719 results about "Bone tissue" patented technology

The invention discloses a real-time pose updating method based on feature prediction and point cloud registration, and belongs to the technical field of image registration, and the method comprises the steps: extracting a bone surface point cloud which at least covers a feature region and an adjacent region from a three-dimensional model of a bone tissue of a patient, the point cloud is used as a target point cloud for registration with a real-time ultrasonic image; an ultrasonic image collected by the ultrasonic patch in real time is obtained, and a two-dimensional ultrasonic image with a spatial position is obtained; predicting the two-dimensional ultrasonic image by using a pre-trained artificial intelligence model to obtain bone-soft tissue interface features, and extracting a plurality of points on a bone-soft tissue interface from the bone-soft tissue interface to form a source point cloud for registration; and registering the source point cloud to the target point cloud to realize real-time pose updating. According to the invention, the pose monitoring in the operation can be realized through the real-time image flow under the non-invasive condition.

The utility model discloses a 3D printing porous pedicle screw which comprises a screw body part and a screw cap part, the screw body part comprises a cortical bone thread area close to one end of the screw cap part and a cancellous bone thread area far away from one end of the screw cap part, and a porous structure area is arranged at one end, not connected with the screw cap part, of the screw body part. The porous structure area comprises an inner core column extending in the axial direction of the nail body part, at least one reinforcing beam and a porous structure, the reinforcing beams extend outwards from the periphery of the inner core column, and the porous structure is annularly distributed on the outer periphery of the inner core column. The porous structure can efficiently induce bone tissue to grow in, the screw and a vertebral body are connected into a whole, stress is effectively dispersed, the stability of the screw is improved, the porous structure is arranged on the vertebral body at the front end of the screw, screw breakage caused by stress concentration of the screw in a vertebral pedicle area can be avoided, meanwhile, the stability of the screw can be better improved through the reinforcing beam, and the service life of the screw is prolonged. The possibility of fracture of a porous area of the screw is reduced, generalization performance is better, and the use experience feeling is improved.

The invention discloses a morphological feature-based cell segmentation and cell nucleus identification method for a turned unstained bone tissue pathological image. The method comprises the following steps of: 1, eliminating tool marks by adopting a tool mark elimination method combining local frequency domain analysis and directional suppression; 2, performing cell segmentation by using a K-means method, and performing morphological expansion and topological analysis on a segmented single cell image to identify a cell nucleus in the single cell image; step 3, calculating morphological characteristic indexes of each region; the method comprises the following steps: establishing a multi-dimensional Gaussian mixture model according to existing bone cell labeled sample information, performing outlier detection according to statistical data analysis, and removing results which do not conform to cell morphology; classifying different regions, and removing non-cell regions; by calculating morphological characteristic indexes of each region, different regions are distinguished according to the indexes, and cells are preliminarily screened. According to the method, high-precision cell segmentation and cell nucleus identification can be carried out on the cut undyed bone tissue pathological image.

The invention belongs to the technical field of biomedical materials and tissue regeneration, and particularly discloses hydrogel with a self-enhanced piezoelectric effect as well as a preparation method and application of the hydrogel. The hydrogel is prepared by taking microphone (MXene), cellulose nanofiber (CNF), tyramine grafted carboxymethyl cellulose (T-CMC) and regenerated silk fibroin (RSF) as main materials through an enzyme crosslinking reaction of horse radish peroxidase (HRP) and hydrogen peroxide (H2O2). The hydrogel has excellent mechanical properties, biocompatibility and safety, and can realize self-enhancement in vivo and generate stable piezoelectric signals. The piezoelectric stimulation can promote proliferation, migration and differentiation of osteogenesis-related cells and regulate and control a bone tissue microenvironment, so that formation and repair of new bones in a bone defect area are remarkably accelerated. The hydrogel can be used as an injectable or moldable bone tissue repair material, and is suitable for bone fracture, bone defect and other bone tissue regeneration scenes.

The invention discloses a photo-thermal-electric coupling titanium-based implant as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The photo-thermal-electric coupling titanium-based implant provided by the invention comprises a porous titanium substrate and a hydrogel layer, the surface of the porous titanium substrate is of a TiO2 nanotube array structure; up-conversion nanoparticles and g-C3N4 nanoparticles are arranged between the porous titanium substrate and the hydrogel layer, and the up-conversion nanoparticles are NaYF4 up-conversion nanoparticles co-doped with Yb < 3 + > and Er < 3 + >; carbon nanotubes and medicinal active ingredients are loaded in the hydrogel layer. According to the titanium-based implant, collaborative coupling in light-heat-electricity multi-energy forms is achieved, the titanium-based implant is endowed with the integrated function of light response, heat conversion, electric signal conduction and local treatment, and an integrated solution with structural supporting, biological activity regulation and treatment effects is provided for bone tissue defect repair.

