34 results about "Ketogenic diet" patented technology

The embodiments of the present invention relate to a stable liquid vigabatrin pharmaceutical compositions in the liquid form of a solution. Particularly, the stable vigabatrin liquid pharmaceutical composition is manufactured as a ready-to-use industrialized premixture that does not require reconstitution or dilution prior to administration to a patient. The vigabatrin liquid pharmaceutical composition is stable six months or longer at room temperature and has levels of total impurities and Vigabatrin-related compound A that are both not more than 0.04% at, or prior to, six months. In some embodiments, the composition has improved stability and patient compliance. In some embodiments, the compositions may be advantageous for the patients having swallowing difficulties or when the patients are unable to take solid oral dosage forms. In some embodiments, the composition improves compliance with ketogenic diet.

The embodiments of the present invention relate to a stable liquid vigabatrin pharmaceutical compositions in the liquid form of a solution. Particularly, the stable vigabatrin liquid pharmaceutical composition is manufactured as a ready-to-use industrialized premixture that does not require reconstitution or dilution prior to administration to a patient. The vigabatrin liquid pharmaceutical composition is stable six months or longer at room temperature and has levels of total impurities and Vigabatrin-related compound A that are both not more than 0.04% at, or prior to, six months. In some embodiments, the composition has improved stability and patient compliance. In some embodiments, the compositions may be advantageous for the patients having swallowing difficulties or when the patients are unable to take solid oral dosage forms. In some embodiments, the composition improves compliance with ketogenic diet.

The invention provides application of a compound azelaic acid in preparation of a medicine for preventing and treating sepsis acute lung injury. Animal experiments show that azelaic acid is highly enriched in intestinal tracts and lungs of mice with ketogenic diet and is closely related to the occurrence and development process of sepsis acute lung injury. The compound azelaic acid can obviously inhibit lung inflammatory cell infiltration, inflammatory factor generation and lung cell apoptosis on the animal level, and can be used for preparing the medicine for preventing and treating acute lung injury caused by sepsis.

Disclosed are a system, techniques and processes for monitoring and modifying a drug treatment regimen when a user partakes in a ketogenic diet. The disclosed system obtains ketone level measurements of a user and indicates a user's adherence to the ketogenic diet as well as modifying a user's total daily dosage of a drug based on the user's following the ketogenic diet.

The invention provides a ketogenic diet component or composition as well as a preparation method and application thereof, and relates to the technical field of foods. According to the ketogenic diet component or composition, the ghee replaces lard oil to serve as a fat source, the ghee moistens intestines and stomach, harmonizes spleen and warms middle, and the ketogenic diet component or composition is rich in various fatty acids beneficial to a human body, such as unsaturated fatty acids, medium-short chain fatty acids and the like, and further contains nutritional ingredients such as vitamin A, vitamin D, vitamin E, vitamin K and the like; the butter contains high medium-chain and short-chain fatty acids which can be quickly absorbed and utilized by a human body, so that quick energy is provided for the brain and the body, and the metabolic rate is increased. The ghee has rich milk flavor, so that the taste and flavor of ketogenic diet food can be remarkably improved, and the acceptability and satisfaction of consumers are improved. The ghee is in a solid state at normal temperature, is easy to store and transport, has good stability in the cooking process, is not easy to oxidize and deteriorate, and can keep the quality and nutrition of food for a long time.

A composition contains a combination of at least one fiber and at least one probiotic and is formulated for administration to a subject in a condition of challenged gut microbiome such that the combination of at least one fiber and at least one probiotic improves and / or maintains optimal cholesterol levels in a subject in a condition of challenged gut microbiome. Preferably the subject is experiencing a microbiome stressor, such as one or more of a dietary stressor, antibiotic, other medications, infections, intense exercise, stress, alcohol, travel and combinations thereof; more preferably at least a dietary stressor; most preferably at least a high fat diet, such as a Western high fat diet or a ketogenic diet. The method can achieve at least one result that is improving and / or maintaining optimal cholesterol levels in a subject in a condition of challenged gut microbiome.

