80 results about "Nitroimidazole" patented technology

The invention discloses a colorectal cancer radiotherapy sensitization medicine and application thereof, belongs to the field of biological medicine, and particularly relates to a colorectal cancer radiotherapy sensitization medicine which comprises active pharmaceutical ingredients and a solvent, the active pharmaceutical ingredients comprise doxorubicin and a nitrogen-containing compound, the nitrogen-containing compound comprises quinoline-6-carbohydrazide and N-benzyloxymethyl-4-nitroimidazole, and the nitrogen-containing compound comprises quinoline-6-carbohydrazide and The colorectal cancer radiotherapy sensitization medicine disclosed by the invention focuses on a key driving gene FOXP4 for colorectal cancer radiotherapy resistance, and FOXP4 protein is degraded through a ubiquitin-proteasome way, so that not only can the sensitivity of tumor cells to radiotherapy be remarkably improved and tumor growth be inhibited, but also damage to normal tissues is reduced; moreover, the problem of drug resistance easily generated by a traditional method is effectively avoided, the research and development cost is greatly reduced, clinical transformation is accelerated, and the method has a good clinical application prospect.

The present invention belongs to the technical field of radiopharmaceutical chemistry and nuclear medicine diagnosis and treatment and relates to a radiolabeled FAPI complex, a preparation method therefor, and a use thereof. The general structural formula of FAPI capable of realizing radionuclide labeling is as shown below: wherein R is a nitroimidazole group or -COOH; X is a chelating group or a chelating structure chelated with a radionuclide; L1 and L2 are linking groups; and A is an adjusting atom of an FAP-targeting group, and all the A atoms are H atoms or F atoms. The synthesis method for a radionuclide-labeled precursor of the present invention is simple and suitable for various nuclide labels, the labeling method is convenient, and the label has high radiochemical purity and good stability. The radiolabeled FAPI complex shows high affinity and specificity for FAP in a cell experiment and a high tumor uptake and target to non-target ratio in a tumor-bearing mouse, and is a potential FAP-targeting radioactive diagnosis and treatment drug.

The invention discloses a universal water-based zinc-based battery electrolyte additive and a battery preparation method, and particularly relates to the technical field of water-based zinc-based secondary batteries, the universal water-based zinc-based battery electrolyte additive is a nitroimidazole organic matter, contains an imidazole ring and a nitryl group, and is characterized in that the nitroimidazole organic matter is a nitroimidazole organic matter; the high-electronegativity zinc ion electrode has one or more functional groups of methyl, hydroxyl, carboxyl, carbonyl, imino, sulfo and halogen, nitryl can be reduced to form imino or imidazole is subjected to ring opening to form an azo compound in the electrochemical process, and high-electronegativity sites can be adsorbed on the surface of the electrode or interact with zinc ions. Nitrogen sites with high electronegativity can be adsorbed to the surface of the zinc negative electrode, contact between water and the zinc negative electrode is isolated, a hydrogen evolution reaction and a corrosion side reaction are limited, the electrochemical environment of an electrode interface is stabilized, and the electrolyte additive can promote 3D diffusion of zinc ions, reduce the critical nucleation size of zinc deposition and inhibit growth of zinc dendrites.

The present invention provides a zeolite imidazolate skeleton polycrystalline membrane and a preparation method thereof, comprising: S1: preparing a precursor solution containing metal ions and organic ligands, coating the precursor solution on a carrier, and heating and cooling the carrier coated with the precursor solution to prepare an amorphous film; the precursor solution includes a metal salt, an organic ligand, and a solvent; the zeolite imidazolate skeleton material is composed of a metal node, an organic ligand A, and an organic ligand B; the organic ligand A is imidazole-2-formaldehyde or 2-methylimidazole, and the organic ligand B is selected from 2-methylimidazole, benzimidazole, 2-aminobenzimidazole, 4,5-dichloroimidazole, 2-nitroimidazole, and 4-methylimidazole-5-formaldehyde; and the solvent is methanol. S2: treating the amorphous film with steam generated by heating a polar solvent to form a crystalline film; S3: activating the crystalline film with a volatile solvent; and the present invention prepares a continuous, dense, defect-free zeolite imidazolate skeleton membrane with strong carrier binding and gas separation performance.

