1266 results about "Bone tissue" patented technology

The invention belongs to the technical field of hydrogel, and relates to piezoelectric / conductive integrated hydrogel for jaw defect repair, which is prepared from methylacryloyl protein, zwitterionic monomer and titanate piezoelectric particles through ultraviolet crosslinking under the action of a crosslinking agent and a photoinitiator, the hydrogel comprises, by mass, 1.0%-10% of methacrylated protein, 1.0%-10% of zwitterionic monomers, 1.0%-10% of titanate piezoelectric particles and 0.1%-5% of an initiator, and the volume fraction of an accelerant is 0.05%-1.0%. The hydrogel disclosed by the invention has excellent mechanical strength and certain flexibility, can realize piezoelectric and conductive functions of the hydrogel, can effectively promote proliferation, differentiation and mineralization of bone cells under the action of an electric field, accelerates bone tissue repair, and has a more remarkable bone regeneration effect compared with a non-electrical stimulation material in the prior art.

The invention relates to bionic matrix hydrogel for constructing bone organs and a preparation method of the bionic matrix hydrogel. The bionic matrix hydrogel is prepared from a bone acellular extracellular matrix, a salmon DNA (Deoxyribose Nucleic Acid) network and a calcium phosphate oligomer under the combination of photo-crosslinking and self-assembly physical crosslinking. The acellular extracellular matrix in the bionic matrix hydrogel can simulate organic components in natural bones, the calcium phosphate oligomer can simulate inorganic components in the natural bones, and sufficient phosphate ions can be provided for biomineralization due to introduction of a DNA network. The biomimetic matrix hydrogel can replace Matrigel to act in bone organoid culture, provide a living environment similar to bone tissue for three-dimensional culture cells, enhance substance exchange and signal transduction between cells, promote proliferation, adhesion and osteogenic differentiation of bone marrow mesenchymal stem cells, and further accelerate the process of biomineralization. The invention provides an optional new material for preparing the functional bone organ.

A high-performance near-pure zinc alloy, a preparation method therefor and a use thereof, relating to the technical field of zinc alloys. The alloy component is that the content of Zn is greater than or equal to 99.5%, and the remaining trace alloy elements include at least two of the following 14 elements: Mg, Mn, Li, Cu, Ag, Ca, Sr, Fe, Zr, Ti, Al, C, Ga, and Si. The alloy has the yield strength ≥ 250 MPa, the tensile strength ≥ 320 MPa, the elongation ≥ 25%, the mechanical property change during one year of room-temperature storage ≤ 5%, the maximum bending force ≥ 2 kN, the stress corrosion sensitivity factor ≤ 15%, the size of corrosion pits after 60 days of immersion ≤ 15 μm, and the standard deviation of the size of corrosion pits ≤ 3 μm. The alloy is suitable for the preparation of biodegradable stents, bone implant devices, medical staplers or anastomotic nails for intestines, blood vessels or nerves, vascular clamps, guided bone or tissue regeneration membranes, heart valve protheses, dura mater repair membranes, soluble bridge plugs and fracturing balls for oil drilling, zinc alloy die castings, electroplated zinc materials, building zinc materials, battery-grade zinc, printing-grade zinc, and zinc-based brazing alloys.

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

The invention relates to the technical field of medical informatics, in particular to a construction method of an osteoporotic fracture risk prediction model. The method comprises the following steps: acquiring an included angle between a foot and the ground, a step speed and a CT image of a target person in a monitoring process; dividing pixel points in the CT image into a plurality of bone tissue areas; according to the shape distribution characteristics of the edge lines in the bone tissue area, bone characteristic values of the bone structure are obtained; obtaining a posture control factor of each gait according to the included angles between the left and right feet of the target person in each gait and the ground; determining an abnormal posture index of each gait in combination with the posture control factor and the corresponding step speed; obtaining a control disorder coefficient of each time period according to the numerical distribution characteristics and the change characteristics of all the posture control factors in each time period; and determining an osteoporosis evaluation value by integrating the bone characteristic value and the disorder control coefficient of the skeleton structure. The accuracy of the bone comprehensive evaluation result of the target person is improved.

The invention relates to the technical field of biological medicine, in particular to recombinant III-type humanized collagen as well as a preparation method and application thereof. In one embodiment, the recombinant III type humanized collagen prepared by the invention has an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 4. The recombinant III-type humanized collagen prepared by the invention has good biological activity, can promote collagen synthesis related gene expression, promote skin fibroblast proliferation, increase the content of skin collagenous fibers and elastic fibers, and improve skin elasticity and compactness; in addition, the expression of osteogenesis related genes is promoted, and the proliferation of osteoblasts is promoted. The results show that the recombinant III-type humanized collagen prepared by the invention has an extremely wide application prospect in developing related medical and cosmetic products for delaying skin aging and promoting wound repair and bone tissue healing.

