772 results about "Benzimidazole" patented technology

The invention discloses a dry-process high-temperature-resistant lithium battery diaphragm and a preparation method thereof, and relates to the technical field of lithium battery diaphragms. The specific preparation method comprises the following steps: activating and cross-linking polypropylene, polyimide, a PP-b-PI block copolymer and a cross-linking agent BIBP under the protection of nitrogen to prepare a polypropylene-polyimide matrix; after melting, adding a pre-sintered ZrO2-coated Al2O3 core-shell filler, hydroxylated boron nitride and zinc borate, and carrying out double-stage screw extrusion, ultrasonic orientation, nitrogen annealing and cold roller quenching to obtain a mixed melt; carrying out warm stretching and hot air circulation heat treatment to prepare a hard elastic crystal base film; carrying out stretching, thermal relaxation and thermal shaping to obtain a microporous base membrane; after slitting, plasma activation is carried out, epoxy silane and tetraethyl orthosilicate / polybenzimidazole aerogel precursors are sprayed, and a nano closed-pore coating is formed through pre-curing and heat shrinkage curing; and finally eliminating static electricity and rolling to obtain a finished product. The lithium battery diaphragm prepared by the invention is excellent in high temperature resistance and low in thermal shrinkage rate.

The invention relates to environment-friendly hydrophobic ink and a preparation method thereof, and belongs to the technical field of water-based ink. A copolymerization modifier capable of being combined in a water-based polyacrylate emulsion in an initiation polymerization mode in the stage of preparing the modified water-based polyacrylate emulsion is prepared, and an o-hydroxy aromatic ketone structure in the copolymerization modifier can endow water-based ink with lasting ultraviolet absorption performance; the trifluoromethyl structure can reduce the surface energy of the water-based ink, and the benzimidazole ring structure can form stable coordinate bonds with metal ions, so that the bonding performance of the water-based ink and a metal substrate is enhanced; when the copolymerization modifier is used for modifying the water-based polyacrylate emulsion, the long-term performance, the hydrophobic and oil-resistant performance and the adhesion performance on the surface of a metal base material of the finished water-based ink can be effectively improved.

The invention discloses a preparation method of a 3-micron ultrathin lithium battery copper foil. The preparation method comprises the following steps: preparing a copper sulfate electrolyte; a wetting agent, a brightening agent and a high resistance agent are added into the copper sulfate electrolyte, the high resistance agent is at least one of thiazolidinethione, polyethyleneimine, 2-mercaptobenzimidazole and ethylene thiourea, and a mixed additive is formed; polishing and grinding a cathode roller by adopting a flying wing wheel, and carrying out electrolytic treatment on the mixed additive through the polished and ground cathode roller to obtain a first-stage copper foil; and the first-stage copper foil is placed in a nitrogen furnace to be subjected to annealing treatment, and the 3-micron ultrathin lithium battery copper foil is obtained. The invention aims to solve the technical problems that in the prior art, edge tearing, foil breaking, warping, dark appearance oxidation and the like are prone to occurring in the production process of the ultrathin copper foil, the tensile strength and the ductility are difficult to consider at the same time, and stable mass production of the 3-micron copper foil is still difficult.

The invention discloses a nanofiber functional dressing for wound healing of burns and scalds, and belongs to the technical field of wound repairing dressings. The dressing is prepared through double-layer electrostatic spinning and comprises a hydrophilic nanofiber layer and a hydrophobic nanofiber layer. The hydrophobic nanofiber layer is prepared by electrostatic spinning of an antibacterial composite modified material and isocyanate-terminated oligomeric lactic acid, and the antibacterial composite modified material is prepared by acylating chlorination of (9I)-2, 4, 8, 10-tetraoxaspiro [5.5] undecane-3, 9-dipropionic acid, reaction of the acylating chlorination product and N, N-bis (2-benzimidazole methyl) amine, and quaternization of benzyl chloride. The tetrooxaspiro rigid structure improves the thermal stability and inhibits the molecular chain from absorbing water and expanding; the quaternized benzimidazole group destroys cell membranes through positive charges, and can efficiently resist bacteria. An amido bond in the hydrophilic layer and a urea bond formed by the antibacterial material and an isocyanate group remarkably improve the liquid absorption capacity; the hydrophobic layer provides mechanical support and ductility; two layers of interfaces are fused through heat treatment, the overall tearing strength is improved, and the joint movement requirement is met.

