131 results about "Benzonitrile" patented technology

Compounds of formula (II) and formula (I) which are inhibitors of QPCTL and QPCT: (II) and (I) are provided herein. Also provided are pharmaceutical compositions containing this compound, as well as compounds for use in methods of treating cancer, neurodegenerative, inflammatory or autoimmune diseases. Exemplary compounds are, for example, 3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]benzonitrile (Example 1): (1), and pharmacological data are provided. TIFF2025524039000368.tif70128

The invention discloses a topological chemical polymerization method based on discotic liquid crystals, and relates to the technical field of liquid crystal polymers. The method comprises the following steps: dissolving 3, 4, 5-tri (hexyloxy) phenylacetonitrile and 1, 3, 5-benzenetricarboxaldehyde in ethanol, adding tetrabutyl ammonium hydroxide, and reacting at 50-60 DEG C for 1-3 hours to obtain a discotic liquid crystal monomer; placing the discotic liquid crystal monomer on a substrate, heating the discotic liquid crystal monomer until the temperature is greater than or equal to 200 DEG C to enable the discotic liquid crystal monomer to be in a molten state, then pressing the discotic liquid crystal monomer to form a thin film, then cooling the discotic liquid crystal monomer to 70-80 DEG C, and then irradiating the thin film sample for 12-48 hours by using ultraviolet light to obtain the one-dimensional polymer material based on the topological chemical polymerization of the discotic liquid crystal. According to the method, the application range of topological chemical polymerization is widened, more adjustability is given to the topological chemical polymerization process, and new possibility is provided for the field of topological chemistry.

The invention discloses a preparation method and application of a catalyst for generating benzonitrile through electrocatalytic oxidation of benzylamine, and belongs to the technical field of nanotechnology and electrocatalytic oxidation. The NiO-NiMoO4 / NF multi-component composite catalyst of a nanorod structure is used as an electrode, NiO and NiMoO4 form a heterogeneous interface synergistic system, rich active sites are achieved, and the catalyst shows remarkable advantages in benzylamine electrocatalytic oxidation. Under the working voltage of 1.55 V vs.RHE, 99% of benzylamine conversion rate and 94% of Faraday efficiency are achieved, the stability is good, and the catalytic effect is not attenuated after multiple times of recycling. The method breaks through the activity limitation of a non-noble metal catalyst in a low-alkalinity medium through a multi-component synergistic effect, has the advantages of low preparation cost and mild reaction, and avoids the problems of harsh reaction conditions, low yield and high toxicity of used reagents in other synthesis methods.

Disclosed herein are compositions and formulations of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile (Compound (I)), wherein Compound (I) has the structure (I) and methods of making and using such compositions and formulations.

The invention relates to a perovskite solar cell and a preparation method thereof, the perovskite solar cell comprises a first electrode layer, a hole transport layer, a perovskite layer, an electron transport layer and a second electrode layer which are stacked in sequence, and the hole transport layer and / or the electron transport layer contains a cyanophenyl compound. According to the perovskite solar cell, the cyanophenyl compound is adopted as a passivation material, the defects of the electron transport layer and the hole transport layer are passivated at the same time, non-radiative recombination at an interface is reduced, and finally the device performance of the perovskite solar cell is improved.

This invention relates to a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative, its preparation method, and its application. A trifluoromethyl-substituted pyrene-phenylacetonitrile derivative has the structural formula: [formula omitted]. The preparation method involves dissolving 1-pyrene formaldehyde, the corresponding trifluoromethylphenylacetonitrile, and an alkaline catalyst in an organic solvent, and carrying out a Knoevenagel condensation reaction under heating conditions. The reaction product is then post-treated to obtain the pyrene-phenylacetonitrile derivative. The application of a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative in electrical storage devices is also discussed. This invention achieves precise control of storage performance by introducing trifluoromethyl groups at different positions on the benzene ring of the pyrene-phenylacetonitrile backbone, providing a novel design approach for developing new multi-level electrical storage materials. The synthesis route is concise and has broad application prospects in the field of high-density non-volatile memory.