The invention discloses a method for removing nitro compounds in water by pyrite-mediated atomic hydrogen reduction. The method comprises the following steps: (1) washing and drying natural pyrite, and grinding by using a ball mill to obtain a grey black powder catalyst; (2) placing the catalyst in an aqueous solution of nitroimidazole or nitrobenzene at normal temperature and normal pressure, then adding sodium borohydride, and continuously bubbling the solution with inert gas; (3) adding a low catalyst (0.8 g / L) and using amount (lt) of sodium borohydride; according to the method, under the condition that the initial concentration is 0.16 g / L, metronidazole, ornidazole and tinidazole with the initial concentration being 20 ppm are thoroughly removed within 1 min, the removal rate of 0.6 mM nitrobenzene within 20 min reaches 98.98%, and a main reduction product is a corresponding amino compound. Natural pyrite is used as a catalyst to generate atomic hydrogen through mediation, the process is simple, reagents are safe, and a practical strategy is provided for reducing nitro compound pollution in the water environment.

The invention relates to a composite membrane of a zeolite imidazate framework (ZIF-71) and a polypropylene (PP) membrane in a metal organic framework, a preparation method of the composite membrane and application of the composite membrane in a non-aqueous flow battery, belongs to the technical field of flow batteries, and provides a ZIF-71 / PP composite membrane which is prepared through different in-situ growth methods and has different surface appearances. The in-situ grown 2-nitroimidazole zinc zeolite imidazate framework layer with different morphologies can effectively prevent active substances from crossing and crossing in the non-aqueous flow battery. In addition, the excellent performance of the non-aqueous flow battery verifies that the composite diaphragm of the metal organic framework and the polypropylene can still keep the structural integrity during long-term operation in an organic medium.

The utility model discloses a purification treatment device for 2-methyl-5-nitroimidazole, which relates to the technical field of chemical equipment and comprises a cleaning box, the lower end of the cleaning box is connected with a first connector of a three-way valve, a second connector of the three-way valve is connected with a crystallization box, and a third connector of the three-way valve is connected with a collection box for temporarily storing liquid discharged from the cleaning box. The cleaning device comprises a cleaning box, a cover plate used for sealing the cleaning box is arranged on the cleaning box, a lifting device is arranged on the cover plate, the lifting device is used for supporting 2-methyl-5-nitroimidazole to ascend and descend to make contact with water in the cleaning box for cleaning, and the lifting device comprises a telescopic rod arranged on the cover plate. A fixed block is arranged at the top of the telescopic rod and used for pushing the fixed block to ascend and descend, and a movable rod is connected to one side of the fixed block. According to the cleaning device for the 2-methyl-5-nitroimidazole, the lifting device is arranged, so that the 2-methyl-5-nitroimidazole can be lifted to be in contact with water for cleaning, the cleaning effect is improved, the water in the cleaning box can better clean the 2-methyl-5-nitroimidazole, and the cleaning time is saved.

The invention discloses an osthole derivative shown in a general formula 3 in the technical field of organic chemistry. The substituent group R of # imgabs0 is nitroimidazole, substituted nitroimidazole, nitrobenzimidazole or nitrotriazole; and n is 3 or 4. The invention further relates to application of the compound shown in the general formula 3 to preparation of antibacterial drugs independently or in combination with antibacterial active ingredients, and bacteria comprise any one of bacteroides fragilis, anaerobic peptostreptococcus, staphylococcus aureus and escherichia coli.

This invention discloses a zinc-based mixed imidazole ligand metal-organic framework (ZIF) adsorbent material for highly efficient separation of CF4 / N2 and its preparation method. By strategically controlling the ratio of benzimidazole and 2-nitroimidazole ligands, a series of ZIF materials with large specific surface areas and suitable pore structures for adsorbing and separating CF4 / N2 are prepared. The 2-nitroimidazole provides a certain polarization effect to the framework, and its own electron-withdrawing effect and relatively long Zn-N bond length (easily broken) make it suitable as a parent material for ligand exchange. The benzene ring on the benzimidazole provides more adsorption sites for the framework. The metal-organic framework adsorbent material prepared by this invention can achieve highly efficient adsorption of CF4 and selective separation of CF4 / N2, exhibiting excellent performance and significant economic and social benefits.

