166 results about "Benzonitrile" patented technology

Compounds of formula (II) and formula (I) which are inhibitors of QPCTL and QPCT: (II) and (I) are provided herein. Also provided are pharmaceutical compositions containing this compound, as well as compounds for use in methods of treating cancer, neurodegenerative, inflammatory or autoimmune diseases. Exemplary compounds are, for example, 3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]benzonitrile (Example 1): (1), and pharmacological data are provided. TIFF2025524039000368.tif70128

The invention discloses a flame-retardant insulating powder coating for a new energy automobile and a preparation method of the flame-retardant insulating powder coating, and belongs to the technical field of coatings. The flame-retardant insulating powder coating for the new energy automobile is prepared from the following raw material components in parts by mass: 380 to 384 parts of epoxy resin, 56 to 58 parts of a toughening agent, 5 to 10 parts of modified flame-retardant filler, 100 to 101 parts of a composite curing agent, 5 parts of a flatting agent, 1 part of benzoin and 0.7 part of an accelerant, the toughening agent is obtained by carrying out a reaction on an isophorone diisocyanate tripolymer, 4-bromophenol and N-p-coumaroyl tyramine; the modified flame-retardant filler is obtained by firstly wrapping hexagonal boron nitride with polydopamine and then modifying with a silane coupling agent; the silane coupling agent is obtained by combining 4-benzonitrile oxygen butyl trimethoxy silane and a sulfydryl silane coupling agent; and the composite curing agent is obtained by combining 4, 4-diaminodiphenylmethane and amino-sulfydryl functional organic polysiloxane.

The present invention relates to fumarate crystalline forms of MRTX0902 ((R)-2-methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile), pharmaceutical compositions comprising the crystalline forms, processes for preparing the crystalline forms and methods of use thereof.

The invention discloses a high-color-purity near ultraviolet heat exciton compound with circular polarization property and application thereof in preparation of a circular polarization organic electroluminescent device, and belongs to the technical field of organic photoelectric materials. The electroluminescent material disclosed by the invention is a high-color-purity near ultraviolet heat exciton compound with circular polarization property, and two pairs of near ultraviolet enantiomers are successfully designed and synthesized by combining a chiral group binaphthol, a weak donor dibenzothiophene, dibenzofuran and an acceptor cyanophenyl; the compounds show obvious circular polarization luminescence property and high fluorescence quantum yield. The electroluminescent devices prepared based on the enantiomers all show near ultraviolet emission, CIE coordinates are respectively (0.168, 0.040) and (0.166, 0.040), and the external quantum efficiencies are respectively 4.3% and 3.4%. According to the near ultraviolet heat exciton material, a new visual angle is provided for developing the near ultraviolet heat exciton material with circular polarization luminescence and high color purity at the same time, and 3D and wide color gamut display can be directly achieved in the future.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

Provided herein are compounds of Formula (II) and Formula (I), which are inhibitors of QPCTL and QPCT: (II) and (I). # imgabs0 # also provides a pharmaceutical composition comprising said compound, as well as said compound for use in a method of treating cancer, a neurodegenerative disease, an inflammatory disease, or an autoimmune disease. Exemplary compounds are, for example, 3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1, 2, 4-triazol-3-yl) piperidin-1-yl] benzonitrile (embodiment 1): (1). Pharmacological data is provided.

Disclosed is a pharmaceutical composition comprising a benzonitrile derivative. The pharmaceutical composition comprises the following components: (a) a compound represented by formula (I); and (b) polyvinylpyrrolidone, wherein components (a) and (b) are mixed and subjected to hot-melt extrusion, and the weight ratio of component (b) to component (a) is 5 to 20. The pharmaceutical composition features good long-term storage stability and a significantly improved dissolution effect.

The invention discloses a topological chemical polymerization method based on discotic liquid crystals, and relates to the technical field of liquid crystal polymers. The method comprises the following steps: dissolving 3, 4, 5-tri (hexyloxy) phenylacetonitrile and 1, 3, 5-benzenetricarboxaldehyde in ethanol, adding tetrabutyl ammonium hydroxide, and reacting at 50-60 DEG C for 1-3 hours to obtain a discotic liquid crystal monomer; placing the discotic liquid crystal monomer on a substrate, heating the discotic liquid crystal monomer until the temperature is greater than or equal to 200 DEG C to enable the discotic liquid crystal monomer to be in a molten state, then pressing the discotic liquid crystal monomer to form a thin film, then cooling the discotic liquid crystal monomer to 70-80 DEG C, and then irradiating the thin film sample for 12-48 hours by using ultraviolet light to obtain the one-dimensional polymer material based on the topological chemical polymerization of the discotic liquid crystal. According to the method, the application range of topological chemical polymerization is widened, more adjustability is given to the topological chemical polymerization process, and new possibility is provided for the field of topological chemistry.

