577 results about "Benzonitrile" patented technology

Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.

The invention discloses a method for synthesizing 4-(3-chloro-4-fluorophenylamino)-7-methoxy -6-[3-(4-morpholinyl)-propoxy] quinoline. The method comprises the following steps: 1) 3-hydroxide radical-4-methoxybenzaldehyde is used as a raw material to prepare 3-hydroxide radical-4-methoxy-benzonitrile; 2) the 3-hydroxide radical-4-methoxy-benzonitrile and 3- chloropropy morpholinehydrochloride are heated to have reflux reaction to obtain 4- methoxy-3-[3-(4- morpholinyl) propoxy] benzonitrile; 3) the 4- methoxy-3-[3-(4-morpholinyl) propoxy] benzonitrile is subjected to nitration to obtain 2- nitryl-4- methoxy -5-[3-(4-morpholinyl) propoxy] benzonitrile; 4) the 2- nitryl-4- methoxy -5-[3-(4-morpholinyl) propoxy] benzonitrile is subjected to reduction to obtain 2-amido-4- methoxy-5-[3-(4-morpholinyl) propoxy] benzonitrile; and 5) the 2-amido-4- methoxy-5-[3-(4-morpholinyl) propoxy] benzonitrile and an azomethine intermediate of 3-chloro-4-fluoroaniline have rearrangement reaction to obtain 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)-propoxy] quinoline. The method has characteristics of environmental protection and high production rate.

The invention relates to an industrial production method for semi-crystal poly(aromatic ether nitrile), which belongs to the field of polymer material. The method comprises the following steps: 2, 6-dichloro benzonitrile and hydroquinone are taken as raw materials; anhydrous potassium carbonate is taken as a catalyst; in the presence of a solvent and a dehydrating agent, the raw materials and the catalyst react under atmospheric pressure to obtain the poly(aromatic ether nitrile) homopolymer with low molecular weight and regular chain segments; and then the molecular weight of polymer is increased through pressurization, so as to obtain the semi-crystal poly(aromatic ether nitrile) polymer with high molecular weight. Due to the increase of crystallinity and molecular weight, the mechanical properties and heat resistance of the semi-crystal poly(aromatic ether nitrile) polymer are obviously improved.

The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

The invention discloses a side group sulfonic acid polyarylether material, a method for preparing the same and application thereof, which belong to the technical field of functional polymer materials. In particular, the method comprises the following steps: performing polycondensation reaction of 2, 5-diphenyl-hydroquinone and dual-halogen monomers such as 4, 4'-difluoro-benzophenone, 4, 4'-difluoro-diphenylsulfone, 2, 6-difluoro-benzonitrile and the like as well as other diphenol monomers, and then preparing a series of side group sulfonic acid polyarylether proton exchange membranes with controllable sulfonation point and sulfonation degree by a moderate post-sulfonation method. The proton exchange membranes prepared by the method have the advantages of high thermal stability, good solubility and film-forming property, excellent hot water dimensional stability, low methanol permeability and high proton conductivity. The membrane materials used by the method have the advantages of simple preparation process, mild and controllable reaction, wide application temperature and excellent performance, thus the membrane materials can be applied to proton exchange membrane fuel cells and direct methanol fuel cells.

The invention relates to compounds of the formula (I), wherein R1, R2, X and Y have the meaning specified in claim 1, are inhibitors of TBK1 and IotaKappaKappaepsilon, and can be used, inter alia, for the treatment of cancer and inflammatory diseases.

The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia.

The invention discloses a defect type covalent triazine framework material derivative material catalyst and a preparation method and application thereof. A preparation process of the catalyst comprises the following steps: dissolving a benzonitrile compound and a pyridine derivative in a first organic solvent; adding strong acid, carrying out heating and refluxing reaction under the condition of oil bath; cooling to the room temperature after the reaction is finished, and pouring a cooled reaction solution into ultrapure water; adjusting the pH to be neutral by adding alkali, and carrying outsuction filtration; washing filter residues, and then drying the filter residues to obtain defect type covalent triazine framework carrier powder; placing the obtained powder, a cyano derivative and ruthenium metal salt into a mortar; adding absolute ethyl alcohol, and uniformly grinding until the absolute ethyl alcohol is completely volatilized; drying, and then carrying out high temperature calcination under protection of inert gas; and washing and drying the calcined product with ultrapure water to obtain the defect type covalent triazine framework material derivative material catalyst. Thecatalyst has a high specific surface area and a porous structure, supported ruthenium metal particles are small, the metal ion dispersity is high, and a catalytic hydrogen evolution reaction effect is good.