The invention discloses an anti-yellowing PVB (Polyvinyl Butyral) adhesive for laminated glass and a preparation method thereof, and relates to the technical field of adhesives. The yellowing-resistant PVB glue for the laminated glass has the advantages that the yellowing resistance is high; the modified PVB / nano silicon dioxide composite material is prepared from the following raw materials in parts by weight: 55 to 65 parts of modified PVB resin, 4 to 6 parts of modified nano silicon dioxide, 15 to 20 parts of dioctyl adipate, 0.5 to 1 part of a compound antioxidant, 0.3 to 0.8 part of an ultraviolet absorbent UV-327, 0.2 to 0.5 part of a silane coupling agent KH-560, 0.3 to 0.6 part of ethylene bis stearamide, 0.1 to 0.3 part of 2-benzimidazole methyl carbamate, 3 to 5 parts of tris (1-chloro-2-propyl) phosphate and 0.1 to 0.3 part of nano titanium dioxide. 5 to 8 parts of isopropanol; 0.8 to 1.2 parts of polycarbodiimide. The special modified PVB resin and the nano silicon dioxide are matched with the auxiliary agents such as the compound antioxidant, the anti-yellowing performance of the PVB glue for the laminated glass is remarkably improved through precise process preparation, the components have a synergistic effect, the process is controllable, the product performance is stable, and the cohesiveness is good.

The invention belongs to the technical field of chemical energy, and particularly relates to an ultralow-potential-difference zinc-air battery containing a copper cluster axial coordination iron monatomic catalyst. Benzimidazole and 2-methylimidazole are synthesized into ZIF-7-NH2, the ZIF-7-NH2 reacts with Fe (NO3) 3.9 H2O and Cu (OAc) 2. H2O in an ion exchange mode to obtain FeCu-ZIF-7-NH2, a urea calcination product g-C3N4 is added, stirring is carried out to obtain Fe-ZIF-7-NH2 / g-C3N4, finally, sintering is carried out under argon to obtain g-SAFe-Cin, the ORR activity and the OER activity of the catalyst are remarkably enhanced by constructing the copper cluster axial coordination iron monatomic catalyst, and the catalyst has the advantages of being high in catalytic activity, high in catalytic activity and high in catalytic activity. And the performance of the assembled zinc-air battery in the charge-discharge cycle is improved. Non-noble metal and a low-cost carbon source are used as raw materials, the synthesis cost of the catalyst is reduced, the yield is high, the preparation period is short, and large-scale commercial application potential is achieved.

The invention discloses an application of NSC348884 in preparation of an antibacterial drug, the bacteria of the NSC348884 are gram-negative bacteria or drug-resistant gram-negative bacteria, and the gram-negative bacteria are acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa or klebsiella pneumoniae; based on an antibacterial drug high-throughput screening technology, it is found from 1280 small molecule compounds that the benzimidazole compound NSC348884 has direct bacteriostasis and sterilization effects on gram-negative bacteria and drug-resistant gram-negative bacteria, and no drug resistance is generated after the benzimidazole compound NSC348884 is continuously applied for 14 days. Further research shows that NSC348884 can interfere with lipid synthesis of gram-negative bacterium cell membranes, inhibit formation of biological membranes and induce lipid metabolism disorder, so that bacteriostatic and bactericidal effects are achieved. In addition, the NSC348884 can also enhance the sensitivity of the drug-resistant bacteria to the imipenem and the polymyxin B.