The invention discloses a preparation method and application of a high-performance polyarylether battery diaphragm. The preparation method comprises the following steps: synthesizing a polyarylether (sulfone or ketone) copolymer with low cyanophenyl group content; dissolving the polyarylether (sulfone or ketone) copolymer in a high-boiling-point solvent, performing liquid-phase thermal crosslinking reaction to obtain a crosslinked crude product, purifying the crosslinked crude product to obtain polyarylether containing a triazine ring structure, and retaining part of the high-boiling-point solvent as a solid pore-forming agent in the purification process; and treating the polyarylether containing the triazine ring structure by adopting an electrostatic spinning membrane forming method or a solution phase transfer membrane forming method to form a porous membrane structure, and drying the porous membrane to obtain the high-performance polyarylether battery diaphragm. The polyarylether battery diaphragm has the characteristics of high flame retardance, high strength, high temperature resistance, impact resistance and the like, can be practically applied to lithium ion batteries, sodium ion batteries and the like, and improves the use performance of the batteries.

The invention relates to a preparation method and device of 2-phenylimidazoline and an obtained product. The method comprises the following steps: adding benzonitrile, ethidene diamine and a catalyst into a reaction kettle, heating the reaction kettle to a reaction temperature in an inert gas atmosphere, starting a reaction, timing from 80 DEG C when the temperature is automatically increased to 155-180 DEG C, preferably 160-170 DEG C and is not increased any more, and reacting for 4-12 hours, preferably about 5-10 hours, after the reaction is finished, carrying out vacuum distillation on the reaction kettle, the product is obtained from the bottom of the reaction kettle (1), the material ratio is that the molar ratio of benzonitrile to ethylenediamine is 1: (1.03-1.20), and the molar ratio of the addition amount of the catalyst to ethylenediamine is (0.004-0.01): 1. The cyanobenzene is almost completely converted, the conversion rate is greater than 99.9%, and the residual quantity of cyanobenzene in the product is less than 0.01%, which is far superior to that of the existing production process.

The invention discloses a preparation method and application of a catalyst for generating benzonitrile through electrocatalytic oxidation of benzylamine, and belongs to the technical field of nanotechnology and electrocatalytic oxidation. The NiO-NiMoO4 / NF multi-component composite catalyst of a nanorod structure is used as an electrode, NiO and NiMoO4 form a heterogeneous interface synergistic system, rich active sites are achieved, and the catalyst shows remarkable advantages in benzylamine electrocatalytic oxidation. Under the working voltage of 1.55 V vs.RHE, 99% of benzylamine conversion rate and 94% of Faraday efficiency are achieved, the stability is good, and the catalytic effect is not attenuated after multiple times of recycling. The method breaks through the activity limitation of a non-noble metal catalyst in a low-alkalinity medium through a multi-component synergistic effect, has the advantages of low preparation cost and mild reaction, and avoids the problems of harsh reaction conditions, low yield and high toxicity of used reagents in other synthesis methods.

Disclosed herein are compositions and formulations of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile (Compound (I)), wherein Compound (I) has the structure (I) and methods of making and using such compositions and formulations.

The invention relates to a novel pure organic multiple illuminant based on aryl carbazole and a preparation method thereof. The reaction structural formula is shown in the specification. The preparation method comprises the following steps: stirring a mixture of 4-bromo-4 '-iodobiphenyl or 2, 6-dibromonaphthalene, carbazole, K2CO3, copper powder and a solvent DMF (Dimethyl Formamide) under nitrogen to react; extracting, drying, filtering and performing rotary evaporation to obtain a crude product; mixing and reacting the obtained crude product, 4-hydroxybenzonitrile, Cs2CO3, CuBr, a ligand 1-(2-pyridyl)-2-acetone and a solvent DMSO (Dimethylsulfoxide); 4-[4 '-(9H-carbazole-9-yl)-4-biphenyloxy] benzonitrile or 4-[6-(9H-carbazole-9-yl)-2-naphthyloxy] benzonitrile with the instant fluorescence-delayed fluorescence-room temperature phosphorescence triple emission characteristic is obtained through drying, filtering, rotary evaporation, separation and purification. The method has good application potential in the fields of anti-counterfeiting, information encryption, organic light-emitting diodes, biosensing imaging and the like. # imgabs0 #