The invention provides a process method for producing high-purity chlorothalonil. The process method has the characteristics of comprising the steps of: sending raw materials containing chlorothalonilm-phthalodinitrile, trichloro-m-phthalodinitrile, pentachloro benzonitrile, hexachloro benzene and water to a light-component removing tower, collecting a mixture of the chlorothalonil containing light components with a mass fraction of <= 0.01% with heavy components from the tower bottom of the light-component removing tower, sending the mixture to a product tower, and collecting the chlorothalonil product with a mass fraction of >= 99.5% from the tower top of the product tower. According to the process method for producing the high-purity chlorothalonil, a rectification process method is adopted to refine the chlorothalonil, the operation process is simple, and the chlorothalonil product with a mass fraction of 99.5% or above can be obtained.

A regiospecific process for the preparation of 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile comprising reacting 4-halomethylbenzonitrile with 4-amino-1,2,4-triazole followed by deamination and reaction with 4-fluorobenzonitrile.

The present invention belongs to chemistry technology field, in particular to a method to synthesize lactone compound with cyclone oxide which is an environmental friendly catalyst. The present invention adopts a composite metal oxide MgO/SnO2compound as the catalyst, adopts hydrogen peroxide as the oxidant, and Benzonitrile together with 1,4-bensodioxanes as the solvents, then the cyclone oxide is catalyzed to synthesize the lactone compound in a specific reaction temperature. The present invention uses ketone adamantine, cyclohexanone, and cyclopentanone available in the market, and the yield can be as high as 90 percent in the mild condition. Meanwhile, because of the hydrogen peroxide adopted ad the oxidant, the oxidation methods in prior art is avoided such as peracid, all of which cause environmental problem, and the aim of environmental friendly catalyzing/conversion is accomplished. The present invention is low in price, but has suitability for industrialized production of lactone compound.

Pharmaceutical compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.

The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01% (w/w) of Z-4-(4-dimethylamino-1-(4-fluorophenyl)-but-1-enyl)-3-hydroxymethyl-benzonitrile, said particles being suitable for use in direct compression. Furthermore, the invention discloses a novel pharmaceutical unit dosage form containing such crystalline particles of escitalopram oxalate as well as methods for manufacture of such crystalline particles of escitalopram oxalate Finally, the invention provides a method for reduction of the amount of hydroxyl containing impurities in a solution of citalopram or escitalopram.

Cyanoacrylate-containing compositions that include, in addition to the cyanoacrylate component, a hydrogenated anhydride and optionally a benzonitrile, are provided. Cured products of the inventive cyanoacrylate compositions demonstrate improved heat resistance without compromising fixture time, stability or color.

The invention provides a preparation method of 2,4,6-trifluorobenzylamine. The preparation method comprises the following steps: S1, by taking pentachloro benzonitrile as a starting material, adding the pentachloro benzonitrile into anhydrous potassium fluoride for fluorination reaction in a first organic solvent, thus obtaining 3,5-dichloro-2,4,6-trifluoro-cyanophenyl; S2a, adding the 3,5-dichloro-2,4,6-trifluoro-cyanophenyl prepared in the step S1 into a second organic solvent, adding organic alkali, feeding hydrogen, and carrying out dehydrochlorination reaction under the action of a firstcatalyst, thus obtaining 2,4,6-trifluoro-cyanophenyl serving as an intermediate; S3, adding the 2,4,6-trifluoro-cyanophenyl prepared in the step S2a into a third organic solvent, adding acid, feedinghydrogen, and reducing the 2,4,6-trifluoro-cyanophenyl serving as the intermediate through a cyanogroup under the action of a second catalyst, thus obtaining 2,4,6-trifluorobenzylamine. By the adoption of the technical scheme, the preparation method has the advantages that steps of a synthesis route are simple and short, conditions are mild, operation is simple and convenient, the raw materials are low in cost and readily available, and the production cost is low; the catalysts and solvents can be recycled for use, so that pollution is reduced; the preparation method is environmentally friendly and suitable for industrial large-scale production.