56 results about "Nitroimidazole" patented technology

The invention discloses a universal water-based zinc-based battery electrolyte additive and a battery preparation method, and particularly relates to the technical field of water-based zinc-based secondary batteries, the universal water-based zinc-based battery electrolyte additive is a nitroimidazole organic matter, contains an imidazole ring and a nitryl group, and is characterized in that the nitroimidazole organic matter is a nitroimidazole organic matter; the high-electronegativity zinc ion electrode has one or more functional groups of methyl, hydroxyl, carboxyl, carbonyl, imino, sulfo and halogen, nitryl can be reduced to form imino or imidazole is subjected to ring opening to form an azo compound in the electrochemical process, and high-electronegativity sites can be adsorbed on the surface of the electrode or interact with zinc ions. Nitrogen sites with high electronegativity can be adsorbed to the surface of the zinc negative electrode, contact between water and the zinc negative electrode is isolated, a hydrogen evolution reaction and a corrosion side reaction are limited, the electrochemical environment of an electrode interface is stabilized, and the electrolyte additive can promote 3D diffusion of zinc ions, reduce the critical nucleation size of zinc deposition and inhibit growth of zinc dendrites.

The invention relates to a composite membrane of a zeolite imidazate framework (ZIF-71) and a polypropylene (PP) membrane in a metal organic framework, a preparation method of the composite membrane and application of the composite membrane in a non-aqueous flow battery, belongs to the technical field of flow batteries, and provides a ZIF-71 / PP composite membrane which is prepared through different in-situ growth methods and has different surface appearances. The in-situ grown 2-nitroimidazole zinc zeolite imidazate framework layer with different morphologies can effectively prevent active substances from crossing and crossing in the non-aqueous flow battery. In addition, the excellent performance of the non-aqueous flow battery verifies that the composite diaphragm of the metal organic framework and the polypropylene can still keep the structural integrity during long-term operation in an organic medium.

This invention discloses a zinc-based mixed imidazole ligand metal-organic framework (ZIF) adsorbent material for highly efficient separation of CF4 / N2 and its preparation method. By strategically controlling the ratio of benzimidazole and 2-nitroimidazole ligands, a series of ZIF materials with large specific surface areas and suitable pore structures for adsorbing and separating CF4 / N2 are prepared. The 2-nitroimidazole provides a certain polarization effect to the framework, and its own electron-withdrawing effect and relatively long Zn-N bond length (easily broken) make it suitable as a parent material for ligand exchange. The benzene ring on the benzimidazole provides more adsorption sites for the framework. The metal-organic framework adsorbent material prepared by this invention can achieve highly efficient adsorption of CF4 and selective separation of CF4 / N2, exhibiting excellent performance and significant economic and social benefits.

The invention relates to a nitroimidazole group meso-substituted heptamethine cyanine dye as well as a preparation method and application thereof. According to the dye, a nitroimidazole group is introduced into the middle position of a heptamethine cyanine parent nucleus, so that the dye has excellent absorption characteristics in a near-infrared region, the excitation wavelength is 730-780 nm, the emission wavelength is 800-860 nm, and the dye has good tissue penetrating power. The nitroimidazole group can effectively quench fluorescence in an excited state through a light-induced electron transfer effect, energy is promoted to be released in a non-radiative transition mode, the photothermal conversion efficiency is remarkably improved, and meanwhile high light stability and low fluorescence quantum yield are kept. The dye can be further prepared into a nano preparation and shows excellent biocompatibility and tumor targeting ability. The compound has wide application prospects in the fields of non-diagnostic or therapeutic protein labeling, bioimaging, photothermal therapy and the like, is especially suitable for preparing efficient photosensitive reagent drugs for tumor photothermal therapy, and provides a new strategy for design of near-infrared photothermal diagnosis and treatment materials.

