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80 results about "Divinyl sulfone" patented technology
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Method for production of antibodies to specific sites of rapamycin
InactiveUS6709873B1Immunoglobulins against fungi/algae/lichensBiological testingPolyclonal antibodiesDivinyl sulfone
Owner:ISODIAGNOSTIKA
Mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and preparation method of mixed gel
The invention relates to a mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and a preparation method of the mixed gel. The polylactic acid microspheres have the molecular weight of 15000-120000 and the average particle size of 10-150mu m, and the mass fraction of the polylactic acid microspheres in the mixed gel is 5-25%; a salt solution of the cross-linked hyaluronic acid gel is obtained by swelling and balancing the cross-linked hyaluronic acid gel in a sodium chloride solution or a phosphate buffer solution with the osmotic pressure of 250-350mOsmol / L and the pH value of 6.5-7.5; the cross-linked hyaluronic acid gel is a hyaluronic acid gel cross-linked by divinyl sulfone or glycidyl ether. A mixed gel product of polylactic acid and cross-linked hyaluronic acid, obtained by directly mixing the polylactic acid microspheres with the cross-linked hyaluronic acid gel obtained by swelling and balancing in the salt solution is uniform, fine, long in partial retention time, good in plasticity and few in side effects, has an obvious effect on eliminating wrinkles, and has few operation steps and stable product quality.
Owner:河北善远科技有限公司
Polymeric materials, their preparation and use
ActiveUS20070036745A1Improve mechanical propertiesImprove cohesionPharmaceutical delivery mechanismPharmaceutical non-active ingredientsCross-linkHardness
Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and / or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and / or implantable devices and as drug delivery systems.
Owner:GENZYME CORP
Polymeric materials, their preparation and use
ActiveUS8524213B2Enhancing mechanical property and cohesion and elasticityPharmaceutical delivery mechanismPharmaceutical non-active ingredientsCross-linkBackbone chain
Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and / or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and / or implantable devices and as drug delivery systems.
Owner:GENZYME CORP
Injection amphiphilic-microsphere-containing hyaluronic acid mixed gel and preparation method thereof
The invention relates to injection amphiphilic-microsphere-containing hyaluronic acid mixed gel and a preparation method thereof. The microsphere material relates to amphiphilic materials of PLLA-PEG, PLGA, PLGA-PEG and the like. The molecular weight of PLLA or PLGA is 10,000-500,000, the molecular weight of PEG is 1,000-10,000, and in PLGA, LA / GA=90 / 10-10 / 90. The average grain diameter of the microsphere is 1-200 [mu[m, and the mass percent of the microsphere in the gel is 1-50%; the gel is made from hyaluronic acid, divinyl sulphone crosslinked hyaluronic acid, or glycidyl ether crosslinked hyaluronic acid, the molecular weight of the hyaluronic acid is 100,000-3,000,000, and the mass percent of the hyaluronic acid is 1-50%. The gel can be also made from animal-derived collagen, chitosan, amino acid cellulose and sodium alginate. The microsphere mixed gel is prepared in a sodium chloride solution or a phosphate buffered solution with the osmotic pressure of 250-350 mOsm / L and pH of 6.5-7.5. According to the invention, the amphiphilic microsphere is directly mixed with hyaluronic acid gel, can be uniformly distributed in the gel easily, and is unlikely to aggregate into blocks in the water environment of a human body after being injected.