The present invention provides a method for preparing 2-trifluoromethyl-4-aminobenzoic acid, belonging to the field of pharmaceutical chemical technology. The preparation method uses a mixed reagent of N,N-dimethylformamide and ethylene glycol in a set ratio as an organic solvent, uses 2-trifluoromethyl-4-amino-benzonitrile and caustic soda as raw materials, and heats the mixture to undergo an alcoholysis reaction to generate 2-trifluoromethyl-4-aminobenzoic acid. The present invention provides a mixed organic solvent of DMF-ethylene glycol, which increases the reaction rate of the alcoholysis of 2-trifluoromethyl-4-amino-benzonitrile to 2-trifluoromethyl-4-aminobenzoic acid, while allowing the intermediate state (amide) produced by the reaction to be more thoroughly converted into the target product, 2-trifluoromethyl-4-aminobenzoic acid.

The utility model provides a bagging machine for quantitative blanking of 2-hydroxy-benzonitrile, which comprises a bottom plate, a top plate is arranged above the bottom plate, a hopper is fixed on the top plate, and a support rod is fixed between the top plate and the bottom plate; a circular plate making contact with the bottom of the discharging end of the hopper is arranged below the top plate, the bottom of the circular plate communicates with a set of vertical cylinders distributed in an annular array, the discharging end of the hopper corresponds to the top of one vertical cylinder, and a motor used for driving the circular plate to rotate is arranged on the top plate; and a sealing plate in contact with the bottom end of the vertical cylinder is arranged below the circular plate. According to the quantitative packing device for the 2-hydroxy-benzonitril, the 2-hydroxy-benzonitril can be effectively and quantitatively packed, it is guaranteed that the weight of the 2-hydroxy-benzonitril in each packing bag reaches the standard, large errors of the weight of the 2-hydroxy-benzonitril in the packing bags are avoided, when the 2-hydroxy-benzonitril is quantitatively packed, it is not needed to stop discharging for a long time to transfer and replace the packing bags, and the packing efficiency is improved. And the packaging efficiency of the 2-hydroxy-benzonitril is improved.

Ophthalmic compositions comprising 4 - (7-hydroxy-2-isopropyl-4-oxo - 4H - quinazolin-3-yl) - benzonitrile (Compound I) are provided.SOLUTION: The present invention provides crystalline Form E of 4 - (7-hydroxy-2-isopropyl-4-oxo - 4H - quinazolin-3-yl) - benzonitrile (Compound I). Further provided are methods of preparing crystalline Form E of Compound I comprising heating a hydrate form of Compound I to a temperature greater than 250 °C. or 260 °C. to provide Compound I as crystalline Form E. Further provided are ophthalmic compositions comprising crystalline Form E of Compound I.SELECTED DRAWING: None

The invention relates to a process for preparing 1,2′-benzisothiazoline-3-one according to formula (I), comprising the following steps: (a) reacting a 2-halogenbenzonitrile compound of general formula (II) with a reaction mixture, containing: (i) alkaline sulphide and / or alkaline hydrogen sulphide and (ii) an alkyl halide compound, represented by general formula (III): R1X (III) for producing an intermediate product of general formula (IV), and (b) reacting the intermediate product of general formula (V) obtained in step (a) with a halogenating agent or an oxidant and subsequent reaction of the 2-(alkylsulfoxy)benzonitrile with an acid to form 1,2-benzisothiazoline-3-one as well as a halide compound of general formula (V) R1X (V).

This invention provides a flexible perovskite photovoltaic module, its fabrication method, and an embedded flexible photovoltaic module anti-glare encapsulated automotive rearview mirror. It relates to the technical field of photovoltaic technology applied to automotive equipment. The conductive substrate flexible perovskite photovoltaic module includes a perovskite thin film layer containing additives; wherein 4-(2-pyridinylthio)benzonitrile is introduced as an additive into the perovskite precursor to form the perovskite thin film layer. This invention innovatively introduces novel molecular additives with multi-site coordination / strong dipole properties into the perovskite precursor solution, which can simultaneously regulate the perovskite nucleation and crystallization process, passivate bulk phase and grain boundary defects, inhibit ion migration, and significantly reduce the density of bulk phase and grain boundary defects. Ultimately, while ensuring process repeatability, it further improves the energy conversion efficiency and long-term stability of the flexible perovskite photovoltaic device.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4 H-quinazolin-3-yl)-benzonitrile.

