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109 results about "Salicylanilide" patented technology
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Salicylanilide is a chemical compound which is the amide of salicylic acid and aniline. It is classified as both a salicylamide and an anilide. Derivatives of salicylanilide have a variety of pharmacological uses. Chlorinated derivatives including niclosamide, oxyclozanide, and rafoxanide are used as anthelmintics, especially as flukicides. Brominated derivatives including dibromsalan, metabromsalan, and tribromsalan are used as disinfectants with antibacterial and antifungal activities.
Trace elements
Owner:WARBURTON TECH
Salicylanilides enhance oral delivery of therapeutic peptides
This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and / or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significantly increases the bioavailability of that peptide. Methods of peptide delivery using such “delivery agents” and pharmaceutical formulations are provided.
Owner:RGT UNIV OF CALIFORNIA
Salicylanilides enhance oral delivery of therapeutic peptides
Owner:RGT UNIV OF CALIFORNIA
Long acting parasiticidal composition containing a salicylanilide compound, a polymeric species and at least one other anti-parasitic compound
ActiveUS20050118221A1Improve bioavailabilityEfficient ConcentrationBiocidePharmaceutical delivery mechanismPolyethylene glycolBlood plasma
A composition prepared for treating animals suffering from parasites which parasites are known to be susceptible to at least one of the avermectins, milbemycins or salicylanilides, comprises for example ivermectin in an amount of from 0.1 to 10%(w / v), a solvent selected from the group consisting of glycerol formal, propylene glycol, polyethylene glycol and combinations thereof, and a salicylanilide such as closantel in a required dosage amount for the animal to be treated, typically about 2.5 mg / kg live weight of the animal to be treated, a polymeric species selected from the group consisting of polyvinylpyrrolidone and polyoxypropylene / polyoxyethylene block copolymers, the said polymeric species improving the bioavailability of closantel to the extend that blood plasma levels of the said compound greater than about 20 ppm over period of treatment are achievable.
Owner:NORBROOK LABORATORIES LIMITED
Electrolyte additive for performance stability of batteries
An organic additive to an electrolyte for a battery cell in an implant able medical device is presented. At least one organic additive is selected from a group comprising one of lithium salivate, hydroxyphthalic anhydride, a hydroxybenzoic acid, salivate ester, salicylamide, and salicylanilide.
Owner:MEDTRONIC INC
Halogenated salicylanilides for treating clostridium infections
ActiveUS10463680B2Reduce probabilityEffective treatmentAntibacterial agentsOrganic active ingredientsDiseaseSalicylanilides
The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhea and C. difficile associated colitis.
Owner:UNION THERAPEUTICS AS
Non-aqueous topical compositions comprising a halogenated salicylanilide
PendingUS20190151231A1Improve antibacterial propertiesReduce the possibilityAntibacterial agentsAerosol deliveryTopical treatmentSalicylanilide
The present invention relates to non-aqueous topical compositions comprising a halogenated salicylanilide and the use of such compositions in the topical treatment or prevention of diseases and infections, particularly conditions caused by Gram-positive bacteria, for example the topical treatment or prevention of skin infections such as acne, atopic dermatitis and impetigo. Also disclosed are methods for preparing the gel composition.
Owner:KBENHAVNS UNIV UNIV OF COPENHAGEN +1
Salicylanilide derivatives, preparation method thereof and application thereof
InactiveCN101698651AImprove specific binding abilityInhibition of signal transductionOrganic active ingredientsOrganic compound preparationHalogenSalicylanilide
The invention discloses salicylanilide derivatives, which have the following general formula, wherein R1 is H or Br; R2 is H or Br; R3 is H or CH3; R4 is F, Cl, Br or I; R5 is F, Cl, Br or I; and R6 is CH3, OCH3, CH(CH3)2 or halogen. The salicylanilide derivatives have obvious inhibiting effect on HEP-G2 and EGFR in liver cancer cells, so the salicylanilide derivatives can be applied in preparing a medicament against liver cancer. The invention discloses a preparation method for the salicylanilide derivatives.
