5 results about "White petrolatum" patented technology

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

This invention belongs to the field of pharmaceutical formulation technology and relates to a clobetasol propionate ointment and its preparation process. The ointment comprises clobetasol propionate, an emulsifier, a solubilizer, a stabilizer, a secondary stabilizer, and an ointment base. The emulsifier is Tween-80, the solubilizer is propylene glycol, the stabilizer is povidone K15 or povidone K25, the secondary stabilizer is potassium chloride, and the ointment base is white petrolatum. This invention, by adding a stabilizer and a secondary stabilizer and screening their types, prepares a clobetasol propionate ointment that exhibits low impurity content and good stability during long-term storage. Furthermore, the preparation process is simple and easy to operate, facilitating industrial production.

This invention provides a method for preparing and applying a long-acting anthelmintic compound microcapsule. The long-acting anthelmintic compound microcapsule is composed of a component containing an anthelmintic drug, white petrolatum, and pollen microcapsules; the anthelmintic drug content is 10-30 wt% of the total weight. Based on a unique supercritical carbon dioxide mixing process, this invention achieves efficient loading of the anthelmintic agent into the pollen microcapsules under mild conditions. This process further utilizes the porous nature of the microcapsules to achieve sustained release of the anthelmintic agent, thereby effectively prolonging the duration of action. Furthermore, thanks to its micron-sized structure, the microcapsule ensures that the anthelmintic component acts only on the body surface, preventing it from penetrating the skin, thus significantly improving the safety of use.

The Formulation describes the preparation of an antimicrobial cream which comprises of humic acid, water and petroleum jelly. The cream acts as a potent antifungal and antibacterial agent and is effective in many skin infections. In clinical trials the cream was found to be effective and well tolerated and free from irritative and allergic reactions.

This invention relates to a peony polyphenol antioxidant face cream, comprising the following ingredients: solution A, solution B, peony polyphenol solution, preservative, and purified water to a final volume of 100 mL; solution A comprises a mixture of glycerol monostearate, cetearyl alcohol, white petrolatum, and isononyl isononanoate; solution B comprises a mixture of 1,3-butanediol, triethanolamine, methyl glucoside sesquistearate, carbomer 940, and glycerin. The formulation of this invention is mild, has good sensory properties, can improve skin photodamage caused by UVB, has anti-photoaging and repair effects, reduces skin thickness changes caused by photodamage, maintains collagen structure, and reduces collagen distortion and breakage; furthermore, the preparation method of this invention is simple and readily available, allowing the efficacy of peony polyphenols to be effectively exerted in this face cream.