92 results about "Benzonitrile" patented technology

Disclosed herein are compositions and formulations of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile (Compound (I)), wherein Compound (I) has the structure (I) and methods of making and using such compositions and formulations.

The invention relates to a perovskite solar cell and a preparation method thereof, the perovskite solar cell comprises a first electrode layer, a hole transport layer, a perovskite layer, an electron transport layer and a second electrode layer which are stacked in sequence, and the hole transport layer and / or the electron transport layer contains a cyanophenyl compound. According to the perovskite solar cell, the cyanophenyl compound is adopted as a passivation material, the defects of the electron transport layer and the hole transport layer are passivated at the same time, non-radiative recombination at an interface is reduced, and finally the device performance of the perovskite solar cell is improved.

This invention relates to a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative, its preparation method, and its application. A trifluoromethyl-substituted pyrene-phenylacetonitrile derivative has the structural formula: [formula omitted]. The preparation method involves dissolving 1-pyrene formaldehyde, the corresponding trifluoromethylphenylacetonitrile, and an alkaline catalyst in an organic solvent, and carrying out a Knoevenagel condensation reaction under heating conditions. The reaction product is then post-treated to obtain the pyrene-phenylacetonitrile derivative. The application of a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative in electrical storage devices is also discussed. This invention achieves precise control of storage performance by introducing trifluoromethyl groups at different positions on the benzene ring of the pyrene-phenylacetonitrile backbone, providing a novel design approach for developing new multi-level electrical storage materials. The synthesis route is concise and has broad application prospects in the field of high-density non-volatile memory.

The utility model provides a bagging machine for quantitative blanking of 2-hydroxy-benzonitrile, which comprises a bottom plate, a top plate is arranged above the bottom plate, a hopper is fixed on the top plate, and a support rod is fixed between the top plate and the bottom plate; a circular plate making contact with the bottom of the discharging end of the hopper is arranged below the top plate, the bottom of the circular plate communicates with a set of vertical cylinders distributed in an annular array, the discharging end of the hopper corresponds to the top of one vertical cylinder, and a motor used for driving the circular plate to rotate is arranged on the top plate; and a sealing plate in contact with the bottom end of the vertical cylinder is arranged below the circular plate. According to the quantitative packing device for the 2-hydroxy-benzonitril, the 2-hydroxy-benzonitril can be effectively and quantitatively packed, it is guaranteed that the weight of the 2-hydroxy-benzonitril in each packing bag reaches the standard, large errors of the weight of the 2-hydroxy-benzonitril in the packing bags are avoided, when the 2-hydroxy-benzonitril is quantitatively packed, it is not needed to stop discharging for a long time to transfer and replace the packing bags, and the packing efficiency is improved. And the packaging efficiency of the 2-hydroxy-benzonitril is improved.

Ophthalmic compositions comprising 4 - (7-hydroxy-2-isopropyl-4-oxo - 4H - quinazolin-3-yl) - benzonitrile (Compound I) are provided.SOLUTION: The present invention provides crystalline Form E of 4 - (7-hydroxy-2-isopropyl-4-oxo - 4H - quinazolin-3-yl) - benzonitrile (Compound I). Further provided are methods of preparing crystalline Form E of Compound I comprising heating a hydrate form of Compound I to a temperature greater than 250 °C. or 260 °C. to provide Compound I as crystalline Form E. Further provided are ophthalmic compositions comprising crystalline Form E of Compound I.SELECTED DRAWING: None

The invention relates to a process for preparing 1,2′-benzisothiazoline-3-one according to formula (I), comprising the following steps: (a) reacting a 2-halogenbenzonitrile compound of general formula (II) with a reaction mixture, containing: (i) alkaline sulphide and / or alkaline hydrogen sulphide and (ii) an alkyl halide compound, represented by general formula (III): R1X (III) for producing an intermediate product of general formula (IV), and (b) reacting the intermediate product of general formula (V) obtained in step (a) with a halogenating agent or an oxidant and subsequent reaction of the 2-(alkylsulfoxy)benzonitrile with an acid to form 1,2-benzisothiazoline-3-one as well as a halide compound of general formula (V) R1X (V).

