1771 results about "Bone tissue" patented technology

The invention relates to the technical field of image processing, and discloses a scoliosis angle intelligent measurement method and system based on spine CT three-dimensional reconstruction. The method comprises the following steps: carrying out adaptive threshold segmentation and gray optimization processing on a spine CT sequence image to obtain a standardized preprocessed image, and carrying out adaptive bone tissue region identification and boundary enhancement processing to obtain spine skeleton segmentation data; performing three-dimensional grid construction and curved surface smoothing processing on the spine skeleton segmentation data to obtain spine three-dimensional model data; carrying out centrum gap identification and key point positioning processing on the spine three-dimensional model data to obtain a centrum feature data set, and carrying out spine midline curve construction and end centrum marking processing to obtain Cobb angle data; and performing three-dimensional space reconstruction and multi-plane projection processing on the Cobb angle data to obtain a measurement result report. According to the method and the device, full-automatic processing from acquisition of the CT image to generation of the final measurement result report is realized on the premise of ensuring the measurement accuracy.

The invention belongs to the technical field of hydrogel, and relates to piezoelectric / conductive integrated hydrogel for jaw defect repair, which is prepared from methylacryloyl protein, zwitterionic monomer and titanate piezoelectric particles through ultraviolet crosslinking under the action of a crosslinking agent and a photoinitiator, the hydrogel comprises, by mass, 1.0%-10% of methacrylated protein, 1.0%-10% of zwitterionic monomers, 1.0%-10% of titanate piezoelectric particles and 0.1%-5% of an initiator, and the volume fraction of an accelerant is 0.05%-1.0%. The hydrogel disclosed by the invention has excellent mechanical strength and certain flexibility, can realize piezoelectric and conductive functions of the hydrogel, can effectively promote proliferation, differentiation and mineralization of bone cells under the action of an electric field, accelerates bone tissue repair, and has a more remarkable bone regeneration effect compared with a non-electrical stimulation material in the prior art.

The invention discloses a preparation method of a metal-based nano-enzyme and application of the metal-based nano-enzyme in treatment of periodontitis, the nano-enzyme combines two metal bases, and the nano-enzyme exerts anti-inflammatory, vascularization and osteogenesis effects through advantage complementation to treat periodontitis. The nano-enzyme for treating periodontitis has excellent anti-oxidation / anti-inflammatory performance, exerts an ROS elimination function in a specific environment, responds to a periodontitis pathology microenvironment to release metal ions, exerts a growth factor-like function of the metal ions and realizes repair of blood vessels and bone tissues. The multifunctional nano material has the advantages of simple process, low cost, high activity and the like, and has a good treatment effect on periodontitis.

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an intermedullary implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.

The invention relates to the technical field of biological medicines, and provides application of an ADRM1 inhibitor in preparation of a medicine for treating osteoporosis. Through the scheme of the invention, the ADRM1 affects bone metabolism, bone tissue morphological structure and osteoporosis progress, and can provide a new drug target for clinical prevention and treatment of osteoporosis. The ADRM1 inhibitor is applied to preparation of the osteoporosis medicine, and bone mass loss can be obviously reduced by down-regulating ADRM1 expression or inhibiting ADRM1 activity and inhibiting differentiation and functions of osteoclasts, so that the effect of treating osteoporosis is achieved.

Manganese-doped hollow mesoporous silica nanoparticles loaded with curcumin and an application in periodontal bone tissue repair are provided in the present disclosure, belonging to the technical field of targeted delivery of nanoparticles and bone tissue regeneration. In the present disclosure, alendronate is grafted on the surface of silica nanoparticles to achieve bone targeting, manganese is doped on the nanoparticles by a chemical method, and curcumin is wrapped in the nanoparticles.

