20 results about "Benzonitrile" patented technology

This invention relates to a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative, its preparation method, and its application. A trifluoromethyl-substituted pyrene-phenylacetonitrile derivative has the structural formula: [formula omitted]. The preparation method involves dissolving 1-pyrene formaldehyde, the corresponding trifluoromethylphenylacetonitrile, and an alkaline catalyst in an organic solvent, and carrying out a Knoevenagel condensation reaction under heating conditions. The reaction product is then post-treated to obtain the pyrene-phenylacetonitrile derivative. The application of a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative in electrical storage devices is also discussed. This invention achieves precise control of storage performance by introducing trifluoromethyl groups at different positions on the benzene ring of the pyrene-phenylacetonitrile backbone, providing a novel design approach for developing new multi-level electrical storage materials. The synthesis route is concise and has broad application prospects in the field of high-density non-volatile memory.

This invention provides a flexible perovskite photovoltaic module, its fabrication method, and an embedded flexible photovoltaic module anti-glare encapsulated automotive rearview mirror. It relates to the technical field of photovoltaic technology applied to automotive equipment. The conductive substrate flexible perovskite photovoltaic module includes a perovskite thin film layer containing additives; wherein 4-(2-pyridinylthio)benzonitrile is introduced as an additive into the perovskite precursor to form the perovskite thin film layer. This invention innovatively introduces novel molecular additives with multi-site coordination / strong dipole properties into the perovskite precursor solution, which can simultaneously regulate the perovskite nucleation and crystallization process, passivate bulk phase and grain boundary defects, inhibit ion migration, and significantly reduce the density of bulk phase and grain boundary defects. Ultimately, while ensuring process repeatability, it further improves the energy conversion efficiency and long-term stability of the flexible perovskite photovoltaic device.

The present application provides a kind of preparation of doravirine intermediate 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy]benzonitrile synthesis method, the method includes from formula D compound and 3-chloro-5-hydroxybenzonitrile in the presence of base, catalyst coupling to obtain formula E compound, formula E compound is cyclized to obtain 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy]benzonitrile in the presence of acid.The method uses cheap starting material, avoids the use of noble metal catalyst and expensive material fragment, process operation and post-processing are simple, suitable for industrial scale production.

The application belongs to the technical field of organic synthesis, and relates to an aryl-substituted halogenated s-triazine compound and a preparation method thereof. The aryl-substituted halogenated s-triazine compound is shown as formula (I). The preparation method of the compound is as follows: a benzonitrile derivative, ethylene glycol methyl ether, dicyandiamide and potassium hydroxide are mixed and heated, and compound 1 is obtained through reaction; compound 1 and acetonitrile are mixed, and a sulfuric acid solution, sodium nitrate and a cuprous chloride solution are added dropwise in sequence, and then reaction is carried out after dropwise addition is completed; and a target product is obtained. The synthesis method has the advantages of less impurity generation, high conversion rate and high product quality.

The application discloses a method for preparing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and relates to the technical field of 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile. A clear hot-solvent pretreatment liquid is formed; a homogeneous supersaturated mother liquor is obtained; a high-activity primary crystal seed suspension is constructed; the remaining main body liquid stream of the supersaturated mother liquor is subjected to nonlinear programmed cooling pretreatment, so that the remaining main body liquid stream enters a phase diagram metastable zone but maintains a stable state without spontaneous nucleation, and a metastable nucleation precursor liquid is formed; and high-purity and uniform-crystal 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile finished products are prepared. The application can extract an absolutely homogeneous and extremely low-impurity pretreatment liquid, and significantly improves the purity standard and optical transmittance of a subsequent crystallization mother liquor.

