103 results about "Microtubule" patented technology

Microtubule encapsulated microcapsules of a phase-change material and preparation thereof are provided. The microcapsules of a phase-change material consist of a phase-change material, truncated microtubules, and a polymer. The truncated microtubules are formed by truncating hollow tubular natural fibers into fiber segments with a length of 0.1 mm-5 cm. The diameter of the hollow tubular natural fiber is 0.1-1000 μm. The phase-change material is encapsulated in the truncated microtubules and the truncated microtubules are covered with the polymer. The microtubules have high energy storage density due to high hollowness, and can transfer energy stably due to the closed structure, transfer heat rapidly due to the very fine micro-tubular structures, and may be used for a long term in view of the heat and chemical stability.

The present disclosure relates to energy storage or collection devices and methods for making such devices having electrode materials containing exfoliated nanotubes with attached electro- or photoactive nanoscale particles or layers.

The exfoliated nanotubes and attached nanoscale particles or layers may be easily fabricated by methods such as coating, solution or casting or melt extrusion to form electrodes. Electrolytes may also be used for dispersing nanotubes and also in a polymeric form to allow melt fabrication methods.

The invention relates to a preparation method of moss scanning electron microscope observation material. The method includes: sorting, to be more specific, sorting moss materials from biological crusts, and stripping leaves after cleaning; fixing, to be more specific, fixing the leaves in glutaraldehyde solution, and washing with buffer solution; dehydrating step by step with alcohol with gradient concentration; replacing, to be more specific, placing the leaves in ethanol-isoamyl acetate mixture for replacing, and placing the leaves in isoamyl acetate solution for replacing; critical point drying; loading onto a table. The method has the advantages that the method is simple and practical, and good in effect, the glutaraldehyde solution serving as the fixing solution is good in fixing effect on polysaccharide, glycoprotein, microtubule and the like, tissue cells do not become brittle after fixing, the influence of leaf cell surface tension can be avoided by the critical point drying, and the microstructures of samples are well preserved; reference is provided for the preparation of ideal moss samples, and the technical blank of related fields in China is filled.

The invention discloses a sulfonamide compound and medicinal compositions thereof, and preparation methods and applications thereof. The sulfonamide compound can be used as a micro-molecular tubulin inhibitor, has an anti-microtubule effect in vitro, can induce the apoptosis of tumor cells in vitro, has an obvious inhibition effect on multidrug resistance cells in vitro, and has a substantial in-vivo oral antitumor activity. Additionally, the compound has the advantages of small molecular weight, simple synthesis, and small toxic side effects. The invention also provides medicinal compositions containing the sulfonamide compound and pharmaceutically acceptable salts thereof as an active component.

The invention provides a preparation method of a magnesium alloy microtubule and a special-purpose die. The preparation method comprises the following key steps: preparation of a cast magnesium alloy blank material; preparation of an ultra-fine grained blank material by a composite die; and the magnesium alloy microtubule is extruded by using an integrated heating method for the blank material and the die. The blank making mould of the magnesium alloy microtubule comprises a male die component, a female die component, and a guiding component, and a composite die is designed for conical die forward extrusion and equal channel angular extrusion. The ultra-fine grained medical magnesium alloy microtubule has the advantages of good mechanical properties, superior corrosion resistance, and high precision. The shaping process is high efficient and practical, the process is easy to operate, and subsequent processing processes are effectively simplified.

The invention discloses a microtubule-associated protein and coding genes and application thereof. The microtubule-associated protein is protein of (a) or (b): (a) protein formed by an amino acid sequence as shown by a sequence one in a sequence table; and (b) protein derived by the sequence one, related to the inhibition of the microtubule de-polymerization activity of MCAK protein and formed ina way the amino acid sequence of the sequence one is substituted and/or deleted and/or added by one to ten amino acid residues. The protein of the invention participates in the regulation and the control of the forward end dynamics of microtubules through the mutual effect with EB1 and MCAK and stabilizes the microtubules through inhibiting the microtubule de-polymerization activity of the MCAK protein. After the coding genes of the low-interference RNA of microtubule-associated protein genes are introduced into a host, the microtubule positioning of the MCAK is seriously affected. The protein and the coding genes thereof play a great role in the medical field and the pharmaceutical field and thereby the application prospect is wide.

The invention discloses an ultrathin-wall microtubule production device and a production method thereof. The ultrathin-wall microtubule production device comprises a nitrogen gas cylinder, a pressure reducing valve, a PU (poly urethane) tube, a caliber conversion device, a thick-wall microtubule, a left microtubule gripper, a right microtubule gripper, another caliber conversion device, a high-precision barometer, a back pressure valve, a long-stroke and high-precision micro displacement platform, a hydrogen-oxygen producing machine, a gas dryer, a gas flow controller, a flame gun, a flame-gun clamping device and a short-stroke and high-precision micro displacement platform. The production method includes that nitrogen with precisely-controlled barometric pressure enters an inner cavity of the microtubule, from the caliber conversion device, to apply outward pressure upon a tubule wall of the microtubule; oxyhydrogen with precisely-controlled flow rate forms oxyhydrogen flame, at a position of a nozzle of the flame gun, to evenly heat the thick-wall microtubule; the microtubule grippers with precisely-controlled speed and distance evenly stretch the microtubule to obtain the ultrathin-wall microtubule finally. The ultrathin-wall microtubule produced by the method is smooth in the tubule wall, a resonant cavity is constructed to ensure a good field evanescent function and a high Q value, and the time for producing one ultrathin-wall microtubule is less than 30 minutes.