The invention relates to bionic matrix hydrogel for constructing bone organs and a preparation method of the bionic matrix hydrogel. The bionic matrix hydrogel is prepared from a bone acellular extracellular matrix, a salmon DNA (Deoxyribose Nucleic Acid) network and a calcium phosphate oligomer under the combination of photo-crosslinking and self-assembly physical crosslinking. The acellular extracellular matrix in the bionic matrix hydrogel can simulate organic components in natural bones, the calcium phosphate oligomer can simulate inorganic components in the natural bones, and sufficient phosphate ions can be provided for biomineralization due to introduction of a DNA network. The biomimetic matrix hydrogel can replace Matrigel to act in bone organoid culture, provide a living environment similar to bone tissue for three-dimensional culture cells, enhance substance exchange and signal transduction between cells, promote proliferation, adhesion and osteogenic differentiation of bone marrow mesenchymal stem cells, and further accelerate the process of biomineralization. The invention provides an optional new material for preparing the functional bone organ.

A high-performance near-pure zinc alloy, a preparation method therefor and a use thereof, relating to the technical field of zinc alloys. The alloy component is that the content of Zn is greater than or equal to 99.5%, and the remaining trace alloy elements include at least two of the following 14 elements: Mg, Mn, Li, Cu, Ag, Ca, Sr, Fe, Zr, Ti, Al, C, Ga, and Si. The alloy has the yield strength ≥ 250 MPa, the tensile strength ≥ 320 MPa, the elongation ≥ 25%, the mechanical property change during one year of room-temperature storage ≤ 5%, the maximum bending force ≥ 2 kN, the stress corrosion sensitivity factor ≤ 15%, the size of corrosion pits after 60 days of immersion ≤ 15 μm, and the standard deviation of the size of corrosion pits ≤ 3 μm. The alloy is suitable for the preparation of biodegradable stents, bone implant devices, medical staplers or anastomotic nails for intestines, blood vessels or nerves, vascular clamps, guided bone or tissue regeneration membranes, heart valve protheses, dura mater repair membranes, soluble bridge plugs and fracturing balls for oil drilling, zinc alloy die castings, electroplated zinc materials, building zinc materials, battery-grade zinc, printing-grade zinc, and zinc-based brazing alloys.

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

The invention relates to the technical field of medical informatics, in particular to a construction method of an osteoporotic fracture risk prediction model. The method comprises the following steps: acquiring an included angle between a foot and the ground, a step speed and a CT image of a target person in a monitoring process; dividing pixel points in the CT image into a plurality of bone tissue areas; according to the shape distribution characteristics of the edge lines in the bone tissue area, bone characteristic values of the bone structure are obtained; obtaining a posture control factor of each gait according to the included angles between the left and right feet of the target person in each gait and the ground; determining an abnormal posture index of each gait in combination with the posture control factor and the corresponding step speed; obtaining a control disorder coefficient of each time period according to the numerical distribution characteristics and the change characteristics of all the posture control factors in each time period; and determining an osteoporosis evaluation value by integrating the bone characteristic value and the disorder control coefficient of the skeleton structure. The accuracy of the bone comprehensive evaluation result of the target person is improved.

The invention relates to the technical field of biological medicine, in particular to recombinant III-type humanized collagen as well as a preparation method and application thereof. In one embodiment, the recombinant III type humanized collagen prepared by the invention has an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 4. The recombinant III-type humanized collagen prepared by the invention has good biological activity, can promote collagen synthesis related gene expression, promote skin fibroblast proliferation, increase the content of skin collagenous fibers and elastic fibers, and improve skin elasticity and compactness; in addition, the expression of osteogenesis related genes is promoted, and the proliferation of osteoblasts is promoted. The results show that the recombinant III-type humanized collagen prepared by the invention has an extremely wide application prospect in developing related medical and cosmetic products for delaying skin aging and promoting wound repair and bone tissue healing.