A minimally invasive ultrasonic knife head and a minimally invasive ultrasonic bone power system, the minimally invasive ultrasonic knife head comprises a knife rod and a head end, the head end is located at the front end of the knife rod, the head end is curved to the side at a certain angle, and the knurled teeth or bevel teeth are arranged on the curved part. By bending the head end, the bone tissue around the intervertebral foramen mirror can be removed, so that the operator has more operation space under the limited foramen mirror channel, and the bone removal efficiency is improved. The knurled teeth or bevel teeth are arranged on the curved part, so that the bone tissue around the intervertebral foramen mirror can be better polished or cut.

The utility model discloses an orthopedic drill bit with controllable drilling depth, which comprises a fixing sleeve for fixing a drill bit body, and a limiter and a locking component are mounted at the bottom of the fixing sleeve; a plurality of telescopic holes are formed in the bottom of the fixed sleeve; the limiting stopper comprises a limiting ring, a plurality of moving rods are installed at the top of the limiting ring, springs are further installed at the ends of the moving rods, and the moving rods, namely the springs, are all installed in the telescopic holes; by means of the limiting stopper and the scales, a user can accurately set and read the drilling depth according to needs, and the drilling accuracy and safety in the operation process are guaranteed; due to the design of the movable rod and the telescopic hole, the depth can be adjusted easily and rapidly, and the operation flexibility in the operation process is improved; the limiting ring and the locking assembly are combined for use, the drill bit can be effectively prevented from excessively drilling in, and therefore bone tissue and surrounding soft tissue of a patient are protected against damage.

The invention discloses a real-time pose updating method based on feature prediction and point cloud registration, and belongs to the technical field of image registration, and the method comprises the steps: extracting a bone surface point cloud which at least covers a feature region and an adjacent region from a three-dimensional model of a bone tissue of a patient, the point cloud is used as a target point cloud for registration with a real-time ultrasonic image; an ultrasonic image collected by the ultrasonic patch in real time is obtained, and a two-dimensional ultrasonic image with a spatial position is obtained; predicting the two-dimensional ultrasonic image by using a pre-trained artificial intelligence model to obtain bone-soft tissue interface features, and extracting a plurality of points on a bone-soft tissue interface from the bone-soft tissue interface to form a source point cloud for registration; and registering the source point cloud to the target point cloud to realize real-time pose updating. According to the invention, the pose monitoring in the operation can be realized through the real-time image flow under the non-invasive condition.

This invention relates to an ultrasonic bone scalpel and an ultrasonic cutting device, belonging to the field of medical device technology. The ultrasonic bone scalpel is used to cut bone tissue from within the medullary cavity, and includes an ultrasonic scalpel body and a retaining assembly. The ultrasonic scalpel body includes a handle and a cutting head mounted on one end of the handle. The retaining assembly includes a pressure bladder mounted on the handle, with the pressure bladder and cutting head arranged radially opposite each other along the handle. The pressure bladder is capable of expanding or contracting. The ultrasonic bone scalpel provided by this invention utilizes the expansion of the pressure bladder to provide continuous cutting pressure based on the cutting action of the ultrasonic scalpel body, reducing the cutting wound on soft tissue, thereby protecting soft tissue while satisfying bone tissue cutting requirements. Furthermore, because this ultrasonic bone scalpel cuts from the inside out of the medullary cavity, it avoids external damage to soft tissue, thus reducing the cutting wound on soft tissue and further protecting it. Therefore, when the cutting wound on soft tissue is reduced, the risk of intraoperative infection is correspondingly reduced, and the healing time is shortened.

The invention discloses an alveolar bone noninvasive detection method based on a spatial offset Raman spectrum technology. The method comprises the following steps: S1, selecting a first near-infrared excitation wavelength and a second near-infrared excitation wavelength to form a multi-wavelength tunable excitation light beam; s2, synchronously acquiring a first group of original Raman spectrum signals under a plurality of spatial offset distances; s3, acquiring a second group of original Raman spectrum signals by using an acousto-optic composite modulation Raman enhancement mechanism; s4, inputting the soft tissue optical parameter set into a joint inversion equation; s5, obtaining a deep alveolar bone Raman characteristic spectrum data set; s6, training an alveolar bone tissue health recognition model; and S7, based on the alveolar bone tissue health recognition model, performing health state judgment on the deep alveolar bone Raman characteristic spectrum data set acquired in real time, and generating an alveolar bone health assessment result. The early screening and dynamic monitoring capabilities of alveolar bone diseases are greatly improved, and the clinical working efficiency of doctors and the doctor-seeing experience of patients are remarkably optimized.