The invention discloses a bone injury detection method based on ultrasonic guided waves and a multi-branch convolutional neural network, and the method comprises the steps: firstly collecting UGW signals of bone tissues, and carrying out the standardization preprocessing of the UGW signals, so as to eliminate the amplitude difference between different samples; then, data enhancement strategies such as Gaussian noise disturbance and amplitude scaling are adopted, a finite sample set is effectively expanded, and the robustness and generalization ability of the model are improved; a multi-branch convolutional neural network (TB-CNN) structure is constructed, the network designs independent branches for time domain, frequency domain and time-frequency domain input, deep features are automatically extracted from the respective branches, and feature splicing and multi-level information integration are realized in a fusion module; finally, regression prediction of the bone injury depth is realized through a full connection layer, so that continuous value output is obtained, and the severity of the bone injury can be reflected more finely.

The invention relates to the technical field of medical apparatuses and instruments, and provides a portable electric vibration micro fracture device which comprises a holding part, one end of the connecting rod assembly is connected with the holding part; the first end of the bent connector is detachably connected with the end, away from the holding part, of the connecting rod assembly, the second end of the bent connector is provided with an execution piece used for bone tissue punching, the interior of the bent connector is detachably connected with an axial vibration driving piece, and the axial vibration driving piece acts on the execution piece and is used for driving the execution piece to reciprocate in the axial direction of the axial vibration driving piece; the power supply assembly is embedded in the holding part and is electrically connected with the vibration driving assembly; the elbow connector and the connecting rod assembly are detachably connected, elbow connectors with different bending angles can be rapidly and conveniently replaced, and the operation requirements of different crowds are met; the axial vibration driving part can drive the executing part to do reciprocating motion in the axial direction, progressive punching is achieved through stable axial vibration, the risk caused by out-of-control operation force can be greatly reduced, and the operation safety is improved.

The invention belongs to the field of biomedical materials and manufacturing thereof, and discloses a composite 3D printing stent with a time sequence regulation blood vessel and bone tissue regeneration function as well as a preparation method and application of the composite 3D printing stent. The method comprises the following steps: respectively loading an osteogenesis inducer and a vascular induced differentiation agent into two carrier materials with different degradation rates, and carrying out 3D printing and gel coating modification according to a reverse sequence of a physiological repair process of carrying out vascularization first and then carrying out osteogenesis to form a composite 3D printing stent of which the inner layer is loaded with the osteogenesis inducer and the outer layer is loaded with the vascular induced differentiation agent. After the composite 3D printing stent is implanted into a body, according to different degradation rates of the composite material, the repair and regeneration process of vascularization and osteogenesis is realized in a manner of degrading the gel coating and degrading the 3D printing stent, and the composite 3D printing stent has good living compatibility, biological activity and mechanical properties, and has good application prospects. The material can be used as a biomedical material for repairing or treating bone defects or self-repairing, and has a good application prospect in treatment and self-repairing of bone defects.

The invention relates to the technical field of biomedical materials, in particular to multi-material 3D printing bionic gradient soft-hard integrated hydrogel as well as a preparation method and application thereof. Based on a copolymerization system of high-strength supramolecular N-acryloylglycinamide and vinyl phosphoric acid, an NAGA aqueous solution and an NAGA-VPA aqueous solution are printed into hydrogel of a gradient structure by adopting a DLP multi-material printing technology, then the hydrogel is sequentially soaked in a calcium-phosphorus mixed aqueous solution (Ca / P = 1.67), ammonia water, a calcium chloride aqueous solution and deionized water, and the hydrogel is prepared through a hydrothermal method. Therefore, in-situ gradient deposition and curing of hydroxyapatite (HAP) are realized. The multi-material 3D printing bionic gradient soft-hard integrated hydrogel prepared by the method has a continuous biochemical-mechanical gradient, a surface layer low-modulus area is matched with cartilage performance, a deep layer high-mineralization area is integrated with bone tissue, the HAP crystallinity of a transition area is in spatial dependence distribution, and the hydrogel is suitable for osteochondral defect repair and manufacturing of bionic joint prostheses.