The invention belongs to the field of medicinal chemistry, and particularly discloses a preparation method and application of a nitroimidazole derivative serving as an anti-tumor radiosensitizer. According to the invention, nitroimidazole is used as a lead compound, and a framework of nitroimidazole is modified through a series of reactions to obtain the novel nitroimidazole derivative. The compound can target a tumor hypoxia region, is reduced by a specific enzyme highly expressed in a hypoxia tumor tissue, and is combined with nucleophilic biological macromolecular free radicals generated by radiation to accelerate cancer cell death. As an anti-tumor radiosensitizer, the compound disclosed by the invention is expected to improve the tumor cell selectivity of the compound and reduce toxic and side effects, and is used for subsequent anti-tumor activity research.

The invention relates to a nitroimidazole group meso-substituted heptamethine cyanine dye as well as a preparation method and application thereof. According to the dye, a nitroimidazole group is introduced into the middle position of a heptamethine cyanine parent nucleus, so that the dye has excellent absorption characteristics in a near-infrared region, the excitation wavelength is 730-780 nm, the emission wavelength is 800-860 nm, and the dye has good tissue penetrating power. The nitroimidazole group can effectively quench fluorescence in an excited state through a light-induced electron transfer effect, energy is promoted to be released in a non-radiative transition mode, the photothermal conversion efficiency is remarkably improved, and meanwhile high light stability and low fluorescence quantum yield are kept. The dye can be further prepared into a nano preparation and shows excellent biocompatibility and tumor targeting ability. The compound has wide application prospects in the fields of non-diagnostic or therapeutic protein labeling, bioimaging, photothermal therapy and the like, is especially suitable for preparing efficient photosensitive reagent drugs for tumor photothermal therapy, and provides a new strategy for design of near-infrared photothermal diagnosis and treatment materials.

The application provides a copper-nitroimidazole complex which is self-assembled by coordination of copper ions and 2-nitroimidazole. The complex only contains copper ions and 2-nitroimidazole, and the simple two-component combination can realize the chemical kinetics treatment of GSH metabolism enhancement and induce iron death. The copper-nitroimidazole complex has GSH response and hypoxia responsiveness as a nanodrug, and can selectively act in tumor cells. The nanodrug releases copper ions and 2-nitroimidazole in tumor cells, 2-nitroimidazole consumes NADPH under hypoxic conditions to hinder the synthesis of GSH, and copper ions also consume GSH. The consumption of GSH enhances the Cu 2+ / Cu + mediated Fenton reaction to produce active oxygen. 2-nitroimidazole and copper ions self-assemble to form a nanodrug, which greatly improves the loading capacity of 2-nitroimidazole.

The invention discloses a metal organic framework compound constructed by an antibacterial agent as well as a preparation method and application of the metal organic framework compound, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving a soluble metal salt and 2-nitroimidazole in an organic solvent, carrying out a mixed reaction, centrifuging to obtain a precipitate, and cleaning the precipitate to obtain the metal organic framework compound. An antibacterial drug metal organic framework compound with ultrasonic and acid responsiveness is constructed by utilizing a single antibacterial agent, active oxygen and active nitrogen can be generated under ultrasonic stimulation, meanwhile, controllable release of the antibacterial agent in a biological membrane infected slightly-acidic environment is achieved, and the antibacterial drug metal organic framework compound has a good antibacterial effect on deep tissue bacterial infection. The compound shows a potential application effect on prevention of oral caries.

The present invention provides use of a rifamycin-nitroimidazole conjugate molecule, or deuterated derivatives thereof, metabolites thereof, pharmaceutically acceptable salts thereof, or prodrugs thereof in the preparation of a drug for the treatment or prevention of a disease caused by Mycobacterium tuberculosis infection. The rifamycin-nitroimidazole conjugate molecule has a structure represented by formula I.The rifamycin-nitroimidazole conjugate molecule or the deuterated derivatives thereof, the metabolites thereof, the pharmaceutically acceptable salts thereof, or the prodrugs thereof in the present invention inhibit Mycobacterium tuberculosis comprising multi-drug-resistant (MDR) and extensive drug-resistant Mycobacterium tuberculosis (XDR-TB), and then are used for treating or preventing infections and a disease caused by Mycobacterium tuberculosis.

