4 carbons, or a halogen atom; one or more second color developing agents containing at least one phenyl ureide compound represented by the following formula (2): wherein R3 and R4 may be the same or different; and each independently represents a hydrogen atom, a halogen atom, a nitro group, an amino group, an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkylcarbonylamino group, an arylcarbonylamino group, an alkylsulfonylamino group, an arsulfonylamino group, a toluenesulfonyl group, a toluenesulfonyloxy phenyl group, a monoalkylamino group, a dialkylamino group, or an arylamino group; and one or more stabilizers selected from the group consisting of compounds represented by formulae (3) and (4) and derivatives thereof.

The present invention provides a method of controlling UV degradation of a compound of formula (I) wherein R is alkyl or alkylaryl; each of X1, X2, X3, X4 and X5 is independently H, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylthio group, a haloalkylthio group, an amino group, an alkylamino group, a dialkylamino group, an alkoxycarbonyl group, an alkylcarbonyl group, a hydroxyalkyl group, an ester, a haloid acid,-SH,-OH,-NH2,-NO2,-CN or CF3; y is O or S; and Z is halogen, comprising protecting the compound of formula (I) from UV light.

This invention discloses a method for synthesizing 2-benzamido-2-phenyl-3-vinyl-1-indanone, relating to the field of chemical synthesis technology of 2-benzamido-2-phenyl-3-vinyl-1-indanone. This invention comprises the following steps: S1: At room temperature, N-(aryl(p-toluenesulfonyl)methyl)amide (0.5 mmol), thiazolyl carbene precursor (40.5 mg, 0.15 mmol, 30 mol%), and o-alkynylbenzaldehyde (0.75 mmol) are added to a dry double-necked round-bottom flask. Under a high-purity nitrogen atmosphere, dry acetonitrile (5 mL) is added using a syringe. The reaction mixture is stirred under nitrogen purging. Et3N (126.3 mg, 1.25 mmol, 2.5 equiv.) is added using a microsyringe. S2: The reaction mixture is stirred under a nitrogen atmosphere to quench the reaction. After removing the solvent, the residue is separated by silica gel column chromatography (PE:EA = 4:1 to 3:1) to obtain the o-amidoketone intermediate. The synthetic method of this invention has high reaction efficiency, easily introduces chiral carbon, has high stereoselectivity, is novel in both method and product, and has a yield of 82%.

The invention relates to a method for preparing 1, 2-bis (4-vinylphenyl) ethane, and relates to the technical field of organic chemistry, the preparation method comprises the following steps: (1) mixing a compound 1, p-toluenesulfonhydrazide and an organic solvent 1, and reacting to obtain a compound 2; and (2) reacting the compound 2 in an organic solvent 2 under the action of alkali and a polymerization inhibitor to generate the 1, 2-bis (4-vinyl phenyl) ethane. The method is mild in reaction condition, simple and convenient to operate, high in product purity, high in yield and suitable for industrial production.

A mild and general method for tosyl protecting group removal from a protected organic nitrogen compound that is additionally suitable for use at commercial scale. A method for the removal of a tosyl protecting group from a protected organic nitrogen compound to form an unprotected nitrogen compound, including azabicyclo[3.1.0]hexane-6-carboxamide derivatives.

The invention discloses a preparation method of 7-p-toluenesulfonyl hydrazone-3-cholesteryl acetate. The 7-p-toluenesulfonyl hydrazone-3-cholesteryl acetate The invention provides a preparation method of a compound shown in a formula I. The preparation method comprises the following step: in an aprotic solvent, in the presence of acid, anhydride and an adsorbent, a compound shown in a formula II and a compound shown in a formula III are subjected to a reaction shown in the specification to obtain the compound shown in the formula I. The method is mild in reaction condition, high in reaction speed, high in conversion rate and few in side reaction, and the compound shown in the formula I and with the purity larger than or equal to 98.5% can be obtained; the obtained crystal particles are large in particle size and high in filtering speed; the method has good process conditions and is suitable for large-scale industrial production.

