27results about How to "Safe" patented technology

The invention belongs to the technical field of biology, and particularly relates to a PD-L1 targeting micromolecule polypeptide and application thereof. On the basis of machine learning and virtual screening technologies, a series of PD-L1 targeting micromolecule polypeptides are screened out, the in-vivo and in-vitro biological activities of the polypeptides are measured, it is found that the micromolecule polypeptides have the capacity of inducing PD-L1 to form dimerization and good anti-tumor activity, and the anti-tumor activity of the polypeptides is superior to that of PD-L1 monoclonal antibodies and compound inhibitors. Meanwhile, the PD-L1 targeting small-molecule polypeptide has no obvious toxicity, has certain safety, and can be developed into a novel small-molecule polypeptide PD-L1 inhibitor drug.

The invention discloses a rabies vaccine and a preparation method thereof. The rabies virus G truncated mutant protein comprises a circular RNA (Ribonucleic Acid) molecule for coding rabies virus G truncated mutant protein and a pharmaceutically acceptable carrier, wherein the amino acid sequence of the rabies virus G truncated mutant protein is as shown in SEQ ID No.13 or a degenerate sequence thereof, and the nucleotide sequence is as shown in SEQ ID No.14 or a degenerate sequence thereof; the nucleotide sequence of the circular RNA molecule is as shown in SEQ ID No. 20. At present, RNA vaccines for resisting rabies virus infection are not applied in batches, the optimized rabies virus G protein circular RNA molecules and the optimized lipid nanoparticles are used for preparing the vaccines, and the process can be industrially amplified. The animal can be induced to generate a high-level neutralizing antibody and a more lasting drug effect only by injecting a low-dose circular RNA vaccine (16 [mu] g / vaccine) once, the vaccine is good in safety and stability, and a basis is provided for industrial preparation and application of the vaccine.

The invention discloses a sighting telescope data communication method, which relates to the technical field of sighting telescope data communication, and comprises the following steps: constructing a virtual network, updating the virtual network into an encrypted virtual network, reserving a frequency spectrum channel as an emergency frequency spectrum channel for each virtual sub-network, acquiring an environment image in real time by each sighting telescope device, and transmitting the environment image to the corresponding virtual sub-network. And a grid method is adopted to process the image collected by the sighting telescope, a three-dimensional terrain model near nodes is established and puffing processing is carried out, an improved bat algorithm is adopted to optimize network node distribution, and all node optimal paths of the virtual subnet are obtained according to the local optimal path solution. According to the invention, a network formed by sighting telescope equipment is encrypted and a frequency hopping technology is used, so that the communication process of the sighting telescope is safe; the improved network node dynamic allocation algorithm enables sighting telescope communication to perform group cooperation intercommunication, dynamic component network, priority information screening, rapid real-time transmission adjustment and attachment to three-dimensional actual terrain allocation node positions.

The invention discloses a Yao bath powder surfactant and a preparation method thereof. The surfactant aims at improving the medicine effect and user experience of Yao bath powder. The Yao bath powder surfactant is prepared from the following raw materials in parts by weight: 4-12 parts of hawthorn leaves, 3-9 parts of all-grass of common tickclover, 4-10 parts of radix puerariae, 6-12 parts of polygonum cuspidatum, 5-15 parts of acanthopanax, 4-12 parts of mussaenda pubescens, 8-16 parts of chamomile, 5-9 parts of astragalus membranaceus, 4-12 parts of glossy privet fruit, 4-12 parts of semen cuscutae, 6-12 parts of codonopsis pilosula and 8-16 parts of erodium stephanianum willd. The invention also provides a preparation method of the Yao bath powder surfactant, which comprises the following steps: firstly, respectively weighing the raw materials in parts by weight; then, uniformly mixing the raw materials, crushing, and sieving (the mesh number is 80-100 meshes); then carrying out sterilization treatment, preferably adopting an infrared sterilization mode; and finally, packaging the treated powder to obtain the Yao bath powder surfactant. The Yao bath powder surfactant disclosed by the invention takes various natural Chinese herbal medicines as raw materials, and has various effects of invigorating spleen and replenishing qi, nourishing heart and tranquilizing mind, soothing liver and relieving depression and the like. The unique surface active component can enhance the contact effect of the Yao bath powder and the human skin, so that the drug effect absorption is improved, and meanwhile, the user experience is improved. In addition, the surfactant is safe and free of side effects, and is suitable for various people, especially people needing to regulate body functions and improve health conditions.