The invention provides a lithium battery diaphragm and a preparation method thereof, and the preparation method comprises the following steps: carrying out a reaction on melamine and terephthalaldehyde in dimethyl sulfoxide to obtain SNW-1COF; the preparation method comprises the following steps: enabling SNW-1COF to react with allyl-1, 3-sultone in acetonitrile, so as to obtain allyl SCOF; the polyarylether benzimidazole, the 2-sulfydryl-5-fluorobenzimidazole, triethylamine and allyl SCOF are subjected to a reaction in a third solvent, and a membrane casting solution is obtained; and applying the membrane casting solution to a base material, and removing the solvent in the membrane casting solution to obtain the lithium battery diaphragm. According to the invention, the OPBI matrix and the propenyl SCOF react to form a covalent cross-linked network, so that the mechanical properties of the diaphragm in the aspects of thermal shrinkage rate, tensile strength, puncture strength and the like and the electrical properties in the aspects of wettability and ionic conductivity are improved.

The invention relates to a hydroxamic acid derivative of benzimidazole as well as a preparation method and application of the hydroxamic acid derivative. Specifically disclosed are a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a stereoisomer thereof. The hydroxamic acid derivative of benzimidazole is novel in structure, has good inhibitory activity on HDAC and / or PARP, and further shows good anti-tumor activity.

The invention relates to the field of flame-retardant textile fabrics, and provides a comfortable flame-retardant aramid fabric and a preparation method thereof. The composite filler with the average length of 3.0-8.0 mu m and the diameter of 0.4-1.0 mu m is prepared by adopting the design of multielement blended composite fibers of hydroxyapatite / magnesium hydroxide composite filler, meta-aramid polymer, para-aramid polymer, polybenzimidazole and the like through a hydro-thermal synthesis process of performing silanization surface activation and accurately controlling the molar ratio of calcium to phosphorus to be 1.60-1.67. The preparation method comprises the following steps: preparing the composite filler with the average length of 3.0-8.0 mu m and the diameter of 0.4-1.0 mu m; then industrial production processes such as graded shearing dispersion, continuous wet spinning, multi-stage stretching heat setting and after-finishing are performed, so that synergistic improvement of flame retardant performance and comfort performance is achieved, and the technical problems that a traditional aramid fiber fabric is poor in flame retardant effect, poor in comfort, unstable in processing performance and the like are solved; the fabric has wide application value in high-end application fields such as fire protection clothing, industrial protection textiles and military protection equipment.

The invention discloses a high-temperature-resistant benzimidazolone polyamide imide battery binder as well as a preparation method and application thereof, and belongs to the technical field of battery materials. The high-temperature-resistant benzimidazolone polyamideimide battery binder with uniformly distributed amide segments and imide segments is prepared through a method for activating aromatic diamine on one side of trimethylchlorosilane and changing the activity of amino groups on the two sides, the comprehensive performance of the high-temperature-resistant benzimidazolone polyamideimide battery binder is excellent, the defects that a traditional binder is poor in heat resistance and insufficient in chemical stability are overcome, and the service life of the high-temperature-resistant benzimidazolone polyamideimide battery binder is prolonged. The introduction of high-polarity groups can improve the wettability and ion transmission capability of the electrolyte, improve the solubility of the electrolyte so as to facilitate electrode forming, and can also form strong chemical bonds or physical adsorption with positive and negative inorganic active materials during application, thereby reducing the structural damage in the cycle process and improving the electrochemical performance of the battery. The lithium ion battery electrode can keep a stable structure in a high-temperature environment, the thermal runaway risk caused by high temperature is remarkably reduced, and the application requirements of the lithium ion battery in a fast charging or high-temperature energy storage scene are well met.