The invention belongs to the technical field of medicines, and particularly relates to a nitroimidazole oxazole derivative as well as a preparation method and application thereof. The invention provides a nitroimidazo oxazole derivative as shown in a formula I. The nitroimidazo oxazole derivative shows better in-vivo and in-vitro anti-tuberculosis activity, has good solubility and bioavailability, can be used for treating diseases caused by mycobacterium tuberculosis infection, and is particularly suitable for diseases caused by drug-resistant mycobacterium tuberculosis.

The invention belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, and relates to a preparation method and application of a co-assembled nano preparation for targeting glioblastoma. The preparation method comprises the following steps: firstly, synthesizing a nitroimidazole dimer with tumor hypoxia-oxidation-reduction triple response, and assembling the nitroimidazole dimer with AOH1996 and HRO761 to prepare the nano preparation. The molar ratio of the AOH1996 to the HRO761 to the nitroimidazole dimer is 1 to 2 to (0.5 to 2). The key scaffold protein PCNA for DNA repair is blocked by the PCNA inhibitor AOH1996, and recruitment and anchoring functions of the key scaffold protein PCNA on repair factors are destroyed, so that the glioblastoma is induced to enter a mismatch repair defect state. On the basis, a WRN inhibitor HRO761 is further used for promoting large-scale breakage of chromosomes and finally inducing cell death. The nitroimidazole dimer and the nitroimidazole dimer are jointly assembled into the nano preparation, and accurate drug release is realized in response to a hypoxia state and oxidation and reduction signals overexpressed in a tumor microenvironment, so that the heterogeneity of the tumor microenvironment is overcome.

The application aims to provide a preparation method of high-purity phosphonic acid levonikosazol ester disodium hydrate, which has the advantages of controllable reaction condition, stable quality, high yield and suitability for industrial production, etc.

The invention relates to a hypoxia targeting hyaluronic acid nano delivery system and a construction method and application thereof, the construction method comprises the following preparation method: S1, dissolving 2-nitroimidazole and K2CO3 in dimethylformamide, carrying out high temperature alkali treatment, adding N-Boc-bromoethylamine, and carrying out high temperature reaction to obtain Boc-NIH; s2, dissolving the Boc-2-NIH in dichloromethane, adding trifluoroacetic acid for deprotection, and adjusting the pH value to be neutral, so as to obtain 2-NIH; s3, dissolving HA in deionized water, sequentially adding EDC and NHS to activate carboxyl, then adding 2-NIH, reacting at room temperature, and dialyzing to obtain a hypoxic targeting hyaluronic acid nano delivery carrier HA-NIH; s4, HA-NIH loads a drug, and the hypoxia targeted hyaluronic acid nano delivery system is formed. According to the invention, a bifunctional nano system with CD44 active targeting and hypoxia response release is successfully constructed, a dynamic regulation and control mechanism of HA molecular weight on a targeting-permeation-retention effect is provided, and a synergistic effect of tumor stem cell microenvironment specific response and drug space-time release is realized.

Oxadiazole antibiotics that exhibit bactericidal activity against C. difficile vegetative cells. We screened a library of 75 oxadiazoles against C. difficile ATCC 43255. The findings from this collection served as the basis for the syntheses of an additional 58 analogs, which were tested against the same strain. We discovered a potent (MIC50=0.5 μg / mL, MIC90=1 μg / mL for 101 C. difficile strains) and narrow-spectrum oxadiazole (3-(4-(cyclopentyloxy)phenyl)-5-(4-nitro-1H-imidazol-2-yl)-1,2,4-oxadiazole; compound 57) that is not active against common gut bacteria or other tested organisms, but is selectively bactericidal against C. difficile and targets cell-wall synthesis. Other similarly effective oxadiazole antibiotics of formula I and II are described herein, several of which inhibit or prevent C. difficile spore germination.