The invention relates to a dendritic sensitizer and an electroluminescent device thereof, and belongs to the field of organic luminescent materials. The technical problem that the efficiency and the color purity of an existing organic light-emitting device are difficult to synergistically improve is solved. According to the invention, a dendritic compound with a broadband system and a high reverse intersystem crossing rate is used as a sensitizer, a dendritic donor unit is used as a branch, a cyanophenyl unit is used as an acceptor central core, a relatively small single triplet state energy level difference is achieved, a thermal activation delayed fluorescence effect can be generated, triplet state excitons can cross to a singlet state in a reverse intersystem manner, and the quantum efficiency is improved. And then energy is transferred to a luminescent dye with a narrow band characteristic through # imgabs0 # energy transfer, so that the organic electroluminescent device based on the dendritic sensitizer provided by the invention can realize synergistic improvement of external quantum efficiency and color purity.

The invention discloses an electrolyte, a lithium ion battery and electric equipment, the electrolyte comprises a lithium salt, a solvent and a functional additive, the functional additive comprises at least one of a first additive, a second additive and a third additive, the first additive comprises vinylene carbonate, methylene methanedisulfonate, divinyl sulfone and 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, and the third additive comprises at least one of vinylene carbonate, methylene methanedisulfonate, divinyl sulfone and 1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate. The first additive comprises at least one of 1, 3-propane sultone, the second additive comprises at least one of 4-(trifluoromethylsulfonyl) benzonitrile and ethylene sulfate, and the third additive comprises at least one of succinic anhydride, adiponitrile and 4-(trifluoromethylsulfonyl) benzonitrile. According to the characteristics and main problems of the lithium manganese iron phosphate battery, corresponding functional additives are respectively matched, so that stable electrolyte interface films are formed on the surfaces of the positive electrode and the negative electrode, dissolution of transition metal manganese ions of the positive electrode and deposition of the negative electrode are inhibited, and gas production of the battery under a high-temperature condition is reduced.

The application provides an alpha-carboxyl-beta-diimine nickel complex and a preparation method and application thereof and a preparation method of ethylene-methyl acrylate copolymer. The alpha-carboxyl-beta-diimine nickel complex has a structure shown in general formula (I): in the general formula (I), Ar is selected from 2,6-dialkylphenyl; X is chlorine or bromine; and L is acetonitrile or benzonitrile. The preparation method of the alpha-carboxyl-beta-diimine nickel complex is that acetylacetone is reacted with 2,6-dialkylaniline, then reacted with ammonium formate under the action of alkyl lithium, and then reacted with a halogenated nickel salt in an acetonitrile or benzonitrile solvent to obtain the alpha-carboxyl-beta-diimine nickel complex. The application further provides a preparation method of ethylene-methyl acrylate copolymer, which uses the alpha-carboxyl-beta-diimine nickel complex as a main catalyst. The application improves the copolymer molecular weight and the methyl acrylate insertion rate, and makes the prepared EMA similar to the branched structure of a commercial product prepared by a free radical process.

The present invention discloses an amination reaction device for the synthesis of benzonitrile products, which relates to the field of benzonitrile product production. The device includes a reaction kettle, a bracket and a motor. A bracket is fixed at the upper end of the reaction kettle, and a motor is fixed on the bracket. A driving gear and a stirring mechanism are fixed on the output shaft of the motor. The stirring mechanism includes a cylinder, which is fixed on the output shaft of the motor. The output end of the cylinder is fixed with a driving rubber wheel, and a movable block is connected to the lower end of the driving rubber wheel through a bearing. The amination reaction device for the synthesis of benzonitrile products adopts a stirring mechanism with automatic speed regulation, which can not only adjust the stirring speed of the materials according to the actual mixing requirements of different products, improve the adaptability of the device, but also reduce the stirring speed when the temperature in the reaction kettle is too high or the pressure is too large during the amination reaction of the same product, so as to reduce the reaction rate of the raw materials and ensure the normal operation of the device.

Disclosed in the present invention is a preparation method for 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile, comprising the following steps: in an organic solvent, under an alkaline condition, enabling compound II and compound III to be subjected to a substitution reaction as shown in the following, wherein R is hydrogen, sulfonyl or p-toluenesulfonyl, and X is F, Cl, or Br. The preparation method of the present invention avoids the use of noble metal as a catalyst, involves low costs, simple operation and high product yield, and is suitable for industrial production.