This invention provides a flexible perovskite photovoltaic module, its fabrication method, and an embedded flexible photovoltaic module anti-glare encapsulated automotive rearview mirror. It relates to the technical field of photovoltaic technology applied to automotive equipment. The conductive substrate flexible perovskite photovoltaic module includes a perovskite thin film layer containing additives; wherein 4-(2-pyridinylthio)benzonitrile is introduced as an additive into the perovskite precursor to form the perovskite thin film layer. This invention innovatively introduces novel molecular additives with multi-site coordination / strong dipole properties into the perovskite precursor solution, which can simultaneously regulate the perovskite nucleation and crystallization process, passivate bulk phase and grain boundary defects, inhibit ion migration, and significantly reduce the density of bulk phase and grain boundary defects. Ultimately, while ensuring process repeatability, it further improves the energy conversion efficiency and long-term stability of the flexible perovskite photovoltaic device.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4 H-quinazolin-3-yl)-benzonitrile.

The application provides an alpha-carboxyl-beta-diimine nickel complex and a preparation method and application thereof and a preparation method of ethylene-methyl acrylate copolymer. The alpha-carboxyl-beta-diimine nickel complex has a structure shown in general formula (I): in the general formula (I), Ar is selected from 2,6-dialkylphenyl; X is chlorine or bromine; and L is acetonitrile or benzonitrile. The preparation method of the alpha-carboxyl-beta-diimine nickel complex is that acetylacetone is reacted with 2,6-dialkylaniline, then reacted with ammonium formate under the action of alkyl lithium, and then reacted with a halogenated nickel salt in an acetonitrile or benzonitrile solvent to obtain the alpha-carboxyl-beta-diimine nickel complex. The application further provides a preparation method of ethylene-methyl acrylate copolymer, which uses the alpha-carboxyl-beta-diimine nickel complex as a main catalyst. The application improves the copolymer molecular weight and the methyl acrylate insertion rate, and makes the prepared EMA similar to the branched structure of a commercial product prepared by a free radical process.

The present application provides a kind of preparation of doravirine intermediate 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy]benzonitrile synthesis method, the method includes from formula D compound and 3-chloro-5-hydroxybenzonitrile in the presence of base, catalyst coupling to obtain formula E compound, formula E compound is cyclized to obtain 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy]benzonitrile in the presence of acid.The method uses cheap starting material, avoids the use of noble metal catalyst and expensive material fragment, process operation and post-processing are simple, suitable for industrial scale production.

The invention relates to the field of organic chemistry, in particular to a method for obtaining 2-phenoxy-1-phenylethan-1-one. The essence of the invention is that the method for obtaining 2-phenoxy-1-phenylethan-1-one according to the invention is characterized in that the interaction of benzonitrile and chloromethoxybenzene is carried out in the presence of the catalyst H3PM012040 for 2 hours.

The application discloses a method for preparing benzonitrile compounds from toluene compounds, and comprises the following steps: adding ammonium salt as a nitrogen source into an organic solvent with Ru / BiOCl as a catalyst, and then passing oxygen into the organic solvent to perform a photochemical reaction, so that the toluene compounds are directly oxidized to generate the benzonitrile compounds. In the application, no cyanide is used as a cyano source, but toluene compounds are used as raw materials, ammonium salt is used as a nitrogen source, and Ru / BiOCl is used as a catalyst, so that a C-H bond is directly converted into a cyano group through a photocatalytic reaction, and the benzonitrile compounds are obtained. The reaction condition is mild and green and environment-friendly.

The present invention relates to crystalline forms of fumarate of MRTX0902 ((R)-2-methyl-3-(1-((4-methyl-7-morpholinopyridino [3, 4-d] pyridazin-1-yl) amino) ethyl) benzonitrile), pharmaceutical compositions comprising the crystalline forms, methods of making the crystalline forms, and methods of use thereof.