A minimally invasive ultrasonic knife head and a minimally invasive ultrasonic bone power system, the minimally invasive ultrasonic knife head comprises a knife rod and a head end, the head end is located at the front end of the knife rod, the head end is curved to the side at a certain angle, and the knurled teeth or bevel teeth are arranged on the curved part. By bending the head end, the bone tissue around the intervertebral foramen mirror can be removed, so that the operator has more operation space under the limited foramen mirror channel, and the bone removal efficiency is improved. The knurled teeth or bevel teeth are arranged on the curved part, so that the bone tissue around the intervertebral foramen mirror can be better polished or cut.

The invention discloses a cerium oxide-based nano material for bone defect repair and a preparation method of the cerium oxide-based nano material. The cerium oxide-based nano material for bone defect repair is prepared by performing surface modification on cerium oxide-based nano enzyme, and the surface modification comprises introducing a targeting ligand and / or carbon quantum dots into the cerium oxide-based nano enzyme. The invention also discloses a cerium oxide-based composite bone scaffold. The cerium oxide-based composite bone scaffold is prepared by compounding the cerium oxide-based nano-enzyme and / or the cerium oxide-based nano-material and the bone tissue engineering material.

The utility model discloses an orthopedic drill bit with controllable drilling depth, which comprises a fixing sleeve for fixing a drill bit body, and a limiter and a locking component are mounted at the bottom of the fixing sleeve; a plurality of telescopic holes are formed in the bottom of the fixed sleeve; the limiting stopper comprises a limiting ring, a plurality of moving rods are installed at the top of the limiting ring, springs are further installed at the ends of the moving rods, and the moving rods, namely the springs, are all installed in the telescopic holes; by means of the limiting stopper and the scales, a user can accurately set and read the drilling depth according to needs, and the drilling accuracy and safety in the operation process are guaranteed; due to the design of the movable rod and the telescopic hole, the depth can be adjusted easily and rapidly, and the operation flexibility in the operation process is improved; the limiting ring and the locking assembly are combined for use, the drill bit can be effectively prevented from excessively drilling in, and therefore bone tissue and surrounding soft tissue of a patient are protected against damage.

The invention discloses a bone regeneration promoting drug-loaded skull implant with a bionic structure and a preparation method of the bone regeneration promoting drug-loaded skull implant, and belongs to the technical field of medical materials. The skull implant is prepared through a flat plate mold pressing technology and is of a bionic three-layer structure, the upper layer and the lower layer of the haft tube imitating structures and the middle layer of the bone trabecula imitating structure are prepared through the water-soluble core, a vascularization channel can be provided, and bone tissue climbing is promoted; a polydopamine-carboxymethyl chitosan coating is used for carrying out surface modification on a porous structure of the implant, hydroxyapatite in-situ forming and bone regeneration promoting medicine loading are achieved through an impregnation process, and the polydopamine coating can provide a hydration environment; hydroxyapatite in-situ forming increases biocompatibility on the premise of not influencing the mechanical properties of implants, in addition, hydroxyapatite degradation and drug release can jointly induce bone tissue regeneration, and skull repair is promoted.

The invention discloses a real-time pose updating method based on feature prediction and point cloud registration, and belongs to the technical field of image registration, and the method comprises the steps: extracting a bone surface point cloud which at least covers a feature region and an adjacent region from a three-dimensional model of a bone tissue of a patient, the point cloud is used as a target point cloud for registration with a real-time ultrasonic image; an ultrasonic image collected by the ultrasonic patch in real time is obtained, and a two-dimensional ultrasonic image with a spatial position is obtained; predicting the two-dimensional ultrasonic image by using a pre-trained artificial intelligence model to obtain bone-soft tissue interface features, and extracting a plurality of points on a bone-soft tissue interface from the bone-soft tissue interface to form a source point cloud for registration; and registering the source point cloud to the target point cloud to realize real-time pose updating. According to the invention, the pose monitoring in the operation can be realized through the real-time image flow under the non-invasive condition.

