406 results about "Benzimidazole" patented technology

The invention relates to environment-friendly hydrophobic ink and a preparation method thereof, and belongs to the technical field of water-based ink. A copolymerization modifier capable of being combined in a water-based polyacrylate emulsion in an initiation polymerization mode in the stage of preparing the modified water-based polyacrylate emulsion is prepared, and an o-hydroxy aromatic ketone structure in the copolymerization modifier can endow water-based ink with lasting ultraviolet absorption performance; the trifluoromethyl structure can reduce the surface energy of the water-based ink, and the benzimidazole ring structure can form stable coordinate bonds with metal ions, so that the bonding performance of the water-based ink and a metal substrate is enhanced; when the copolymerization modifier is used for modifying the water-based polyacrylate emulsion, the long-term performance, the hydrophobic and oil-resistant performance and the adhesion performance on the surface of a metal base material of the finished water-based ink can be effectively improved.

The invention discloses polyacrylate anti-deposition and cerium chloride synergistic composite corrosion inhibitor cooling liquid, relates to the field of cooling liquid, and is particularly suitable for a multi-metal cooling system. According to the method, polyacrylate, cerium chloride, benzotriazole, benzimidazole, ethylene glycol, deionized water and triethanolamine serve as core raw materials, during preparation, equipment and the raw materials are pretreated, then a base solution is prepared, the pH value is adjusted to be alkalescent, then polyacrylate and cerium chloride are dissolved and coordinated, an auxiliary corrosion inhibitor is added, and synergistic protection is formed. And defoaming, filtering and filling. The cooling liquid adapts to multi-metal material protection through the synergistic effect of deposition resistance of polyacrylate and corrosion inhibition and synergism of cerium chloride, the cooling liquid is diluted according to working conditions during application, waste cooling liquid is discharged after being subjected to combined treatment of biological contact oxidation and Fenton oxidation, a finished product needs to be stored in a proper environment in a sealed mode, and the protection performance, the environmental protection property and the storage stability are effectively considered.

A novel salt form of Compound (I) represented by the following structural formula, and its corresponding pharmaceutical compositions, are disclosed.Particular single crystalline forms of 1:1 Compound (I) tartrate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating cancer in a subject.

The invention relates to the technical field of brass materials, in particular to a high-strength and high-toughness brass material and a preparation method thereof.The preparation method comprises the steps that a porous oxide film layer is prefabricated on the surface of brass through plasma electrolytic oxidation, and an oxide film layer doped with double-bond silver-loaded graphene oxide is constructed on the surface of the brass; the preparation method comprises the following steps: firstly, preparing modified MXene, then preparing a photocurable hole sealing coating for hole sealing treatment, introducing double-bond silver-loaded graphene oxide and the modified MXene as fillers into the photocurable hole sealing coating, firstly performing sulfhydrylation on the MXene by using 3-mercaptopropyltriethoxysilane, and then grafting a double-bond-containing bis-benzimidazole ring derivative through light click to obtain the modified MXene; vinyl-terminated polyurethane is used as a cross-linking agent, o-phenyl phenoxyethyl acrylate, butyl acrylate, glycidyl methacrylate and octadecyl acrylate are compounded to serve as an acrylic monomer, a diluent and a solvent are introduced, a complex cross-linked network is constructed, and the service life of the brass material is prolonged.

The invention discloses a flame-retardant heat-insulating aluminum foil reinforced composite material and a preparation method thereof, and belongs to the technical field of aluminum foil reinforced composite materials. The flame-retardant heat-insulating aluminum foil reinforced composite material prepared by the invention sequentially comprises an aluminum foil layer, a reinforced net, kraft paper and a flame-retardant adhesive layer for bonding the aluminum foil layer and the reinforced net and bonding the reinforced net and the kraft paper from bottom to top, the flame-retardant adhesive layer comprises the following raw material components: a dianhydride monomer, an amine monomer and a heat-insulating filler; the amine monomer comprises 4, 4 '-diaminodiphenyl ether, flame-retardant diaminobenzimidazole and 4-aminobenzonitrile, the heat-insulating filler is prepared from hydroxyapatite nanowires, montmorillonite nanosheets and aminated polyvinyl alcohol, and the flame-retardant heat-insulating aluminum foil reinforced composite material prepared by the preparation method disclosed by the invention is relatively good in flame retardance and heat insulation.