Owner:南京大学中国医药城研发中心
Cream shampoo for scalp itching relieving and preparation method thereof
The invention relates to cream shampoo for scalp itching relieving and a preparation method thereof. The cream shampoo comprises, by mass, the following components of 0.5-2.5 parts of olive oil, four to ten parts of stearic acid, four to 12 parts of glycerinum, 10-20 parts of laurinol polyoxyethylene ether sodium, one to four parts of glycol distearate, 0.5-1.2 parts of carboxymethylcellulose, 0.06-0.14 part of salicylanilide, 0.2-0.6 part of oleoyl sodium methyl taurate, 0.2-0.5 part of xanthan gum, two to seven parts of potassium hydroxide, 0.5-1.2 parts of selenium sulfide, 42-55 parts of water, 0.08-0.15 part of essence, 0.5 to two parts of borneol, 0.5 to two parts of rosin and 0.3 to one part of fructus kochiae. The cream shampoo can clean hair and the scalp effectively and fast, foam is exquisite and easy to wash off, and meanwhile the cream shampoo can effectively restrain itching caused by the dry scalp, and has the refreshing effect.
Owner:JIANGSU QILIKANG SKIN PHARMA
Application of 4-hydroxy salicylanilide to preparation of medicament for preventing and treating hepatitis B
InactiveCN102920688AEnhance killing activityHigh RR enzyme inhibitory activityOrganic active ingredientsDigestive systemRibonucleotide reductaseMedicine
The invention provides new application of 4-hydroxy salicylanilide in the field of pharmacy. 4-hydroxy salicylanilide is an inhibitor of ribonucleotide reductase (RR) and inhibits the enzyme activity of RR, so that the compounding of dNTPs required by reproduction of HBV is blocked, and the aims of inhibiting reproduction of HBV, treating hepatitis and particularly treating hepatitis B are fulfilled. The 4-hydroxy salicylanilide can be used for preventing and treating the hepatitis B and has a significant application prospect.
Owner:ZHEJIANG UNIV +1
Methods for treating diseases or infections caused by or associated with h. pylori using a halogenated salicylanilide
ActiveUS20200268693A1Prevent and reduce riskInhibit and prevent progressionAntibacterial agentsOrganic active ingredientsDiseaseBiology
Disclosed are methods for the prevention or treatment of a disease or infection caused by or associated with H. Pylori in a subject infected by H. Pylori, the method comprising orally administering a halogenated salicylanilide such as niclosamide to the subject. The method may be used for the prevention or treatment of, for example dyspepsia, gastritis, peptic ulcer disease, premalignant gastric lesions, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
Owner:RHODE ISLAND HOSPITAL
Antimicrobial pbt material and preparation method thereof
InactiveCN105860452ALarge specific surface areaMultiple potential active sitesSodium diacetatePolyethylene terephtalate
The invention discloses an antimicrobial pbt material. The antimicrobial pbt material is prepared from, by weight, 3-5 parts of polyvinylpyrrolidone, 70-80 parts of caprolactam, 10-13 parts of attapulgite, 1-1.4 parts of zinc acetate, 2-3 parts of gamma-aminopropyltriethoxysilane, 18-20 parts of oxalic acid, 300-370 parts of polybutylene terephthalate, 6-8 parts of octyl isothiazolinone, 1-2 parts of zinc sulfate, 1.7-2 parts of n-salicylanilide, 10-14 parts of butyl acrylate resin, 1-2 parts of bi-decyl dimethyl ammonium bromide, 0.7-1 part of nickel aminosulfonate and 2-3 parts of sodium diacetate. Polyvinylpyrrolidone, sodium diacetate and the like are further added to the material, and therefore the antimicrobial performance of the finished product is further improved.