Disclosed are crystalline salt forms of the compound 4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromeno[7,8-d]imidazol-8-yl)benzonitrile, also known as CF3CN, wherein the desired salt has a sodium, calc

The present application provides a kind of preparation of doravirine intermediate 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy]benzonitrile synthesis method, the method includes from formula D compound and 3-chloro-5-hydroxybenzonitrile in the presence of base, catalyst coupling to obtain formula E compound, formula E compound is cyclized to obtain 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy]benzonitrile in the presence of acid.The method uses cheap starting material, avoids the use of noble metal catalyst and expensive material fragment, process operation and post-processing are simple, suitable for industrial scale production.

The invention relates to the field of organic chemistry, in particular to a method for obtaining 2-phenoxy-1-phenylethan-1-one. The essence of the invention is that the method for obtaining 2-phenoxy-1-phenylethan-1-one according to the invention is characterized in that the interaction of benzonitrile and chloromethoxybenzene is carried out in the presence of the catalyst H3PM012040 for 2 hours.

The present invention relates to a high-toughness shape memory eutectic gel and a preparation method thereof, belonging to the technical field of gel materials. The shape memory eutectic gel is obtained by photoinitiated polymerization of a first polymerized monomer and a second polymerized monomer; the molar ratio of the first polymerized monomer to the second polymerized monomer is 1 to 4:1; the first polymerized monomer is prepared by reacting 4-(2-aminoethyl)benzonitrile hydrochloride and acryloyl chloride; and the second polymerized monomer is 1-methyl-3-(4-vinylbenzyl)imidazolium chloride. The eutectic gel provided by the present invention has excellent mechanical strength and shape memory function, and the mechanical strength and electrical conductivity are adjustable to meet different usage requirements.

The application discloses a method for preparing benzonitrile compounds from toluene compounds, and comprises the following steps: adding ammonium salt as a nitrogen source into an organic solvent with Ru / BiOCl as a catalyst, and then passing oxygen into the organic solvent to perform a photochemical reaction, so that the toluene compounds are directly oxidized to generate the benzonitrile compounds. In the application, no cyanide is used as a cyano source, but toluene compounds are used as raw materials, ammonium salt is used as a nitrogen source, and Ru / BiOCl is used as a catalyst, so that a C-H bond is directly converted into a cyano group through a photocatalytic reaction, and the benzonitrile compounds are obtained. The reaction condition is mild and green and environment-friendly.

The present invention relates to crystalline forms of fumarate of MRTX0902 ((R)-2-methyl-3-(1-((4-methyl-7-morpholinopyridino [3, 4-d] pyridazin-1-yl) amino) ethyl) benzonitrile), pharmaceutical compositions comprising the crystalline forms, methods of making the crystalline forms, and methods of use thereof.

The present invention discloses a thermally activated delayed fluorescent material based on pillar[5]arene derivatives, a preparation method thereof, and an OLED application. The structural formula of the material is #imgabs0#, wherein: R is a host unit, which is 9-hexyl-9-hydro-carbazole, 9'-hexyl-9'-hydro-9,3':6',9''-tricarbazole, 9-(4-(hexyloxy)phenyl)-hexyloxy-9-hydro-carbazole or 9,9'-(5-(hexyloxy)-1,3-phenylene)bis(9-hydro-carbazole); R1 is a guest luminescent unit, which is 2,3,5,6-tetra(3,6-di-tert-butyl-9-hydro-carbazolyl-9-yl)-4-(4-(hexyloxy)phenoxy)benzonitrile. The material has a high relative molecular mass and solubility of non-conjugated alkyl chains, ensuring that the molecule has good film-forming properties, and solves the problem that traditional host-guest material doped wet process devices are prone to phase separation.

The invention discloses a strongly-bundled high-insulation glass fiber cloth and a preparation method thereof, and relates to the technical field of glass fiber cloth preparation, the glass fiber cloth is obtained by dipping a fiber cloth obtained by crushing, melting, drawing, yarn preparation, sizing and weaving of a glass raw material in a surface treating agent, after the yarn is subjected to sizing treatment, the strong bundling property meets the requirement, and the surface treating agent is obtained by mixing waterborne polyurethane emulsion prepared from functional diisocyanate and the like with a reinforcing agent and the like. The functional diisocyanate is obtained by carrying out a reaction on 1, 3-dihydroxyethyl adamantane, 3-amino-5-nitrobenzoic acid methyl ester, 4-amino-3-methyl benzonitrile, oleanolic acid and the like; the reinforcing agent is obtained by loading a product e containing aza-adamantane, phosphamide, cyano, hydroxyl and castor oil-based alkane long chains on halloysite nanotubes. The glass fiber cloth disclosed by the invention has relatively high insulativity, mechanical strength, high temperature resistance and flame retardance.