The application provides a copper-nitroimidazole complex which is self-assembled by coordination of copper ions and 2-nitroimidazole. The complex only contains copper ions and 2-nitroimidazole, and the simple two-component combination can realize the chemical kinetics treatment of GSH metabolism enhancement and induce iron death. The copper-nitroimidazole complex has GSH response and hypoxia responsiveness as a nanodrug, and can selectively act in tumor cells. The nanodrug releases copper ions and 2-nitroimidazole in tumor cells, 2-nitroimidazole consumes NADPH under hypoxic conditions to hinder the synthesis of GSH, and copper ions also consume GSH. The consumption of GSH enhances the Cu 2+ / Cu + mediated Fenton reaction to produce active oxygen. 2-nitroimidazole and copper ions self-assemble to form a nanodrug, which greatly improves the loading capacity of 2-nitroimidazole.

The present invention provides use of a rifamycin-nitroimidazole conjugate molecule, or deuterated derivatives thereof, metabolites thereof, pharmaceutically acceptable salts thereof, or prodrugs thereof in the preparation of a drug for the treatment or prevention of a disease caused by Mycobacterium tuberculosis infection. The rifamycin-nitroimidazole conjugate molecule has a structure represented by formula I.The rifamycin-nitroimidazole conjugate molecule or the deuterated derivatives thereof, the metabolites thereof, the pharmaceutically acceptable salts thereof, or the prodrugs thereof in the present invention inhibit Mycobacterium tuberculosis comprising multi-drug-resistant (MDR) and extensive drug-resistant Mycobacterium tuberculosis (XDR-TB), and then are used for treating or preventing infections and a disease caused by Mycobacterium tuberculosis.

The invention belongs to the technical field of medicines, and particularly relates to a nitroimidazole oxazole derivative as well as a preparation method and application thereof. The invention provides a nitroimidazo oxazole derivative as shown in a formula I. The nitroimidazo oxazole derivative shows better in-vivo and in-vitro anti-tuberculosis activity, has good solubility and bioavailability, can be used for treating diseases caused by mycobacterium tuberculosis infection, and is particularly suitable for diseases caused by drug-resistant mycobacterium tuberculosis.

The application aims to provide a preparation method of high-purity phosphonic acid levonikosazol ester disodium hydrate, which has the advantages of controllable reaction condition, stable quality, high yield and suitability for industrial production, etc.

The invention relates to a hypoxia targeting hyaluronic acid nano delivery system and a construction method and application thereof, the construction method comprises the following preparation method: S1, dissolving 2-nitroimidazole and K2CO3 in dimethylformamide, carrying out high temperature alkali treatment, adding N-Boc-bromoethylamine, and carrying out high temperature reaction to obtain Boc-NIH; s2, dissolving the Boc-2-NIH in dichloromethane, adding trifluoroacetic acid for deprotection, and adjusting the pH value to be neutral, so as to obtain 2-NIH; s3, dissolving HA in deionized water, sequentially adding EDC and NHS to activate carboxyl, then adding 2-NIH, reacting at room temperature, and dialyzing to obtain a hypoxic targeting hyaluronic acid nano delivery carrier HA-NIH; s4, HA-NIH loads a drug, and the hypoxia targeted hyaluronic acid nano delivery system is formed. According to the invention, a bifunctional nano system with CD44 active targeting and hypoxia response release is successfully constructed, a dynamic regulation and control mechanism of HA molecular weight on a targeting-permeation-retention effect is provided, and a synergistic effect of tumor stem cell microenvironment specific response and drug space-time release is realized.

Oxadiazole antibiotics that exhibit bactericidal activity against C. difficile vegetative cells. We screened a library of 75 oxadiazoles against C. difficile ATCC 43255. The findings from this collection served as the basis for the syntheses of an additional 58 analogs, which were tested against the same strain. We discovered a potent (MIC50=0.5 μg / mL, MIC90=1 μg / mL for 101 C. difficile strains) and narrow-spectrum oxadiazole (3-(4-(cyclopentyloxy)phenyl)-5-(4-nitro-1H-imidazol-2-yl)-1,2,4-oxadiazole; compound 57) that is not active against common gut bacteria or other tested organisms, but is selectively bactericidal against C. difficile and targets cell-wall synthesis. Other similarly effective oxadiazole antibiotics of formula I and II are described herein, several of which inhibit or prevent C. difficile spore germination.