Owner:CHUZHOU YOUSHENG HIGH POLYMER MATERIAL
Double-wall corrugated pipe
InactiveCN103542192AGood chemical stabilityImprove aging resistanceFlexible pipesRigid pipesPolymer scienceSalicylanilide
The invention discloses a double-wall corrugated pipe. The double-wall corrugated pipe is characterized by comprising the flowing raw materials, by weight, 63 to 70 parts of PVC (Poly Vinyl Chloride) resin, 4 to 6 parts of chlorinated polyethylene, 1 to 2 parts of calcium magnesium powders, 4 to 6 parts of light calcium carbonate, 2 to 3 parts of decabromodiphenylethane, 3 to 4 parts of permethrin, 1 to 2 parts of maleic anhydride, 1 to 2 parts of 4, 4'-methylene diphenyl diisocyanate, 2 to 3 parts of triethylene glycol, 1 to 2 parts of pentaerythritol, 1 to 2 parts of n-salicylanilide and 5 to 10 parts of composite fillers. The double-wall corrugated pipe has the advantages of being excellent in chemical stability, aging resistant performance and environmental stress cracking performance, rapid to construct and easy to maintain.
Owner:SINOMACH GENERAL MACHINERY SCIENCE & TECHNOLOGY CO LTD
Electrolyte additive for performance stability of batteries
Owner:MEDTRONIC INC
Halogenated salicylanilides for treating clostridium infections
ActiveUS20180207179A1Useful in treatingReduce usageAntibacterial agentsOrganic active ingredientsBacteroidesSalicylanilides
The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhoea and C. difficile associated colitis.
Owner:UNION THERAPEUTICS AS
Wear-resisting elevator belt rubber material containing silicon
InactiveCN104672909AImprove heat resistanceImprove heat aging resistanceRubber materialPolymer science
The invention discloses a wear-resisting elevator belt rubber material containing silicon. The wear-resisting elevator belt rubber material is characterized by comprising the following raw materials in percentage by weight: 25-35 parts of reinforced silicone rubber, 25-35 parts of styrene-butadiene rubber, 4-7 parts of zinc oxide, 5-8 parts of stearic acid, 0.6-0.8 part of an accelerant TMTD, 0.4-0.6 part of silicon dioxide hydrate, 0.3-0.5 part of an anti-aging agent, 2-4 parts of sulphur, 5-8 parts of acetylene black, 3-5 parts of pottery clay powder, 1-3 parts of salicylanilide, 0.7-0.9 part of bi-(3-triethoxypropyl-silane)-tetrasulfide, 0.8-1 part of a dispersing agent, 0.4-0.6 part of tetramethyl thiuram monosulfide and 0.4-0.6 part of an assistant. The obtained elevator belt rubber material has excellent heat resistance, heat-aging resistance, stretch resistance and wear-resisting property.
Owner:QINGDAO ALLPOLY CONVEYOR BELT
Antibacterial Use of Halogenated Salicylanilides
InactiveUS20170258816A1Reduced rate of appearanceReduce developmentAntibacterial agentsOrganic active ingredientsStreptococcus pyogenesRafoxanide
The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Gram positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.
Owner:UNION THERAPEUTICS AS
Environment-friendly, antibacterial and mouldproof rubber
The invention discloses an environment-friendly, antibacterial and mouldproof rubber which comprises the following components in parts by weight: 20-50 parts of chloroprene rubber, 5-10 parts of smoked sheet 1# rubber, 10-15 parts of light calcium carbonate, 5-10 parts of salicylanilide, 1-5 parts of figuline powder, 20-30 parts of conductive carbon black, 1-2 parts of sodium tetraborate and 1-3 parts of paraffin oil. Compared with the prior art, the mouldproof rubber provided by the invention has the advantages that the mouldproof rubber is mainly made of chloroprene rubber and natural rubber, and since the natural rubber has good tensile strength and good electrical insulating property and is soft at a low temperature, the chloroprene rubber has the advantages of fire resistance, atmosphere corrosion resistance, mould prevention, heat resistance and the like, the mouldproof effect is greatly improved by addition of magnesium stearate, and the mechanical and physical properties are excellent.
