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54results about How to "Uniform refractive index" patented technology

Transparentizing reagent and application thereof in biological tissue material optical imaging as well as living body skin tissue transparentizing imaging method

The invention discloses a transparentizing reagent and application thereof in biological tissue material optical imaging as well as a living body skin tissue transparentizing imaging method. The transparentizing reagent is mannose or a mixture formed by dissoving mannose and 1,3-dimethyl-2-imidazolinone in a solvent. The transparentizing reagent can be applied to the biological tissue material optical imaging. The living body skin tissue transparentizing imaging method comprises the following steps: removing hairs on the surface, cleaning and drying; fixing and placing a skin tissue on a focalplane of an optical imaging system; dropwise adding the transparentizing reagent to the skin tissue at an imaging position, and standing for 5-30 minutes; imaging; and after the imaging is finished,wiping the transparentizing reagent, and repeatedly scrubbing and cleaning the surface of the skin tissue with normal saline or phosphate buffer solution, so that the skin tissue restores the originalstate. The reagent disclosed by the invention can not produce obvious tissue expansion or tissue shrinkage when in use, a detailed structure of a biological material can be completely stored, transparentizing time is short, transparentizing capability is high, and the reagent can be applied to the biological tissue material optical imaging.
Owner:SHENZHEN TECH UNIV

Silicon-dioxide optical waveguide production process for manufacturing optical divider

The invention discloses a silicon-dioxide optical waveguide production process for manufacturing an optical divider. The silicon-dioxide optical waveguide production process includes a lower waveguide wrapping layer manufacturing step, a waveguide core layer manufacturing step, a lower waveguide wrapping layer and waveguide core layer annealing and hardening step, a photoetching step, a non-waveguide area treatment step, an upper waveguide wrapping layer manufacturing step and an upper waveguide wrapping layer annealing and hardening processing step. The lower waveguide wrapping layer manufacturing step includes growing a SiO2 layer on a silicon wafer by the flame hydrolysis method or the chemical vapor deposition process, and doping phosphorous and boron ions as a lower waveguide wrapping layer. The waveguide core layer manufacturing step includes growing another SiO2 layer on the lower wrapping layer as a waveguide core layer by the flame hydrolysis method or the chemical vapor deposition process. The lower waveguide wrapping layer and waveguide core layer annealing and hardening step includes adopting annealing and hardening to let the two SiO2 layers be compact and uniform; the photoetching step includes protecting required waveguide graphs with photoresist. The non-waveguide area processing step includes etching a non-waveguide area by the reactive ion etching process. The upper waveguide wrapping layer manufacturing step includes removing the photoresist, covering another SiO2 layer on the waveguide core layer again by the flame hydrolysis method or the chemical vapor deposition process and doping the boron and phosphorous ions as an upper waveguide wrapping layer. The upper waveguide wrapping layer annealing and hardening step is used for fining and compacting the SiO2 layer of the upper waveguide wrapping layer. According to the above theory, the optical divider manufactured by the silicon dioxide optical waveguide is low internal residual stress, insignificant in birefrigent effect and is good in mechanical performance and thermal stability.
Owner:成都康特电子高新科技有限责任公司

Technological treatment method and device

InactiveCN106245006AWill not affect the coating effectCoating effect is consistentChemical vapor deposition coatingGraphiteSilicon chip
The invention provides a technological treatment method and device applicable to a film plating system using graphite boat for film plating on silicon chips. The method includes: determining the marks of graphite boats needing film plating; in the film plating system, presetting the used number of times of all graphite boats according to the marks of the graphite boats; determining the used number of times of the graphite boats according to the marks; determining the special gas flow parameters and film plating time parameters in the film plating process according to the used number of times of the graphite boats; and conducting film plating according to the special gas flow parameters and film plating time parameters. When the graphite boats are employed to perform film plating operation on silicon chips, the special gas flow parameters and film plating time parameters can be determined according to the used number of times of the graphite boats, the graphite boats with different used numbers of times adopt different special gas flows and film plating time. Even if the surface smoothness of graphite boat sheets in the graphite boats is reduced, the film plating effect of the silicon chips is not affected, the film formed on the silicon chip has consistent thickness and consistent refractivity, and the silicon chip film coating effect is more unified.
Owner:JIANGXI RISUN SOLAR ENERGY CO LTD