In various aspects and embodiments, the disclosure provides methods for treating a patient with a CAR-T therapy or improving chimeric antigen receptor (CAR)-T therapy, the methods including administering to a subject in need thereof a therapeutically effective amount of a CAR-T therapy and a ketogenic composition comprising a ketogenic diet, beta-hydroxybutyrate (BHB), a BHB salt, a BHB precursor, a ketone diester, or a combination thereof.

The invention relates to a hotpot condiment adopting D-psicose and a preparation method of the hotpot condiment. The preparation method comprises the following steps: combining X parts by weight of D-psicose with Y parts by weight of a compound composition, blending with a flavoring to form a substantially homogeneous flavoring composition; adding the oil material into a pot, heating to 200 DEG C, cooling, pouring the tomato sauce, boiling to 95 DEG C, and continuously stirring until the oil material and the tomato sauce are completely fused; controlling the temperature to be reduced to 80 DEG C or below, adding a seasoning composition, and stirring at constant temperature to form the hotpot condiment. According to the invention, D-psicose is adopted to replace white sugar, so that'health attribute upgrading and flavor naturalization 'are realized, and the problem of harm to the body caused by long-term consumption of white sugar is solved. The requirements of modern consumers on low-sugar and low-calorie diets are met. Different from a traditional high-sugar base material, health declarations such as low cards and the like can be marked, and the global sugar reduction trend is met. The hot pot can cover traditional hot pot evaders such as diabetic people, healthy people and ketogenic eaters, and the customer group is expanded.

Methods are provided for treating and diagnosing diseases and disorders associated with retinal degeneration, such as retinitis pigmentosa. Dietary supplementation with specific metabolites and vitamins can prolong vision and provide a neuroprotective effect. In particular, dietary supplementation with a-ketoglutarate, or a derivative thereof, significantly prolongs photoreceptor cell survival and visual function. In addition, dietary supplementation with B vitamins and a ketogenic diet also improves photoreceptor cell survival and delays disease progression in some cases. Additionally, compositions, methods, and kits are provided for diagnosing a subject with retinitis pigmentosa based on expression levels of vitreous biomarkers.

The composition contains a combination of at least one type of fiber and at least one type of probiotic, and the combination of at least one type of fiber and at least one type of probiotic is formulated for administration to a subject with a stressed gut microbiome to improve and / or maintain optimal cholesterol levels in the subject with a stressed gut microbiome. Preferably, the subject is experiencing one or more microbiome stressors, e.g., dietary stressors, antibiotics, other drugs, infections, strenuous exercise, stress, alcohol, travel, and combinations thereof; more preferably, at least dietary stressors; most preferably, at least a high-fat diet, e.g., a Western high-fat diet or a ketogenic diet. The method can achieve at least one outcome, which is improving and / or maintaining optimal cholesterol levels in a subject with a stressed gut microbiome.

Beta-hydroxybutyrate (BHB) mineral salts and / or beta-hydroxybutyrate (βHB) free acid in combination with 1,3-butanediol (1,3-BD) were used to induce ketosis, achieving blood ketone levels of (2-7 mmol / L), with or without dietary restriction. A combination of the ketogenic compounds, βHB acid and / or βHB salt in together with 1,3BD was more than additive. What has been unknown until now, and what was unexpected is that the specific combination of the partially buffered βHB free acid, (created as a mixture of βHB free acid and βHB salt), together with 1,3-BD in a particular combination is far more than additive. When used together this mixture raises serum levels far higher, up to 70% higher, than would be expected by using 1,3BD together with βHB salt and / or BHB acid. The synergistic combination is 5 times more powerful at raising serum βHB than the enantiomerically pure acid or salt alone and 1.23 times more powerful than the corresponding enantiomerically pure ester compounded from βHB and 1,3-BD. Given the far higher potency, it is now possible to deliver a suitably buffered formulation orally or intravenously in order to achieve a variety of therapeutic benefits without exceeding unsafe salt loads which have in the past, prevented the widespread use of ketone salt and acid. The concurrent co-administration of these compounds is useful to improve metabolic health, cognitive performance, physical performance, enhance disease prevention, mitigate the damage of Ischemia Reperfusion Injury and provide a fuel substrate that is not affected by glucose impairment associated with neurodegenerative diseases. Elevated serum ketones have demonstrated to improve the cognitive function in persons suffering from neurodegenerative diseases such as Alzheimer's and Parkinson's Diseases by providing fuel starved neurons a direct source of fuel, that unlike glucose, is not effected by the glucose and pyruvate dehydrogenase impairments described extensively in the brains of patients suffering from neurodegenerative diseases. This invention results in rapid keto adaptation, which is useful for the avoidance of glucose withdrawal symptoms or “keto flu” commonly experienced by individuals initiating a ketogenic diet. It also minimizes the loss of lean body mass during dietary restriction and does not adversely impact lipid profiles.