The invention discloses application of a propanamide derivative in preparation of a medicine for treating nervous system diseases, and belongs to the technical field of medicines, and the propanamide derivative is N-[(6-methoxy-1H-benzimidazole-2-yl) methyl]-3-(pyridine-3-yl) propanamide. The invention discloses the neuroprotection application of the propanamide derivative for the first time by adopting the propanamide derivative to prepare a medicine for treating nervous system diseases, and the protection efficacy of the propanamide derivative is equivalent to that of a positive medicine MK-801.

The invention discloses N-alkylated / sulfonated benzimidazole polyaryletherketone / polyaryletherketone sulfone with controllable grafting density as well as a preparation method and application of the N-alkylated / sulfonated benzimidazole polyaryletherketone / polyaryletherketone sulfone. The preparation method comprises the following steps: firstly, introducing a protecting group on a phenolic hydroxyl group of a bisphenol monomer containing a benzimidazole structure, then carrying out nucleophilic substitution reaction on alkyl halide / alkyl halide sulfonic acid and-NH, and then removing the protecting group to obtain an N-alkylated / sulfonated benzimidazole functionalized bisphenol monomer; copolymerizing the monomer, a bisphenol monomer and a difluoro monomer to obtain a polymer; alkyl or alkyl sulfonic acid is introduced to a benzimidazole ring, so that-NH bonds are passivated, a steric hindrance effect is formed, and gelation of the polymer under a high polymerization degree is avoided; by adjusting the molar ratio of the monomers, the retention stability of the functional groups can be effectively controlled, and compared with the traditional grafting on the polymer, the non-regulation of functionalization and the gelation of the polymer are effectively avoided.

The application discloses a preparation method and application of modified hyperbranched polyurethane for track traffic field finish paint, and comprises the following raw materials: 2,2-dimethylol propionic acid, dicyclohexyl methane-4,4'-diisocyanate, modified chain extender and catalyst. The modified hyperbranched polyurethane containing double benzimidazole structures and curcumin and the phosphorus-nitrogen six-membered ring functional agent A containing a large number of hindered phenol structures are used in the preparation of the track traffic finish paint, so that the finish paint has excellent ultraviolet aging resistance, heat aging resistance and mechanical properties, and also has the effect of flame retardation.

The invention relates to the technical field of DNA intercalating agents, in particular to a near-infrared luminous ruthenium (II) complex, a preparation method thereof and application of the complex as a DNA intercalating agent. The preparation method comprises the following steps: firstly, preparing a precursor 4 '-(1H-benzimidazole-2-yl)-2, 2': 6 ', 2' '-terpyridyl; then, preparing a target precursor, namely, 2-(4-(anthracene-10-yl)-6-(pyrazine-2-yl) pyridine-2-yl) pyrazine as a ligand; and finally, synthesizing a complex [Ru (An-di (2-Pz) Py) (Bitpy)]. The complex is inserted into a DNA base pair as an intercalating agent, has very strong interaction with DNA, and provides basic research for researching the interaction mode of the ruthenium (II) polypyridine complex of the tridentate ligand and DNA and taking the ruthenium (II) polypyridine complex as a diagnosis and treatment reagent.

