The application discloses a preparation method of a modified
ketogenic diet composition and application thereof, and the
ketogenic diet composition is prepared by the following steps: obtaining a
protein peptide mixture by fermenting glycosylated
lupin protein and collagen by probiotics; and then forming an oil gel by shearing and emulsifying the
protein peptide mixture,
coconut oil,
sunflower seed oil and thiolated
chitosan, loading
inulin,
betaine and
baicalin, and compounding vitamins and mineral elements. The
solubility and interfacial activity of the
protein peptide can be improved by the
fermentation of the probiotics, a stable
polysaccharide-protein peptide covalent network is constructed by combining the thiolated
chitosan to form a compact three-dimensional gel structure, the oil holding capacity of the oil gel is greatly improved, the oil gel can maintain the structure intact in
gastric acid, and the active ingredients can be responsively degraded and released after entering the intestinal tract; in addition, the probiotics can degrade
methionine,
threonine and
tryptophan contained in the protein, reduce the supply of key amino acids for the proliferation of
glioma cells, and strengthen the metabolic intervention and
tumor inhibition effect of
baicalin and
betaine, so that the target metabolic
adjuvant treatment of the
ketogenic diet is realized.