Owner:IMEIK TECH DEV CO LTD
Expanded bed adsorption medium with sulfhydryl ethylpyridine and sulfone group as ligand separation antibody and preparation method
InactiveCN101284224AHigh selectivityAchieve selective adsorptionOther chemical processesPeptide preparation methodsCelluloseMicrosphere
The invention discloses an expanded bed adsorption medium for separating antibodies by taking mercapto ehtylpyridine and sulfonyl groups as petunidins, and a preparation method. In the composition of the medium, interstitial substance is cellulose / inorganic weighting-agent composite microspheres, and the petunidins are sulfonyl groups or mercapto ehtylpyridine. The cellulose / inorganic weighting-agent composite microspheres which are used as the interstitial substance are obtained by adopting an opposite-phase suspension thermal-reproduction method; dried activation interstitial substance, the mercapto ehtylpyridine and sodium hydroxide containing ammonium persulfate are mixed for coupling to obtain the expanded bed adsorption medium for separating the antibodies by taking the mercapto ehtylpyridine and the sulfonyl groups as the petunidins. The novel expanded bed adsorption medium developed in the invention enhances the selectivity of mercapto ehtylpyridine petunidin to the antibodies through bring in the sulfonyl groups, has good adsorption separation selectivity to the antibodies, and can be used for the large-scale preparation of the antibodies.
Owner:ZHEJIANG UNIV
Electrolyte for lithium ion battery to control swelling
InactiveUS20050233207A1Improve intrinsic propertyReduce swellingSolid electrolyte cellsLi-accumulatorsElectrolysisCompound (substance)
Disclosed is an electrolyte for a lithium-ion secondary battery comprising an additive to prevent swelling of the battery caused by a gas generated in the battery upon storage at a high temperature, thereby inhibiting destruction of the SEI layer. According to the present invention, there is provided an electrolyte for a lithium-ion battery using any one of LiCoO2, LiMn2O4, LiNiO2, or a composite compound (LiMxNyO2), wherein M and N are a metal element; and x and y are a rational number from 0 to 2, as an anodic active material, and crystalline or amorphous carbon or lithium as a cathodic active material, in which the electrolyte comprises: a mixed solvent comprising at least one carbonate type solvent; at least one lithium salt of LiPF6, LiBF4, LiClO4, LiN(SO2CF3)2 and LiN(SO2CF2CF3)2 as an electrolytic salt; and a mixed additive of 2-sulfobenzoic acid cyclic anhydride and divinyl sulfone.
Owner:E SQUARE TECH CO LTD
Mixing mode expanded adsorbent bed medium and method for producing the same
InactiveCN101279243ALarge adsorption capacityHigh selectivityOther chemical processesPeptide preparation methodsCelluloseMicrosphere
The invention discloses a mixed model expanded adsorbent bed medium and a preparation method thereof. In the composition of medium, matrix is a composite microsphere with fibrin / inorganic weighting agent, and petunidin is sulfonyl group and mercapto benzimidazole. The composite microsphere with fibrin / inorganic weighting agent is acquired by inverse suspension thermal regeneration and is taken as the matrix to mix divinyl sulfone, soda buffer solution and DMSO for activation, then swab-off activation matrix, the mercapto benzimidazole and sodium hydroxide containing ammonium persulfate are mixed for coupling, thus acquiring the mixed model expanded adsorbent bed medium taking the mercapto benzimidazole and the sulfonyl group as the petunidin. The novel expanded bed adsorbing medium developed by the invention combines with a plurality of petunidin-protein interaction mechanisms such as hydrophobic interaction, charge induction action, thiophilic action, etc, to form mixed model adsorption, which has the advantages of large adsorption capacity, high selectivity, etc., thus being used for high efficient separation and purification of bioactivators such as antibody, etc.
Owner:ZHEJIANG UNIV
Method for preparing crosslinking hyaluronic acid gel
The invention provides a crosslinking hyaluronic acid gel and its preparation method. The method is characterized in that divinylsulfone is combined with polyethylene glycol for generating a novel cross-linking agent at first, the novel cross-linking agent is reacted with a hyaluronic acid molecule for producing a crosslinking hyaluronic acid gel. The crosslinking sodium hyaluronate gel obtained in the invention has good biological compatibility and longer half life period, and the particle is small and uniform, and is suitable for beautifying shaping, tissue filling, bone articular lubrication or medicine sustained-release preparation and the like.