The invention discloses an iron-loaded sulfonated carbon nitride heterogeneous catalyst as well as a preparation method and application thereof, and belongs to the field of heterogeneous catalysts. The iron-loaded sulfonated carbon nitride heterogeneous catalyst consists of monatomic Fe and a sulfonated graphite phase carbon nitride carrier, so that the prepared iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the reaction of benzoxazole and absolute ethyl alcohol, is high in catalytic efficiency, can catalyze the reaction of benzimidazole or benzothiazole and absolute ethyl alcohol, and is high in catalytic efficiency. Therefore, 2-(1-hydroxyethyl)-benzimidazole or 2-(1-hydroxyethyl)-benzothiazole is synthesized, and concentrated acid does not need to be used as a catalyst in the synthesis process. The sulfonation degree of the iron-loaded sulfonated carbon nitride heterogeneous catalyst can be regulated and controlled, the iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the construction of a directional C-C bond, and the iron-loaded sulfonated carbon nitride heterogeneous catalyst keeps stable in the reaction process and can be recycled for 5 times or more.

The invention relates to the field of corrosion-resistant coatings, and discloses a corrosion-resistant coating and application of the corrosion-resistant coating in an aluminum alloy heat exchange tube, the corrosion-resistant coating comprises waterborne epoxy resin, modified silicon dioxide nanotubes, modified composite filler and auxiliaries; the modified silicon dioxide nanotube is prepared by carrying out acylating chlorination on a silicon dioxide nanotube by using 4-isocyanobenzoyl chloride and then reacting with an amination modifier; the amination modifier is prepared by synthesizing spirocyclic phosphate diacyl chloride by using pentaerythritol and phosphorus oxychloride, and then carrying out substitution on 2-aminobenzimidazole, 3, 5-diamino-1, 2, 4-triazole and the spirocyclic phosphate diacyl chloride; the modified composite filler is prepared by forming a polydopamine layer on the outer surface of mica through auto-polymerization of dopamine, then wrapping the outer layer of dopamine modified mica with zinc oxide through a sol-gel method and high-temperature calcination, and then modifying with KH550. The coating prepared by the invention has good mechanical properties, corrosion resistance, heat insulation performance, flame retardant effect and antibacterial effect.

The invention provides a glass fiber impregnating compound for reinforcing epoxy resin as well as a preparation method, a product and application of the glass fiber impregnating compound. The impregnating compound comprises effective components and water, the solid content is 5.0%-10.0%, and the balance is water; the impregnating compound comprises the following effective components in percentage by mass: 5%-32% of the silane coupling agent, 35%-80% of the film-forming agent, 10%-30% of the lubricant, 1%-6% of the surface additive, 2%-10% of the cross-linking agent and 1%-6% of the pH value regulator. The silane coupling agent is a mixture of a cationic aminotoluene functionalized silane coupling agent and a cationic benzimidazole silane coupling agent. The glass fiber yarn produced by adopting the impregnating compound is less in hairiness, good in flexibility, good in interface compatibility with epoxy resin, excellent in transverse tensile property and suitable for producing a wind power blade base material, and when the base material and the epoxy resin are used for vacuum infusion, the resin is rapidly and completely soaked, and the service life of the resin is prolonged. And the poured composite material has few forming defects and excellent static mechanical properties and fatigue resistance.

The invention discloses polyacrylate anti-deposition and cerium chloride synergistic composite corrosion inhibitor cooling liquid, relates to the field of cooling liquid, and is particularly suitable for a multi-metal cooling system. According to the method, polyacrylate, cerium chloride, benzotriazole, benzimidazole, ethylene glycol, deionized water and triethanolamine serve as core raw materials, during preparation, equipment and the raw materials are pretreated, then a base solution is prepared, the pH value is adjusted to be alkalescent, then polyacrylate and cerium chloride are dissolved and coordinated, an auxiliary corrosion inhibitor is added, and synergistic protection is formed. And defoaming, filtering and filling. The cooling liquid adapts to multi-metal material protection through the synergistic effect of deposition resistance of polyacrylate and corrosion inhibition and synergism of cerium chloride, the cooling liquid is diluted according to working conditions during application, waste cooling liquid is discharged after being subjected to combined treatment of biological contact oxidation and Fenton oxidation, a finished product needs to be stored in a proper environment in a sealed mode, and the protection performance, the environmental protection property and the storage stability are effectively considered.