The invention relates to a perovskite solar cell and a preparation method thereof, the perovskite solar cell comprises a first electrode layer, a hole transport layer, a perovskite layer, an electron transport layer and a second electrode layer which are stacked in sequence, and the hole transport layer and / or the electron transport layer contains a cyanophenyl compound. According to the perovskite solar cell, the cyanophenyl compound is adopted as a passivation material, the defects of the electron transport layer and the hole transport layer are passivated at the same time, non-radiative recombination at an interface is reduced, and finally the device performance of the perovskite solar cell is improved.

This invention relates to a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative, its preparation method, and its application. A trifluoromethyl-substituted pyrene-phenylacetonitrile derivative has the structural formula: [formula omitted]. The preparation method involves dissolving 1-pyrene formaldehyde, the corresponding trifluoromethylphenylacetonitrile, and an alkaline catalyst in an organic solvent, and carrying out a Knoevenagel condensation reaction under heating conditions. The reaction product is then post-treated to obtain the pyrene-phenylacetonitrile derivative. The application of a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative in electrical storage devices is also discussed. This invention achieves precise control of storage performance by introducing trifluoromethyl groups at different positions on the benzene ring of the pyrene-phenylacetonitrile backbone, providing a novel design approach for developing new multi-level electrical storage materials. The synthesis route is concise and has broad application prospects in the field of high-density non-volatile memory.

The invention discloses a quinolinone derivative and a preparation method thereof, and the quinolinone derivative comprises a 3-phenyl-6, 7-dimethoxy isoquinolin-1 (2H)-one derivative and a 3-phenyl-6, 7-dimethoxy quinolin-2 (1H)-one derivative which are shown in the structural general formulas of formula (I) and formula (II). Wherein 4, 5-dimethoxy-2-methyl benzaldehyde is synthesized firstly, then the 4, 5-dimethoxy-2-methyl benzaldehyde and substituted cyanophenyl are subjected to cycloaddition reaction under the action of potassium tert-butoxide and LiHMDS, and the 4, 5-dimethoxy-2-methyl benzaldehyde is obtained; the preparation method of the 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide comprises the following steps: synthesizing 2-amino-4, 5-dimethoxybenzaldehyde, carrying out acylation reaction on the 2-amino-4, 5-dimethoxybenzaldehyde and substituted phenylacetic acid under the action of HATU to obtain 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide, and carrying out cyclization reaction on the 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide under the action of K2CO3 to obtain the 2-(substituted phenyl)-N-(2-formyl-4, 5-dimethoxyphenyl) acetamide. The preparation method has the characteristics of mild reaction conditions, simplicity in operation, high efficiency, environment friendliness and the like.

The present invention provides a method for preparing 2-trifluoromethyl-4-aminobenzoic acid, belonging to the field of pharmaceutical chemical technology. The preparation method uses a mixed reagent of N,N-dimethylformamide and ethylene glycol in a set ratio as an organic solvent, uses 2-trifluoromethyl-4-amino-benzonitrile and caustic soda as raw materials, and heats the mixture to undergo an alcoholysis reaction to generate 2-trifluoromethyl-4-aminobenzoic acid. The present invention provides a mixed organic solvent of DMF-ethylene glycol, which increases the reaction rate of the alcoholysis of 2-trifluoromethyl-4-amino-benzonitrile to 2-trifluoromethyl-4-aminobenzoic acid, while allowing the intermediate state (amide) produced by the reaction to be more thoroughly converted into the target product, 2-trifluoromethyl-4-aminobenzoic acid.