The invention discloses a synthesis method of 5-(1H-pyrrole-1-yl)-2-mercaptobenzimidazole, which comprises the following steps: carrying out cyclization condensation reaction on o-phenylenediamine and thiourea in an acidic environment provided by hydrochloric acid to obtain 2-mercaptobenzimidazole; the preparation method comprises the following steps: carrying out nitration reaction on 2-mercaptobenzimidazole, sulfuric acid and nitric acid to obtain 2-mercapto-5-nitrobenzimidazole; the preparation method comprises the following steps: carrying out nitro reduction reaction on 2-sulfydryl-5-nitrobenzimidazole and hydrogen under the catalysis of nickel to obtain 5-amino-2-sulfydryl benzimidazole; the preparation method comprises the following steps: carrying out an N-alkylation reaction on 5-amino-2-mercapto benzimidazole and tetrahydro-2, 5-dimethoxyfuran under the catalysis of copper chloride to generate 5-(1H-pyrrole-1-yl)-2-mercapto benzimidazole, and carrying out a reaction on the 5-amino-2-mercapto benzimidazole and tetrahydro-2, 5-dimethoxyfuran to generate the 5-(1H-pyrrole-1-yl)-2-mercapto benzimidazole. The method disclosed by the invention has the outstanding advantages of mild and easily-controlled conditions, simple and convenient post-treatment, high yield, economy, environmental protection, suitability for large-scale production and the like, conforms to the green chemical development concept, and has important application value.

The application provides a PET sandwich composite wood grain plate and a preparation process thereof, and has a surface micro-crease structure, comprises a primer and a topcoat, and the polymerizable monomers, namely, vinyl benzimidazole and vinyl imidazole, in the topcoat have photosensitive groups, namely, benzimidazole and imidazole, can synergize with a photoinitiator, promote the generation and transmission of free radicals under the action of UV light, increase the free radical concentration, can strengthen the UV energy gradient change from the topcoat to the primer, increase the micro-crease size, promote the diffuse reflection of light on the surface layer, reduce the gloss, and improve the scratch resistance and hardness.

This invention belongs to the field of animal model technology, specifically disclosing a method for constructing a primary ciliary motor disorder hydrocephalus model, comprising the following steps: screening benzimidazole as a modeling agent; administering benzimidazole solution to experimental animals and setting up a blank control group; conducting experimental verification through pathological morphology and behavioral methods; if the experimental animals show significant ventricular enlargement and significant decrease in motor ability, the primary ciliary motor disorder hydrocephalus model is successfully constructed. This invention employs the above-mentioned novel method for constructing a primary ciliary motor disorder hydrocephalus model. The constructed hydrocephalus model exhibits good stability and repeatability, is objective and simple, and is highly operable, reducing other possible interfering factors. It provides a necessary experimental foundation for studying the mechanism of primary ciliary motor disorder hydrocephalus and developing treatment methods.

The application discloses a preparation method of a lithium ion battery adhesive and the product. The preparation method of the adhesive comprises the following steps: first, taking a bisphenol A type diether dianhydride and a functional group-containing diamine into a polar aprotic solvent to perform a polycondensation reaction, adding a condensation activator into the obtained polyamide acid solution, and uniformly blending to obtain the adhesive; wherein the functional group-containing diamine is composed of 50-80 mol% of amide diamine monomers and the balance of 2-(4-aminophenyl)-5-aminobenzimidazole in terms of molar percentage, the amide diamine monomers are 4,4'-diaminobenzanilide and / or N,N'-bis(4-aminophenyl)terephthalamide; and the activator is one or a combination of two or more selected from N,N'-carbonyldiimidazole, N,N'-thiocarbonyldiimidazole and diimidazolylbenzene. The adhesive is applied to a lithium battery positive / negative slurry to further manufacture a battery, and the battery has good battery characteristics.

Tetradentate platinum complexes including an imidazole / benzimidazole carbene having a structure of Formula Iis disclosed. In Formula I, M is Pd or Pt. These platinum carbenes with the specific substituents disclosed herein are novel and provides phosphorescent emissive compounds that exhibit physical properties that can be tuned, such as sublimation temperature, emission color, and device stability.