The invention relates to a semi-solid electrolyte and a preparation method and application thereof, and belongs to the technical field of lithium ion secondary batteries. The semi-solid electrolyte provided by the invention is prepared from a polymerizable monomer, a lithium salt, an initiator and a deep eutectic solution according to a specific proportion. The deep eutectic solution is composed of a hydrogen bond acceptor and a hydrogen bond donor containing nitryl. Wherein the hydrogen bond acceptor is a lithium salt, and the hydrogen bond donor is one or more of a nitrourea-containing material, a nitrosulfonyl-containing material and a nitroimidazole-containing material. By introducing the deep eutectic solution into the semi-solid electrolyte, the movement capability of a polymer chain segment can be improved, so that the ionic conductivity of the semi-solid electrolyte at room temperature is improved. In addition, a nitro-containing hydrogen bond donor in the deep eutectic solution is beneficial for forming a stable solid electrolyte interface film on the interface of the negative electrode and the positive electrode. When the electrolyte is applied to the lithium ion battery, the electrolyte shows good stability with a positive electrode and a negative electrode, and the cycling stability of the battery can be improved.

The present invention relates to the technical field of pharmaceutical synthesis, and specifically discloses a method for synthesizing morinidazole. First, the present invention performs a substitution reaction between morpholine and epichlorohydrin to obtain the intermediate 4-(2,3-epoxypropyl)morpholine; then, 4-(2,3-epoxypropyl)morpholine is subjected to a condensation reaction with 2-methyl-5-nitroimidazole to obtain a material system containing morinidazole; and then, through salification and liberation, morinidazole is obtained. Using morpholine, epichlorohydrin, and 2-methyl-5-nitroimidazole as raw materials, the raw materials are all bulk chemicals, the product quality is stable, and the price is low. The synthesis method of the present invention has a simple operation process, relatively mild reaction conditions, and low preparation cost. The purity of the prepared morinidazole can reach more than 99.9%, and the total yield can reach more than 73%, which is suitable for large-scale industrial production and has good industrial prospects and social benefits.

The present invention provides a preparation method and application of a magnetic imprinted polymer, which includes mixing the vinylated Fe3O4 microspheres, virtual template, functional monomer, and porogen, standing still to form a prepolymer, and then carrying out a polymerization reaction with a crosslinking agent and an initiator. The product is ground, the template is removed, and then vacuum dried to obtain the magnetic imprinted polymer. The magnetic imprinted polymer prepared by the present invention has high affinity and specific adsorption for nitroimidazole drugs, and has broad application potential as a magnetic dispersive solid-phase extraction material for the pretreatment of environmental samples and animal food matrices.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a fully continuous flow preparation method and system of nitroimidazole antibacterial drugs. According to the method, glyoxal is taken as a starting raw material, a full-continuous device system consisting of a plurality of micro-mixers, micro-reactors, gas-liquid separators and on-line solvent switching and low-boiling-point reagent feeding equipment which are communicated in sequence is used, and the high-purity nitroimidazole antibacterial drugs are obtained through multi-step chemical reaction and continuous post-treatment processes. The sulfuric acid and formic acid are recycled and reused, the use amount of the sulfuric acid can be reduced by more than 60%, the generation of waste acid and waste salt is effectively reduced, the production efficiency and the process control accuracy are greatly improved, the stable product quality is ensured, and the production cost is reduced.

This invention belongs to the field of pharmaceutical formulations and relates to a compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection, its preparation method, and its application. By weight percentage, the compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection comprises 0.1-2.0% of a nitroimidazole compound, 0.05-3.0% of an isoxazoline compound, 0.1-1.5% of a gelling polymer, 1.0-8.0% of a complex solubilizing system, 0.1-3.0% of pharmaceutically acceptable excipients, and the balance being water. The complex solubilizing system includes polyvinylpyrrolidone and cyclodextrin derivatives. This invention effectively solves the problem of poor solubility of isoxazoline drugs through a complex solubilizing system, and the combination of the two drugs has a significant synergistic acaricidal effect. Combined with a gelling polymer, it can achieve in-situ gelation on the ocular surface, prolong retention, and sustained drug release, with low ocular irritation, providing a highly effective, long-lasting, and safe new local treatment option for Demodex mite-related eye diseases.