The invention discloses a magnesium-titanium composite material with an interpenetrating phase structure for bone implantation, the magnesium-titanium composite material is formed by interpenetrating a reinforced phase made of a titanium alloy material and a matrix phase made of magnesium or a magnesium alloy material, and the reinforced phase and the matrix phase are respectively kept continuous in a three-dimensional space; a reinforcing phase and a matrix phase of the magnesium-titanium composite material have gradient structures in the radial direction; the invention further discloses a preparation method of the interpenetrating phase structure magnesium-titanium composite material for bone implantation. According to the magnesium-titanium composite material disclosed by the invention, the structure is designed into a structure in which the reinforcing phase and the matrix phase are three-dimensionally continuous and interspersed with each other and the two phases are in gradient in the radial direction, so that the magnesium-titanium composite material implant and healthy bone tissue at a bone defect part of a patient realize good biomechanical adaptation; the material is suitable for being used as a bone implant in the field of biomedical metal materials.

The invention discloses a design and preparation method of a personalized gradient thickness invisible orthodontic appliance model, relates to the technical field of tooth orthodontics, and aims to overcome the defects that the thickness is uncontrollable and preset mechanical properties cannot be accurately realized when an invisible orthodontic appliance is manufactured by a traditional hot press molding process. The method comprises the following steps: firstly, reconstructing a personalized dental model containing tooth roots and bone tissues based on CBCT data of a patient; designing a plurality of gradient thickness appliance schemes; through finite element analysis and simulation, selecting an optimal scheme which is most favorable for realizing correction effects such as overall movement of teeth; and finally, integrally forming and manufacturing the selected appliance by adopting a direct 3D printing technology. The direct 3D printing ensures that the appliance can be manufactured in a high-precision and high-fidelity manner from a complex gradient thickness structure with thick gingiva and thin occlusal surface, so that the optimized mechanical property verified by simulation can accurately reproduce in a real object, the inherent defects of a hot-pressing film process are thoroughly overcome, and the accuracy and predictability of correction are remarkably improved.

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.

Among other things, in general, methods, apparatus, systems, and compositions are provided for rendering bone tissue sufficiently acoustically transparent for ultrasound imaging or ultrasound therapy or both. The bone tissue is rendered acoustically transparent by use of a decalcifying treatment (with or without concomitant sonication) within a pre-thinned cavity of bone. Ultrasound imaging and therapy examining a region of interest within brain, spinal column, carpal tunnel, etc. is thereby enabled.

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The invention relates to a bone tumor ablation target region identification and real-time updating method. The method comprises the following steps: processing a multi-modal medical image acquired before an operation, performing information trust empowerment on a bone tumor area according to an image source type, structural definition, bone tissue shielding degree and spatial distribution complexity, and dividing the bone tumor area into a core target area, a semi-trusted marginal area and a dispute area; in the intraoperative ablation process, an ablation temperature change path, power response distribution and navigation position information are continuously monitored, and when it is detected that temperature response is sparse, a needle tip is static and energy motivates discontinuous feature combination in a semi-credible marginal area or a dispute area, target area offset warning logic is triggered; according to the bone tumor target region identification mechanism based on the multi-modal medical image trust empowerment, multi-dimensional information factors such as the image source type, the structure definition, the bone tissue shielding degree and the spatial distribution complexity can be considered at the same time.

The invention provides a mechanical property dynamic prediction method after stent implantation, and the method combines CT image three-dimensional reconstruction, finite element simulation analysis and data-driven modeling to construct a whole-process mapping relation from'stent model structure parameters-new bone growth characteristics-mechanical response '; a training data set is constructed through a large amount of simulation data, a proper analysis method is introduced to establish a prediction model, the performance change trend under different structural designs can be efficiently predicted, stent parameters can be reversely optimized, the individualized adaptability and the function-oriented design capability of the stent are improved, and the method is suitable for large-scale popularization and application. Meanwhile, a complex structure parameter space is covered by combining real bone growth data simulation, and the requirement for rapid optimization design of the stent is met; according to the method, the minimum repetitive unit of the model structure is improved and optimized, and meanwhile, the real growth condition of the new bone tissue is combined, so that the method can be more accurately and truly applied to predicting the mechanical property of the bone tissue in the growth process after the stent is implanted.

The invention discloses a minimally invasive degradable reduction device for thoracolumbar vertebral fracture, and relates to the technical field of medical instruments. The mounting mechanism is mounted on the outer wall of the connecting rod in a sleeving manner; the pedicle screw is movably inserted into the middle of the top end of the mounting mechanism; an implantation mechanism; through cooperative work of the connecting rod, the mounting mechanism, the pedicle screw and the connecting mechanism, the whole reduction device adapts to minimally invasive approach modes such as percutaneous puncture and can be implanted into the body of a patient through a percutaneous puncture channel, a skin incision of the minimally invasive approach is small, damage to surrounding tissue is greatly reduced, and the reduction effect is good. Due to the layered design of the screw body in the pedicle screw, bone tissue ingrowth is promoted while the supporting strength is kept, and the reduction device is made of degradable materials, can be gradually degraded along with fracture healing after an operation and is metabolized and absorbed by an organism, and does not need to be taken out through a secondary operation, so that physical and mental pain of a patient is relieved; and the medical cost and the potential risk of the secondary operation are also reduced.