The utility model provides a bagging machine for quantitative blanking of 2-hydroxy-benzonitrile, which comprises a bottom plate, a top plate is arranged above the bottom plate, a hopper is fixed on the top plate, and a support rod is fixed between the top plate and the bottom plate; a circular plate making contact with the bottom of the discharging end of the hopper is arranged below the top plate, the bottom of the circular plate communicates with a set of vertical cylinders distributed in an annular array, the discharging end of the hopper corresponds to the top of one vertical cylinder, and a motor used for driving the circular plate to rotate is arranged on the top plate; and a sealing plate in contact with the bottom end of the vertical cylinder is arranged below the circular plate. According to the quantitative packing device for the 2-hydroxy-benzonitril, the 2-hydroxy-benzonitril can be effectively and quantitatively packed, it is guaranteed that the weight of the 2-hydroxy-benzonitril in each packing bag reaches the standard, large errors of the weight of the 2-hydroxy-benzonitril in the packing bags are avoided, when the 2-hydroxy-benzonitril is quantitatively packed, it is not needed to stop discharging for a long time to transfer and replace the packing bags, and the packing efficiency is improved. And the packaging efficiency of the 2-hydroxy-benzonitril is improved.

The present invention discloses an electrolyte for a lithium-ion fast-charging battery, which comprises a solvent, a lithium salt and an additive; the additive comprises at least one of benzonitrile compounds having the structure shown in Formula I, wherein n is an integer from 0 to 3; the present invention uses fluoroethylene carbonate, an organic substance containing a fluorine element additive, as a fast-charging film-forming additive for the lithium-ion electrolyte. This additive has a lower oxidation potential and can form a dense and stable interfacial film on the surface of the positive electrode during the first charging process, optimizing the surface of the positive electrode, inhibiting the generation of HF, reducing the oxidative decomposition of substances on the electrode surface and the electrolyte, and effectively ensuring the cycle performance of the battery.

Ophthalmic compositions comprising 4 - (7-hydroxy-2-isopropyl-4-oxo - 4H - quinazolin-3-yl) - benzonitrile (Compound I) are provided.SOLUTION: The present invention provides crystalline Form E of 4 - (7-hydroxy-2-isopropyl-4-oxo - 4H - quinazolin-3-yl) - benzonitrile (Compound I). Further provided are methods of preparing crystalline Form E of Compound I comprising heating a hydrate form of Compound I to a temperature greater than 250 °C. or 260 °C. to provide Compound I as crystalline Form E. Further provided are ophthalmic compositions comprising crystalline Form E of Compound I.SELECTED DRAWING: None

The invention relates to a process for preparing 1,2′-benzisothiazoline-3-one according to formula (I), comprising the following steps: (a) reacting a 2-halogenbenzonitrile compound of general formula (II) with a reaction mixture, containing: (i) alkaline sulphide and / or alkaline hydrogen sulphide and (ii) an alkyl halide compound, represented by general formula (III): R1X (III) for producing an intermediate product of general formula (IV), and (b) reacting the intermediate product of general formula (V) obtained in step (a) with a halogenating agent or an oxidant and subsequent reaction of the 2-(alkylsulfoxy)benzonitrile with an acid to form 1,2-benzisothiazoline-3-one as well as a halide compound of general formula (V) R1X (V).

This invention provides a flexible perovskite photovoltaic module, its fabrication method, and an embedded flexible photovoltaic module anti-glare encapsulated automotive rearview mirror. It relates to the technical field of photovoltaic technology applied to automotive equipment. The conductive substrate flexible perovskite photovoltaic module includes a perovskite thin film layer containing additives; wherein 4-(2-pyridinylthio)benzonitrile is introduced as an additive into the perovskite precursor to form the perovskite thin film layer. This invention innovatively introduces novel molecular additives with multi-site coordination / strong dipole properties into the perovskite precursor solution, which can simultaneously regulate the perovskite nucleation and crystallization process, passivate bulk phase and grain boundary defects, inhibit ion migration, and significantly reduce the density of bulk phase and grain boundary defects. Ultimately, while ensuring process repeatability, it further improves the energy conversion efficiency and long-term stability of the flexible perovskite photovoltaic device.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4 H-quinazolin-3-yl)-benzonitrile.