The application discloses a transition metal-based catalyst, a preparation method and application in plastic resource recycling, and belongs to the technical field of heterogeneous catalytic plastic chemical upgrading and recycling. The transition metal-based catalyst is synthesized through a gel sol-two-step calcination strategy, has a multi-level mesoporous structure, rich oxygen vacancies and both Bronsted acid and Lewis acid sites, and has excellent photo-thermal response performance and catalytic oxidation activity. The application uses water as a solvent, and through photo-thermal co-catalysis or photo-thermal synergistic catalysis, efficiently and directionally converts polystyrene into high-value-added chemicals such as benzoic acid, benzonitrile and benzamide, and the highest yield of benzoic acid reaches 71.34%, and the transition metal-based catalyst can be reused for at least 5 times. The technology breaks through the bottleneck of traditional plastic recycling, that is, dependence on organic solvents, harsh reaction conditions and low conversion efficiency, and provides a scalable and feasible path for green upgrading and recycling of polystyrene.

The application belongs to the technical field of organic synthesis, and relates to an aryl-substituted halogenated s-triazine compound and a preparation method thereof. The aryl-substituted halogenated s-triazine compound is shown as formula (I). The preparation method of the compound is as follows: a benzonitrile derivative, ethylene glycol methyl ether, dicyandiamide and potassium hydroxide are mixed and heated, and compound 1 is obtained through reaction; compound 1 and acetonitrile are mixed, and a sulfuric acid solution, sodium nitrate and a cuprous chloride solution are added dropwise in sequence, and then reaction is carried out after dropwise addition is completed; and a target product is obtained. The synthesis method has the advantages of less impurity generation, high conversion rate and high product quality.

The application relates to a high-color-purity near-ultraviolet hot exciton compound with circular polarization properties and application in preparation of circular polarization organic electroluminescent devices, and belongs to the technical field of organic photoelectric materials. The electroluminescent material is a high-color-purity near-ultraviolet hot exciton compound with circular polarization properties. Two pairs of near-ultraviolet enantiomers are successfully designed and synthesized by combining a chiral group binaphthol, a weak donor dithiophene and a weak donor dibenzofuran, and an acceptor benzonitrile. The two pairs of near-ultraviolet enantiomers all show obvious circular polarization luminescence properties and high fluorescence quantum yields. Electroluminescent devices prepared based on the enantiomers all show near-ultraviolet emission, and the CIE coordinates are (0.168, 0.040) and (0.166, 0.040) respectively, and the external quantum efficiencies are 4.3% and 3.4% respectively. The application provides a new perspective for developing near-ultraviolet hot exciton materials with circular polarization luminescence and high color purity, and is favorable for directly realizing 3D and wide color gamut display in the future.

This invention relates to the field of organic synthesis technology, specifically a method for synthesizing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and its application, comprising the following steps: S1. Compound 1a is added to a first organic solvent under inert gas protection and reacted with vinyl isobutyl ether under the conditions of a catalyst and potassium carbonate to obtain a system containing compound 2a; S2. The pH of the system containing compound 2a obtained in step S1 is adjusted to 2-3, and after reaction, compound 1 is obtained through post-treatment; S3. Compound 1 is added to a second organic solvent, and ethyl formate and sodium ethoxide are added to react and obtain a system containing compound 4a; S4. Acetic acid is added to the system containing compound 4a obtained in step S3 for neutralization, and under inert gas protection, hydrazine hydrate is added dropwise to react and the product is obtained through post-treatment. The synthesis method provided by this invention uses readily available raw materials, has a simple processing procedure, does not require column chromatography, simplifies the operation, and facilitates industrial-scale production.

The present invention relates to a compound for use in the treatment of schizophrenia, also known as CF3CN and referred to herein as the compound of formula I, 4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromeno[7,8-d]imidazole-8-yl)benzonitrile. Preferably, the treatment of schizophrenia is the treatment of one or more symptom categories of schizophrenia. More preferably, the treatment is for the negative symptoms of schizophrenia. Alternatively, the treatment is for the cognitive symptoms of schizophrenia.