Owner:QINGDAO BOYUTE RUBBER & PLASTIC PRODS
Parasiticidal composition
ActiveUS20060142216A1Improve bioavailabilitySuitable for topical administrationBiocideSalicyclic acid active ingredientsPolyethylene glycolBlood plasma
An anti-parasiticidal composition presented as a topical “pour-on” product for treating animals infected by parasites which are known to be susceptible to salicylanilides, especially closantel, alone or together with at least one other anti parasitic compound of the avermectin or milbemycin type and offers enhanced bioavailability of the salicylanilide by provision of a delivery system comprising at least 20% (v / v) of one or more alcohols, and optionally including a polymeric moiety selected from the group consisting of polyvinylpyrrolidone (PVP), polyoxypropylene / polyoxyethylene block copolymers (poloxamer), and polyethylene glycols (PEG), thereby improving the bioavailability of e.g. closantel (as assessed with respect to blood plasma levels of closantel).
Owner:NORBROOK LABORATORIES LIMITED
Topical parasiticide formulations and methods of treatment
InactiveUS20060121072A1Improved pharmacokinetic resultGreat CmaxBiocideCarbohydrate active ingredientsActive agentWater insoluble
The present invention discloses aqueous micellar formulations for topical administration of benzimidazoles or salicylanilides with macrocyclic lactones to livestock for the control of endo- and ecto-parasites, comprising a first active agent selected from water insoluble benzimidazoles, salicylanilides and active derivatives or salts thereof, in combination with a second active agent selected from macrocyclic lactones or active derivatives or salts thereof, and also comprising, per litre of formulation: from about 100 to about 400 g veterinary acceptable surfactant(s); from about 200 to about 750 g veterinary acceptable water-miscible solvent(s); and from about 50 to about 350 g water, as well as methods for dosing livestock with such formulations, and methods for controlling and / or preventing diseases or parasite infection in livestock.
Owner:SCHERING PLOUGH ANIMAL HEALTH +2
Hydrophobic whisker composite material and preparation method thereof
The invention discloses a hydrophobic whisker composite material which is prepared from the following raw materials in parts by weight: 0.7-2 parts of calcium ricinoleate, 100-130 parts of polypropylene, 24-30 parts of 3-(trifluoromethyl) benzophenone, 7-9 parts of hydroquinone, 10-13 parts of calcium carbonate whiskers, 0.4-1 part of potassium carbonate, 0.2-0.5 part of sodium carbonate, 100-120 parts of sulfolane, 0.5-1 part of 1H,1H,2H,2H-perfluorodecyl triethoxysilane, 2-3parts of hydroxystearicacid, 0.5-1 part of propylene glycol alginate, 6-8parts oftetrabutyl titanate, 0.8-1 part of aluminum ammonium sulfate, 0.6-1 part of 1,2-dimethylimidazole and 0.1-0.3 part of n-salicylanilide. The composite material has good hydrophobic property and excellent overall performance.
Owner:ANHUI LIFENG MACHINERY TOOL
Anti-static cable sheath material and preparation method thereof
The invention discloses an anti-static cable sheath material. The anti-static cable sheath material is composed of, by weight, 2-4 parts of erucyl amide, 570-600 parts of polyvinyl chloride, 17-20 parts of fulvic acid, 0.06-0.1 part of sodium iodide, 40-50 parts of isopropyl alcohol, 70-100 parts of saponite, 2-3 parts of sp80, 20-30 parts of lactide, 0.2-0.25 part of L-arginine, 4-6 parts of polyving akohol, 1.6-2 parts of salicylanilide, 3-5 parts of sodium potassium silicate, 2-4 parts of 3-phenoxy-1-propanol, 10-18 parts of cresyl diphenyl phosphate and 2-4 parts of calcium palmitate. According to the cable sheath material, the components such as the erucyl amide and the salicylanilide are added, good anti-static property is achieved, the anti-static cable sheath material is suitable for protection of wires of electronic products such as household appliances and instruments, and the safety is high.