An osteoinductive and osteoconductive composition including DBM fibers having multiple geometries, as well as a method of producing the same are disclose. For example, such a method may include: obtaining bone tissue; cleaning the bone tissue obtained with a plurality of washes; milling the cleaned bone tissue into a plurality of fibers of two or more geometries including a long wide fiber, a long narrow fiber, a short wide fiber, and a short narrow fiber; demineralizing the plurality of fibers of two or more geometries to expose one or more biologically active components; and neutralizing the plurality of demineralized fibers of two or more geometries resulting in demineralized bone matrix.

A method for constructing a microfluidic bone organoid-on-chip can continuously observe the impacts of different external factors on a bone tissue structure based on the “ternary regulation theory” of bone angiogenesis-bone resorption-osteogenesis coupling. The method includes: (1) building a visual three-dimensional cell cultivation platform to continuously observe impacts of different external factors on a ternary regulation theory based on angiogenesis of osteoclast precursors, osteoblasts and osteoclasts, such that a user is allowed to directly observe interactions among various kinds of cells; (2) designing microfluidic channels in a chip to allow a reagent involved to present a concentration gradient distribution in the chip; and (3) adding three bioinks including osteoblasts, osteoclasts and vascular endothelial cells respectively, so as to reflect the three cell components individually, in pairs, and as a whole in the chip. An apparatus for constructing a microfluidic bone organoid-on-chip is further provided.

The invention provides an interface-enhanced regenerated bone scaffold for sustained-release medicines as well as a preparation method and application of the interface-enhanced regenerated bone scaffold, and belongs to the technical field of bone tissue engineering. According to the invention, polycaprolactone and hydroxyapatite are taken as matrix components of the regenerated bone scaffold, so that the regenerated bone scaffold has mechanical strength matched with a host bone and good biocompatibility; the polydopamine coating is loaded on the surface and internal pores of the regenerated bone scaffold matrix, surface functional modification is easy to perform, and a catechol structure in the polydopamine coating can perform coordination binding with metal ions in MOFs, so that the falling rate of MOFs particles is reduced, and the MOFs particles are uniformly and stably distributed; the MOFs particles are used for loading the eucommia ulmoides extract, safety and non-toxicity are achieved, the eucommia ulmoides extract is encapsulated in the MOFs particles, the stability of the eucommia ulmoides extract can be improved, and a better drug release effect and a better bone regeneration promoting effect are achieved.

The invention provides a multi-parameter feature fused vertebral CT image standardization preprocessing method and system. The method comprises the following steps: carrying out initial segmentation on an input original vertebral CT image; carrying out enhancement processing on the image by adopting an anisotropic diffusion filtering algorithm of multi-scale structure perception; establishing a tissue specificity density mapping model of multi-parameter fusion; adopting a self-adaptive segmentation histogram mapping method to map gray distribution of an original image to a standard template; and constructing a rigid-elastic mixed registration model. According to the invention, a complete quality evaluation system is established, the processing quality can be automatically detected and reported, and the reliability of an output result is ensured. By introducing a patient individualized correction mechanism, individual difference information is fully reserved while the standardization effect is ensured, and diagnosis information loss caused by excessive standardization is avoided. The multi-parameter fusion strategy ensures complete reservation of bone tissue density, texture and structure information.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention discloses a bone scaffold fusion design and preparation method based on mirror image registration, and the method comprises the steps: firstly, based on a three-dimensional medical image of a femoral defect region of a patient, combining an opposite-side complete femoral CT image, and achieving the automatic recognition and complementation of the defect region through the mirror image transformation and ICP registration technology; after defect boundary extraction is completed, three-dimensional reconstruction is carried out on the individualized outer contour of the left bone tissue, and an STL format model is exported. According to the femur functional partition characteristics, a Diamond structure is adopted in a cortical bone area to enhance mechanical support, and a Gyandroid structure is selected in a cancellous bone area to achieve porosity gradient filling, so that the permeability is optimized, and cell proliferation is promoted. Continuous transition among the structures is realized through a Sigmoid function, and the stability and the biological adaptability of the whole structure are improved. And finally, the stent model is subjected to selective laser melting, and a Zn-3Mg alloy material is utilized to complete printing manufacturing.

