128 results about "Para-toluene sulfonate" patented technology

The present invention relates to a method of synthesizing trioxymethylene from formaldehyde by the catalytic action of an acidic ionic liquid. In the method, formaldehyde solution with a concentration of 30˜80 wt % is used as reactant, and an ionic liquid is used as catalyst. The cation moiety of the catalyst is selected from either imidazoles cation or pyridines cation, and the anion moiety of the catalyst is selected from one of p-tolyl benzene sulfonate, trifluoromethyl sulfonate, and hydrogen sulfate. In the present invention, ionic liquid is used, for the first time, as a catalyst to synthesize trioxymethylene from formaldehyde. The catalyst can be circularly used for continuous sampling.

The invention discloses a new medicinal salt of (E)-1-{4-[(3',4',5'-trimethoxy cinnamon acyl]-1-piperazidine} acetopyrrole as cinprazole, which comprises the following parts: mesilate, phosphate, nitrate, sulfate, hydrobromide, p-toluenesulfonic acid salt, tartrate, fumarate, citrate, succinate, malonate, optimizing the mesilate, nitrate, phosphate and sulfate, for mesilate at best. The drug can be used to treat and / or prevent cardiovascular and cerebrovascular disease and peripheral vessel disease. The drug possesses good stability and superior solubility, which can be made into acceptable pharmacy agent.

The invention provides a method for synthesizing a novel beta-cyclodextrin derivative modified by radicals containing oxazoline by using beta-cyclodextrin, and also provides a method for modifying the surface of common silica gel into hydrogenated silica gel and bonding the cyclodextrin derivative to the hydrogenated silica gel by using appropriate small molecules. An oxazoline derivative ligand used in the method provided by the invention has a very good rigid structure and a chiral recognition site, and is beneficial for improving the separation selectivity of a chiral selector to an enantiomer, and expanding the separation range of chiral compounds. According to the methods provided by the invention, 6-deoxy-6-R,S-(4-phenyl)-4,5-dihydrogen oxazoline-beta-cyclodextrin and 6-deoxy-6-R,S-(4-pyridine p-toluene sulfonate methyl)-4,5-dihydrogen oxazoline-beta-cyclodextrin are synthesized respectively by virtue of simple and easy operation steps, and are bonded to the hydrogenated silica gel to prepare a hydrogenated silica gel stationary phase. The whole synthetic route is simple in operation and mild in reaction condition, and the product is easy to purify and high in yield. The methods provided by the invention are applied to chiral separation, and are used for performing qualitative researches on certain chiral aromatic alcohols, ferrocene derivatives, amino acid and mandelic acid derivatives and chiral drugs in a polar organic mode and a reversed phase mode.

Polypyrrole / carbon (PPy / C) composite doped with organic anion p-toluenesulfonate (pTS) is utilized as an electrode in supercapacitor for energy storage application. The surface initiated in-situ chemical oxidative polymerization yields a composite material PPy / C in the presence of varying concentrations of pTS. The novelty of the present invention lies in the doping of PPy / C composite with organic anion pTS and consequent enhancement of its electrochemical activity and stability. The conjugation length and electrical conductivity of pTS doped PPy / C composites increase with the increase in dopant concentration. The pTS doped PPy / C composite synthesized using equimolar concentration (0.1 M) of pTS to pyrrole shows the maximum specific capacitance of ˜395 F / g in 0.5 M Na2SO4 aqueous solution with significant stability ˜95% capacitance retention after ˜500 cycles.

Lactamium based ionic liquids are described. They comprise at least one of:the reaction product of a lactam compound having a general formulawherein n is 1 to 8,and a Brønsted acid HX; or a Brønsted acid HX, where X is a halide, and a metal halide; where the reaction product is p-toluenesulfonate, halide, or the halometallate;orthe reaction product of a lactam compound having a general formulawherein the ring has at least C—C one double bond, and n is 1 to 8,and a Brønsted acid HX; or a Brønsted acid HX, where X is a halide, and a metal halide;orthe reaction product of a lactam compound having a general formulawherein n is 1 to 8, m is 1 to 8, and the rings can be saturated or unsaturated;and a Brønsted acid HX; or a Brønsted acid HX, where X is a halide, and a metal halide.

The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer.Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.

The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer.Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.

The invention discloses a preparation method of methacycline. The method includes: firstly taking water as a solvent, adding a ruthenium precursor into a carrier activated carbon, carrying out hydrogenation activation to obtain a ruthenium-carbon catalyst, and hydrogenating the ruthenium-carbon catalyst for reaction with 11alpha-chloro-6-methenyl oxytetracycline p-toluenesulfonate to obtain methacycline. The method has the advantages of simple process, mild reaction conditions and high total yield, enhances the product selectivity, lowers the production cost, and avoids the generation of threewastes, thus having favorable industrial prospects.

The present application belongs to the technical field of inorganic chemistry, and particularly relates to a preparation method for perfluoroisobutyronitrile. The method includes the following steps:step 1, in the presence of an organic solvent and an alkaline solution, performing condensation on heptafluoroisobutyramide and p-toluenesulfonyl chloride to obtain heptafluoroisobutyryl p-toluenesulfonate; and step 2, performing a reaction on the heptafluoroisobutyryl p-toluenesulfonate at the temperature of -30 DEG C to 20 DEG C to produce the perfluoroisobutyronitrile and p-toluenesulfonate. The preparation method for the perfluoroisobutyronitrile disclosed by the present application can effectively solve the technical defects that a current method for preparing perfluoroisobutyronitrile has a low yield and high costs, and the generated perfluoroisobutyronitrile is difficult to store in the system.