The application discloses a transition metal-based catalyst, a preparation method and application in plastic resource recycling, and belongs to the technical field of heterogeneous catalytic plastic chemical upgrading and recycling. The transition metal-based catalyst is synthesized through a gel sol-two-step calcination strategy, has a multi-level mesoporous structure, rich oxygen vacancies and both Bronsted acid and Lewis acid sites, and has excellent photo-thermal response performance and catalytic oxidation activity. The application uses water as a solvent, and through photo-thermal co-catalysis or photo-thermal synergistic catalysis, efficiently and directionally converts polystyrene into high-value-added chemicals such as benzoic acid, benzonitrile and benzamide, and the highest yield of benzoic acid reaches 71.34%, and the transition metal-based catalyst can be reused for at least 5 times. The technology breaks through the bottleneck of traditional plastic recycling, that is, dependence on organic solvents, harsh reaction conditions and low conversion efficiency, and provides a scalable and feasible path for green upgrading and recycling of polystyrene.

The application belongs to the technical field of organic synthesis, and relates to an aryl-substituted halogenated s-triazine compound and a preparation method thereof. The aryl-substituted halogenated s-triazine compound is shown as formula (I). The preparation method of the compound is as follows: a benzonitrile derivative, ethylene glycol methyl ether, dicyandiamide and potassium hydroxide are mixed and heated, and compound 1 is obtained through reaction; compound 1 and acetonitrile are mixed, and a sulfuric acid solution, sodium nitrate and a cuprous chloride solution are added dropwise in sequence, and then reaction is carried out after dropwise addition is completed; and a target product is obtained. The synthesis method has the advantages of less impurity generation, high conversion rate and high product quality.

This invention relates to the field of organic synthesis technology, specifically a method for synthesizing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and its application, comprising the following steps: S1. Compound 1a is added to a first organic solvent under inert gas protection and reacted with vinyl isobutyl ether under the conditions of a catalyst and potassium carbonate to obtain a system containing compound 2a; S2. The pH of the system containing compound 2a obtained in step S1 is adjusted to 2-3, and after reaction, compound 1 is obtained through post-treatment; S3. Compound 1 is added to a second organic solvent, and ethyl formate and sodium ethoxide are added to react and obtain a system containing compound 4a; S4. Acetic acid is added to the system containing compound 4a obtained in step S3 for neutralization, and under inert gas protection, hydrazine hydrate is added dropwise to react and the product is obtained through post-treatment. The synthesis method provided by this invention uses readily available raw materials, has a simple processing procedure, does not require column chromatography, simplifies the operation, and facilitates industrial-scale production.

The present invention relates to a compound for use in the treatment of schizophrenia, also known as CF3CN and referred to herein as the compound of formula I, 4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromeno[7,8-d]imidazole-8-yl)benzonitrile. Preferably, the treatment of schizophrenia is the treatment of one or more symptom categories of schizophrenia. More preferably, the treatment is for the negative symptoms of schizophrenia. Alternatively, the treatment is for the cognitive symptoms of schizophrenia.

The invention discloses a molecular crystal for realizing broadband photo-induced mechanical motion through thermal polymorphic transformation as well as preparation and application of the molecular crystal. Relates to a 4-[(1Z, 3E)-1-cyano-4-phenyl-1, 3-butadiene-1-yl] benzonitrile molecular crystal, and a bulk crystal (Form I) can be obtained through a solvent method. When the Form I is heated to 142-165 DEG C, thermal phase change from single crystal to single crystal can occur, and the Form I is converted into Form II, so that the light response range is expanded from ultraviolet light (365 nm) to visible light (490 nm), meanwhile, the types of light products are increased, and optical mechanical behaviors are enriched. The Form II can show various optical mechanical behaviors such as fragmentation, movement, jumping and the like under the irradiation of visible light. And a film prepared by compounding the graphene / PVA composite material and PVA has good flexibility and repeatable bending performance, can push an object which is heavier than the graphene / PVA composite material by several times, and has application potential in the fields of optical driving devices, soft robots and the like.

