14 results about "Tosylhydrazone" patented technology

This invention relates to a method for the trivalent rhodium-catalyzed synthesis of 2-cyanenylindole compounds, belonging to the field of organic chemistry. The method uses [Cp*RhCl2]2 as a catalyst and N-pyrimidine indole compounds and alkynyl-N-cyano-N-phenyl-p-toluenesulfonamide compounds as raw materials. The reaction is carried out in an organic solvent at 60°C with lithium chloride assistance, and the 2-cyanenylindole compounds are obtained after separation and purification. This invention utilizes a cyano group migration strategy to achieve a tandem reaction of indole C-H alkenylation and cyano group introduction, constructing C-C and C-CN bonds in one step, with a target product yield of 31%–82%. Compared with existing technologies, this invention uses a non-toxic cyanide source instead of traditional highly toxic cyaniding reagents, and has advantages such as simple operation, mild reaction conditions, wide substrate applicability, and high atom economy.

This invention discloses a method using arylmethyl ketones and 2-aryl- N This invention relates to a method for synthesizing dihydropyrrole derivatives using toluenesulfonylaziridine as a starting material, belonging to the field of organic synthetic chemistry. The method uses tris(dibenzylacetone)dipalladium (Pd2(dba)3) as a catalyst, and 2-iodobenzoic acid (IBX) and potassium persulfate (K2S2O8) as co-oxidants. N,N Using dimethylformamide (DMF) as both solvent and carbon source, the reaction is carried out in an oil bath at 100℃–120℃ for 15–24 h, followed by post-treatment to obtain dihydropyrrole derivatives. This invention utilizes readily available raw materials, is simple to operate, employs mild reaction conditions, exhibits broad functional group compatibility, provides high product selectivity, and is environmentally friendly. Yields can reach 51%–90%, making it suitable for large-scale preparation of structurally diverse dihydropyrrole derivatives. It has significant application value in drug development, natural product synthesis, and materials chemistry.

The present invention relates to fungicidal combinations comprising at least two components: (1) a polyphenol-based component and (2) 5-fluoro-4-imino-3-methyl-1-tosyl-3,4 dihydropyrimidin-2(1H)-one represented by the following structure,

This invention relates to a highly water-resistant and moisture-proof protective coating for wood products and its preparation method, belonging to the technical field of high-performance waterproof coatings. The coating components include silanized rosin-based polyol, modified montmorillonite, modified nano-silica, a composite catalyst, an antifungal and bactericidal agent, HDI trimer, p-toluenesulfonyl isocyanate, silane-modified titanate, KH-560, etc. The silanized rosin-based polyol is prepared by catalytic esterification of acrylic rosin with trimethylolpropane to obtain a rosin-based polyol intermediate, followed by a catalytic reaction with KH-550. The silane-modified titanate is prepared by reacting tetrabutyl titanate with KH-550 in anhydrous isopropanol. The modified montmorillonite is prepared by reacting sodium montmorillonite with octadecyltrimethylammonium chloride to obtain organomontmorillonite, followed by modification with KH-560. The modified nano-silica is prepared by modifying hydrophobic nano-fumed silica with methyltrimethoxysilane. The combined use of these components provides excellent waterproof and moisture-proof properties.

The application discloses a high-curing-rate sealing glue for new energy vehicles and a preparation method thereof, and belongs to the technical field of adhesive preparation. The high-curing-rate sealing glue for new energy vehicles comprises components A and B. The preparation raw materials of the component A comprise a double-bond-containing polyurethane oligomer, glycerol, a magnetic sensing filler, diisodecyl phthalate, fumed silica and p-toluenesulfonyl isocyanate; and the preparation raw materials of the component B comprise an MDI type isocyanate prepolymer, a composite catalyst, heavy calcium carbonate and diisodecyl phthalate. The sealing glue has a long operable time, a fast curing rate, excellent adhesion and moisture and heat resistance.

This invention relates to the field of fine chemical technology and discloses a safe and efficient synthesis process for o-p-toluenesulfonamide. The process uses p-toluenesulfonyl chloride and ammonia as raw materials, and tetrabutylammonium bromide as a phase transfer catalyst. In an acetone-water mixed solvent, an amination reaction is carried out in a continuous flow pipeline reactor to generate p-toluenesulfonamide in one step. After continuous extraction and separation in a countercurrent extraction tower, the organic phase is continuously recovered from dichloromethane and acetone via thin-film evaporation and recycled. The crude product is then purified by gradient vacuum distillation to obtain high-purity p-toluenesulfonamide. The aqueous phase is stripped to recover excess ammonia and reused. Wastewater is treated biochemically to meet discharge standards, and solid waste is incinerated for resource utilization. By employing continuous extraction and solvent recovery technologies, the consumption of organic solvents is significantly reduced and recycling is achieved. Simultaneously, gradient distillation instead of recrystallization avoids the generation of saline organic wastewater, thereby reducing wastewater discharge and achieving environmentally friendly production.

