6 results about "Microtubule" patented technology

The present disclosure relates to polynucleotides and methods of inhibiting the activities of development-associated pathways, including the Wnt, Hedgehog, and Notch pathways, and the invasive capacity of malignant cells to treat primary or secondary solid tumors.

The application discloses a kind of porous carbon load PEDOT microtubule composite water collection materials and preparation method and application thereof, belong to water collection material preparation field.The material includes porous carbon and its surface load PEDOT microtubule, and the PEDOT microtubule is poly 3,4-ethylenedioxythiophene with microtubule structure.The preparation of the material is that oxidizing compound M and carbon source are mixed, carbonization is carried out to obtain porous carbon precursor;Again, the porous carbon precursor is polymerized with 3,4-ethylenedioxythiophene monomer and acid in closed environment to obtain.The composite water collection material of the application shows efficient, fast, reversible atmospheric water capture capacity in wide humidity range, and excellent cycle stability, with significant engineering practical value and industrialization prospect.

The utility model provides a quick -plug formula microtubule reducing joint of sealing structure area belongs to precision instrument technical field. Including the connector, still including the reinforcement subassembly, reinforcement subassembly includes setting up the support pipe of connector one side, the one side of support pipe all is seted up with the sliding slot, the inside of sliding slot is provided with the rolling ball and slides, the one side of support pipe is provided with the connecting soft pad, reinforcement subassembly at the time of use, support pipe plays the basic support effect, sliding slot provides the sliding space for the rolling ball, and the rolling ball can be in the flexible movement in the groove, be used for adjusting position, and the connecting soft pad can enhance the sealing property in the connection, reduce the attrition between parts, thereby make the whole reinforcement subassembly realize the effect of firm connection and good sealing in use, the connecting pipe's fixed groove and the connecting soft pad of support pipe joint, enhance the connection sealing property, the connecting pipe slot place is equipped with the rotating shaft, and the shaft interlocking block can rotate around the shaft, and the spring piece of slot place connects the interlocking block, provides the elasticity.

The present invention provides a medicine for treating a neurodegenerative disease, which employs LEFTY2 (Left-Right Determination Factor 2) generated by co-culturing mesenchymal stem cells of mammals with nerve cells having mutations in the APP (Amyloid precursor protein) gene, or a specific protein. The LEFTY2 has an effect of inhibiting Beta amyloid and a hyperphosphorylated neuronal microtubule-associated protein (Tau protein), without affecting the development of nerve cells and having the ability to promote the growth of the nerve cells; and the two types of proteins have a crucial impact on the neurodegenerative diseases.

The present application provides a compound shown in formula (I), a pharmaceutical composition and a preparation method and application thereof. The compound has good KIF18A inhibition effect, can be combined with microtubules to form a complex to regulate KIF18A protein, is used for treating KIF18A-mediated diseases and / or diseases, such as tumor diseases, and is used for preparing medicines for such diseases or diseases.

The present application provides a compound shown in formula (I), a pharmaceutical composition and a preparation method and application thereof. The compound has good KIF18A inhibition effect, can be combined with microtubules to form a complex to regulate KIF18A protein, is used for treating KIF18A-mediated diseases and / or diseases, such as tumor diseases, and is used for preparing medicines for such diseases or diseases.