The invention provides a method for preparing crisaborole through metal-free catalysis. The method comprises the following steps: taking 4-[4-bromo-3-(hydroxymethyl) phenoxy] benzonitrile as a raw material, and cyclizing by adopting a metal-free catalytic borane reaction to obtain crisaborole. The process method has the advantages of short steps, adoption of metal-free free radical reaction for boronization, avoiding of the use of an expensive metal catalyst and harsh reaction conditions, no generation of the problem of metal residue in the product, simple and safe post-treatment operation, low cost, high total yield, good economic benefits, suitableness for industrial production, and good application prospects.

The present invention provides an improved process for the preparation of benzonitrile compounds More particularly, the present invention relates to an improved process for the preparation of benzonitrile compounds of Formula (I) by nitrilation of the corresponding benzotrichloride compounds of Formula (II).

The invention relates to the technical field of organic chemical industry, and discloses an efficient synthesis method applied to 2-hydroxy-benzonitrile production. The method comprises the following steps: dissolving urea in gamma-valerolactone, mixing the gamma-valerolactone with methyl salicylate to form a raw material solution, introducing the raw material solution into a fixed bed reactor filled with a special catalyst, carrying out first-stage and second-stage reactions at different temperatures in sequence, and carrying out post-treatment on the reaction solution to obtain a 2-hydroxy-benzonitrile product. The catalyst is prepared by taking mesoporous silica as a carrier through amino modification, cerium-zinc composite oxide loading and histidine modification, and has high activity and stability. The method realizes continuous synthesis of 2-hydroxy-benzonitrile, has the advantages of mild process conditions, continuous and efficient reaction, high product yield and excellent purity, avoids the use of toxic raw materials in the traditional process, reduces the production cost, and is suitable for large-scale production.

The present disclosure provides certain processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro- 1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile (Compound 1) and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound 1 and processes for preparing such polymorph forms.

The application provides a non-doped blue light-emitting material containing anthracene and a preparation method and application thereof in an organic electroluminescent device, and belongs to the technical field of organic photoelectric materials.The non-doped blue light-emitting material containing anthracene provided by the application has a structure shown in formula I.In the application, carbazole is used as an effective electron donor group, has a rigid molecular structure, multiple chemical modification sites, high chemical and thermal stability and the like;anthracene has very strong fluorescence quantum efficiency and good thermal stability, and can be used as a pi bridge chain;the introduction of benzonitrile realizes partial overlap and partial separation of HOMO and LUMO of the blue light-emitting material, obtains a hybrid local charge transfer state light-emitting material coexisting with LE state and CT state, improves photoluminescence efficiency, and ensures a certain exciton utilization rate, so that the emission blue light can be ensured while the light-emitting efficiency and thermal stability of the light-emitting material are ensured.

The invention discloses a nitrile functional group-containing material as well as a preparation method and application thereof. The nitrile functional group-containing material has the following structural formula, wherein X is or; y is or; r is a C2-C6 carbon chain cyano group or a cyanophenyl group; according to the invention, the cycle performance of the lithium ion battery is effectively improved (especially the cycle performance in a high-voltage system is obviously improved), and the service life of the battery is prolonged; meanwhile, the preparation method of the pyrosulfuric acid / pyroboric acid material containing the nitrile functional group, provided by the invention, is simple, mild in reaction condition, free of relatively high reaction requirements, free of use of a catalyst with high cost, low in energy consumption, high in product yield and very suitable for large-scale industrial production.

The present application relates to the field of herbicides, in particular to a preparation method of 2-nitro-4-(trifluoromethyl)benzonitrile. The method comprises the following steps: 1) under the presence of a first solvent, a compound shown in formula I is subjected to ammoniation reaction with an ammoniation reagent under ammoniation reaction conditions to obtain a compound shown in formula II, wherein X represents halogen in formula I; 2) under the presence of a second solvent, the compound shown in formula II is subjected to diazotization reaction with a diazotization reagent under diazotization reaction conditions to obtain a diazotization reaction product; 3) under the presence of a base, the diazotization reaction product obtained in step 2) is subjected to cyanation reaction with cyanide under cyanation reaction conditions. The method has mild reaction conditions, does not need to be carried out under high temperature conditions, and does not need to use a catalyst, so that the production cost is greatly reduced, and meanwhile a higher product yield and purity can be obtained.