Owner:XIAN LIBANG PHARMA
Preparation method of vinyl sulfone derivatives
ActiveCN105820095AHigh yieldImprove conversion rateOrganic chemistryOrganic compound preparationVinyl sulfoneNitrogenous heterocyclic compound
The invention relates to a preparation method of vinyl sulfone derivatives. The vinyl sulfone derivatives have the structure disclosed as General Formula I. According to the preparation method, compounds i react with divinyl sulfone in the presence of a catalyst, wherein R is selected from H or C1-C8 alkyl; n is a whole number which is greater than or equal to 1; and the catalyst is selected from triaryl phosphine compounds or nitrogen heterocycle compounds. Under the action of the selected catalyst, the reaction can quickly occur under room temperature conditions to obtain the products. The method has the advantages of mild conditions, high reaction speed, high conversion rate and the like. The prepared products have the advantages of hydrolysis resistance, alkali resistance, broad reaction spectrum and the like, and have very high application value.
Owner:DALIAN UNIV OF TECH
Nanometer polymer blocking agent for water-based drilling fluid and preparation method thereof
ActiveCN104927051AEffective sealingPrevent intrusionDrilling compositionWater basedDiethylenetriamine
The invention discloses a nanometer polymer blocking agent for a water-based drilling fluid and a preparation method thereof. The blocking agent contains a large amount of nano particles. The preparation method comprises the following steps that 1, piperazine and diethylenetriamine are dissolved in water or an organic solvent, divinyl sulphone is added, the mole ratio of the divinyl sulphone to the piperazine to the diethylenetriamine is 2:1:1-3:1:1, N2 is continuously led into the water or the organic solvent to perform reaction at the temperature of 40-60 DEG C for 12-24 hours; 2, methyl alcohol is adopted to achieve product precipitate and washing, and vacuum drying is performed for 12-24 hours to obtain the nanometer polymer blocking agent. The blocking agent can effectively prevent drilling fluid filtrate from invading a stratum so as to prevent well wall collapse and other accidents, can be resistant to the temperature of 250 DEG C and is especially suitable for nanometer blocking of an ultra-high-temperature shale stratum of an ultra-deep well. The preparation method is reliable in principle, simple and convenient to operate and lower in cost, raw material sources are abundant, industrial production is easily achieved, and the nanometer polymer blocking agent has wide market prospect.
Owner:SOUTHWEST PETROLEUM UNIV
Hydrophobic electric charge induced type thiophil expanded adsorbent bed medium and method for producing the same
InactiveCN101279244AImprove adsorption capacityOptimizing Coupling ReactionsOther chemical processesPeptide preparation methodsCelluloseMicrosphere
The invention discloses a charge-induced sulphophile expanded adsorbent bed medium with hydrophobic nature and a preparation method thereof. In the composition of the medium, matrix is a composite microsphere with fibrin / inorganic weighting agent, petunidin is sulfonyl group and mercapto benzimidazole. The composite microsphere with fibrin / inorganic weighting agent is acquired by inverse suspension thermal regeneration and is taken as the matrix to mix divinyl sulfone, soda buffer solution and DMSO for activation, then swab-off active matrix, the mercapto benzimidazole and sodium hydroxide containing ammonium persulfate are mixed for coupling, thus acquiring the charge-induced sulphophile expanded adsorbent bed medium with the hydrophobic nature. The expanded bed adsorbing medium developed by the invention combines with three protein separation principles of hydrophobic charge induced chromatography, thiophilic chromatography and expanded bed adsorption, etc., which has the advantages of large density of the petunidin, large protein adsorption capacity, strong specificity, mild conditions of adsorption and elution, etc., and shows the characteristic of the integration of technology and process, thus being used for high efficient separation and purification of proteins such as antibody, etc.