According to the chronic obstructive pulmonary disease grading system and method based on the X-ray chest radiograph, the original X-ray chest radiograph is obtained, and the original X-ray chest radiograph is preprocessed; a conditional generative adversarial network is adopted to separate the preprocessed original X-ray chest radiograph, and a bone suppression image and a bone tissue feature image are obtained; inputting the bone tissue feature image into the constructed double-branch deep neural network to obtain a pulmonary parenchyma feature map and a rib feature map; obtaining a clinical variable, preprocessing the clinical variable, performing cross-modal fusion on the preprocessed clinical variable, the lung parenchyma feature map and the rib feature map, and generating a fusion feature vector; processing the fusion feature vector by combining a regression-classification output header model to obtain an FEV1% predicted value and a GOLD staging result; a conditional generative adversarial network, a double-branch deep neural network, cross-modal fusion and a joint regression-classification output head model are introduced, and low-cost, low-radiation and high-universality GOLD automatic grading can be realized.

The utility model discloses a 3D printing porous pedicle screw which comprises a screw body part and a screw cap part, the screw body part comprises a cortical bone thread area close to one end of the screw cap part and a cancellous bone thread area far away from one end of the screw cap part, and a porous structure area is arranged at one end, not connected with the screw cap part, of the screw body part. The porous structure area comprises an inner core column extending in the axial direction of the nail body part, at least one reinforcing beam and a porous structure, the reinforcing beams extend outwards from the periphery of the inner core column, and the porous structure is annularly distributed on the outer periphery of the inner core column. The porous structure can efficiently induce bone tissue to grow in, the screw and a vertebral body are connected into a whole, stress is effectively dispersed, the stability of the screw is improved, the porous structure is arranged on the vertebral body at the front end of the screw, screw breakage caused by stress concentration of the screw in a vertebral pedicle area can be avoided, meanwhile, the stability of the screw can be better improved through the reinforcing beam, and the service life of the screw is prolonged. The possibility of fracture of a porous area of the screw is reduced, generalization performance is better, and the use experience feeling is improved.

The invention discloses a morphological feature-based cell segmentation and cell nucleus identification method for a turned unstained bone tissue pathological image. The method comprises the following steps of: 1, eliminating tool marks by adopting a tool mark elimination method combining local frequency domain analysis and directional suppression; 2, performing cell segmentation by using a K-means method, and performing morphological expansion and topological analysis on a segmented single cell image to identify a cell nucleus in the single cell image; step 3, calculating morphological characteristic indexes of each region; the method comprises the following steps: establishing a multi-dimensional Gaussian mixture model according to existing bone cell labeled sample information, performing outlier detection according to statistical data analysis, and removing results which do not conform to cell morphology; classifying different regions, and removing non-cell regions; by calculating morphological characteristic indexes of each region, different regions are distinguished according to the indexes, and cells are preliminarily screened. According to the method, high-precision cell segmentation and cell nucleus identification can be carried out on the cut undyed bone tissue pathological image.

The invention relates to a two-phase hydrogel system based on space-time gradient regulation and control as well as a preparation method and application of the two-phase hydrogel system. The biphase hydrogel system can also be expressed as a GelMA composite hydrogel scaffold of a porous structure, the whole biphase hydrogel system is of a core-shell structure, the inner layer core mineralizes SilMA hydrogel microspheres, the porous GelMA hydrogel scaffold is used as an outer layer, and the angiogenesis promoting factor dimethyl oxalaminoacetic acid, the human umbilical vein endothelial cells and the bone marrow mesenchymal stem cells are loaded on the outer layer. Wherein the inner-layer core mineralized SilMA hydrogel microspheres realize continuous release of osteogenesis signals by slowly releasing nHAp, and the outer-layer porous GelMA hydrogel stent releases DMOG by rapid degradation to realize early angiogenesis, so that space-time coupling construction of blood vessels and bone tissues is realized. Through differential degradation characteristics of inner and outer layers of hydrogel, precise time sequence cooperative regulation and control of angiogenesis and bone tissue remodeling can be realized, and the bionic property and function integration capability of a vascularized bone organ structure can be improved, so that the clinical transformation potential of the vascularized bone organ structure is improved.