The invention provides a laser oral cavity therapeutic instrument which comprises a therapeutic instrument body, a laser generation assembly, a water vapor nozzle assembly and a gas-liquid-electricity external connection assembly, the laser generation assembly, the water vapor nozzle assembly and the gas-liquid-electricity external connection assembly are arranged in the therapeutic instrument body, and the laser generation assembly is used for generating a high-energy laser beam; the oral cavity treatment is performed through the high-energy laser beam; the water vapor spray head assembly is used for forming water vapor spray so as to cooperatively clean or cool the oral cavity; the gas-liquid-electricity external connection assembly is used for connecting external gas, water and electric signals so as to ensure normal work of the laser oral cavity therapeutic instrument. The laser generating assembly, the steam spray head assembly and the gas-liquid-electric external connection assembly are arranged in the therapeutic instrument body, the laser generating and emitting function and the steam mixing and cooling function are integrated into one structure, the operation requirements of basic decontamination and sterilization, soft and hard tissue cutting, bone tissue removal and the like are met, and meanwhile the therapeutic instrument has the advantages of being high in integration degree, reasonable in structure, convenient to operate and the like.

The invention discloses an application of polygonatum kingianum exosome in preparation of medicines for preventing and treating osteoporosis, the polygonatum kingianum exosome has good biocompatibility, can significantly inhibit osteoclast differentiation, promote osteocyte differentiation, effectively target bone tissues and significantly improve osteoporosis conditions, and has potential in preparation of medicines for preventing and treating osteoporosis. The polygonatum kingianum exosome is rich in source, has natural components with potential activity, is low in cost and is suitable for large-scale batch production.

The application discloses a bone drilling force prediction method based on CT and drilling working conditions, which comprises the following steps: step 1, extracting the contact surface image sequence of the drill bit and the bone tissue on the bone drilling path from the CT image and performing pretreatment; step 2, inputting the pretreated contact surface image and the drilling working condition parameters into a multi-physical factor fusion module to obtain an image sequence of the fused working condition physical information; step 3, inputting the image of the fused working condition physical information into an image coding network to extract the drilling force features in the section; and step 4, inputting the sequence composed of the drilling force features of all sections on the drilling path into a sequence regression network ATP-UNeXt to obtain the prediction of the drill bit stress sequence on the drilling path. The application has the advantages that the drilling force related physical factors can be comprehensively considered, more accurate preoperative stress prediction can be provided, the model reasoning speed is fast, the application is suitable for a clinical operation auxiliary system, and the cost of the operation auxiliary system is reduced.

The invention belongs to the technical field of medical instruments, and particularly discloses a biopsy puncture tool capable of effectively grabbing bone tissue, which comprises a puncture handle, a puncture needle is fixedly connected to one side of the puncture handle, scales are arranged on the outer wall of the puncture needle, annular teeth are arranged on one side, far away from the puncture handle, of the puncture needle, an arc-shaped slope is arranged inside the annular teeth, and the arc-shaped slope is arranged on the outer wall of the puncture needle. A grabbing pipe is inserted into the puncture needle, and a push rod is inserted into the grabbing pipe; the positioning assembly is used for limiting and guiding the needle feeding direction of the puncture needle, and the positioning assembly is connected with the puncture needle. By arranging the grabbing pieces, when the bone tissue is grabbed and sampled, the multiple grabbing pieces are closed to form the sealed space, and the joint between the bone tissue inside the sealed space and the bone tissue outside the sealed space is cut off, so that the grabbed bone tissue can be taken out together when the puncture tool is taken out from the interior of a patient; the grabbing and sampling success rate of the puncture tool is improved, and medical staff can use the puncture tool conveniently.

The invention provides hydrogel, a porous titanium / hydrogel composite implant material and a preparation method of the porous titanium / hydrogel composite implant material. The hydrogel is obtained by photo-crosslinking and curing a hydrogel precursor solution containing acrylated beta-cyclodextrin, acrylated alendronate sodium, gelatin and a chemotactic factor. The hydrogel has a porous network structure, high elastic modulus, high fatigue resistance and excellent biocompatibility, and also has the capability of recruiting bone marrow mesenchymal stem cells (BMSCs) and the capability of promoting osteogenic differentiation of the BMSCs; the porous titanium / hydrogel composite implant material prepared from the hydrogel can effectively promote the growth of new bone tissues, has excellent osseointegration capability, obviously improves the osteogenesis repair effect and the osseointegration effect, provides a new treatment approach for the repair treatment of segmental bone defects, and has important medical significance.