The application provides application of tetrahydropalmatine in preparation of a medicine for treating acute and chronic contact dermatitis. Experiments show that tetrahydropalmatine can significantly inhibit redness, desquamation and ear swelling of acute and chronic contact dermatitis, reduce itching, inhibit epidermal thickening and inflammatory infiltration. The mechanism of action includes double inhibition of TSLP and TNF-alpha protein levels, and recovery of EDEM3 expression by directly combining EDEM3 protein (KD=3.69±0.21 muM), inhibition of endoplasmic reticulum stress, and thus down-regulation of epithelial alarm substances IL25, IL33 and TSLP. The effect of tetrahydropalmatine disappears after EDEM3 is silenced, confirming that EDEM3 is a functional target protein. In addition, tetrahydropalmatine is also effective for non-histamine-dependent allergic contact dermatitis, and has no side effects such as skin atrophy and weight loss, and the safety is better than that of dexamethasone. The application also relates to similar application of tetrahydropalmatine and cortex phellodendri extract. The application provides a safe, effective and mechanism-confirmed new type of therapeutic drug for contact dermatitis.

The invention relates to an application of violacein in preparation of a product for inhibiting or killing bacillus cereus, the violacein not only has inhibiting and killing effects on nutritional and spore bacillus cereus, but also can inhibit the formation of a bacillus cereus biofilm and remove the biofilm formed by the bacillus cereus; the bacillus cereus toxin gene expression can be inhibited, and the bacillus cereus is inhibited from generating toxin; therefore, the bacillus cereus can be used for preparing a product for preventing and removing bacillus cereus pollution, preparing a medicine for preventing and treating bacillus cereus infection and / or preparing a medicine for preventing and treating diseases caused by bacillus cereus infection.

The invention relates to a chemical leaching method for leaching battery black powder with sulfuric acid, which comprises the following steps of: roasting the ground black powder to obtain a roasted sample; adding the roasted sample into dilute sulphuric acid, carrying out primary leaching under the conditions that the water bath heating temperature is 90 DEG C and the reaction time is 2 hours, controlling the pH at the leaching reaction end point to be 3.5-4.0 and the final liquid-solid mass ratio to be 2.8-3.0: 1, and carrying out suction filtration after the leaching is finished to respectively obtain primary leaching liquid and primary leaching residues; the primary leaching residues are added into dilute sulfuric acid, secondary leaching is carried out under the conditions that the water bath heating temperature is 90 DEG C and the reaction time is 2 h, the pH of the leaching reaction end point is controlled to be 1.0, and secondary leaching liquid and secondary leaching residues are obtained through suction filtration after leaching is finished; and combining the second immersion liquid with the first immersion liquid. The method is efficient, safe and environment-friendly.

The invention discloses an acidic tumor microenvironment activated nano probe as well as a synthesis method and application thereof, and belongs to the technical field of nano material preparation. In order to solve the problems of low treatment efficiency, lack of tumor targeting and the like caused by limitation of hypoxia of a tumor microenvironment when the existing photosensitizer is applied to a photodynamic therapy (PDT) process, a metal Fe < 2 + >, an anti-angiogenic drug thalidomide and a photosensitizer hematoporphyrin monomethyl ether approved by FDA are self-assembled, so that the anti-angiogenic drug thalidomide is prepared. The low pH response type intelligent nano diagnosis and treatment probe is prepared. Before the probe is degraded at a tumor part, the photodynamic therapy performance is opened, and a magnetic resonance imaging (MRI) signal is closed. Along with continuous enrichment of the material in tumor tissues, under low-pH stimulation of a tumor microenvironment, an MRI signal is gradually opened and thalidomide is released, oxidative stress is amplified by increasing ROS / consuming GSH, tumor cell ferroptosis is induced, and finally an excellent anti-tumor effect is achieved in cooperation with chemical kinetics / chemotherapy / photodynamic force.