The invention belongs to the field of diet management, and particularly discloses a diet management system and a diet management method for type 2 diabetes mellitus through combination of food failure and ketogenesis, and the system comprises an applicable population screening module which is configured to lock patients based on biochemical indexes; the blood ketone dynamic monitoring module is configured to detect a blood ketone value in real time through a micro-fluidic chip sensor; the nutrition execution module is configured to output the following stage schemes: a feed-off period scheme; a ketogenic stage scheme; a transitional period scheme; according to the invention, through the staged management of the food failure combined ketogenic diet, in combination with the precise screening of suitable people, the dynamic monitoring of blood ketogen and the scientific configuration of a nutrition scheme, the blood glucose index of the type 2 diabetes mellitus patient can be effectively improved, and at the same time, by supplementing electrolyte, compound nutrients, antioxidants and the like, the intestinal health is maintained, the mitochondrial function is improved, and the blood uric acid is regulated and controlled, so that the health of the type 2 diabetes mellitus patient is improved. And after the HbA1c reaches the standard, the patient is assisted to smoothly transit to low-sugar diet, so that scientific management and control on the type 2 diabetes mellitus are realized.

Provided herein is an endophytic ketone composition comprising (i) a lipid portion comprising 45 to 65 g of a lipid, (ii) a carbohydrate portion comprising 5 to 12 g of a digestible carbohydrate, and (iii) a protein portion comprising 15 to 25 g of a protein per 100 g of a ketogenic composition, and its therapeutic use, the endophytic ketone composition comprising (i) a lipid portion comprising 45 to 65 g of a lipid, (ii) a carbohydrate portion comprising 5 to 12 g of a digestible carbohydrate, and (iii) a protein portion comprising 15 to 25 g of a protein per 100 g of the ketogenic composition, the ketogenic weight ratio of the endophytic ketogenic composition is between 1.5: 1 and 3.0: 1.

The present invention relates to a baking mixture comprising micropowdered fat for preparing different food products. The purpose of this product is to provide a baking mixture comprising palm oil in a minimum amount of 60% w / w and other ingredients compatible with a ketogenic diet. The composition was specifically designed to prepare a wide range of ketogenic food products, such as brownies, waffles and arepas.

Ketogenic food formulations comprising fats, fibers, possibly carbohydrates and proteins, wherein the formulations comprise beta-hydroxybutyrate (BHB) di- and poly-esters, and medium chain triglycerides (MCTs) and the formulations for use in a ketogenic diet or for use by individuals affected by particular physiological and / or pathological conditions, on the basis of which particular dietary regimens characterized by a low carbohydrate content may be recommended and beneficial; as well as food products comprising the ketogenic food formulations.