The present disclosure relates to compounds according to Formula I or a pharmaceutically acceptable salt and / or solvate thereof, wherein X 1 is H, F, or CI; R 1 is H, alkyl, or cycloalkyl; R 2 is H, alkyl, or cycloalkyl; R 3 is H, halo, alkyl, cycloalkyl, heterocyclyl, heteroaryl, or N(R 4 )(R 5 ); and one of R 4 and R 5 is H, alkyl, cycloalkyl, heterocyclyl, or heteroaryl, and the remaining one of R 1 and R 2 is H or alkyl, or R 4 and R 5 together with the nitrogen atom to which they are bound are heterocyclyl or heteroaryl. Furthermore, the present disclosure demonstrates that the compounds of the present disclosure penetrate the central nervous system, thereby allowing for the treatment of central nervous system cancers.

The invention belongs to the technical field of materials, and discloses an anti-aging rare earth butadiene-isoprene rubber material and a preparation method thereof.The anti-aging rare earth butadiene-isoprene rubber material is prepared by taking rare earth butadiene-isoprene rubber as a base material and taking an inorganic reinforced additive, a composite anti-aging agent and the like as auxiliary materials through mixing and extrusion; wherein the inorganic reinforced additive is prepared by modifying epoxidized natural rubber on the surface of filler illite, and after surface modification, illite can exist in the material in a physical crosslinking core form, so that good stress absorption and stress dispersion effects can be generated, and the mechanical property of the material is enhanced; the compound type anti-aging agent structure not only contains an ammonia anti-aging agent, but also contains a benzimidazole anti-aging agent, so that a synergistic anti-aging effect can be realized through different action principles and action stages, and the anti-aging performance of the material is effectively enhanced.

The invention discloses a benzimidazole-based polymer which is one of ideal materials as an ion solvation membrane filler, and a prepared benzimidazole-based polymer ion solvation membrane shows excellent electrochemical performance and stability, has good universality and has great significance in application in flow batteries.

This invention discloses a metal corrosion protective impregnating agent and its preparation method, relating to the field of organic impregnating agents. The impregnating agent comprises: a monofunctional acrylate monomer, a difunctional acrylate monomer, a polyfunctional acrylate monomer, a metal corrosion protective reactive monomer, a surfactant, a polymerization inhibitor, and an initiator; the metal corrosion protective reactive monomer has the structural formula [formula missing] or [formula missing], where R is a hydrocarbon group containing at least one alkenyl group and consisting of C5-C18 atoms. This invention uses benzimidazole-2-carboxylic acid ester as the reactive monomer, which is chemically bonded and cured with the acrylate monomer upon heating. This imparts the impregnating agent with low viscosity, high hardness, high heat resistance, and high aging resistance. More importantly, this impregnating agent possesses excellent metal corrosion protection properties, preventing corrosion from tap water during the cleaning of ADC12 die-cast parts, avoiding subsequent removal of corrosion spots and rust prevention processes, effectively reducing processing difficulty and production costs.

The invention relates to the technical field of organic photoelectric materials and photovoltaic devices, in particular to a fluorine-substituted benzimidazolyl aniline compound and a synthesis method and application thereof. The structural general formula of the compounds is as shown in a formula I in the specification. The compound is introduced into a perovskite precursor solution as an additive and is used for preparing a perovskite thin film and a trans-perovskite solar cell. According to the compound provided by the invention, synergistic passivation of multi-site defects such as uncoordinated Pb < 2 + > and iodine vacancies is realized through aniline amino and benzimidazole ring N atoms in molecules, and non-radiative recombination is remarkably reduced; the strong electronegativity of fluorine atoms can enhance the electrostatic interaction between molecules and a perovskite Pb-I skeleton, meanwhile, a large conjugated system promotes pi-pi accumulation, and experimental results show that the photoelectric conversion efficiency of a champion device based on the additive can reach 23.3%; .