A novel salt form of Compound (I) represented by the following structural formula, and its corresponding pharmaceutical compositions, are disclosed.Particular single crystalline forms of 1:1 Compound (I) tartrate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating cancer in a subject.

The invention discloses a degradation agent based on benzimidazole fused covalent warheads as well as a preparation method and application of the degradation agent, and relates to the technical field of drug development. The structural formula of the degradation agent based on the benzimidazole fused covalent warhead is shown in the specification, wherein, is phenyl or substituted phenyl; r is methyl or tertiary butyl; the structure is selected from one of the following structures:,,,,,,,,, and; and a connection site is represented. According to the invention, a series of degradation agents based on benzimidazole fused covalent warheads are obtained by utilizing the modular design of a benzimidazole guiding group and an acrylate covalent warhead and then connecting with a BRD4 protein inhibitor JQ1 through a connexon. The degradation agent based on the benzimidazole fused covalent warhead can target the BRD4 protein and efficiently degrade the BRD4 protein. Therefore, targeted degradation of the BRD4 protein is realized while a protein degradation targeted chimera molecular library is enriched.

The invention relates to the technical field of brass materials, in particular to a high-strength and high-toughness brass material and a preparation method thereof.The preparation method comprises the steps that a porous oxide film layer is prefabricated on the surface of brass through plasma electrolytic oxidation, and an oxide film layer doped with double-bond silver-loaded graphene oxide is constructed on the surface of the brass; the preparation method comprises the following steps: firstly, preparing modified MXene, then preparing a photocurable hole sealing coating for hole sealing treatment, introducing double-bond silver-loaded graphene oxide and the modified MXene as fillers into the photocurable hole sealing coating, firstly performing sulfhydrylation on the MXene by using 3-mercaptopropyltriethoxysilane, and then grafting a double-bond-containing bis-benzimidazole ring derivative through light click to obtain the modified MXene; vinyl-terminated polyurethane is used as a cross-linking agent, o-phenyl phenoxyethyl acrylate, butyl acrylate, glycidyl methacrylate and octadecyl acrylate are compounded to serve as an acrylic monomer, a diluent and a solvent are introduced, a complex cross-linked network is constructed, and the service life of the brass material is prolonged.

The present application belongs to the technical field of high-temperature-resistant coatings, and particularly relates to a core-shell polyimide-based high-temperature-resistant water-based coating and a preparation method thereof. The coating comprises the following components by mass percentage: core-shell emulsion 35-38%, wherein the core layer is polyimide resin, the transition layer is organic silicon emulsion modified by 5,6-dimethylbenzimidazole and silane coupling agent KH-550, and the shell layer is polyamide-imide resin; modified high-temperature filler 28-32%; functional additive 6-7.5%; and deionized water in the rest. The present application improves the high-temperature resistance, adhesion and environmental friendliness of the coating through gradient design of the core-shell emulsion, synergistic effect of multi-scale fillers and low-temperature gradient curing process.

The present invention relates to the field of skin cosmetics, and in particular to a soothing, long-lasting, sun-protective isolation cream and its preparation method. The isolation cream's raw materials include butylene glycol, isododecane, polydimethylsiloxane, ethylhexyl salicylate, phenylbenzimidazole sulfonic acid, butyloctanol salicylate, diisopropyl sebacate, diisopropyl adipate, vinyl polydimethylsiloxane / polymethylsilane silsesquioxane crosspolymer, ethylhexyl triazone, p-hydroxyacetophenone, disteardimonium hectorite, aluminum hydroxide, Piper mesenteriae leaf / root / stem extract, Gentiana scabra extract, and water. The isolation cream prepared by the present invention has good soothing, long-lasting, and sun-protective effects, as well as excellent free radical resistance and moisturizing effects. It is easy to apply and can improve skin gloss to a certain extent.