An operating method of a ketogenic dietary evaluation system includes steps as follows. The electroencephalogram data of a responder group and the electroencephalogram data of a non-responder group are preloaded, in which each electroencephalogram datum includes electroencephalograms of channels. The electroencephalograms of the channels are preprocessed to obtain the preprocessed electroencephalograms of the channels. A connectivity matrix is obtained on a basis of the phase synchronization between each two of the preprocessed electroencephalograms of the channels. The connectivity matrix is sampled and analyzed through different frequency bands and different proportion threshold values to obtain graphical parameters. A predictive model is established on a basis of a reduction rate of a predetermined event of the responder group, a reduction rate of the predetermined event of the non-responder group and the parameters.

The invention discloses a qualified ketogenic diet evaluation method and application thereof, and belongs to the technical field of healthy diet evaluation.The method comprises the steps that diet data recorded by multiple users are obtained and preprocessed to obtain a data set, a heterogeneous graph of the data set is constructed, and a ketogenic diet evaluation result is obtained; a graph neural network is adopted to carry out characterization analysis on the composition to obtain a knowledge graph corresponding to the recipe information, a message propagation network is adopted to carry out optimization analysis on the knowledge graph according to the recipe information to obtain a user health model, and qualified ketogenic diet evaluation is carried out on each user based on the user health model and a preset evaluation index to obtain an evaluation result; through multi-dimensional data collection and analysis, the evaluation quality and accuracy of the ketogenic diet are improved, personalized healthy diet recommendation is provided for the user, and thus powerful support is provided for reasonable application and effective management of the ketogenic diet.

A dough composition and manufacturing process suitable for a ketogenic diet, a low-carbohydrate diet, a sugar-restricted diet, and / or a gluten-restricted diet. The dough composition comprises psyllium powder 4% by weight; chewing gum 2% to 4% by weight; pea protein 16-20% by weight; pea fiber 18-49% by weight; and chickpea flour 0-27% by weight. Another dough composition comprises cauliflower powder 0-8% by weight; psyllium powder 5-10% by weight; flaxseed flour 0-10% by weight; pea protein 15-36% by weight; pea fiber 18-46.5% by weight; and oat flour 0-25% by weight. Finally, another dough composition comprises psyllium powder 10% by weight; cauliflower powder between 0-12.5% ​​by weight; pea protein between 18-31.5% by weight; pea fiber between 22-42% by weight; baking powder between 1-3.25% by weight; and salt between 0.75-1.7% by weight.

The invention discloses a preparation method of a zero-carbohydrate dairy product, which comprises the following steps: S1, performing purification treatment on raw milk, degreasing, and separating to obtain cream and skimmed milk; s2, feeding the skimmed milk into membrane separation equipment through a pump, and performing circular treatment for 10-60 minutes to obtain a concentrated solution; s3, adding an eluent at 60-70 DEG C into the concentrated solution in the step S3, and continuously circulating for 20-40 minutes; s4, sampling and detecting the contents of lactose and total carbohydrates in the concentrated solution, backfilling cream, and homogenizing; and S5, circulating the homogenized material at 60-70 DEG C for 20-40 minutes to complete pasteurization, and performing hot filling to obtain the carbohydrate-free dairy product. According to the preparation method of the zero-carbohydrate milk product, lactose and various oligosaccharides in skimmed milk can be thoroughly stripped, the carbohydrate content of the final product is less than or equal to 0.5 g / 100g, the zero-carbohydrate standard is really achieved, the strict requirements of ketogenic diet, diabetic patients and sugar-controlled people are completely met, and the market prospect is wide. And blood sugar fluctuation and metabolic burden caused by sugar intake are avoided from the source.

The application discloses a preparation method of a modified ketogenic diet composition and application thereof, and the ketogenic diet composition is prepared by the following steps: obtaining a protein peptide mixture by fermenting glycosylated lupin protein and collagen by probiotics; and then forming an oil gel by shearing and emulsifying the protein peptide mixture, coconut oil, sunflower seed oil and thiolated chitosan, loading inulin, betaine and baicalin, and compounding vitamins and mineral elements. The solubility and interfacial activity of the protein peptide can be improved by the fermentation of the probiotics, a stable polysaccharide-protein peptide covalent network is constructed by combining the thiolated chitosan to form a compact three-dimensional gel structure, the oil holding capacity of the oil gel is greatly improved, the oil gel can maintain the structure intact in gastric acid, and the active ingredients can be responsively degraded and released after entering the intestinal tract; in addition, the probiotics can degrade methionine, threonine and tryptophan contained in the protein, reduce the supply of key amino acids for the proliferation of glioma cells, and strengthen the metabolic intervention and tumor inhibition effect of baicalin and betaine, so that the target metabolic adjuvant treatment of the ketogenic diet is realized.