Owner:ZHEJIANG UNIV
Sodium alginate/carboxylated cellulose nanocrystal hydrogel microsphere for adsorbing lead ions
ActiveCN108014760AReduce use costImprove uniformityOther chemical processesWater contaminantsPorosityDivinyl sulfone
The invention discloses a sodium alginate / carboxylated cellulose nanocrystal hydrogel microsphere for adsorbing lead ions. The sodium alginate / carboxylated cellulose nanocrystal hydrogel microsphere comprises, by weight, 5-8 parts of sodium alginate, 6-8 parts of carboxylated cellulose nanocrystals, 0.5-0.52 parts of divinyl sulfone, 150-180 parts of distilled water and 30-40 parts of a 0.1-0.2 mol / L calcium chloride solution. The sodium alginate / carboxylated cellulose nanocrystal hydrogel microsphere has the following advantages: the sodium alginate and microcrystalline cellulose which are used as raw materials in the method are natural materials, so the microsphere is nontoxic and harmless, is friendly to the environment, and realizes appreciation and full utilization of materials as a water purifier; and the prepared hydrogel microsphere has a good homogeneity, a uniform particle size, no toxic or side effects, a large specific surface area and a large porosity, has high adsorptioncapability to lead ions and other heavy metal ions, can be used as a safe and efficient lead ion adsorbent, and has a broad industrial application prospect.
Owner:ZHEJIANG OCEAN UNIV
Non-aqueous electrolyte secondary battery
ActiveUS20060105240A1High charge and discharge capacityImprove featuresOrganic electrolyte cellsActive material electrodesDivinyl sulfoneMetal
A non-aqueous electrolyte secondary battery including a positive electrode containing a positive active material, a negative electrode containing a negative active material and a non-aqueous electrolyte, characterized in that lithium transition metal complex oxide A formed by allowing LiCoO2 to contain at least both of Zr and Mg and lithium transition metal complex oxide B having a layered structure and containing at least both of Mn and Ni as transition metals are mixed and used as said positive active material, and vinylene carbonate and divinyl sulfone are contained in said non-aqueous electrolyte.
Owner:SANYO ELECTRIC CO LTD
Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making them
InactiveUS6262255B1Minimizing antigenic contaminantSure easyOrganic active ingredientsPowder deliveryCellulose(Hydroxyethyl)methacrylate
Non-immunogenic biocompatible macromolecular sheet composition are formed from a cellulosic membrane, a binding moiety having a plurality of functional groups, and a glycosaminoglycan (GAG). The binding moiety has the formula of R1-X-R2 wherein R1 and R2 are the same or different. The binding moiety, through functional groups binds the cellulosic membrane with the glycosaminoglycan. R1 is covalently bound to a carbon or an oxygen of the cellulosic membrane. R2 is covalently bound to a carbon, an oxygen, or a nitrogen of the glycosaminoglycan. The binding moiety can be bis-oxyrane, butanediol-diglycidyl ether (BDE), or divinyl sulfone. The cellulosic membrane can be a cellulosic membrane, partially acetylated cellulose and a copolymer of hydroxyethyl-methacrylate with methyl methacrylate, abbreviated as HEMA-MMA. The non-immunogenic biocompatible macromolecular sheet composition can be formed into a pouch to encapsulate cells, tissues, pharmaceuticals, or biological metabolic products. In addition, the non-immunogenic biocompatible macromolecular sheet composition can also be used as a skin graft or a skin substitute. Further, these non-immunogenic biocompatible macromolecular sheet composition can also be used as a surface to culture cells in vitro.
Owner:BIOMM
Preparation method of composite crosslinking sodium hyaluronate gel microspheres for facial injection
InactiveCN104387600AGood biocompatibilityImprove water retentionProsthesisOrganic solventMicrosphere
The invention discloses a preparation method of composite crosslinking sodium hyaluronate gel microspheres for facial injection. The preparation method comprises the following steps: (1) preparing sodium hyaluronate into 10-30 percent g / ml sodium hyaluronate alkali liquor gel, adding an oil phase containing an emulsifier, carrying out emulsification at a high speed by a shearing machine to form an emulsion liquid of sodium hyaluronate microsphere particles, fully mixing, regulating a pH value to be 8-11 by using an alkaline solution, and standing to remove bubbles; (2) dissolving polyvinyl alcohol in hot water for injection with concentration to be 10-20 percent (m / v); (3) uniformly mixing the emulsion liquid of the sodium hyaluronate microsphere particles obtained in the first step and divinyl sulphone as a crosslinking agent according to the ratio of 2:1, standing to remove bubbles, and centrifugally removing the oil phase; (4) adding a polyvinyl alcohol solution obtained in the second step in the microsphere particle gel obtained in the third step according to the ratio of (1:4)-(4:1), mixing, and removing bubbles; and (5) washing the microsphere particles obtained in the fourth step by a soluble organic solvent, removing the residual oil phase, and regulating a pH value by the alkaline solution to be neutral.