The present disclosure provides a safe conductive coating slurry, a composite current collector and a preparation method thereof, and a battery, and belongs to the field of battery materials. The safe conductive coating slurry for the composite current collector comprises, in terms of mass fraction, 15-30 parts of a main material, the main material comprising microcrystalline glass; 10-30 parts of a binder; 10-20 parts of a solvent; 0.5-2 parts of a dispersing agent; 0.5-1 part of a wetting agent; and 0.5-1 part of a leveling agent. The coating slurry of the present disclosure comprises microcrystalline glass, which can simultaneously play the roles of a conductive coating and a safe coating by only coating one layer of coating, thereby simplifying the preparation process and the coating process; when combined with an electrode active material, the coating slurry does not cause the electrode active material to fall off; and the safe conductive coating has no cracking phenomenon. The technical problems of the prior art, such as the complexity of the slurry preparation process and the coating process when the two-layer structure of the conductive coating and the safe coating is coated on the composite current collector, the easy falling off of the electrode active material when combined with the electrode active material, and the easy cracking of the conductive coating, are avoided.

The invention discloses a stable natural polypeptide broad-spectrum bacteriostatic agent as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing a polypeptide bacteriostatic agent culture medium 1; (2) preparing a polypeptide bacteriostatic agent culture medium 2; (3) inoculating streptococcus thermophilus in the PPBM1, and culturing to obtain a PPBM1 culture; inoculating bifidobacterium animalis subsp. Lactis to the PPBM2, and culturing to obtain a PPBM2 culture; and (4) mixing the PPBM1 culture and the PPBM2 culture under a sterile condition, continuing to culture, centrifuging and filtering to obtain a filtrate, namely the stable natural polypeptide broad-spectrum bacteriostatic agent. The bacteriostatic agent disclosed by the invention has safety and is not easy to generate drug resistance; the antibacterial agent has the advantages that the antibacterial agent is a natural antibacterial agent, has the safety performance of no hemolysis and no allergy, has relatively strong stability, has good stability under strong ultraviolet rays, has heat resistance, acid resistance, cholate resistance and broad-spectrum bacteriostasis, and is a safe and harmless natural antibacterial agent with wide application.

The present application relates to the field of locator, propose a kind of pet locator's binding method and locator binding device, locator binding device includes base, mechanical arm and main controller, by using the pressure sensor on base receives pet standing information, main controller controls the contraction and binding of binding belt of mechanical arm, solve the problem that pet locator installation is easy to fall off in prior art, installation is not firm, achieved the firmness of improvement pet positioning installation, improve the automation level and portability of pet locator binding, with the beneficial effects of high security and practicality.

A rocking chair or trolley with wheels, comprising a support frame with a seat frame, a mounting portion for setting wheels on the support frame, an electric drive mechanism for driving the wheels to rotate back and forth on the support frame, the electric drive mechanism comprising a driving motor fixed on the support frame, a rotating member fixedly connected to the output shaft of the driving motor, a driving member pivoted on the rotating member at a position deviating from its axis, a swinging member for driving the wheels to rotate back and forth pivoted on the other end of the driving member, the pivot point between the driving member and the swinging member deviates from the axis of the swinging member, the swinging member is pivoted on the mounting portion, and the electric drive mechanism also includes a clutch device arranged between the swinging member and the wheel or between the swinging member and the driving motor. The rocking chair or trolley with wheels adopting the above structure has the advantages of simple structure, safety, and fully automatic electric drive and control of the rocking chair function.

The utility model relates to the technical field of coating barrel transfer, and discloses a coating barrel transfer device which comprises a platform plate, a U-shaped plate is fixedly connected to the top of the platform plate, a material storage mechanism is arranged on the U-shaped plate and comprises a main body plate, the main body plate is arranged on the top of the platform plate, a threaded rod is rotationally connected to the inner side of the U-shaped plate, and the threaded rod is arranged on the top of the platform plate. One end of the threaded rod is rotationally connected with the top of the platform plate. Through the design of the material storage mechanism, the coating barrels are placed and stored in different placing frames, then the platform plate is controlled to move to transfer the coating barrels, during loading and unloading in the transfer process, a motor works to drive a threaded rod to rotate, the threaded rod is promoted to drive a main body plate to ascend and descend, and therefore when the coating barrels are loaded and unloaded, the placing frames are controlled to descend to the low position, and the coating barrels are transferred. And compared with the operation that the coating barrel needs to be manually loaded and unloaded to the high position, more physical strength is saved, and safety is achieved.