The invention discloses a cyanophenyl metal-based ultraviolet absorbent, a preparation method and application thereof, and a modified polyvinyl chloride material, and belongs to the technical field of ultraviolet absorbents. The preparation method of the cyanophenyl metal-based ultraviolet light absorber comprises the following steps: adding a cyanophenyl compound into a first organic solvent, adding a metal hydroxide, carrying out a heating reaction, and cooling to obtain a solid precipitate; and dissolving the solid precipitate in a second organic solvent to obtain the cyanophenyl metal-based ultraviolet light absorber. The invention also provides application of the cyanophenyl metal-based ultraviolet light absorber as a modified material. The invention also provides a modified polyvinyl chloride material which is prepared by the following steps: dissolving the polyvinyl chloride material and the cyanophenyl metal-based ultraviolet light absorber in an organic solvent, pouring, drying and washing to obtain the modified polyvinyl chloride material. The novel ultraviolet light absorber solves the problems that an existing polyvinyl chloride material is weak in ultraviolet resistance, easy to age and easy to decompose to generate harmful substances.

The application discloses a method for preparing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and relates to the technical field of 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile. A clear hot-solvent pretreatment liquid is formed; a homogeneous supersaturated mother liquor is obtained; a high-activity primary crystal seed suspension is constructed; the remaining main body liquid stream of the supersaturated mother liquor is subjected to nonlinear programmed cooling pretreatment, so that the remaining main body liquid stream enters a phase diagram metastable zone but maintains a stable state without spontaneous nucleation, and a metastable nucleation precursor liquid is formed; and high-purity and uniform-crystal 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile finished products are prepared. The application can extract an absolutely homogeneous and extremely low-impurity pretreatment liquid, and significantly improves the purity standard and optical transmittance of a subsequent crystallization mother liquor.

This invention relates to a method for preparing polyarylene ether nitrile by copolymerizing 2,5-dichlorobenzonitrile and 2,4-dichlorobenzonitrile with mixed diphenols, comprising: mixing 2,5-dichlorobenzonitrile and 2,4-dichlorobenzonitrile in a molar ratio of 1:9 to 9:1, and performing stepwise polycondensation with mixed diphenols in anhydrous potassium carbonate catalysis and an N-methylpyrrolidone / toluene composite solvent system at 140 to 200°C, to obtain a polyarylene ether nitrile with a number-average molecular weight of 35,000 to 80,000 g / mol, a glass transition temperature of 175 to 240°C, a 5% thermal weight loss temperature of not less than 400°C, a tensile strength of 80 to 120 MPa, and a solubility in N-methylpyrrolidone at 25°C of not less than 15 wt%. This invention effectively breaks the regularity and symmetry of the main chain by simultaneously introducing asymmetric benzonitrile ether structural units derived from 2,5-dichlorobenzonitrile and ortho / para-substituted benzonitrile ether structural units derived from 2,4-dichlorobenzonitrile into the polymer main chain, thereby inhibiting early crystallization and precipitation of chain segments during polymerization and achieving stable synthesis of high molecular weight polymers under homogeneous conditions.

Disclosed herein are methods of treating cancer with a hypoxia inducible factor-2α (HIF-2α) inhibitor, 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile ((Compound (I)) having the structure: (I)

A spray-dried solid dispersion comprising: (a) 3-[4-(4-amino-piperidin-l-yl)-3-(3,5-difluoro-phenyl)-quinolin-6-yl]-2-hydroxy-benzonitrile or a pharmaceutically acceptable salt or solvate thereof; and (b) a pharmaceutically acceptable polymer; wherein the API is dispersed in a polymer matrix formed by the pharmaceutically acceptable polymer. A tablet comprising the spray-dried solid dispersion and one or more pharmaceutically acceptable ingredients selected from one or more diluents, one or more disintegrants, one or more lubricants, one or more glidants. The tablet is for use in the treatment of acromegaly or a neuroendocrine tumor or both in a human by oral administration.