The invention discloses an acid-alkali resistant rubber material formula, comprising the following components in parts by weight: 100 parts of ethylene propylene rubber, 50 parts of styrene butadiene rubber, 40 parts of chlorinated polyethylene, 50 parts of neoprene, 7 parts of zinc oxide, 3 parts of magnesium oxide, 25 parts of butadiene-styrene rubber, 3 parts of an acid-absorbing agent DHT-4A, 7 parts of decabrominated dipheny ethane, 4 parts of microcrystalline paraffin, 4 parts of chlorinated polyethylene, 10 parts of barium carbonate, 8 parts of vermicular carbon, 8 parts of polyglycerol ricinoleate, 0.2 part of wintergreen oil, 6 parts of 3-hydroxybenzoic acid, 12 parts of carbon black, 2 parts of lauryl alcohol sulfate, 6 parts of plant saponin, 0.3 part of ginger juice, 2 parts of white mica powder, 0.2 part of terpineol, 3 parts of sulfur, 15 parts of naphthenic oil and 1 part of methacrylic ester. The rubber manufactured according to the acid-alkali resistant rubber material formula disclosed by the invention is hardly corroded, and is oil-resistant, high-pressure-resistant and acid-alkali resistant.