This invention relates to a method for preparing polyarylene ether nitrile by copolymerizing 2,5-dichlorobenzonitrile and 2,4-dichlorobenzonitrile with mixed diphenols, comprising: mixing 2,5-dichlorobenzonitrile and 2,4-dichlorobenzonitrile in a molar ratio of 1:9 to 9:1, and performing stepwise polycondensation with mixed diphenols in anhydrous potassium carbonate catalysis and an N-methylpyrrolidone / toluene composite solvent system at 140 to 200°C, to obtain a polyarylene ether nitrile with a number-average molecular weight of 35,000 to 80,000 g / mol, a glass transition temperature of 175 to 240°C, a 5% thermal weight loss temperature of not less than 400°C, a tensile strength of 80 to 120 MPa, and a solubility in N-methylpyrrolidone at 25°C of not less than 15 wt%. This invention effectively breaks the regularity and symmetry of the main chain by simultaneously introducing asymmetric benzonitrile ether structural units derived from 2,5-dichlorobenzonitrile and ortho / para-substituted benzonitrile ether structural units derived from 2,4-dichlorobenzonitrile into the polymer main chain, thereby inhibiting early crystallization and precipitation of chain segments during polymerization and achieving stable synthesis of high molecular weight polymers under homogeneous conditions.

This invention relates to the field of bis(cyanobenzene)palladium dichloride preparation technology, and discloses a method for preparing bis(cyanobenzene)palladium dichloride, comprising the following steps: mixing benzonitrile and palladium chloride in a certain proportion and grinding them in a grinding device; after grinding, drying the mixture to obtain high-purity benzonitrile palladium chloride. This method for preparing bis(cyanobenzene)palladium dichloride achieves high purity of the product with a high yield under low temperature and less solvent process conditions, with a product purity exceeding 99.9%, high safety, and greatly reduces energy consumption and environmental pressure. It is also very beneficial for producing high-purity pharmaceutical and liquid crystal products, enabling people to enjoy a better life.

This invention discloses a method for the dehydration cyclization of 6-hydroxyhexanoic acid to synthesize ε-caprolactone. The method includes the following steps: adding 6-HA, H-ZSM-5 catalyst, and benzonitrile solvent to a reactor, reacting at 170-210℃ for 6-10 h under mechanical stirring, directly obtaining ε-CL in one step; wherein the material ratio is: 0.013-0.065 g of catalyst per 1 mmol of 6-HA. This invention solves the problem of harsh reaction conditions (vacuum environment) in current ε-CL synthesis routes, providing a more practical and easily scalable technical solution for the industrial production of ε-CL.

This invention belongs to the field of organic chemistry, specifically relating to a method for preparing and applying a class of bis(trichloromethyl)S-triazine compounds. The method provides that benzonitrile compounds are used as starting materials, undergoing a cyclotrimerization reaction with trichloroacetonitrile, followed by a Knevengel reaction with benzaldehyde compounds to obtain bis(trichloromethyl)S-triazine compounds. The preparation method of this invention is simple, with easily controllable temperature and few impurities throughout the process; it significantly reduces costs and greatly improves purity and yield, achieving purities >99% and yields >70%; the products have good solubility; more importantly, almost all compounds exhibit more active inhibitory effects on HepG2 human liver cancer cells than the control cisplatin; making these compounds not only suitable as photochemical agents in the chemical industry but also beneficial for screening tumor therapeutic drugs.

The present invention aims to provide a compound having excellent solvent solubility and excellent heat resistance, thermal decomposition stability, thermal conductivity, and flame retardancy, and a curable resin composition containing the compound. A multifunctional vinyl resin represented by the following general formula (1A) or an epoxy resin represented by the following general formula (1B) is provided. In formula (1), R 1 ~R 6 each independently represents a hydrogen atom or a monovalent hydrocarbon group having 1 to 6 carbon atoms, X independently represents a structure represented by formula (2), a benzonitrile structure, a diphenylsulfonyl structure, a xylylene structure, or - (CH2) m -, m represents a number of 3 to 10, and n represents a number of 1 to 15. (1A) (1B) (2).

The invention provides a method for preparing 2-alkylsulfonyl substituted benzoic acid derivatives of formula (I) by conversion of 2-alkylthio substituted benzonitrile compound of formula (II), which are useful as intermediates in the preparation of herbicidally active compounds like pyrasulfotole or isoxaflutole.