The disclosure relates to a method of treating cancer or reducing the risk of recurrence of cancer in a subject, the method comprising administering to the subject an inhibitor of Monocarboxylate Transporter 1 (MCT1). In one embodiment, the cancer is associated with overexpression of CD147 in one or more tumor initiating cells. In one embodiment, the cancer comprises lung cancer such as non-small cell lung cancer (NSCLC). In one embodiment, the cancer is a ketone-dependent cancer. In one embodiment, the subject is one who has been provided a ketogenic diet.

The invention discloses a method for constructing a fat-rich hepatocellular carcinoma mouse model based on combination of high-pressure hydrodynamic injection and ketogenic diet and application, and belongs to the technical field of biomedicine. Expression plasmids containing Nras oncogene, Myc oncogene and sleeping beauty transposase are introduced into the body of a mouse in a high-pressure hydrodynamic tail vein injection mode, the ratio of the volume of a plasmid solution to the body weight of the mouse is 0.1 mL / g, injection is conducted within 5-8 seconds, and the plasmids enter hepatocytes; after injection is completed, ketogenic diet is given to the mice every 7 days, the mice are continuously fed for 6-8 weeks, and modeling is conducted; and verifying the characteristics of the fat-rich hepatocellular carcinoma. The method disclosed by the invention is short in construction period, simple and convenient to operate, low in death rate, high in modeling rate and clear in tumor specific lipid droplet deposition. The model truly simulates the pathological characteristics and metabolic state of SH-HCC, and can be used for SH-HCC generation mechanism research, targeted drug screening and immunotherapy evaluation.

The invention relates to the technical field of food, in particular to a meal replacement composition for controlling body weight based on glycopeptide micro-control and a preparation method thereof, adopts an innovative combination mode of glycopeptide micro-control, solves the defect of uneven nutrition easily caused by original ketogenic diet, and improves the body weight. And the common problems of low protein energy supply ratio, excessive fat intake and the like of the meal replacement powder in the field are solved. The meal replacement composition comprises cereal dietary fiber powder, functional peptide, red date powder, chitosan oligosaccharide, Yixin sugar, Chinese wolfberry fruit powder, a mulberry leaf extract and eucommia seed oil micro-capsule powder. According to the invention, the cereal fibers are treated through extrusion puffing and low-temperature ultrahigh-pressure methods, so that the variety and content of dietary fibers are redistributed, the dietary fibers are easy to absorb by human bodies, and the obtained product has excellent sensory evaluation and has a good effect of controlling body weight.

The invention relates to a solid beverage formula for reducing weight and inhibiting weight gain. The food formula mainly comprises resistant starch, medium chain triglyceride microcapsule powder, mulberry leaf extract, psyllium husk powder and other auxiliary food raw materials. The auxiliary food raw materials comprise one or a mixture of more of resistant dextrin, milk powder and fruit and vegetable powder. The formula comprises the following components in percentage by weight: 40%-80% of resistant starch, 2%-20% of medium chain triglyceride microcapsule powder, 2%-20% of psyllium husk powder, 0.5%-10% of mulberry leaf extract and 1%-20% of other auxiliary food raw materials. According to the solid beverage prepared by the formula, the food intake can be reduced by enhancing satiety; ketogenic heat consumption and fat gluconeogenesis are increased, and more fat is consumed; therefore, the purposes of reducing weight and inhibiting weight gain are achieved. According to the formula, on the basis of balancing diet, the goal of reducing weight to a certain degree can be achieved, and meanwhile, the health risk of traditional extremely-low carbon water ketone-producing diet is avoided. The formula is beneficial to regulating the balance of intestinal flora and improving glycometabolism and lipid metabolism. All ingredients in the formula are food raw materials.