The invention relates to a semi-solid electrolyte and a preparation method and application thereof, and belongs to the technical field of lithium ion secondary batteries. The semi-solid electrolyte provided by the invention is prepared from a polymerizable monomer, a lithium salt, an initiator and a deep eutectic solution according to a specific proportion. The deep eutectic solution is composed of a hydrogen bond acceptor and a hydrogen bond donor containing nitryl. Wherein the hydrogen bond acceptor is a lithium salt, and the hydrogen bond donor is one or more of a nitrourea-containing material, a nitrosulfonyl-containing material and a nitroimidazole-containing material. By introducing the deep eutectic solution into the semi-solid electrolyte, the movement capability of a polymer chain segment can be improved, so that the ionic conductivity of the semi-solid electrolyte at room temperature is improved. In addition, a nitro-containing hydrogen bond donor in the deep eutectic solution is beneficial for forming a stable solid electrolyte interface film on the interface of the negative electrode and the positive electrode. When the electrolyte is applied to the lithium ion battery, the electrolyte shows good stability with a positive electrode and a negative electrode, and the cycling stability of the battery can be improved.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a fully continuous flow preparation method and system of nitroimidazole antibacterial drugs. According to the method, glyoxal is taken as a starting raw material, a full-continuous device system consisting of a plurality of micro-mixers, micro-reactors, gas-liquid separators and on-line solvent switching and low-boiling-point reagent feeding equipment which are communicated in sequence is used, and the high-purity nitroimidazole antibacterial drugs are obtained through multi-step chemical reaction and continuous post-treatment processes. The sulfuric acid and formic acid are recycled and reused, the use amount of the sulfuric acid can be reduced by more than 60%, the generation of waste acid and waste salt is effectively reduced, the production efficiency and the process control accuracy are greatly improved, the stable product quality is ensured, and the production cost is reduced.

This invention belongs to the field of pharmaceutical formulations and relates to a compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection, its preparation method, and its application. By weight percentage, the compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection comprises 0.1-2.0% of a nitroimidazole compound, 0.05-3.0% of an isoxazoline compound, 0.1-1.5% of a gelling polymer, 1.0-8.0% of a complex solubilizing system, 0.1-3.0% of pharmaceutically acceptable excipients, and the balance being water. The complex solubilizing system includes polyvinylpyrrolidone and cyclodextrin derivatives. This invention effectively solves the problem of poor solubility of isoxazoline drugs through a complex solubilizing system, and the combination of the two drugs has a significant synergistic acaricidal effect. Combined with a gelling polymer, it can achieve in-situ gelation on the ocular surface, prolong retention, and sustained drug release, with low ocular irritation, providing a highly effective, long-lasting, and safe new local treatment option for Demodex mite-related eye diseases.

The invention provides a metal organic framework for removing reactive oxygen free radicals in cigarette smoke as well as a preparation method and application of the metal organic framework. The metal organic framework comprises a three-dimensional porous organic framework formed by coordination assembly of organic ligands and metal ions, the organic ligand comprises any one of 2-methylimidazole, 1-methylimidazole and 2-nitroimidazole; the organic ligand comprises any one of 2-methylimidazole, 1-methylimidazole and 2-nitroimidazole; the metal ions comprise cerium ions and manganese ions; the molar ratio of the organic ligand to the metal ions is (20-30): (80-95); the molar ratio of the cerium ions to the manganese ions is (35-43): (45-52). In the metal organic framework provided by the invention, an organic ligand is used as a basic framework, metal ions are used as connecting nodes, and the formed nano structure has activity similar to catalase and superoxide dismutase, is high in thermal stability and large in specific surface area, can effectively catalyze and remove reactive oxygen free radicals in cigarette smoke, and can be used for preparing cigarette smoke. The harm of cigarette smoke to a human body is reduced.