Owner:杨子中
Loss circulation compositions (LCM) having portland cement clinker
ActiveUS10144860B1Reduce probabilityMitigate and prevent lost circulationSolid waste managementFlushingFiberPortland cement
Portland cement clinker LCMs that include Portland cement clinker to mitigate or prevent lost circulation in a well are provided. A Portland cement clinker LCM may include Portland cement clinker, Portland cement, a carrier fluid, and an inorganic consolidation activator. Another Portland cement clinker LCM may include Portland cement clinker and a crosslinked fluid, such as a polyuronide crosslinked via calcium ions or a polysaccharide crosslinked via divinyl sulfone. Yet another Portland cement clinker LCM may include Portland cement clinker and polymer fibers or particulate glass. Methods of lost circulation control using a Portland cement clinker LCM are also provided.
Owner:SAUDI ARABIAN OIL CO
Lithium-ion battery electrolyte and lithium-ion battery containing same
ActiveCN101656332AImprove thermal stabilityReduce bloatSecondary cellsHigh temperature storageBoiling point
The invention provides a lithium-ion battery electrolyte and a lithium-ion battery containing the same. The electrolyte comprises a solvent and a lithium salt electrolyte, further comprises an addition agent LiFOB and an alkylene unsaturated compound of which the boiling point is between 180 DEG C and 250 DEG C, wherein the alkylene unsaturated compound is one or more of divinyl sulfone and dimethyl sulphoxide. The electrolyte provided by the invention can effectively improve high-temperature storage performance and cycle performance of the lithium-ion battery prepared by using the electrolyte.
Owner:SHANGHAI BYD
Active dye printing process
The invention discloses an active dye printing process which includes the steps of printing, drying, roll alkali treatment, steaming fixation, washing, soaping and washing. In the printing process, dyes in printing paste are divinyl sulfone active dyes or 'double-active-group active dyes comprising a vinyl sulfone active group and a chorotriazine active group'. In roll alkali treatment, mangle expression is 30-50%. Adopted fixation alkali liquor comprises 5-15% of sodium carbonate, 5-10% of sodium silicate, 0.5-2% of sodium hydroxide and the balance water. In the printing process, alkali agents and urea added into the printing paste can be omitted, roll alkali treatment and steaming fixation are performed after printing and drying, urea is omitted in the process, ammonia nitrogen emissioncan be greatly reduced, and sewage discharge can reach standards. Besides, dye hydrolysis can be reduced, the stability of the color paste is prolonged, steaming time is shortened, steaming efficiencyis improved, and product production cost is reduced.
Owner:SHANGHAI ANOKY GRP +5
Thiophilic porous material, and preparation method and application thereof
The invention discloses a thiophilic porous material, and a preparation method and application thereof, wherein the preparation method comprises the following step of mixing divinyl sulfone, N,N-methylene-bisacrylamide and first organic solvent under the condition of existence of an initiator, so that the thiophilic porous material is prepared. According to the design, the divinyl sulfone and the crosslinking agent of N,N-methylene-bisacrylamide take a copolymerization reaction under the initiation effect of a free radical reaction initiator to form a crossed linked framework structure and mutually penetrated through hole passages, so that the specificity mutual action can be generated with antibodies and compounds containing disulfide base groups under the existence of certain concentration of salts. Meanwhile, through the technical scheme, the operation of introducing sulfuryl into the thiophilic porous material by a double-bond polymerization method is provided for the first time; meanwhile, a one-kettle method is used for preparing the thiophilic porous material, and the simplicity, convenience and high speed of the preparation process are realized; the preparation method is simple; the effect of good repeatability is achieved.