Owner:HEFEISHI SHENZHAO ELECTRONICS
Trace Elements
The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium; and at least one component selected from the group comprising a vitamin, a vaccine, a growth stimulant, a dewormer, iron dextran, an antibiotic and a synchronisation preparation. The synchronisation preparation is a combination of injectable hormonal preparations, inplantable hormonal preparations, intravaginal hormonal preparation and other slow release hormonal preparation. The antibiotics include oral, injectable and implantable theurapeutic remedies. The vaccine includes antigens and a combination of antigens and adjuvents. The growth stimulants include zeranol, estradiol, testosterone, progesterone and trenbolone acetate. The dewormer includes macrocydic lactones, leramizoles, benzimidazoles and salicylanilides. The macrocydic lactones include doramectin, ivermectin, abamectin and moxidectin.
Owner:WARBURTON TECH
Application of 4-hydroxyl salicylanilide in preparation of anti-tumor drugs
ActiveCN105663147AEnhance killing activityImprove securityOrganic active ingredientsCapsule deliveryOncologySalicylanilide
Owner:施菊妹
Composite rubber health track
InactiveCN101822899AIncrease elasticityHigh strengthSki bindingsWater-skiingPolymer scienceSports facility
The invention relates to athletic sports facilities, in particular to a composite rubber health track. The track compounded from an upper layer and a lower layer, wherein the upper layer is a composite rubber layer, the lower layer is a regenerated rubber layer; the composite rubber layer is mainly made from butyl rubber, silicon rubber, natural rubber, ceramic clay, stearic acid, naphthenic oil, salicylanilide, sulfuretted rubber powder and phthalocyanine blue, and the thickness ratio of the composite rubber layer to the regenerated rubber layer is 1:0.8-1.2. Because the silicon rubber and fluorine rubber are added to the prescription, the track has favorable elasticity, intensity, toughness and damping effects, has the properties of wear resistance, dust prevention, inflaming retarding, static prevention, mildew proof, corrosion prevention, ultraviolet resistance, multivariant weather resistance without being affected by meteorological conditions, realizes the industrial large-scale production, can be installed and laid all over the world and be recycled and is green, environment friendly and safe.
Owner:JIEDONG KANGJIAN SPORTS EQUIP
Dyeing and finishing process of underwear fabric
InactiveCN105421046AExcellent flame retardantExcellent mothproofHeat resistant fibresGrip property fibresPolymer scienceBromine
The invention discloses a dyeing and finishing process of underwear fabric, which comprises the following steps: (1) pretreatment; (2) dyeing; (3) finishing: adding 1-2 parts by weight of gamma-(3-glycidoxypropyl) trimethoxysilane, 1.2 parts by weight of 4-Br-2-n-octylisothiazolinone, 0.9 part by weight of salicylanilide and 3.6 parts by weight of acrylic acid into 15 parts by mass of deionized water, and stirring uniformly; then adding 0.9 part by weight of bioresmethrin, 0.7 part by weight of isocyanuric acid triallyl ester, 0.9 part by weight of polyamide and 1.4 parts by weight of 3-(2-aminoethyl)-aminopropyl methyl dimethoxy silane, and continuously stirring till full and uniform mixing to prepare finishing liquid; then padding the fabric in the finishing liquid, taking out and drying at constant temperature.The fabric dyed and finished by the dyeing and finishing process has excellent mildewproof, mothproof, antibacterial, antiflaming and antistatic performances, and is high in washing resistance and soft in handfeel.