The present application relates to photoresist stripping liquid technical field, especially to a kind of photoresist organic stripping liquid and its preparation method and application.The present application provides a kind of photoresist organic stripping liquid, according to mass fraction, including organic amine 10~30 parts, ether / alcohol organic solvent 70~90 parts and additive 1~5 parts;The additive includes 1-(2-hydroxyethyl) piperazine, N-(2-hydroxyethyl) ethylenediamine, methyl benzene propyl triazoles, imino dipropylamine, 2,4-dihydroxy pyrimidine, succinic acid, N-ethyl pyrrolidone, 1-methyl-5-nitroimidazole, thiourea, 4-hydroxy butyric acid lactone, citric acid, glucose, gluconic acid and malic acid one or several kinds.The photoresist organic stripping liquid has higher stripping efficiency and stripping effect, energy saving and environmental protection, while avoiding strong corrosive substance.

The invention discloses a synthesis method of a tetra-substituted (4-nitroimidazole) borane compound, which comprises the following steps: adding anhydrous CH2Cl2 into a single-mouth flask at-20 DEG C, mixing 4-nitroimidazole with the anhydrous CH2Cl2, quickly injecting BCl3, and stirring; the subsequent reaction is detected through 11B NMR to ensure that BCl3 is completely converted; after filtering, washing by using a mixed solution of ethanol and acetonitrile, and filtering and drying to obtain white powder, namely a target compound with a structural formula as shown in the specification. The tetra-substituted (4-nitroimidazole) borane compound disclosed by the invention is relatively good in density sensitivity, relatively simple in synthesis method and relatively mild in reaction condition.

The invention discloses a preparation method of a nitro-functionalized ZIF-25-mnImx material and application of the nitro-functionalized ZIF-25-mnImx material in separation of acetoin and 2, 3-butanediol, and belongs to the field of inorganic functional materials. The preparation method comprises the following steps: mixing and dissolving 4, 5-dimethylimidazole (dmeIm), 4-methyl-5-nitroimidazole (mnIm) and Zn (OAc) 2.2 H2O in methanol, and reacting at 120 DEG C for 24 hours; and after the reaction is finished, washing an obtained yellowish-brown sample with methanol for multiple times, and filtering and drying at room temperature to obtain the ZIF-25-mnImx material. The nitro-functionalized ZIF-25-mnImx provided by the invention has relatively high adsorption capacity on acetoin in a biological fermentation liquid, so that the separation cost of the biological fermentation liquid is reduced; due to the existence of a competitive mechanism, acetoin is preferentially adsorbed in a mixed solution, so that the method is suitable for separating acetoin and 2, 3-butanediol from a low-concentration aqueous solution, and has a wide application prospect.

The application relates to a preparation method of high-purity moricizine, specifically, 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole and morpholine are used as raw materials, reaction is carried out under alkaline conditions, and then recrystallization is carried out to obtain moricizine, the reaction conditions, especially the crystallization mode, are optimized, the yield of the moricizine crude product can reach more than 90%, the total yield after refining can reach more than 85%, the purity can reach 100%, and the 30kg-level pilot test verification is carried out, the process has good reproducibility, and is suitable for large-scale production.

We provide safe mitochondrial uncoupling agents. [Solution] The present invention provides 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole, a novel phenyl derivative, or a pharmaceutically acceptable salt thereof. This compound is useful for regulating mitochondrial activity, reducing obesity, and treating diseases including diabetes and diabetic complications.

The application relates to the oil field chemical technology field, and particularly discloses an oil field corrosion and bactericidal treatment agent and a preparation method thereof, the preparation method comprises the following steps: (1) reacting epichlorohydrin, a long-chain alkyl tertiary amine and a nitroimidazole compound to obtain an imidazole heterocyclic double quaternary ammonium salt; (2) dissolving the imidazole heterocyclic double quaternary ammonium salt in an organic solvent to form an organic phase, dispersing quercetin-ovophospholipid in water to form an aqueous phase, mixing the organic phase and the aqueous phase, adding a composite emulsifier, uniformly stirring and obtaining the oil field corrosion and bactericidal treatment agent. The imidazole heterocyclic double quaternary ammonium salt is wrapped by quercetin-ovophospholipid to form a core-shell structure, the bactericidal performance of the agent is improved, and the oil field corrosion and bactericidal treatment agent is endowed with long-acting performance.