The invention discloses a bone organ chip loaded with a microelectrode array and a use method, and relates to the technical field of organ chips, the bone organ chip is made of a polydimethylsiloxane material, and the bone organ chip comprises a three-layer structure: a top layer, a middle layer and a bottom layer; the middle layer comprises two blood vessel micro-channels, two osteoblast micro-channels and a neuron micro-channel, the channels are separated through columns and micro-columns, and cell interaction in a bone micro-environment is simulated; a microelectrode array is arranged on the top layer and is used for monitoring electrical activity of neurons in real time; the bottom layer is provided with a pneumatic valve which can control opening and closing of the micro-channel. According to the invention, nerve and blood vessel channels are introduced, a nerve-blood vessel-immunoregulation bone microenvironment is constructed, physiological processes such as osteogenesis-blood vessel formation coupling and the like are embodied, intervals of different sizes can enhance intercellular crosstalk and allow blood vessels and neuron axons to selectively pass through, so that the chip can simulate a complex microenvironment of bone tissues, and the microenvironment of the bone tissues can be simulated; and an efficient and accurate in-vitro model is provided for bone disease mechanism research and drug development.

The invention relates to the technical field of bone tissue materials, and discloses a metal-doped biomimetic mineralized dECM cryogel and a preparation method and application thereof.The preparation method of the cryogel comprises the steps that firstly, hyaluronic acid and methacrylic anhydride are mixed in a solvent, the pH value is adjusted, a reaction is conducted, and methacrylic acid hyaluronic acid is obtained; then under the condition of a photoinitiator, mixing the methacrylic acid hyaluronic acid with an acellular extracellular matrix, and performing freezing and crosslinking treatment to obtain the cryogel, and finally, soaking the cryogel in a mineralization solution containing Ca < 2 + > and / or Mg < 2 + >, adding a buffer solution containing phosphite ions, incubating, and washing to obtain the crystal gel. The biomimetic mineralized dECM cryogel prepared by the method disclosed by the invention is good in ion release stability, can significantly improve the migration ability of HUVECs, contributes to promoting proliferation of rMSCs and improving the osteogenic differentiation potential of the rMSCs, and can be used for regeneration and repair of bone defects.

The invention provides a method for preparing a degradable bone-guided regeneration membrane with an asymmetric membrane layer, which comprises the following steps of: cutting a magnesium metal sheet into a magnesium net or a magnesium bracket with small holes by laser, carrying out heat treatment on the magnesium net or the magnesium bracket by using HF (Hydrogen Fluoride) to obtain a layer of MgF4 coating on the surface, and immersing the magnesium net or the magnesium bracket into a macromolecular solution until a solvent of the macromolecular coating is completely volatilized; then preparing an electrostatic spinning membrane on the surface of the sample: preparing a dense polymer membrane layer containing an antibacterial drug on the surface of the sample close to one side of the fiber tissue by adopting a hot pressing method, or preparing a dense electrostatic spinning ordered fiber membrane which contains an antibacterial nano-drug and is arranged in parallel by adopting an electrostatic spinning method; the designed structure and the used materials can realize an antibacterial function and shield fiber tissues from growing in. The nanofiber membrane which contains osteogenesis promoting substances such as nano-hydroxyapatite or nano-strontium and is conveyed disorderly is prepared on the side close to the bone tissue by adopting an electrostatic spinning technology, and the designed structure and the contained substances can promote osteogenesis.

The invention belongs to the technical field of biomedical materials and tissue regeneration, and particularly discloses hydrogel with a self-enhanced piezoelectric effect as well as a preparation method and application of the hydrogel. The hydrogel is prepared by taking microphone (MXene), cellulose nanofiber (CNF), tyramine grafted carboxymethyl cellulose (T-CMC) and regenerated silk fibroin (RSF) as main materials through an enzyme crosslinking reaction of horse radish peroxidase (HRP) and hydrogen peroxide (H2O2). The hydrogel has excellent mechanical properties, biocompatibility and safety, and can realize self-enhancement in vivo and generate stable piezoelectric signals. The piezoelectric stimulation can promote proliferation, migration and differentiation of osteogenesis-related cells and regulate and control a bone tissue microenvironment, so that formation and repair of new bones in a bone defect area are remarkably accelerated. The hydrogel can be used as an injectable or moldable bone tissue repair material, and is suitable for bone fracture, bone defect and other bone tissue regeneration scenes.