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.

The invention discloses a bone-like osteoma microwave ablation thermal injury assessment method based on all-optical parameters, which comprises the following steps: respectively considering thermal injury models of cortical bone and cancellous bone under different microwave ablation conditions by constructing a simulation model conforming to bone tissue characteristics; according to the method, construction of an incomplete P5 approximation model is proposed, bone tissue all-optical parameter anti-construction research based on steady-state radiance is carried out, the accuracy is high, calculation is convenient, temperature parameters and biological tissue all-optical parameters are analyzed in a combined mode, a tissue thermal damage model of the temperature and tissue all-optical parameters is established through theoretical research, and due to the characteristics of different bone tissues, the tissue thermal damage model can be used as a tissue thermal damage model of the temperature and tissue all-optical parameters. The tissue types are considered in the thermal damage model, and effective bone tissue thermal damage factors are designed based on different tissues, so that the evaluation accuracy is ensured.

An implant removal tool designed for efficient and precise removal of an acetabular cup or similar implants is disclosed. The tool includes an outer shaft and an internal shaft configured to move relative to the outer shaft. The internal shaft is operably connected to a cutting assembly comprising multiple inwardly curving, wedge-shaped blades. The blades transition from a retracted position to a closed position, forming a semicircular cutting path slightly larger than the outer diameter of the implant. This configuration allows for controlled rotation of the blades around the implant's outer surface, effectively severing surrounding bone while minimizing damage to adjacent bone and soft tissues. The tool may include interchangeable components to accommodate implants of varying sizes, ensuring adaptability across surgical scenarios. Additional features, such as a helical thread mechanism or drill compatibility, enhance usability and precision during revision surgeries.

CT images from the neck, lung, cardiac, abdominal, pelvis, hip, spine or lower extremity areas are obtained and analyzed by a computer to measure trabecular bone density on each level it is available, in the spine and hip. Any bone tissue associated with vertebrae that is fractured is excluded, along with Schmorl's nodes, large blood vessels, and cortical bone, to accurately average the trabecular bone density on a scan. The density of fat, heart, and muscle tissue of a subject is used to calibrate the results. That data may be input to an absolute fracture risk model (Fracture Risk Algorithm calculator). Information such as bone density, T score, Z score, fracture risk, and identification of vertebral fractures (if present) may be determined and reported.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

This invention discloses an interlocking bone tissue repair scaffold, assembled from several notched links connected in an interlocking manner. The notches in one link allow passage through the notches in another link, but not through the remaining main body of the other link. The links are 3D printed from calcium phosphate ceramic powder. The porosity of the final assembled chain can be flexibly controlled by adjusting the shape, size, thickness, and combination of links of different sizes, allowing for precise customization according to specific application scenarios. This scaffold structure is flexible and adjustable, adaptable to different implantation areas, significantly expanding the product's applicability. After implantation, it creates a microenvironment more closely aligned with human tissue growth patterns, optimizing local tissue compatibility and providing excellent conditions for cell adhesion, retention, and proliferation, effectively improving the scaffold's biocompatibility and clinical application efficacy.

The present invention relates to a method for producing cartilage tissue by selecting and choosing from chondrocytes or spheroids, and use thereof as pharmaceutical composition, medicinal product or transplant. In particular, the invention relates to markers for identifying suitable chondrocytes for producing cartilage tissue, in particular for the purpose of transplantation.

The utility model discloses a kind of hollow intramedullary nail combined with pure magnesium physics, specifically including nail rod and splicing piece, nail rod is titanium alloy nail rod;Splicing piece includes the first release layer, second release layer, third release layer and fourth release layer set gradually, first release layer is magnesium alloy coating, second release layer is low-porosity pure magnesium layer, third release layer is high-porosity pure magnesium layer, fourth release layer is dense pure magnesium layer;Release groove is set on nail rod, release groove is connected with splicing piece, release groove is set in fracture end, for releasing magnesium ion.By being provided with splicing piece on titanium alloy nail rod, splicing piece releases magnesium ion of different concentration in different time period, magnesium ion can stimulate osteoblast differentiation and proliferation, accelerate bone tissue regeneration rate, while guaranteeing the mechanical structure intensity of intramedullary nail, realizes the acceleration fracture healing rate.