The invention relates to the field of fine chemical engineering, and discloses a method for continuously synthesizing 2-methyl-5-nitroimidazole based on a microchannel reactor, which comprises the following steps: 1) mixing 2-methylimidazole with concentrated sulfuric acid to obtain a mixture A; 2) mixing fuming nitric acid with glacial acetic acid to obtain a mixture C; 3) taking acetic anhydride as a material B, simultaneously, respectively and continuously conveying the mixture A, the material B and the mixture C into a microchannel reactor for nitration reaction, and controlling the temperature to be 10-30 DEG C; 4, quenching reaction is conducted after the reaction, solids are neutralized and separated out, and filtering, washing and drying are conducted to obtain the 2-methyl-5-nitroimidazole. According to the method, a low-temperature nitration system (10-30 DEG C) is adopted, yellow smoke can be prevented from being generated, the oxidation reaction can still be effectively inhibited under the condition that ammonium sulfate is not added, and therefore the purity and yield of the product can be effectively improved.

The application discloses a zeolite-like imidazole framework material and a preparation method and application thereof, and comprises the following steps: adding benzimidazole, 4-nitroimidazole and a zinc source into an amide solvent to mix, to obtain a mixed solution; after heating and reacting the mixed solution, cooling, washing and drying, the zeolite-like imidazole framework material is obtained. In the reaction process of benzimidazole and the zinc source, 4-nitroimidazole is added, the benzimidazole in the original structure of ZIF-7 is replaced by 4-nitroimidazole, a polar group (-NO2) is introduced, the NO2-ZIF-7-0.4 zeolite-like imidazole framework material is obtained, the pore size is concentratedly distributed in the vicinity, is highly matched with the kinetic diameter of Rn atoms, the original narrow window of the ZIF-7 material is widened, the limitation of the window on the diffusion of Rn atoms in the adsorption material is avoided, the limited effect and the polarization effect are synergistically effective, and the adsorption performance of the modified ZIF-7 material on Rn is increased.

The invention discloses a metal-based (copper or manganese) nitroimidazole derivative nano-enzyme as well as a preparation method and application thereof. After phenylboronic acid or dopamine is modified by a nitroimidazole skeleton, the nitroimidazole skeleton is complexed with metal ions to form nano-particles (NPs), so that the solubility of the nano-particles can be improved, various biological molecules and microorganisms can be combined in a targeted manner, the generation and evolution of drug-resistant strains can be weakened or inhibited, and the antibacterial activity can be enhanced. The preparation method is simple, the preparation conditions are mild, the operation is simple, the obtained copper-based nitroimidazole derivative nano-enzyme has excellent POD-like activity, the obtained manganese-based nitroimidazole derivative nano-enzyme has excellent CAT-like activity, and the two metal nano-enzymes both have good anti-staphylococcus aureus activity.

The invention discloses application of H36-E4 in preparation of a medicine for preventing and treating chronic kidney diseases, the chemical name of the H36-E4 is 1-(1-methyl-4-nitro-1H-imidazole-5-yl)-4-piperidinecarboxamide (1-(1-methyl-4-nitro-1H-idazol-5-yl)-4-piperidinecarboxamide), the molecular formula of the H36-E4 is C10H15N5O3, and the CAS number of the H36-E4 is 688310-17-0. The compound can remarkably improve the renal fibrosis degree of a chronic kidney disease model mouse, so that the effect of improving the chronic kidney disease is achieved, and the compound has a good clinical application prospect.

The application discloses a medicine composition for killing trichomonas vaginalis, and the active ingredients of the medicine composition are composed of fibraureus and metronidazole; the mass ratio of the fibraureus and the metronidazole is 1:1-8:1; in the process of killing the trichomonas vaginalis, the concentration of the fibraureus is 0.01-0.04 g / L, and the concentration of the metronidazole is 0.005-0.02 g / L. The medicine composition can effectively kill the trichomonas vaginalis, the fibraureus combined with the metronidazole can effectively reduce the medication time and the dosage of the metronidazole, can avoid the risk of premature delivery of pregnancy medication, and can reduce the health problems of breast-feeding infants during the medication period; the problems of adverse reactions and drug resistance of the metronidazole and other nitroimidazole drugs in treating trichomonas vaginalis disease are solved; the application provides a theoretical basis for treating drug-resistant trichomonas vaginalis vaginitis by combining traditional Chinese medicine with western medicine, and further expands the clinical application of the fibraureus.