The invention relates to the technical field of PUR automobile roof glue, and discloses anti-skinning and anti-bubble dual-functional moisture-curing reaction type PUR automobile roof glue and a preparation method thereof. The raw materials comprise crystalline polyester polyol, amorphous polyester polyol, polycarbonate polyol, trimethylolpropane, diisocyanate, modified starch, p-toluenesulfonyl isocyanate, carbodiimide, a zinc-bismuth composite catalyst, an antioxidant and a polymerization inhibitor according to the weight, the modified starch is prepared from the following raw materials: starch, octenyl succinic anhydride, epoxidized soybean oil, a silane coupling agent KH-560, calcium stearate and nano montmorillonite. Through dual modification of octenyl succinic anhydride and a silane coupling agent KH-560, the modified starch obtains high hydrophobicity and interface reaction activity, and by virtue of the strong hydrophobicity and excellent compatibility with a PUR system and cooperation with carbodiimide, the adhesive strength of the PUR system is improved while the excellent bonding strength of the PUR system is maintained. The problem that the PUR is easy to crust and blister when being used as the automobile roof adhesive is solved.

This invention discloses a method for preparing high-performance tin-containing perovskite solar cells using bifunctional acylhydrazide small molecules. The method focuses on selecting bifunctional acylhydrazide small molecules such as p-toluenesulfonylhydrazide (PTSH) and oxaloyl dihydrazide (ODZ) as additives to enhance the performance of tin-containing perovskite (ASn) solar cells. x Pb 1‑x X3) Modification of the active layer of solar cells. Compared to traditional Sn 2+ The coordination strategy of the bifunctional hydrazide small molecule selected in this invention can, in addition to coordinating with Sn... 2+ In addition to providing an antioxidant environment through coordination, Sn can also achieve... 4+ To Sn 2+ The reduction of Sn in perovskite films can be minimized. 4+ This leads to the P-type self-doping effect and defect density. The photoelectric conversion efficiency and device stability of the tin-containing perovskite solar cells prepared based on this invention are effectively improved.

This invention relates to a method for the trivalent rhodium-catalyzed synthesis of 2-cyanenylindole compounds, belonging to the field of organic chemistry. The method uses [Cp*RhCl2]2 as a catalyst and N-pyrimidine indole compounds and alkynyl-N-cyano-N-phenyl-p-toluenesulfonamide compounds as raw materials. The reaction is carried out in an organic solvent at 60°C with lithium chloride assistance, and the 2-cyanenylindole compounds are obtained after separation and purification. This invention utilizes a cyano group migration strategy to achieve a tandem reaction of indole C-H alkenylation and cyano group introduction, constructing C-C and C-CN bonds in one step, with a target product yield of 31%–82%. Compared with existing technologies, this invention uses a non-toxic cyanide source instead of traditional highly toxic cyaniding reagents, and has advantages such as simple operation, mild reaction conditions, wide substrate applicability, and high atom economy.

The invention discloses a high-efficiency and environment-friendly electrochemical method which is used for synthesizing a 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivative. The invention further discloses a preparation method of the 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivative. Aiming at the problems of tedious steps, harsh conditions, serious pollution and the like of the traditional synthesis method, the method disclosed by the invention takes an alkenyl urea compound which is easy to obtain as a raw material, and realizes efficient synthesis of a target product through a one-step electrochemical iodine cyclization reaction under a mild condition. According to the method, the active iodine species are generated in situ by utilizing an electrochemical means, expensive or toxic reagents are not needed, and the environmental pollution and the synthesis cost are remarkably reduced. The reaction is carried out at normal temperature and normal pressure, the operation is simple and easy to control, and the method has wide substrate applicability. By optimizing reaction conditions, efficient selective synthesis of a target product can be realized. The method has the remarkable advantages of no need of high temperature and high pressure, green and environment-friendly reagents, simple reaction steps and clear product structure. Experimental results show that the method can efficiently synthesize various 4-(iodomethyl)-1-phenyl-3-toluenesulfonyl imidazolidine-2-ketone derivatives, has a good application prospect, and provides a new way for development of related drugs and functional materials. In conclusion, the invention provides a novel strategy with great potential for green synthesis of the imidazolidine-2-ketone compound.