The invention discloses a photo-thermal-electric coupling titanium-based implant as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The photo-thermal-electric coupling titanium-based implant provided by the invention comprises a porous titanium substrate and a hydrogel layer, the surface of the porous titanium substrate is of a TiO2 nanotube array structure; up-conversion nanoparticles and g-C3N4 nanoparticles are arranged between the porous titanium substrate and the hydrogel layer, and the up-conversion nanoparticles are NaYF4 up-conversion nanoparticles co-doped with Yb < 3 + > and Er < 3 + >; carbon nanotubes and medicinal active ingredients are loaded in the hydrogel layer. According to the titanium-based implant, collaborative coupling in light-heat-electricity multi-energy forms is achieved, the titanium-based implant is endowed with the integrated function of light response, heat conversion, electric signal conduction and local treatment, and an integrated solution with structural supporting, biological activity regulation and treatment effects is provided for bone tissue defect repair.

The invention discloses a bone injury detection method based on ultrasonic guided waves and a multi-branch convolutional neural network, and the method comprises the steps: firstly collecting UGW signals of bone tissues, and carrying out the standardization preprocessing of the UGW signals, so as to eliminate the amplitude difference between different samples; then, data enhancement strategies such as Gaussian noise disturbance and amplitude scaling are adopted, a finite sample set is effectively expanded, and the robustness and generalization ability of the model are improved; a multi-branch convolutional neural network (TB-CNN) structure is constructed, the network designs independent branches for time domain, frequency domain and time-frequency domain input, deep features are automatically extracted from the respective branches, and feature splicing and multi-level information integration are realized in a fusion module; finally, regression prediction of the bone injury depth is realized through a full connection layer, so that continuous value output is obtained, and the severity of the bone injury can be reflected more finely.

The invention discloses an electroactive dressing used for promoting bone cell differentiation and bone regeneration and used for negative pressure therapy and a manufacturing method. The manufacturing method of the electroactive dressing comprises the steps that S1, a PLLA / BG spinning solution is prepared; s2, preparing a PLLA / BG nanofiber membrane through electrostatic spinning; s3, vacuum drying; s4, PAMAM-NH2 surface modification, the negative pressure treatment dressing relates to the technical field of negative pressure treatment dressings, when mechanical deformation is generated during negative pressure work, the piezoelectric biological film generates continuous electric stimulation, and the electric stimulation has positive and beneficial effects on osteoblasts and bone tissue physiological processes. The generated electric effect continuously collects functional electrolyte in surrounding tissues, and the functional electrolyte is separated in the wound by the dendrimer PAMAM-NH2, so that excessive exudation caused by negative pressure treatment is effectively made up. Meanwhile, the flow of the electrolyte further strengthens a local electric signal, so that cell migration and osteoblast proliferation and differentiation are effectively promoted.

The invention relates to the technical field of bone biomechanical simulation, and discloses a bone biomechanical modeling method and system based on a multi-modal image, and the method comprises the steps: S1, collecting a CT image and an MRI image of a to-be-detected bone structure, and generating a multi-modal image; s2, adopting a depth variation inference algorithm to extract common features of the multi-modal images, adopting a generative adversarial network algorithm to optimize the common features, and performing information fusion on the multi-modal images to generate comprehensive image data; s3, reconstructing a three-dimensional bone structure model based on the comprehensive image data; s4, simulating mechanical property parameters of the three-dimensional bone structure model under different external loads and physiological states by adopting a nonlinear finite element method based on the three-dimensional bone structure model, and outputting mechanical properties of bone tissues; and S5, based on the three-dimensional bone structure model and the mechanical characteristics of the bone tissue, generating a personalized bone biomechanical model by using a depth variation inference algorithm. According to the method, an accurate personalized bone biomechanical modeling scheme can be provided.

The invention provides an integrated splicable porous mandibular implant prosthesis, which comprises a left prosthesis module, a right prosthesis module, a splicing connection part and a porous structure part, and is characterized in that the left prosthesis module and the right prosthesis module are detachably connected through the splicing connection part to form an integral structure; porous structure parts are arranged in the middle main body areas of the left prosthesis module and the right prosthesis module respectively, a plurality of double-end guide holes are evenly formed in the porous structure parts, and each double-end guide hole forms an independent hole opening in the front surface and the rear surface of the corresponding prosthesis module. The front hole opening and the rear hole opening are communicated with each other through communicating hole channels formed in the porous structure part; the splicing connecting part comprises an insertion tenon part arranged on the left prosthesis module and a mortise groove part arranged on the right prosthesis module; the splicing connecting part is provided with a limiting clamping structure; the left prosthesis module and the right prosthesis module are respectively provided with a plurality of fixing holes. During use, rapid assembly of the prosthesis modules is facilitated, and growth of bone tissue is facilitated.