To provide an oral supplement for ketogenic diet therapy that contains the components of a special milk containing medium-chain fatty acid oil and β-hydroxybutyric acid, which have been conventionally used as supplemental foods for enhancing blood ketone bodies in ketogenic diet therapy, and has an improved taste. [Solution] An oral composition containing 5-40% by mass of protein, 30-80% by mass of lipids, 0-15% by mass of carbohydrates, and 5-20% by mass of β-hydroxybutyric acid or its salt, wherein the ratio of medium-chain fatty acid oil in the lipids is 30% by mass or more.

The invention discloses low-carbon water vegetarian medium-chain triglyceride micro-capsule powder and a preparation method thereof, and belongs to the field of functional grease processing technology and functional food application. The low-carbon water vegetarian medium-chain triglyceride microcapsule powder comprises the following components in percentage by mass: 1-80% of carbohydrate containing dietary fibers, 0-80% of vegetable protein, 10-80% of medium-chain triglyceride and 0-5% of an emulsifier, the prepared low-carbon water vegetarian medium-chain triglyceride micro-capsule powder has the advantages that the content of available carbohydrates is not higher than 5g / 100g, low carbohydrates can be claimed according to GB-28050, and meanwhile, the prepared low-carbon water vegetarian medium-chain triglyceride micro-capsule powder is good in stability and low in surface oil, can be used as a functional food raw material to be processed into various foods, and can be applied to various foods. The food is used for vegetarian people, low-carbon diet people, hyperglycemia people, senile people with slow gastrointestinal motility and digestion, ketogenic diet people, weight-losing and weight-managing people and the like.

The present invention relates to a method for calculating technified ketogenic therapy to induce a ketogenic state. The method comprises analysing a user's physiological and health data to determine calorie intake, food diet percentage and food formula, and a ketogenic rate derived from food diet. The aforementioned data are used to define the macronutrients required for the user to enter ketosis and the amount of a food formula to be administered to the user depending on their physical and medical conditions, reduce side effects related to a ketogenic diet, and ensure that the user enters a ketogenic state.

The present application relates to the technical field of special medical food, in particular to a ketogenic weight loss composition and a preparation method thereof, comprising the following components by weight percentage: 15-25% of immediate-release C8 MCT microcapsule powder, 20-30% of concentrated whey protein powder, 10-20% of resistant dextrin, 5-12% of marine fish collagen peptide-3-hydroxybutyric acid sodium chelate, 3-8% of black tea extract, 2-5% of pomegranate peel polyphenol-resistant dextrin enzymatic grafting, 10-15% of CLA glyceride microcapsule particles, 3-8% of fructooligosaccharide, 3-6% of natural composite flavoring agent, 1-3% of sweetener, and 0.3-0.8% of compound vitamin and mineral premix; the present application solves the deep problems of the "pseudo plateau", muscle loss, appetite fluctuation and intestinal imbalance under the ketogenic diet, improves the bioavailability and action efficiency of active ingredients, solves the problem of mismatched release under the traditional single embedding technology, and ensures the stable function and uniform mixing of the final product.

The invention pertains to a substantially gluten-free ketogenic flour blend having a ketogenic weight ratio between 2.3:1 and 2.9:1, preferably between 2.4:1 and 2.9:1, the blend comprising between 50 and 70 gram lipid per 100 g dry weight, comprising at least one, more preferably at least two, most preferably all of: (a) between 15 and 20 g MCT / 100 g dry weight; (b) MCT providing 20 – 30% of the total energy content of the blend; (c) between 20 and 35 wt% MCT based on total weight of the lipid, and further comprising at least 2.5 g / 100 g dry weight of fructo-oligosaccharides (FOS) and / or galacto- oligosaccharides (GOS), preferably FOS.