The invention provides a sludge drying weight reduction method and a low-temperature drying box, and the method comprises the following steps: S1, carrying out filter pressing on sludge, and enabling the sludge after filter pressing to enter a sludge hopper; s2, the sludge hopper is conveyed to a low-temperature drying box to be dried; and S3, bagging the sludge dried in the step S2 in a sludge bucket, and transporting the sludge outwards. The system has the beneficial effects that the newly added dehumidification low-temperature drying system does not influence the safe operation of the original sludge treatment system. The dehumidifying and drying system meets the demand for sludge drying, and a design safety margin is reserved. And the particles are dried at low temperature of 70 DEG C or below, the temperature of the particles is lower than 70 DEG C, and dust and explosion danger are avoided. And the discharging temperature is low (less than 50 DEG C), cooling is not needed, and direct storage can be realized.

The utility model relates to a lifting appliance for manufacturing a bulletin board, and relates to the technical field of lifting appliances. Comprising a support frame; the driving assembly is arranged on the support frame; the lifting assembly is connected with the driving assembly and located on the support frame; the clamping assembly is arranged in the support frame and connected with the lifting assembly. According to the scheme, the flexible clamping heads and the barbs are arranged, the parts can be taken according to the sizes of the parts for installing the bulletin board, and the parts can be vertically rotated after being taken or hung, so that the parts can be directly installed on the bulletin board and can be lifted through the racks, and the bulletin board is convenient to use. And the problem that parts shake due to rope hanging is avoided, and certain safety is achieved.

This invention provides a fluororubber using naphthylhydrazone imide as a crosslinking agent, its preparation method, and its applications, belonging to the field of chemical materials. It is prepared from raw materials comprising the following parts by weight: 100 parts of fluororubber raw rubber, 10-30 parts of reinforcing filler, 0-3 parts of internal release agent, 5-20 parts of acid scavenger, 0.5-2 parts of naphthylhydrazone imide, and 0.5-1.5 parts of accelerator; wherein the naphthylhydrazone imide is a monohydroxy-substituted naphthylhydrazone. This invention uses naphthylhydrazone imide to replace bisphenol AF as the crosslinking agent in the fluororubber system. When its addition amount is only half that of bisphenol AF, a fluororubber with the same excellent mechanical properties, aging properties, and oil resistance as the bisphenol AF system can be obtained. The fluororubber of this invention is legal, compliant, safe, and possesses excellent comprehensive performance, providing a feasible alternative for the application of fluororubber in high-end environmentally friendly fields.

The application discloses a kind of data storage method and system based on object chain, which comprises: using N nodes to store data and text;N nodes are linked to form M string chain under the guarantee of security guarantee mechanism;M string chain freely constitutes X object unit;X object unit is linked to form block chain by control library firmware, realize the storage of multiple data and text;The system makes the above-mentioned method carry out data storage and management;System includes support layer, functional layer and interface layer;Wherein, support layer includes: directory service module;Functional layer includes: authentication service module, identity management module, authorization management module, role management module, resource management module and configuration management module;Interface layer includes: API interface module, Web service module and management tool module;Different functional components can be connected through API interface module, can adapt to various different platforms, and the performance is stable and reliable;And data storage efficiency and security are very high, and storage is not limited.

The utility model discloses a metal plate processing machine tool, which belongs to the field of machine tool processing and is characterized in that a material conveying plate is arranged at the top end of a bearing frame, a steel plate locking component is arranged at the top end of the material conveying plate, and a blanking mechanism is arranged on one side of the material conveying plate back to a bearing bridge. When the device is used, a steel plate to be processed is clamped in the rectangular clamping cavity in the middle of the overturning plate, after one side face of the steel plate is machined, the material conveying motor drives the material conveying rollers to rotate, the material conveying belt between the material conveying rollers can drive the positioning plate to move, and at the moment, the positioning plate slides in a reciprocating mode along the carrying wire groove; when the positioning plate moves along the straight line, the translation gear at the end of the overturning plate can be shifted by the rack at the fixed position, the overturning plate can be twisted by 180 degrees while translating, the steel plate can be automatically overturned by stepping of the equipment, and the positions of the overturning plate and the steel plate are also changed, so that the steel plate can be automatically overturned. And the effects of automatically overturning the steel plate and automatically positioning are achieved.

