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Leishmania /liːʃˈmeɪniə/ is a genus of trypanosomes that are responsible for the disease leishmaniasis. They are spread by sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World. At least 93 sandfly species are proven or probable vectors worldwide. Their primary hosts are vertebrates; Leishmania commonly infects hyraxes, canids, rodents, and humans.
Azido tellurium ether derivative, and preparation method and application thereof
The application belongs to the technical field of organic synthesis chemistry, and particularly relates to an azido tellurium ether derivative and a preparation method and application thereof. In an organic solvent, an olefin, ditelluride and azidotrimethylsilane are used as raw materials, and a stirring reaction is carried out under the presence of a photocatalyst and under the condition of visible light irradiation to obtain the azido tellurium ether derivative. The method has mild reaction conditions, simple operation, high yield and good functional group compatibility, and conforms to the principle of green chemistry. Meanwhile, the azido tellurium ether derivative provided by the application has good inhibitory activity on Leishmania, which provides a drug lead compound for the development of a new type of antiparasitic drug, and has important significance for the prevention and / or treatment of Leishmaniasis.
Owner:NANTONG UNIV