Owner:常熟市大唐王子服饰厂
Antibacterial anticorrosive led heat-dissipation coating and preparation method thereof
InactiveCN105086755AHigh impact strengthImprove adhesionAntifouling/underwater paintsPaints with biocidesPropanoic acidDiethylenetriamine
The invention discloses an antibacterial anticorrosive led heat-dissipation coating. The coating comprises, by weight, 1-2 parts of N-salicylanilide, 2-3 parts of 8-copper quinolinate, 310-400 parts of high-density polyethylene, 100-130 parts of sodium hydroxide, 400-420 parts of biaphenol A, 160-180 parts of epoxy chloropropane, 10-12 parts of silicon nitride, 2-3 parts of acrylamide, 1-1.6 parts of ammonium chloride, 0.05-0.1 part of N,N-methylene-bisacrylamide, 3-4 parts of ammonium persulfate, 0.01-0.02 part of TritonX114, 1.8-2 parts of ammonium hydroxide, 10-20 parts of diethylenetriamine, 30-42 parts of carbon nano-tubes, 4-5 parts of 2,2-dimethylol propionic acid, 2-3 parts of calcium propionate, 5-7 parts of chlorinated paraffin, 20-30 parts of isopropanol and 1-3 parts of aluminum hydroxide. The N-salicylanilide, the 8-copper quinolinate, the calcium propionate and others are blended, in this way, the antibacterial anticorrosive performance of the coating can be effectively improved, working requirements of different environments are met, weather resistance is good, and the service life is long.
Owner:YANYANG LAMP SET TIANCHANG CITY
Durable fabric odor-resisting and antistatic finishing agent
InactiveCN104790207AImprove bindingLong-lasting antibacterial and deodorant propertiesFibre treatmentPentachlorophenolBetaine
The invention relates to a durable fabric odor-resisting and antistatic finishing agent. The durable fabric odor-resisting and antistatic finishing agent is prepared from the following raw materials: pentachlorophenol zinc, tri-n-butyl tin acetate, salicylanilide, sulfated glycine betaine, polyvinyl alcohol, citric acid, pyridine mercury oleate, organic silicon, SCJ-877, magnesium chloride, cellulose acetate butyrate and sodium polyacrylate. A fabric treated by the finishing agent has antibacterial, mold-proof and antistatic effects, can resist water washing and has the advantages of low toxicity, no environment pollution and low cost.
Owner:宣海成
Salicylanilide modified peptides for use as oral therapeutics
Owner:RGT UNIV OF CALIFORNIA
Polymer waterborne polyurethane coating and preparation method thereof
InactiveCN105925165AHigh tensile strengthPromote absorptionAntifouling/underwater paintsPaints with biocidesPotassium perfluorobutanesulfonateDispersity
The invention discloses a polymer waterborne polyurethane coating. The polymer waterborne polyurethane coating is composed of the following raw materials in parts by weight: 0.1 to 0.3 part of konjac glucomannan, 0.1 to 0.3 part of ascorbic acid, 10 to 14 parts of titanium tetrachloride, 0.3 to 0.7 part of hexahydrated ferric chloride, 30 to 40 parts of a hydrogen peroxide solution with a concentration of 28 to 30%, 600 to 700 parts of poly epsilon-caprolactone glycol, 470 to 500 parts of isophorone diisocyanate, 20 to 30 parts of acetone, 13 to 20 parts of dimethylolpropionic acid, 4 to 6 parts of diethylene glycol, 0.1 to 0.16 part of stannous octoate, 5 to 7 parts of triethylamine, 1 to 3 parts of polyether glycol, 1.4 to 2 parts of sodium polyacrylate, 0.4 to 1 part of potassium perfluorobutanesulfonate, 0.07 to 0.1 part of octadecyl isocyanate, 2 to 4 parts of titanium dioxide and 0.2 to 0.6 part of n-salicylanilide. The coating provided by the invention is added with polymer materials like sodium polyacrylate, so the dispersity of nano-sized molecules in the polymer is effectively improved, and the stability of a finished coating film is enhanced.
Owner:李强
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