The application provides a method for synthesizing benzimidazole Michael addition derivatives in a continuous flow reactor, and 2-methylbenzimidazole and alpha, beta-unsaturated olefins are used to catalyze the online synthesis of benzimidazole Michael addition derivatives in a microfluidic channel reactor by using a lipase Lipozyme RM IM. The method not only greatly shortens the reaction time, but also has high conversion rate; meanwhile, the Michael addition reaction of 2-methylbenzimidazole and alpha, beta-unsaturated olefins is catalyzed by using the economical lipase Lipozyme RM IM in methanol, the reaction cost is reduced, the post-processing step is simplified, and the method has the advantages of green environmental protection, economy and efficiency.

The invention belongs to the technical field of fine chemical engineering, and relates to a method for recovering 5-acetoacetamidobenzimidazolone, which comprises the following steps: adding a stabilizer into AABI acylation wastewater, concentrating under reduced pressure, cooling to 25-30 DEG C, carrying out suction filtration, and taking a filter cake for later use; adding methanol into a filter cake, dispersing and stirring for 0.5 hour, adding corresponding sodium alkoxide, stirring for 0.5 hour, adding activated carbon, stirring for 0.5 hour, decolorizing, carrying out suction filtration, and concentrating filtrate until no fraction appears; and adding water into the concentrated filtrate for refining, dropwise adding acetic acid to adjust the pH value, stirring for 0.5 h, carrying out suction filtration, and washing and drying a filter cake to obtain an AABI product. The gallic acid is selected as a stabilizer, in the high-temperature concentration process, the AABI structure cannot be damaged, water-soluble salts are filtered out after concentration, impurities are removed through alcohol dispersion and alkali adjustment through sodium alcoholate, then a qualified product is obtained through aqueous phase inversion, the purity is larger than or equal to 99.60%, operation is simpler, conversion is easier, and application and popularization are facilitated.

The application discloses application of a benzimidazolone compound in preparation of a medicine for treating intervertebral disc degeneration. 11 H 14 N4O2, and has a CAS number of 881591-33-9. The application provides an innovative treatment strategy capable of intervening in an early stage of the disease and influencing disease progression from a cause level by targeting activation of SOD1 activity which is a newly found pathogenic link of intervertebral disc degeneration.

Discloses an aqueous antimicrobial coating composition comprising: (A) a polymer obtained by a multistage polymerisation and composed of: 75% to 95% of a first-stage polymer and from 5% to 25% of a second-stage polymer; wherein the first-stage polymer comprises: monoethylenically unsaturated functional monomers carrying at least one functional group selected from a carboxyl, carboxylic anhydride, sulfonic acid, amide, sulfonate, phosphoric acid, phosphonate, phosphate, or hydroxyl group (e.g. acrylic acid, acrylamide); <1.0% of a monomers bearing imidazole, benzotriazole, or benzimidazole; and monoethylenically unsaturated nonionic monomers (e.g. alkyl acrylate); wherein the second-stage polymer has MW=8000 to 30000 g / mol and comprises: residues of C6-C24 alkyl thiol (e.g. dodecyl mercaptan); monomers bearing imidazole, benzotriazole, or benzimidazole (e.g. vinyl imidazole); and monomers of alkyl acrylate; wherein the monomers bearing imidazole, benzotriazole, or benzimidazole in a multistage polymer are present at a total concentration of 0.5% to 8%; and (B) 1 to 10000 ppm of a silver, wherein the mol ratio of monomers bearing imidazole, benzotriazole, or benzimidazole to silver is greater than 4; and (C) <500 ppm of coagulum (coagulates having diameter>44 micrometers); and a method of preparing such aqueous antimicrobial composition and a coating composition comprising such aqueous antimicrobial composition and a pigment.

The present disclosure provides a solid form of 5-fluoro-1-(((5S, 7S, 8R)-8-fluoro-3-(5-(2-hydroxypropyl-2-yl) pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro [4.5] decane-7-yl) methyl)-1H-benzo [d] imidazole-6-formonitrile: which is useful as a TRPV4 antagonist.