Method for making large size column mirror grating

The invention discloses a method for manufacturing a large-size cylindrical lens grating, which comprises the following steps: step one, at least one first cylindrical lens grating sub mold is generated on a substrate through at least one cylindrical lens grating case mold and light-curing adhesive; and step two, when the number of the first cylindrical lens sub molds generated on the substrate in the step one is one, the same light-curing adhesive is adopted, and a cylindrical lens grating with the same specification as the first cylindrical lens grating case mold is used as a case mold for widening the first cylindrical lens grating sub mold; and when the number of the first cylindrical lens grating sub molds generated on the substrate in the step one is two, the same light-curing adhesive is used to fill the clearance between every two first cylindrical lens gratings, and the first cylindrical lens grating case mold is used as the case mold so as to shape and cure light-curing adhesive at the clearance position between every two first cylindrical lens grating sub molds and make every two first cylindrical lens grating sub molds connected. The method has the advantages of simple operation, wide selective range of refractive index of manufactured cylindrical lens grating, high surface precision of the produced cylindrical lens grating, and good uniformity.
Owner:SUPERD CO LTD

Optical clearing agent for bone tissue

The present invention discloses an optical clearing agent for bone tissue. The optical clearing agent comprises dimethyl sulfoxide, sodium bicarbonate, and at least two materials selected from polyethylene glycol-400, methyl salicylate, ethylenediaminetetraacetic acid, sodium diatrizoate, glycerol, glucose, sodium dodecylbenzene sulfonate, sorbitol and laurinol, wherein a volume percentage of the dimethyl sulfoxide in the optical clearing agent for bone tissue is 40-80%, a mass percentage of the sodium bicarbonate in the optical clearing agent for bone tissue is 1-2%, the balance is other materials, and the pH value of the optical clearing agent for bone tissue is 6-11. After the optical clearing agent for bone tissue in the present invention acts on bone tissue, a refractive index inside the tissue can be quickly homogenized, and scattering inside the tissue can be reduced, such that the tissue provides improved transparency for light, the imaging depth is increased, and a new method for obtaining cortex neuron subcellular structures and microvascular information is provided. After the optical clearing agent for bone tissue is locally coated on the bone tissues or is adopted to soak the bone tissues, the bone tissue can provide improved transparency for light.
Owner:HUAZHONG UNIV OF SCI & TECH

A skull light-transparency reagent and reversible skull tissue light-transparency method

The invention discloses a skull optical clearing reagent and a reversible skull tissue optical clearing method, belonging to the technical field of bioimaging. The optical clearing reagent comprises a first solution and a second solution, wherein the first solution is an alcohol solution having the mass concentration being 25-30 % and composed of an amide organic compound and a derivative of the amide organic compound; the second solution comprises a water solution of an anionic surfactant, and a water-soluble penetration enhancer, the mass concentration of the water solution of the anionic surfactant is 15-20 %, and the use amount of the water-soluble penetration enhancer is 5-10 % of the total volume of the second solution. By dropwise adding the first solution and the second solution on the surface of the skull sequentially, the optical transparency of the skull tissue is realized, and the reagent can be used in an optical microscopic imaging system for imaging. With the reagent and the method, the nondestructive and non-invasive transparent skull window is established, the high-resolution imaging of a cortex microvessel system is realized, the operation is simple, the imaging quality is high, and the repeated imaging for a plurality of times can be realized.
Owner:佳维斯(武汉)生物医药有限公司
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