The invention belongs to the technical field of TPV materials, and particularly relates to an anti-ultraviolet halogen-free flame-retardant TPV material and a preparation method thereof. The TPV material comprises the following components in parts by weight: 100 parts of ethylene propylene diene monomer, 10-30 parts of an ethylene-vinyl acetate copolymer, 20-30 parts of polypropylene, 50-100 parts of paraffin oil, 1-5 parts of an antioxidant, 1-3 parts of a cross-linking agent, 1-5 parts of a lubricant and 10-20 parts of functional phosphate. According to the invention, a phosphate structure with a flame-retardant effect and a benzimidazole structure with an ultraviolet absorption function are introduced into the same molecule to realize multi-functionalization of the modifier, so that the prepared TPV material has excellent flame-retardant and anti-ultraviolet properties.

The invention discloses a flame-retardant heat-insulating aluminum foil reinforced composite material and a preparation method thereof, and belongs to the technical field of aluminum foil reinforced composite materials. The flame-retardant heat-insulating aluminum foil reinforced composite material prepared by the invention sequentially comprises an aluminum foil layer, a reinforced net, kraft paper and a flame-retardant adhesive layer for bonding the aluminum foil layer and the reinforced net and bonding the reinforced net and the kraft paper from bottom to top, the flame-retardant adhesive layer comprises the following raw material components: a dianhydride monomer, an amine monomer and a heat-insulating filler; the amine monomer comprises 4, 4 '-diaminodiphenyl ether, flame-retardant diaminobenzimidazole and 4-aminobenzonitrile, the heat-insulating filler is prepared from hydroxyapatite nanowires, montmorillonite nanosheets and aminated polyvinyl alcohol, and the flame-retardant heat-insulating aluminum foil reinforced composite material prepared by the preparation method disclosed by the invention is relatively good in flame retardance and heat insulation.

The invention provides a vanillin compound spliced by polyheterocycles. The polyheterocycles are one of a benzimidazole ring, a thiadiazole ring, an oxadiazole ring and a thiazole ring; the vanillin compound spliced by polyheterocycles is one of vanillin derivatives containing a benzimidazole ring, a thiadiazole ring, an oxadiazole ring and a thiazole ring, and the chemical general formula is shown in the specification. The polyheterocycle spliced vanillin compound is prepared through a condensation reaction and a condensation-cyclization reaction, and the compound has good antibacterial activity on valsa mali, red kidney bean root rot, fusarium graminearum, millet pyricularia grisea, botrytis cinerea, alternaria solani and watermelon fusarium oxysporum. The compound can be used for preparing a novel efficient antibacterial agent and is applied to prevention and treatment of the pathogenic bacteria.

The invention discloses application of a propanamide derivative in preparation of a medicine for treating nervous system diseases, and belongs to the technical field of medicines, and the propanamide derivative is N-[(6-methoxy-1H-benzimidazole-2-yl) methyl]-3-(pyridine-3-yl) propanamide. The invention discloses the neuroprotection application of the propanamide derivative for the first time by adopting the propanamide derivative to prepare a medicine for treating nervous system diseases, and the protection efficacy of the propanamide derivative is equivalent to that of a positive medicine MK-801.