The invention provides a metal organic framework for removing reactive oxygen free radicals in cigarette smoke as well as a preparation method and application of the metal organic framework. The metal organic framework comprises a three-dimensional porous organic framework formed by coordination assembly of organic ligands and metal ions, the organic ligand comprises any one of 2-methylimidazole, 1-methylimidazole and 2-nitroimidazole; the organic ligand comprises any one of 2-methylimidazole, 1-methylimidazole and 2-nitroimidazole; the metal ions comprise cerium ions and manganese ions; the molar ratio of the organic ligand to the metal ions is (20-30): (80-95); the molar ratio of the cerium ions to the manganese ions is (35-43): (45-52). In the metal organic framework provided by the invention, an organic ligand is used as a basic framework, metal ions are used as connecting nodes, and the formed nano structure has activity similar to catalase and superoxide dismutase, is high in thermal stability and large in specific surface area, can effectively catalyze and remove reactive oxygen free radicals in cigarette smoke, and can be used for preparing cigarette smoke. The harm of cigarette smoke to a human body is reduced.

Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole or a pharmaceutically acceptable salt thereof to a subject in need thereof. 5-[(2,4-Dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole is useful in treating mitochondria-related disorders or conditions including obesity, diabetes, hypertension, cardiovascular disease, and liver diseases.

The present application relates to photoresist stripping liquid technical field, especially to a kind of photoresist organic stripping liquid and its preparation method and application.The present application provides a kind of photoresist organic stripping liquid, according to mass fraction, including organic amine 10~30 parts, ether / alcohol organic solvent 70~90 parts and additive 1~5 parts;The additive includes 1-(2-hydroxyethyl) piperazine, N-(2-hydroxyethyl) ethylenediamine, methyl benzene propyl triazoles, imino dipropylamine, 2,4-dihydroxy pyrimidine, succinic acid, N-ethyl pyrrolidone, 1-methyl-5-nitroimidazole, thiourea, 4-hydroxy butyric acid lactone, citric acid, glucose, gluconic acid and malic acid one or several kinds.The photoresist organic stripping liquid has higher stripping efficiency and stripping effect, energy saving and environmental protection, while avoiding strong corrosive substance.

The invention discloses a synthesis method of a tetra-substituted (4-nitroimidazole) borane compound, which comprises the following steps: adding anhydrous CH2Cl2 into a single-mouth flask at-20 DEG C, mixing 4-nitroimidazole with the anhydrous CH2Cl2, quickly injecting BCl3, and stirring; the subsequent reaction is detected through 11B NMR to ensure that BCl3 is completely converted; after filtering, washing by using a mixed solution of ethanol and acetonitrile, and filtering and drying to obtain white powder, namely a target compound with a structural formula as shown in the specification. The tetra-substituted (4-nitroimidazole) borane compound disclosed by the invention is relatively good in density sensitivity, relatively simple in synthesis method and relatively mild in reaction condition.

The invention discloses a preparation method of a nitro-functionalized ZIF-25-mnImx material and application of the nitro-functionalized ZIF-25-mnImx material in separation of acetoin and 2, 3-butanediol, and belongs to the field of inorganic functional materials. The preparation method comprises the following steps: mixing and dissolving 4, 5-dimethylimidazole (dmeIm), 4-methyl-5-nitroimidazole (mnIm) and Zn (OAc) 2.2 H2O in methanol, and reacting at 120 DEG C for 24 hours; and after the reaction is finished, washing an obtained yellowish-brown sample with methanol for multiple times, and filtering and drying at room temperature to obtain the ZIF-25-mnImx material. The nitro-functionalized ZIF-25-mnImx provided by the invention has relatively high adsorption capacity on acetoin in a biological fermentation liquid, so that the separation cost of the biological fermentation liquid is reduced; due to the existence of a competitive mechanism, acetoin is preferentially adsorbed in a mixed solution, so that the method is suitable for separating acetoin and 2, 3-butanediol from a low-concentration aqueous solution, and has a wide application prospect.

The application relates to a preparation method of high-purity moricizine, specifically, 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole and morpholine are used as raw materials, reaction is carried out under alkaline conditions, and then recrystallization is carried out to obtain moricizine, the reaction conditions, especially the crystallization mode, are optimized, the yield of the moricizine crude product can reach more than 90%, the total yield after refining can reach more than 85%, the purity can reach 100%, and the 30kg-level pilot test verification is carried out, the process has good reproducibility, and is suitable for large-scale production.