The invention relates to a dendritic sensitizer and an electroluminescent device thereof, and belongs to the field of organic luminescent materials. The technical problem that the efficiency and the color purity of an existing organic light-emitting device are difficult to synergistically improve is solved. According to the invention, a dendritic compound with a broadband system and a high reverse intersystem crossing rate is used as a sensitizer, a dendritic donor unit is used as a branch, a cyanophenyl unit is used as an acceptor central core, a relatively small single triplet state energy level difference is achieved, a thermal activation delayed fluorescence effect can be generated, triplet state excitons can cross to a singlet state in a reverse intersystem manner, and the quantum efficiency is improved. And then energy is transferred to a luminescent dye with a narrow band characteristic through # imgabs0 # energy transfer, so that the organic electroluminescent device based on the dendritic sensitizer provided by the invention can realize synergistic improvement of external quantum efficiency and color purity.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a cyclobenzaprine intermediate 5H-dibenzo [a, d] cycloheptatriene-5-ketone. The preparation method comprises the following steps: preparing a magnesium Grignard reagent by taking 2-(2-chlorine or bromostyrene) benzonitrile as an initial raw material, and performing intramolecular cyclization and acidification to obtain a target compound I; the whole process is moderate in reaction temperature and mild in condition, use of expensive catalysts and special production equipment is avoided, and the production cost can be effectively reduced; meanwhile, the use of carbon tetrachloride and bromine with higher toxicity is avoided, the operation is safe, and the method is more suitable for industrial application.

The present invention relates to crystalline forms of MRTX0902 ((R)-2-methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile), pharmaceutical compositions comprising the crystalline forms, processes for preparing the crystalline forms and methods of use thereof.

The invention discloses an electrolyte, a lithium ion battery and electric equipment, the electrolyte comprises a lithium salt, a solvent and a functional additive, the functional additive comprises at least one of a first additive, a second additive and a third additive, the first additive comprises vinylene carbonate, methylene methanedisulfonate, divinyl sulfone and 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, and the third additive comprises at least one of vinylene carbonate, methylene methanedisulfonate, divinyl sulfone and 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate. The first additive comprises at least one of 1, 3-propane sultone, the second additive comprises at least one of 4-(trifluoromethylsulfonyl) benzonitrile and ethylene sulfate, and the third additive comprises at least one of succinic anhydride, adiponitrile and 4-(trifluoromethylsulfonyl) benzonitrile. According to the characteristics and main problems of the lithium manganese iron phosphate battery, corresponding functional additives are respectively matched, so that stable electrolyte interface films are formed on the surfaces of the positive electrode and the negative electrode, dissolution of transition metal manganese ions of the positive electrode and deposition of the negative electrode are inhibited, and gas production of the battery under a high-temperature condition is reduced.

The application provides an alpha-carboxyl-beta-diimine nickel complex and a preparation method and application thereof and a preparation method of ethylene-methyl acrylate copolymer. The alpha-carboxyl-beta-diimine nickel complex has a structure shown in general formula (I): in the general formula (I), Ar is selected from 2,6-dialkylphenyl; X is chlorine or bromine; and L is acetonitrile or benzonitrile. The preparation method of the alpha-carboxyl-beta-diimine nickel complex is that acetylacetone is reacted with 2,6-dialkylaniline, then reacted with ammonium formate under the action of alkyl lithium, and then reacted with a halogenated nickel salt in an acetonitrile or benzonitrile solvent to obtain the alpha-carboxyl-beta-diimine nickel complex. The application further provides a preparation method of ethylene-methyl acrylate copolymer, which uses the alpha-carboxyl-beta-diimine nickel complex as a main catalyst. The application improves the copolymer molecular weight and the methyl acrylate insertion rate, and makes the prepared EMA similar to the branched structure of a commercial product prepared by a free radical process.

The present invention discloses an amination reaction device for the synthesis of benzonitrile products, which relates to the field of benzonitrile product production. The device includes a reaction kettle, a bracket and a motor. A bracket is fixed at the upper end of the reaction kettle, and a motor is fixed on the bracket. A driving gear and a stirring mechanism are fixed on the output shaft of the motor. The stirring mechanism includes a cylinder, which is fixed on the output shaft of the motor. The output end of the cylinder is fixed with a driving rubber wheel, and a movable block is connected to the lower end of the driving rubber wheel through a bearing. The amination reaction device for the synthesis of benzonitrile products adopts a stirring mechanism with automatic speed regulation, which can not only adjust the stirring speed of the materials according to the actual mixing requirements of different products, improve the adaptability of the device, but also reduce the stirring speed when the temperature in the reaction kettle is too high or the pressure is too large during the amination reaction of the same product, so as to reduce the reaction rate of the raw materials and ensure the normal operation of the device.