The application provides a circuit board high-density protective film surface treatment method and a circuit board. The circuit board high-density protective film surface treatment method comprises the following steps: obtaining a circuit board; placing the circuit board into a modified OSP solution for soaking, wherein the modified OSP solution comprises an alkyl amide benzimidazole composition, a transition metal salt, an organic acid solvent, a chelating agent and water; using a cooling circulation spraying device to spray the soaked circuit board; and drying the sprayed circuit board to obtain the circuit board. By the method, the heat resistance of a traditional organic compound film is improved, the stability of the metal-organic compound film itself is improved, a high-density metal-organic compound film is obtained to improve the protection of the copper surface, the wastewater discharge amount is reduced, energy saving and emission reduction are achieved, and the water recycling rate is improved.

The application belongs to the field of pharmaceutical chemistry, and specifically discloses a benzimidazole amine derivative, a preparation method thereof and application of the benzimidazole amine derivative as a beta2-adrenergic receptor allosteric antagonist. In the benzimidazole amine derivative, R1 is a hydrogen atom or a bromine atom; and R2 is a substituted benzoyl group or a substituted benzyl group. Pharmacological results show that the benzimidazole amine derivative has good antagonistic activity on beta2AR and can negatively allosterically regulate the functional activity of isoprenaline (ISO).

The application relates to the technical field of organic fluorescent probes, and particularly discloses a lipid droplet and hypochlorous acid sequence response type fluorescent probe, a structural formula of which is as shown in the figure; wherein R is a cyano group, a benzothiazole group, a benzimidazole group, an amido group, an ethoxycarbonyl group or an acetyl group. The precise imaging lipid droplet and hypochlorous acid sequence response fluorescent probe of the application takes a phenothiazine-coumarin dye support as a matrix, utilizes a double trifluoromethyl benzyl group as a lipid droplet targeting group, adjusts the dye emission wavelength by introducing different electron-withdrawing groups, synthesizes a series of probes, and realizes high-targeting sequence imaging of lipid droplets and hypochlorous acid in atherosclerotic plaques.

The invention discloses an alpha-dideuterium methylated sulfone compound as well as a synthesis method and application thereof, and belongs to the field of organic chemistry. In an air atmosphere, benzyl methyl sulfone and 2-((3, 5-dimethyl-4-methoxypyridine-2-yl) methylsulfonyl)-5-methoxy-1H-benzo [d] imidazole are used as substrates, in the presence of a catalyst [Cp * IrCl2] 2 and cesium carbonate, deuterated paraformaldehyde is used as a carbon source, sodium formate is used as an additive, and the alpha-dideuterium methylated sulfone compound is obtained through a reaction in an acetonitrile solvent at 120 DEG C. The reaction does not need to use a ligand and hydrogen, the reaction is simple and efficient, the potential value of the compound in medicinal chemistry is shown, and the compound has a certain inhibition effect on H3N2 subtype influenza viruses and has remarkable application potential.

The invention relates to an imidazolium grafted anion exchange membrane, a preparation method and application of the imidazolium grafted anion exchange membrane in a non-aqueous flow battery, and belongs to the technical field of flow batteries. According to the alkyl imidazolium grafted cross-linked polybenzimidazole anion exchange membrane with the three-dimensional multi-stage topological structure, the diaphragm is endowed with excellent organic solvent resistance stability by a cross-linking process, and the ionic conductivity of the diaphragm in an organic solution is remarkably improved by a subsequent imidazolium cation grafting strategy. In combination with in-situ and ex-situ characterization and molecular dynamics simulation, it is found that the grafted imidazolium cation can effectively promote jump conduction of anions. In addition, the excellent performance of the non-aqueous flow battery verifies that the diaphragm can still keep the structural integrity during long-term operation in an organic medium due to the cross-linked structure.