This application provides an anion exchange membrane and its preparation method, as well as a water electrolysis hydrogen production device, belonging to the field of water electrolysis hydrogen production technology. The anion exchange membrane includes a support layer and a homogeneous layer located on one side of the support layer's thickness direction. The homogeneous layer includes anion exchange resin and a plasticizer, and the support layer includes a porous substrate and anion exchange resin and plasticizer filled in the porous substrate. The anion exchange resin includes compounds represented by Formula I. The plasticizer includes N-ethyl-p-toluenesulfonamide. The anion exchange membrane provided by this application possesses good mechanical strength and pressure resistance, reduces film surface resistivity, ensures uniform thickness throughout, and exhibits excellent overall performance. Its preparation is cost-effective and suitable for large-scale production applications.

This invention discloses a method for preparing α-cyclodextrin-based magnetic nanoparticle-antibody conjugates, along with their products and applications. The invention leverages the hydrophobic cavity of α-cyclodextrin to bind with the methoxy PEG on the surface of magnetic nanoparticles via host-guest interactions, achieving a non-covalent bond between α-cyclodextrin and the magnetic nanoparticles. Furthermore, the toluenesulfonyl group modified on the α-cyclodextrin surface undergoes a nucleophilic substitution reaction with the amino group of the antibody, resulting in a stable binding between the antibody and cyclodextrin. This structural design enables a low-cost method for preparing cyclodextrin-based nanoparticle-antibody conjugates. This method offers advantages such as high antibody conjugation rate, simple preparation process, and good biocompatibility, and can be used in fields such as immunomagnetic sorting and targeted drug delivery. It also provides a novel approach and method for the binding of nanoparticles and antibodies.

The application relates to a method for preparing 1,2-bis(4-vinylphenyl)ethane and relates to the technical field of organic chemistry, wherein the preparation method comprises the following steps: (1) mixing compound 1, p-toluenesulfonyl hydrazide and organic solvent 1, and then performing reaction to obtain compound 2; (2) reacting the compound 2 in organic solvent 2 under the action of alkali and a polymerization inhibitor to generate 1,2-bis(4-vinylphenyl)ethane. The method has the advantages of mild reaction conditions, simple operation, high product purity, high yield and suitability for industrial production.

This invention provides a low-odor, latent-curing, one-component polyurethane sealant and its preparation method, belonging to the field of one-component polyurethane adhesives. Every 100 parts of this polyurethane sealant comprises the following components: 25-35 parts of isocyanate-terminated polyurethane prepolymer, 35-60 parts of filler, 5-10 parts of a first plasticizer or 20-30 parts of an organic thixotropic agent, 0.1-0.5 parts of p-toluenesulfonyl isocyanate, 0.1-0.5 parts of an oxazolidine latent-curing agent, 0.01-0.5 parts of a stabilizer, 0.5-1.5 parts of hydrophobic fumed silica, 0.1-0.5 parts of a silane coupling agent, and 0.1-1 parts of a first catalyst; the polyurethane prepolymer is composed of the following components: 50-75 parts of polyether polyol, 5-25 parts of a second plasticizer, 10-20 parts of 4,4'-diphenylmethane diisocyanate, and 0.01-1 parts of a second catalyst. This polyurethane sealant features low odor, no bubbling during high-temperature baking, and good storage stability.

This invention provides a method for the rearrangement nitrogen insertion reaction of indole phosphonium salts and tert-butyl (p-toluenesulfonyloxy) carbamate under potassium carbonate-promoted conditions, synthesizing a series of 3-aminoindole compounds. The technical solution of this invention has the following significant advantages: it eliminates the need for expensive metal catalysts, significantly reducing production costs; the reaction conditions are mild and simple, and the reaction can be carried out efficiently at room temperature with only the addition of a base and an amine source, achieving excellent chemoselectivity, regioselectivity, broad functional group compatibility, and excellent atom economy.

This invention discloses a reaction vessel for the preparation of p-toluenesulfonylmethylformamide, relating to the field of reaction vessel technology. The vessel includes a vessel body with a lid mounted on top. One end of the vessel body has a multi-position dripping device located inside the vessel body, and the top of the vessel body has a docking unit connected to the multi-position dripping device. By using the multi-position dripping device, when the connecting block rotates, it drives the annular storage tank to rotate, causing the guide block to move up and down along a reciprocating screw. When the guide block drives the annular stopper plate upwards, the formamide inside the inlet pipe enters the annular storage tank through a one-way valve. As the annular storage tank rotates, the dripping pipe oscillates relative to the annular storage tank while revolving around the center of the stirring shaft, thereby increasing the dripping range of the formamide and ensuring sufficient contact and reaction between the formamide and the mixture inside the reaction vessel.

A method for preparing trifluoromethyl-substituted 1,2,4-triazole hydrazone derivatives is disclosed, relating to the field of organic synthesis. This invention uses readily available and inexpensive trifluoromethylhydrazone chloride and N-cyano-N-aryl-p-toluenesulfonamide as starting materials. Under alkaline conditions, derivatives containing trifluoromethyl, 1,2,4-triazole rings, and hydrazone structures are constructed in one step via a tandem cyclization and nucleophilic substitution reaction. This process requires no catalysts, metal reagents, or additional oxidants, features mild reaction conditions, simple operation, low equipment requirements, excellent atom economy, high starting material conversion rate, few byproducts, and is easy to scale up and promote. It provides a practical and economical synthetic route for the development of potentially bioactive trifluoromethyltriazole hydrazone compounds.