The present invention belongs to the field of genetic engineering technology, and relates to a method for efficiently delivering gene editing plasmids in aquatic animals such as fish, shrimp, and shellfish. First, sgRNA is obtained based on the gene design of aquatic animals, and the sgRNA is inserted into the Cas9 plasmid vector to obtain CRISPR / Cas9 plasmid; at the same time, the fertilized eggs of aquatic animals treated with the exosome agonist monensin are collected, and the supernatant III containing the fertilized egg cytoplasmic matrix and the solution IV containing the fertilized egg cell membrane are separated; the supernatant III and the solution IV are mixed, and the ATP regeneration system, the incubation buffer, and the CRISPR / Cas9 plasmid are added in sequence to mix evenly to obtain a reaction solution, the reaction solution is placed in a metal bath for reaction, the precipitate is collected by centrifugation and resuspended with PBS, and then the engineered exosomes loaded with CRISPR / Cas9 plasmid are obtained after enrichment and purification; the engineered exosomes loaded with CRISPR / Cas9 plasmid are mixed with fertilized eggs and incubated to obtain gene-edited aquatic animal larvae. The present invention is non-invasive or non-invasive to fertilized eggs, and can achieve high-throughput and high-efficiency gene editing effects.

The invention provides a protein-like modified edible peptide with an osteogenesis promoting effect and a preparation method thereof. The preparation method comprises the following steps: (1) preparing a salmon skin gelatin solution; (2) preparing salmon skin gelatin hydrolysate by using papain; (3) introducing glycine into the hydrolysate under the catalysis of papain; and (4) carrying out proteoid reaction on the salmon skin gelatin hydrolysate to prepare the proteoid modified peptide. According to the novel protein-like modified edible peptide with the osteogenesis promoting effect and the preparation method of the novel protein-like modified edible peptide, the osteogenesis promoting functional characteristics of salmon skin gelatin hydrolysate are improved, and the salmon skin gelatin protein-like modified peptide provides nutritional and health-care effects for promoting bone growth, bone regeneration, bone health care and osteoporosis prevention; the composition can be used as a potential oral supplement for bone joint tissue recovery. The invention belongs to the technical field of health food processing, and the edible peptide has the advantages of edibility, compatibility and safety, can be easily and fully absorbed by human bodies, and has the advantages of strengthening bodies of specific osteoporosis people and the like.

The invention relates to a recording and playback method and system for sensor data in automatic driving, and the method comprises the steps: transmitting sensor data msg collected by each sensor to an upper computer, and triggering a recording function when the upper computer receives a frame of sensor data msg; the size maxmsgsize of the sensor data msg is defined based on the type of the sensor data msg, and a message header BAGHEAD is defined based on the sensor id, the size maxmsgsize and a message timestamp; after the message header BAGHEAD and the sensor data msg are serialized into a cache region buf, all content of the buf is written into a file msg.bag to obtain a message frame, and recording of the sensor data msg is completed; after the content of the file msg.bag is read into a data buffer area buf, data frames in the buf are analyzed in a deserialization mode, and the sensor data msg are sent to a sensor for playback based on a message timestamp control playback frequency; the problems that hardware equipment is insufficient and no open source software is used for recording sensor data in automatic driving are solved.

The invention discloses a load control device and a load control method for a pipe lifting machine, and belongs to the technical field of engineering machinery. The control device comprises a sensor assembly used for detecting the acceleration of the inclination angle of an upper vehicle platform, the angle of an arm support and the hoisting weight of the pipe hoisting machine; the control unit is used for receiving the detection data of the sensor assembly, comparing the detection data with a set value, judging whether load throwing operation is carried out or not according to a comparison result, and outputting an operation signal; and the executing mechanism is used for starting or ending the load throwing action according to the operation signal of the control system. The construction state of the pipe hoisting machine is judged by collecting the data of the state information of the whole machine, the control unit is used for contrastive analysis and controlling the load throwing mechanism, and the anti-overturning load throwing action is completed; the pipe lifting machine can carry out load throwing operation through a reasonable control strategy in the state that the vehicle body begins to tip over due to overload of the load, and the accident that the vehicle turns over is prevented; and the adaptive capacity of the pipe lifting machine to terrains is stronger and safer.