The invention discloses N-alkylated / sulfonated benzimidazole polyaryletherketone / polyaryletherketone sulfone with controllable grafting density as well as a preparation method and application of the N-alkylated / sulfonated benzimidazole polyaryletherketone / polyaryletherketone sulfone. The preparation method comprises the following steps: firstly, introducing a protecting group on a phenolic hydroxyl group of a bisphenol monomer containing a benzimidazole structure, then carrying out nucleophilic substitution reaction on alkyl halide / alkyl halide sulfonic acid and-NH, and then removing the protecting group to obtain an N-alkylated / sulfonated benzimidazole functionalized bisphenol monomer; copolymerizing the monomer, a bisphenol monomer and a difluoro monomer to obtain a polymer; alkyl or alkyl sulfonic acid is introduced to a benzimidazole ring, so that-NH bonds are passivated, a steric hindrance effect is formed, and gelation of the polymer under a high polymerization degree is avoided; by adjusting the molar ratio of the monomers, the retention stability of the functional groups can be effectively controlled, and compared with the traditional grafting on the polymer, the non-regulation of functionalization and the gelation of the polymer are effectively avoided.

The invention relates to a continuous casting-continuous extrusion short-process forming process for a large-width copper plate strip, and belongs to the technical field of metal processing. The method comprises the following steps: preheating and drying high-purity cathode copper, melting in a smelting device, covering the surface of molten copper with charcoal and graphite flakes, carrying out on-line degassing, deoxidizing and stirring, upwards leading a copper rod by adopting a traction unit, and extruding between an extrusion wheel and a compaction wheel; a four-high rolling mill is used for rolling; cleaning and passivating the annealed copper plate strip, spraying a lanthanum (III)-containing silane-benzimidazole lubricant solution on the surface of the copper plate strip, and drying; slitting to obtain a large-width copper plate strip; the lanthanum (III)-silane-benzimidazole lubricant is prepared from vinyltriethoxysilane, deionized water, ethanol, benzimidazole and lanthanum nitrate hexahydrate (III), and the lanthanum (III)-silane-benzimidazole lubricant is prepared from the vinyltriethoxysilane, the deionized water, the ethanol, the benzimidazole and the lanthanum nitrate hexahydrate (III); the prepared copper plate strip is high in purity, low in oxygen content, high in conductivity and excellent in mechanical property, and the technical requirements of the high-end field for the high-purity high-conductivity oxygen-free copper plate strip are met.

The application discloses a preparation method and application of modified hyperbranched polyurethane for track traffic field finish paint, and comprises the following raw materials: 2,2-dimethylol propionic acid, dicyclohexyl methane-4,4'-diisocyanate, modified chain extender and catalyst. The modified hyperbranched polyurethane containing double benzimidazole structures and curcumin and the phosphorus-nitrogen six-membered ring functional agent A containing a large number of hindered phenol structures are used in the preparation of the track traffic finish paint, so that the finish paint has excellent ultraviolet aging resistance, heat aging resistance and mechanical properties, and also has the effect of flame retardation.

Provided herein are compounds, preferably (R)-N-(4-(chlorodifluoromethoxy) phenyl)-2-(difluoromethyl)-1-(1-hydroxypropan-2-yl)-7-(pyrimidin-5-yl)-1H-benzo[d]imidazole-5-carboxamide having the Formula Ior a pharmaceutically acceptable salt or tautomer thereof, that inhibits tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and / or symptomology of the disease.

The invention relates to the technical field of DNA intercalating agents, in particular to a near-infrared luminous ruthenium (II) complex, a preparation method thereof and application of the complex as a DNA intercalating agent. The preparation method comprises the following steps: firstly, preparing a precursor 4 '-(1H-benzimidazole-2-yl)-2, 2': 6 ', 2' '-terpyridyl; then, preparing a target precursor, namely, 2-(4-(anthracene-10-yl)-6-(pyrazine-2-yl) pyridine-2-yl) pyrazine as a ligand; and finally, synthesizing a complex [Ru (An-di (2-Pz) Py) (Bitpy)]. The complex is inserted into a DNA base pair as an intercalating agent, has very strong interaction with DNA, and provides basic research for researching the interaction mode of the ruthenium (II) polypyridine complex of the tridentate ligand and DNA and taking the ruthenium (II) polypyridine complex as a diagnosis and treatment reagent.