Owner:ANHUI NORMAL UNIV
Schizophyllan modified sodium hyaluronate microsphere gel, preparation method of sodium hyaluronate microsphere gel, and application of sodium hyaluronate microsphere gel in cosmetics
InactiveCN108888529AHigh moisture absorptionSmall hindranceCosmetic preparationsToilet preparationsCross-linkMicrosphere
The invention provides schizophyllan modified sodium hyaluronate microsphere gel, a preparation method of the sodium hyaluronate microsphere gel, and application of the sodium hyaluronate microspheregel in cosmetics. The method comprises the following steps: adding dried sodium hyaluronate powder into a hyaluronidase solution, and performing enzymolysis to obtain a sodium hyaluronate small-molecule solution; slowly adding the sodium hyaluronate small-molecule solution into a mixed oil phase, slowly stirring, adding a mixed cross-linking agent of calcium chloride and divinyl sulfone, cross-linking and curing to obtain sodium hyaluronate microspheres; adding the sodium hyaluronate microspheres and pre-treated schizophyllan into an alkaline solution containing polyethylene glycol, uniformlystirring, regulating the pH value of the system to be neutral, adding a phosphate buffer solution, standing and aging, thereby obtaining the schizophyllan modified sodium hyaluronate microsphere gel.The schizophyllan modified sodium hyaluronate microsphere gel prepared by the method disclosed by the invention is small in particle size, easily penetrates into the deep part of skin, can form tiny gel with protein-water, achieves the effect of deeply moisturizing for a long time, and has excellent moisture retention property.
Owner:DONGGUAN LIANZHOU INTPROP OPERATION MANAGEMENT CO LTD
Cross-linked hyaluronic acid derivatives preparation and the preparing technique
The invention relates to a preparation technique of crosslinked hyaluronic acid gel preparation, characterized in that divinylsulphone reacts with hydroxyl group of hyaluronic acid to form ether linkage. The steps are that the raw material of hyaluronic acid being put into container and dissolving in alkali reagent; stirring to make it thoroughly dissolve; mixing the alkaline hyaluronic acid solution and divinylsulphone in container to form crosslinked hyaluronic acid gel clot; adding substance riched in hydroxyl groups into the reaction solution; extracting the crosslinked hyaluronic acid gel clot and putting it into agitator to stir; and then crosslinked hyaluronic acid gel becoming micro grained. The advantages thereof are that the gel preparation is suitable for injection in vivo, with long residence timen in humans and good filling effect.
Owner:SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD +1
Preparation method of controlled release carrier of glucose-responsive drug
ActiveCN103191437AEasy to fixEffectively fixedMacromolecular non-active ingredientsControl releaseVinyl sulfone
The invention provides a preparation method of a controlled release carrier of a glucose-responsive drug, solves insufficiencies that ConA and sugar ligands thereof are needed to be modified in prior art. The method comprises: (1) dissolving sugar-containing polymer units in a lye, adding divinyl sulfone, adjusting a pH to stop reaction, and dialyzing to obtain a sugar-containing polymer with vinyl sulfone groups; (2) dissolving the prepared substances in a buffer solution, adding a ConA activating solution; (3) adjusting pH of the mixture obtained in step (2) by using the buffer solution, adjusting the pH, adding drop by drop the product into a mixed solution of cyclohexane and an emulsion stabilizer, reacting, removing an oil phase at an upper level, and depositing a lower level to obtain the glucose-responsive carrier. By introducing the divinyl sulfone into the ConA-sugar-containing polymer carrier, the preparation steps for the carrier can be simplified, the sugar-containing polymer can be directly crosslinked with the ConA, thereby being simple and high-efficiency to fix the ConA, low in cost, convenient to implement, and beneficial for large-scale production.