The invention belongs to the technical field of water conservancy and transportation engineering maintenance, and particularly relates to a ship lock concrete surface repairing coating in a seawater soaking environment and a construction method of the ship lock concrete surface repairing coating. Comprising a permeation anchoring bottom coating, a stress buffering middle coating and a super-weather-resistant protective surface coating which are sequentially arranged from inside to outside, and the permeation anchoring bottom coating is a bi-component epoxy-biomineralization composite system. The construction method of the ship lock concrete surface repairing coating comprises the steps that a base plane is diagnosed and cleaned; constructing a negative pressure microenvironment; carrying out in-situ vacuum dehydration and exclusion; negative-pressure prime coat leading-in is carried out; performing controlled ventilation and re-pressing permeation; and constructing a multi-layer system. According to the method, capillary water wedge resistance can be overcome under the condition that a dry base plane does not need to be stopped for a long time, deep penetration and high-strength anchoring of a repairing material to concrete microcracks are achieved, and the chloride ion penetration resistance and durability of a ship lock structure are greatly improved.

The utility model relates to the technical field of restraint assistors, and discloses a patient restraint assistor which comprises a treatment bed, and auxiliary mechanisms are arranged on the left side and the right side of the top of the treatment bed. According to the patient restraint assist device, through the arrangement of the assisting mechanism, the sliding blocks and the fixing mechanisms, the four fixing mechanisms move under the action of the two sliding rails until the fixing mechanisms move to proper positions, then four inserting rods penetrate through four clamping blocks and penetrate into four circular holes in a plurality of circular holes, and then the fixing mechanisms can be fixed; then the four limbs of the patient are clamped into the four limiting rings, air pipes on one sides of the four air bags are pressed until the four air bags expand to fix the four limbs of the patient, the positions of the foot rings and the hand rings can be adjusted according to the stature characteristics and requirements of the patient, the foot rings and the hand rings are better attached to the body of the patient, and the comfort level and safety are improved; four groups of air bags are arranged, so that the four limbs of the patient can be prevented from being injured by the limiting rings when the patient struggles off, and certain safety is achieved.

The utility model relates to the technical field of neurology, and discloses a rehabilitation nursing walking aid device which comprises a stabilizing frame, one side of the stabilizing frame is connected with an operation plate used for facilitating pressing adjustment in a clamped mode, the top of the stabilizing frame is connected with a bearing rod used for supporting in a clamped mode, and one side of the bearing rod is fixedly provided with an attaching plate used for preventing position deviation. A clamping groove plate used for stretching the height is clamped into the bearing rod, an auxiliary ring used for rotating operation is clamped to one side of the clamping groove plate, and frames used for positioning are fixedly installed on the two sides of the clamping groove plate. According to the rehabilitation nursing walking aid device, through cooperative arrangement of a stabilizing frame, an operation plate, a bearing rod, an attaching plate, a clamping groove plate and an auxiliary ring, the device can be better adjusted in a vertical lifting mode when used, it is ensured that the device can adapt to more people, manual pressing operation can be conveniently carried out when the device stops moving, the friction area of the bottom of the device is increased, and the practicability is high. And sliding is prevented.

The utility model relates to the technical field of machine tool manufacturing, in particular to a high-speed vertical machining center sliding rail positioning device which comprises a working table, an adjusting box and a machining table, a buffering protection mechanism is arranged on the side edge of the machining table, and a portable installation mechanism is connected between the working table and the adjusting box. When the high-speed vertical machining center sliding rail positioning device is used, by means of the characteristic that the springs can contract synchronously under impact force and buffer the impact force, when the sliding rails drive the working table to move to the outermost edge to make the working table abut against a control box of a machining center, the working table is driven to move to the outermost edge, and the working table is driven to move to the control box of the machining center. At the moment, the buffering protection effect can be achieved through contraction buffering of the springs, compared with an existing device which is not provided with a related protection mechanism to protect the workbench, the design has higher safety, meanwhile, the good safety protection effect on the part machining platform is achieved, and the overall practical effect is good.

The invention belongs to the technical field of biological medicines, and particularly relates to application of h018JAK as an active component in preparation of a medicine for treating myelofibrosis. The h018JAK is used as an inhibitor to specifically inhibit a JAK-STAT signal channel and block the cascade amplification effect mediated by tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 and IL-6 cytokines, so that the symptoms of the damaged joint of the RA patient are improved. The JAK1 inhibitor provides a treatment choice for RA patients, breaks through the treatment approach of traditional rheumatism drugs and biological drugs, is still effective for patients with poor treatment response of traditional DMARD and TNF inhibitors, improves the health-related life quality of the patients, is exact in safety, and is more popular with the patients in oral treatment.