The application discloses a stacking device for benzene nitrile product storage based on industrial vision, and relates to the technical field of industrial vision, which comprises a tray and a walking trolley, storage barrels for benzene nitrile product storage are uniformly arranged on the tray, a fixing frame is fixed on the walking trolley, a driving mechanism is installed on the fixing frame, the driving mechanism is used for lifting and visually positioning and stacking the storage barrels, and the driving mechanism is connected with a lifting mechanism. The stacking device for benzene nitrile product storage based on industrial vision is characterized in that the driving mechanism drives the visual camera to move synchronously, the height of the visual camera is adapted to the stacking height in real time, accurate visual detection can be realized in the whole process of lifting, transferring and stacking, the fork plate, the limiting block and the tray can be accurately matched, the alignment accuracy of multiple sets of trays and storage barrels during stacking is ensured, the problems of unstable stacking, dumping and the like caused by positioning deviation are effectively avoided, the stacking quality is improved, and the demand for large-scale stacking is met.

The utility model discloses a trifluoromethyl benzonitrile centrifugal drying equipment, including the casing, the top of casing is provided with the feed pipe, and the top of feed pipe is provided with the top cover with screw thread, the bottom of casing is provided with the discharge pipe, and is provided with the manual valve on the discharge pipe, the inside fixed support round plate of casing, the side of support round plate is equipped with the liquid discharge hole, and the liquid discharge hole is about the center axis equiangular distribution of support round plate, this trifluoromethyl benzonitrile centrifugal drying equipment, starts first servo motor, and first servo motor can make filter drum rotate, can complete to filter drum inside trifluoromethyl benzonitrile centrifugal, starts the air heater, and the hot air of air heater can be sprayed to the rotating filter drum through several air jets, thereby completes the trifluoromethyl benzonitrile drying in the filter drum, thereby can combine trifluoromethyl benzonitrile centrifugal and drying together, and the trifluoromethyl benzonitrile processing efficiency has been improved.

The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

The utility model discloses a kind of waste liquid separation and recovery devices in trifluoromethyl benzonitrile production process, including rectifying column, input pipe is installed in rectifying column side, lifting pump is installed in input pipe bottom, input pipe bottom end is connected with the top side of separation tank fixedly, the bottom of separation tank one side is fixed with liquid inlet pipe, booster pump is installed on liquid inlet pipe, the inner wall of separation tank one side is fixed with first baffle, the inner wall of separation tank other side is fixed with second baffle, the top of first baffle is fixed with first separation net, the bottom of second baffle is fixed with second separation net, top window is arranged in the top center of separation tank.The waste liquid separation and recovery device in trifluoromethyl benzonitrile production process adopts novel structure design, not only can the solid impurities in waste liquid be efficiently intercepted, and main adsorption filter mechanism can be conveniently disassembled and cleaned, so that the overall filter structure can work stably for a long time.

The application provides a synthesis method of a 4-cyano-2-fluoro-5-methyl benzoate method, relates to the technical field of organic chemical synthesis, and comprises the following steps: raw material 5-fluoro-2-methyl benzonitrile is added into methanol under the condition that the temperature is room temperature; then, a catalyst, 1,1-bis(diphenylphosphino) ferrocene palladium dichloride dichloromethane complex and triethylamine are added into the reaction solution; the reaction is carried out under the condition that the carbon monoxide gas pressure is 15 psi and the temperature is 60-70 DEG C until the reaction is completed; after the reaction is completed, the reaction solution is poured into water; the aqueous phase is extracted with ethyl acetate; the organic phases are combined and washed with saturated brine; the obtained mixture is dried with anhydrous sodium sulfate, filtered, and spin-dried and columned to obtain a product; the synthesis method has a short process route, the raw material and auxiliary materials are cheap and easy to obtain, the reaction activity is high, the operation is simple and easy to control, the yield of the obtained target product is high, and the method is convenient for industrial amplification.

This invention relates to compound 4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromene[7,8-d]imidazol-8-yl)benzonitrile, also known as CF3CN, and referred herein as compound I, for use in the treatment of positive symptoms of schizophrenia.