Owner:江阴智产汇知识产权运营有限公司
A hybrid gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and its preparation method
The invention relates to a mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and a preparation method of the mixed gel. The polylactic acid microspheres have the molecular weight of 15000-120000 and the average particle size of 10-150mu m, and the mass fraction of the polylactic acid microspheres in the mixed gel is 5-25%; a salt solution of the cross-linked hyaluronic acid gel is obtained by swelling and balancing the cross-linked hyaluronic acid gel in a sodium chloride solution or a phosphate buffer solution with the osmotic pressure of 250-350mOsmol / L and the pH value of 6.5-7.5; the cross-linked hyaluronic acid gel is a hyaluronic acid gel cross-linked by divinyl sulfone or glycidyl ether. A mixed gel product of polylactic acid and cross-linked hyaluronic acid, obtained by directly mixing the polylactic acid microspheres with the cross-linked hyaluronic acid gel obtained by swelling and balancing in the salt solution is uniform, fine, long in partial retention time, good in plasticity and few in side effects, has an obvious effect on eliminating wrinkles, and has few operation steps and stable product quality.
Owner:河北善远科技有限公司
Non-aqueous electrolyte secondary battery with vinylene carbonate and divinyl sulfone containing electrolyte
ActiveUS7608363B2High charge and discharge capacityLead-acid accumulatorsOrganic electrolyte cellsDivinyl sulfoneMetal
A non-aqueous electrolyte secondary battery including a positive electrode containing a positive active material, a negative electrode containing a negative active material and a non-aqueous electrolyte, characterized in that lithium transition metal complex oxide A formed by allowing LiCoO2 to contain at least both of Zr and Mg and lithium transition metal complex oxide B having a layered structure and containing at least both of Mn and Ni as transition metals are mixed and used as said positive active material, and vinylene carbonate and divinyl sulfone are contained in said non-aqueous electrolyte.
Owner:PANASONIC ENERGY CO LTD
Hyaluronic acid mixed gel containing amphiphilic microspheres for injection and preparation method thereof
ActiveCN105126166BIrritant effectDifficult to assembleOrganic active ingredientsProsthesisPhosphateMicrosphere
The invention relates to a hyaluronic acid mixed gel containing amphiphilic microspheres for injection and a preparation method thereof. The microsphere material involves amphiphilic materials such as PLLA-PEG, PLGA, and PLGA-PEG. The molecular weight of PLLA or PLGA is 10,000-500,000, and that of PEG is 1,000-10,000. In PLGA, LA / GA=90 / 10-10 / 90. The average particle size of the microspheres is 1-200 μm, and the mass fraction in the gel is 1-50%; the gel component is hyaluronic acid, or hyaluronic acid cross-linked with divinyl sulfone or glycidyl ether, The molecular weight of hyaluronic acid is 100,000-3,000,000, and the mass fraction is 1-50%. The gel component can also be animal-derived collagen, chitosan, amino acid cellulose, sodium alginate, and the like. The microsphere mixed gel is prepared in a sodium chloride solution or a phosphate buffer solution with an osmotic pressure of 250-350 mOsm / L and a pH of 6.5-7.5. In the present invention, the amphiphilic microspheres are directly mixed with the hyaluronic acid gel, and the amphiphilic microspheres are easily and uniformly distributed in the gel, and after being injected into the human body, they are not easy to assemble into lumps in the water environment of the human body.
Owner:IMEIK TECH DEV CO LTD
Polyethylene glycol hydrogel material and preparing method thereof
The invention discloses a polyethylene glycol hydrogel material and a preparing method thereof. The preparing method includes the steps that under the condition that a catalyst exists, polyethylene glycol, and the raw material obtained in the mode that a polyhydroxy compound and divinyl sulfone are mixed to be even is reacted to form gel. In the preparing method, hydroxyl-terminated polyethylene glycol serves as a raw material, the divinyl sulfone serves as a cross-linking agent, the polyhydroxy compound is added, the network structure is formed, and a one-step reaction is carried out at the room temperature under the catalyst condition. The method is simple, and adjustment of mechanical performance of hydrogel can be achieved by controlling the species and the proportion of the polyhydroxy compound and the chain length of the polyethylene glycol; solvent selection is wide, the polyethylene glycol hydrogel material is suitable for multiple hydroxyl-compound raw materials, and the hydrogel material meeting the requirements is further obtained.
