Footpad skin tissue optical clearing agent

A technology of foot pad skin tissue and light transparent agent, which is applied in the field of biomedical optical imaging, can solve problems such as restricting the application of optical imaging technology, and achieve the effects of reducing tissue scattering and improving imaging depth
CN103263678BInactive Publication Date: 2015-05-20HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2015-05-20
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a footpad skin tissue optical clearing agent, which includes fructose, ethanol, water, and at least three of the following substances: polyethylene glycol-400, sorbitol, glucose, propylene glycol, glycerol, sodium dodecyl benzene sulfonate, dimethyl sulfoxide, butylbenisothiazolene, azone, peppermint oil and petroleum jelly, wherein the mass percentage of fructose in the footpad skin tissue optical clearing agent is 20%-75%, the mass percentage of ethanol in the footpad skin tissue optical clearing agent is 0.8%-1.5%, the mass percentage of water in the footpad skin tissue optical clearing agent is 7%-30%, and the balance of other substances. The present invention acts on the footpad skin tissue, so that the refractive index in the tissue can be quickly uniform, the scattering in the tissue is reduced, the tissue becomes transparent to light, imaging depth is improved, and a new method is provided to obtain information of skin blood vessels and blood flows.
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Description

technical field

[0001] The invention relates to the technical field of biomedical optical imaging, in particular to a light transparent agent for foot pad skin tissue, which is a mixed solution capable of changing the light transparency of foot pad skin tissue. Background technique

[0002] The footpad is the window of in vivo optical imaging. The hairless and easy-to-obtain characteristics of the footpad skin make it of great significance in the study of tumors and peripheral vascular diseases. The use of optical imaging technology can not only achieve the monitoring and tracking of cells at the single-cell level. However, the opaque nature of the footpad skin limits the depth of light penetration into the tissue, making these techniques only able to image superficial tissues with low image contrast. The recently proposed biological tissue light-transparency technology has brought new ideas to solve this problem. It reduces the scattering of the tissue by introducing a hig...

Claims

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