The invention provides an interpenetrating network anti-tumor hydrogel with body temperature gelling and heat release functions as well as a preparation method and application of the interpenetrating network anti-tumor hydrogel. The preparation method comprises the following steps: (1) dissolving 6-(2-nitroimidazole) hexanoic acid, EDC (ethylene dichloride) and NHS (N-Hydroxysuccinimide) in an aqueous solution of DMF (Dimethyl Formamide); then adding an amino chitosan acid solution for reaction; after the reaction is finished, precipitating and centrifuging to obtain CS-NI; (2) dissolving CS-NI in an acetic acid solution, and adding NIPAM, ammonium persulfate and TEMED to obtain a gel A solution; and mixing the gel A solution and the gel B solution to perform gel forming reaction to obtain the hydrogel, wherein the glue solution B is obtained by adding acrylamide on the basis of the glue solution A. According to the in-situ injection hydrogel prepared by the invention, the synergistic treatment effect of starvation therapy and thermal therapy is obtained for the first time.

Described herein are compositions, methods, and kits for detecting antibiotic resistance genes in a sample, such as a wound swab. One embodiment described herein is primer pairs and probes for individual or multiplex polymerase chain reaction (PCR) based assays for the detection of one or more antibiotic resistance gene targets comprising resistance to molecularly characterized extended-spectrum β-lactamases (MESBLs); extended-spectrum β-lactamases (ESBLs); carbapenemase; AmpC β-lactamase; β-lactamase; lincosamide, macrolide, streptogramin; trimethoprim; macrolides; methicillin; colistin; sulfonamide; tetracycline; vancomycin; nitroimidazole; quinolone; or aminoglycoside.

The invention relates to the field of pharmaceutical preparations, in particular to a preparation method and application of a stable nitroimidazole ophthalmic pharmaceutical composition. Specifically, the invention relates to an ophthalmic pharmaceutical composition, which comprises a nitroimidazole drug, a solubilizer, a stabilizer, a thickener, an osmotic pressure regulator and a pH regulator, and the stabilizer comprises a block polymer. The invention also relates to a preparation method of the ophthalmic pharmaceutical composition and application of the ophthalmic pharmaceutical composition in prevention / treatment of demodex blepharitis and meibomian gland dysfunction.

The application discloses a continuous synthesis process of dimetridazole raw medicine. The application specifically discloses a preparation method of dimetridazole, which comprises the following steps: introducing a heterogeneous suspension into a tubular reactor to prepare dimetridazole through a substitution reaction; and the heterogeneous suspension contains 2-methyl-5-nitroimidazole, dimethyl sulfate and an aromatic hydrocarbon solvent. The preparation method has one or more of the following advantages: high safety, simple operation, high yield, easy control of reaction progress, difficulty in generation of double-substituted impurities and fast reaction speed.

The present application relates to the technical field of medicine, in particular to a potential genotoxic impurity in a morpholine nitroimidazole raw material and preparation and a preparation method and application thereof.The potential genotoxic impurity is 2-methyl-5-nitro-1-nitrosoimidazole.A new structure compound 2-methyl-5-nitro-1-nitrosoimidazole of diazoles is found in the synthesis process of the morpholine nitroimidazole raw material for the first time.The compound is identified as a potential genotoxic impurity because of containing a nitrosamine warning structure.A method for analyzing the potential genotoxic impurity 2-methyl-5-nitro-1-nitrosoimidazole by using ultra-high performance liquid chromatography-mass spectrometry is established for the first time, which is of great significance to the quality control of the morpholine nitroimidazole raw material and preparation.The detection method provides a reference for the quality evaluation of other starting materials, intermediates and raw materials that can produce 2-methyl-5-nitro-1-nitrosoimidazole.