Owner:DALIAN UNIV OF TECH
Hydrophobic electric charge induced type thiophil expanded adsorbent bed medium and method for producing the same
InactiveCN101279244BImprove adsorption capacityOptimizing Coupling ReactionsOther chemical processesPeptide preparation methodsCelluloseActive matrix
The invention discloses a charge-induced sulphophile expanded adsorbent bed medium with hydrophobic nature and a preparation method thereof. In the composition of the medium, matrix is a composite microsphere with fibrin / inorganic weighting agent, petunidin is sulfonyl group and mercapto benzimidazole. The composite microsphere with fibrin / inorganic weighting agent is acquired by inverse suspension thermal regeneration and is taken as the matrix to mix divinyl sulfone, soda buffer solution and DMSO for activation, then swab-off active matrix, the mercapto benzimidazole and sodium hydroxide containing ammonium persulfate are mixed for coupling, thus acquiring the charge-induced sulphophile expanded adsorbent bed medium with the hydrophobic nature. The expanded bed adsorbing medium developed by the invention combines with three protein separation principles of hydrophobic charge induced chromatography, thiophilic chromatography and expanded bed adsorption, etc., which has the advantagesof large density of the petunidin, large protein adsorption capacity, strong specificity, mild conditions of adsorption and elution, etc., and shows the characteristic of the integration of technology and process, thus being used for high efficient separation and purification of proteins such as antibody, etc.
Owner:ZHEJIANG UNIV
Vinyl sulfone-functionalized polysulfone membrane and preparation method and application thereof
ActiveCN110343285AWide range of substratesMild reaction conditionsSurface/boundary effectOrganic solventCoupling
The invention discloses a vinyl sulfone-functionalized polysulfone membrane and a preparation method and application thereof. Vinyl sulfone groups are contained on the surface of the vinyl sulfone-functionalized polysulfone membrane, and the preparation method comprises the steps: dissolving the polysulfone particles in an organic solvent, performing chloromethylation, performing a reaction between the obtained material with diethanolamine so as to introduce hydroxyl groups, and performing a reaction between the introduced product with divinyl sulfone under catalytic conditions so as to introduce vinyl sulfone functional groups on the surface of the membrane. Through the prepared vinyl sulfone-functionalized polysulfone membrane, further coupling of functional molecules can be achieved, the substrate has a wide application range, the reaction conditions are mild, the operation is simple, and environmental protection is achieved; and the vinyl sulfone-functionalized polysulfone membraneis a broad-spectrum polysulfone membrane which is a surface-functionalized substrate and has great potential.
Owner:DALIAN UNIV OF TECH
Preparation Method of Cross-Linked Sodium Hyaluronate Gel
ActiveUS20200407516A1Easily raw materialMild reaction conditionsTissue regenerationProsthesisEngineeringCross linker
A preparation method of a cross-linked sodium hyaluronate gel is disclosed, which including: preparing an alkaline aqueous solution of hyaluronic acid: formulating a sodium hyaluronate alkali liquor with the concentration of 10-30% g / ml; and carrying out a cross-linking reaction: the cross-linking agent used in the cross-linking reaction being divinyl sulfone or 1,4-butanediol diglycidyl ether, the cross-linking reaction being carried out in an alkaline aqueous solution of hyaluronic acid, the reaction temperature of the cross-linking reaction being 20-40° C., the time of the cross-linking reaction being 4-8 h, and the like. The method of this invention has many advantages, such as easily available raw materials, mild reaction conditions, high cross-linking efficiency, simple process and post-treatment, and easy operation. The obtained cross-linked sodium hyaluronate has a three-dimensional network structure by the crosslinking reaction with good mechanical properties, and can be used as a good drug carrier and a tissue engineering scaffold material.
Owner:HANGZHOU SINGCLEAN MEDICAL PROD +1
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