The invention relates to the technical field of compound synthesis, in particular to (Z)-p-toluenesulfonyl hydrazone derivatives and a preparation method thereof. The (E)-p-toluenesulfonyl hydrazone derivative, a photosensitizer and a solvent are mixed and react under illumination to obtain the (Z)-p-toluenesulfonyl hydrazone derivative. The photosensitizer selected by the method is green and low in cost, free of heavy metal residues, wide in substrate application range, high in isomerization efficiency, short in reaction time and good in cis-product stability, the system is easy for amplified production, the high-purity hydrazone compound and the photoisomerization product thereof can be efficiently, mildly and greenly prepared, and the method is suitable for industrial production. The application potential in the fields of drug synthesis, precise drug delivery and functional materials is obviously improved.

The invention belongs to the technical field of water treatment, and relates to a thermosensitive color developing agent F-103 production wastewater treatment method, which comprises the following steps: carrying out multi-stage treatment on wastewater, firstly carrying out alkaline chemical separation reaction on the wastewater, and removing part of acidic polar organic matters such as 3-p-toluenesulfonyl semicarbazide phenol, p-toluenesulfonic acid and the like in water; then carrying out acidic chemical separation reaction to further remove alkaline polar organic matter intermediates MAPOTs and the like in water; then carrying out adsorption reaction by using activated carbon to further remove organic matters and inorganic impurities in the water; and finally evaporating and concentrating, and recovering salt sodium chloride. According to the wastewater treatment method disclosed by the invention, on the premise of solving the toxicity problem of organic matters in the wastewater, the sodium chloride salt in the wastewater is subjected to resource recovery, and the harmlessness of the wastewater and the reduction of hazardous wastes are realized.

The application provides a constant-temperature difference continuous crystallization control method for p-toluenesulfonamide, which comprises the following steps: S1, preliminary cooling, 75 DEG C decoloring liquid is filtered through activated carbon, and then enters a p-amine refining primary cooling kettle and is cooled through circulating water; S2, secondary cooling, the liquid is further cooled to 38 DEG C through circulating water and then enters a p-amine refining secondary pre-cooling kettle; S3, continuous cooling and crystallization, the decoloring liquid after the preliminary cooling and the secondary cooling enters two parallel p-amine refining deep cooling kettles, i.e., a p-amine refining deep cooling kettle one and a p-amine refining deep cooling kettle two, and is centrifuged in the deep cooling kettles through 7 DEG C cold water to 16 DEG C. The application can achieve the constant-temperature crystallization effect, reduce the labor intensity of operators and greatly improve the crystallization efficiency.

The invention relates to a nickel foil and a preparation method and application thereof, and the method comprises the following steps: placing an insoluble anode and a cathode in an electrolyte for electrolysis, and electrodepositing the nickel foil on the cathode; the electrolyte comprises nickel salt, a chlorinating agent, a brightener, a wetting agent and a buffering agent; in the electrolyte, the mass concentration of nickel ions is 50 g / L-100 g / L, the mass concentration of chloride ions is 80 mg / L-400 mg / L, the mass concentration of a brightening agent is 30 mg / L-70 mg / L, the mass concentration of a wetting agent is 10 mg / L-40 mg / L, and the mass concentration of a buffering agent is 20 g / L-50 g / L; the brightener is prepared from at least one of saccharin sodium salt, p-toluene sulfonamide, sulfinyl acetic acid, 1, 4-butynediol, propargyl alcohol and polyvinylpyrrolidone; the wetting agent comprises at least one of lauryl sodium sulfate, sodium dodecyl benzene sulfonate, polyethylene glycol, N-lauroyl sodium glutamate and perfluoroalkyl ether; the buffering agent comprises at least one of boric acid, sodium citrate, citric acid, sodium acetate and glycine; and the pH value of the electrolyte is 3.0-4.5. The nickel foil has high tensile strength and good uniformity and density.