The present application discloses a novel carbazole sulfonamide derivative eutectic and a preparation method thereof. The carbazole sulfonamide derivative eutectic is formed by oxalic acid, maleic acid, malonic acid or glutaric acid, and a carbazole sulfonamide derivative, has an antimicrotubular effect, and significant tumor resistance, and has the advantages of simple synthesis, small side effects, and high dissolution rate and solubility.

The present invention discloses an extra-high sensitive magnetic field sensor based on multiple-mode interference optical microcavity. Microfiber, a microtubule and a magnetofluid are fixedly sealed to form an optical microcavity; the microfiber is wound around the microtubules in a spiral mode; the microtubule is hollow and internally packaged with the magnetofluid; the input end and the output of the microfiber are respectively connected with a broadband optical source and a spectrum analyzer; the part of the microfiber winding the outer wall of the microtubule is taken as a fiber wrapping region, and the electromagnetic wave is able to generate multiple-mode interference wherein; the electromagnetic wave is emitted by the broadband optical source and is transmitted to the fiber wrapping region through the microfiber; and the evanescent wave part of the electromagnetic wave in the fiber wrapping region is able to pass through the microtubule wall into the magnetofluid, pass through the electromagnetic wave of the optical microcavity and then pass through the microfiber to output to a spectrum analyzer. The extra-high sensitive magnetic field sensor based on a multiple-mode interference optical microcavity is provided with a structure winding the microfiber onto the microtubule so as to greatly increase the contact of the electromagnetic wave and the magnetofluid, and therefore the sensitivity is higher.

A method of creating a model of a biological cell. The method features providing a circular base with indentations disposed therein, forming a cell membrane and at least one organelle from a mixture formed by mixing all-purpose flour and water. Organelles may include a nuclear membrane, a cell wall, mitochondria, a smooth endoplasmic reticulum (ER), a rough ER, a vacuole, a golgi apparatus, a nucleolus, a nucleoplasm, chromatin, a ribosome, DNA, RNA, transcription machinery, a histone, and a microtubule. The outside edge of the base is lined with the cell membrane. The organelles are inserted into indentations or atop the base. The organelles can be secured with glue.

The invention discloses a histone deacetylase and microtubule dual target inhibitor and a preparation method thereof. The inhibitor is as shown in I) or II) in description, and the inhibitor has the dual inhibitory activity of microtubules and histone deacetylase simultaneously.

The present invention discloses a photoelectric composite cable for high-definition multimedia transmission. The cable comprises electrical units, an optical unit, reinforcers and over sheaths. The reinforcers are arranged at the upper side and the lower side of the optical unit, the upper portions of the reinforcers are provided with the electrical units, the electrical units, the reinforcers and the optical unit are coated with the over sheaths, the electrical units are insulation electron beams or twisted wires, the optical unit comprises a tight tube optical fiber or an optical fiber microtubule located at the center, a reinforcement layer is coated with the tight tube optical fiber or the optical fiber microtubule, the reinforcement layer performs external plastic extruding of an inner sheath, and the inner sheath is coated with a waterproof layer. The photoelectric composite cable has good stretching resistance and flattening resistance performances, the optical unit portion has water-blocking and flame retardation performances and good bending resistance performance and can be used in the outdoor hostile environment, the optical fiber is employed to perform data transmission to effectively perform interference resisting, the transmission distance is long, the transmission capacity is large, and the optical unit and the electrical units are easy to be separated so as to facilitate processing the composite cable into a connector module in later period.

The purification of native RB (retinoblastoma) as a complex, including P107, P130, and a 600 kDa subunit, termed MTAF600 (microtubule associated factor 600) is described. MTAF600 binds to RB regardless of the phosphorylation status of RB, and binds to RB without disrupting the interaction between RB and E2F. It is further shown that E2F and DP proteins co-purified with MTAF600 and RB, such that hypophosphorylated RB may gain access to E2F as a complex with MTAF600. In addition, MTAF600 binds to microtubules and plays a role in active repression of E2F-responsive genes, cell cycle arrest, and genomic stability. The sequence of MTAF600 is described herein, along with its binding properties to proteins such as RB and microtubules, and its sequence homology. Further, methods and reagents for assaying the presence of MTAF600 or mutants thereof, pharmaceutical formulations, and methods for treating disease are also described.

The invention discloses a method of single time measurement of atractylenolide and atractylon. The procedure includes preparing mobile phase resolution A and B made of chromatographic pure methanol, acetonitrile and redistilled water, preparing the mixed control solution made of atractylenolide I, atractylenolide III and atractylon, preparing sample solution, testing the three absorption peaks of control solution and samples at three different time respectively by chromatograph of liquid according to the setting gradient of mobile phase A and B and the time, and calculating the content of atractylenolide I, atractylenolide III and atractylon according to the formula X=(peak area of sample is multiplied by density of control then is divided by peak area of control and is multiplied by density of sample) is multiplied by 100 percent. The invention can determine the content of atractylenolide I, atractylenolide III and atractylon in atractylodes macrocephala by only one sample injection. Thus the operation is simplified, the error of multiple sample injection is reduced and analysis of the constituent ration of the three ingredients is convenient. The invention is of important academic value and meaningful in practical application.

The invention relates to a combination comprising (a) a compound selected from the class of prostaglandins and (b) a compound selected from the class of tubulin/microtubule interfering agents and/or (c) a compound selected from the class of cyclooxygenase inhibitors.

Disclosed are compounds of formula (1)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.