The invention relates to the technical field of high polymer materials, and particularly discloses an environment-friendly high-temperature-resistant polyurethane adhesive as well as a preparation method and application thereof. The adhesive comprises a component A, a component B and a component C, the component A is prepared from polypropylene carbonate glycol, 1, 4-butanediol, an isocyanate-terminated CTBN prepolymer, a silane coupling agent and calcium sulfate whiskers; the component B is prepared from isophorone diisocyanate, trimethylolpropane monoallyl ether and aluminum acetylacetonate; the component C comprises an organic bismuth catalyst, an organic zinc catalyst and p-toluenesulfonyl isocyanate. The polyurethane adhesive prepared by the invention can simultaneously meet high temperature resistance, rapid curing property, aging resistance and environmental protection property.

The invention relates to the field of high polymer materials, in particular to a preparation method of a single-component moisture-cured polyurethane sealant, which comprises the following steps: synthesis of a hydroxyl-terminated siloxane chain extender (BK), synthesis of a polyurethane (PU) prepolymer, synthesis of side-chain silane modified polyurethane resin, synthesis of a side-chain silane modified polyurethane resin, and preparation of the single-component moisture-cured polyurethane sealant. Finally, SPU-BK, a green plasticizer, carbon black, nano calcium carbonate, p-toluenesulfonyl isocyanate, an ultraviolet light absorber, an anti-aging agent, a coupling agent and dimorpholinyl diethyl ether are mixed, and the sealant is obtained.The prepared side chain silane modified polyurethane has excellent hydrophobicity, mechanical property and curing efficiency; the requirements on high-performance polyurethane materials in the fields of coatings, adhesives and the like can be met.

The invention discloses a method for synthesizing a sulfonate compound based on a flowing photochemical technology, which comprises the following steps: (1) carrying out azidation reaction on a phenylacetate compound and p-toluenesulfonyl azide under the action of alkali to obtain an alpha-diazophenylacetate compound; and (2) respectively dissolving a sulfonic acid compound and the alpha-diazophenylacetate compound obtained in the step (1) in an organic solvent to form solutions, then continuously inputting the solutions into a microchannel reactor, carrying out an illumination reaction under an illumination condition, and after the reaction is finished, carrying out post-treatment to obtain the sulfonate compound. The preparation method can realize continuous reaction and is high in yield.

This invention discloses a method using arylmethyl ketones and 2-aryl- N This invention relates to a method for synthesizing dihydropyrrole derivatives using toluenesulfonylaziridine as a starting material, belonging to the field of organic synthetic chemistry. The method uses tris(dibenzylacetone)dipalladium (Pd2(dba)3) as a catalyst, and 2-iodobenzoic acid (IBX) and potassium persulfate (K2S2O8) as co-oxidants. N,N Using dimethylformamide (DMF) as both solvent and carbon source, the reaction is carried out in an oil bath at 100℃–120℃ for 15–24 h, followed by post-treatment to obtain dihydropyrrole derivatives. This invention utilizes readily available raw materials, is simple to operate, employs mild reaction conditions, exhibits broad functional group compatibility, provides high product selectivity, and is environmentally friendly. Yields can reach 51%–90%, making it suitable for large-scale preparation of structurally diverse dihydropyrrole derivatives. It has significant application value in drug development, natural product synthesis, and materials chemistry.

The invention provides a synthesis method of a tergorazan intermediate, which comprises the following steps: taking 1-benzyl-4-hydroxy-2-methyl-1H-benzimidazole-6-carboxylic acid as an initial raw material, and sequentially carrying out amidation, esterification reaction with acetyl, catalytic hydrogenation debenzylation and sulfonic acid esterification to obtain the tergorazan intermediate. The preparation method comprises the following steps: carrying out deacetylation protection on a tergorazan intermediate, namely 4-hydroxyl-N, N, 2-trimethyl-1-p-toluenesulfonyl-1H-benzo [D] imidazole-6-formamide, and carrying out deacetylation protection on the tergorazan intermediate. According to the preparation method, amidation and esterification reactions are carried out in sequence, high-activity carboxyl is converted into stable amide at first, amido bonds are very stable in the subsequent esterification and hydrogenation reactions, and side reactions are avoided.