This invention relates to an ultrasonic bone scalpel and an ultrasonic cutting device, belonging to the field of medical device technology. The ultrasonic bone scalpel is used to cut bone tissue from within the medullary cavity, and includes an ultrasonic scalpel body and a retaining assembly. The ultrasonic scalpel body includes a handle and a cutting head mounted on one end of the handle. The retaining assembly includes a pressure bladder mounted on the handle, with the pressure bladder and cutting head arranged radially opposite each other along the handle. The pressure bladder is capable of expanding or contracting. The ultrasonic bone scalpel provided by this invention utilizes the expansion of the pressure bladder to provide continuous cutting pressure based on the cutting action of the ultrasonic scalpel body, reducing the cutting wound on soft tissue, thereby protecting soft tissue while satisfying bone tissue cutting requirements. Furthermore, because this ultrasonic bone scalpel cuts from the inside out of the medullary cavity, it avoids external damage to soft tissue, thus reducing the cutting wound on soft tissue and further protecting it. Therefore, when the cutting wound on soft tissue is reduced, the risk of intraoperative infection is correspondingly reduced, and the healing time is shortened.

The invention discloses an alveolar bone noninvasive detection method based on a spatial offset Raman spectrum technology. The method comprises the following steps: S1, selecting a first near-infrared excitation wavelength and a second near-infrared excitation wavelength to form a multi-wavelength tunable excitation light beam; s2, synchronously acquiring a first group of original Raman spectrum signals under a plurality of spatial offset distances; s3, acquiring a second group of original Raman spectrum signals by using an acousto-optic composite modulation Raman enhancement mechanism; s4, inputting the soft tissue optical parameter set into a joint inversion equation; s5, obtaining a deep alveolar bone Raman characteristic spectrum data set; s6, training an alveolar bone tissue health recognition model; and S7, based on the alveolar bone tissue health recognition model, performing health state judgment on the deep alveolar bone Raman characteristic spectrum data set acquired in real time, and generating an alveolar bone health assessment result. The early screening and dynamic monitoring capabilities of alveolar bone diseases are greatly improved, and the clinical working efficiency of doctors and the doctor-seeing experience of patients are remarkably optimized.

The invention belongs to the field of biological medicines, and discloses an application of Akkermansia muciniphila or an extracellular vesicle of the Akkermansia muciniphila in preparation of a medicine for alleviating the ischemic necrosis of the alcoholic femoral head. Based on the pathogenesis characteristics of the AIONFH, the Akk bacteria and the extracellular vesicles thereof are used for treating the AIONFH for the first time, the molecular mechanism of the Akk bacteria and the extracellular vesicles thereof for regulating and controlling the intestinal tract-skeleton axis function, inhibiting bone cell apoptosis and improving the bone trabecula microstructure is deeply researched, the anti-pressure ability of bone tissue is improved, and the research blank in the field is filled. Compared with a traditional treatment method, the osteonecrosis pathological change is improved through a single way, and a novel multi-target treatment strategy is provided from multiple aspects of regulating inflammatory response, recovering bone metabolism balance, promoting intraosseous blood supply and the like.

The invention discloses a bone repair material based on pH controlled release and a preparation method thereof. The bone repair material comprises the following raw materials: polycaprolactone, nano hydroxyapatite and nano magnesium oxide. The composite bone repair scaffold has the beneficial effects that the composite bone repair scaffold with excellent biocompatibility, excellent osteogenesis performance, excellent degradation performance and pH controlled release of magnesium ions is prepared by printing the bone repair material through a 3D printing technology, a temporary three-dimensional structure can be provided for cells, cell adhesion, proliferation and differentiation are promoted, growth factors are released at the same time, and the growth rate of the cells is increased. The formation of new bone tissues is guided; the composite bone repair scaffold can continuously and quantitatively release magnesium ions through pH value control, when osteoarthritis or bone tissue inflammation occurs at a bone defect part due to improper operation and rejection reaction, the magnesium ion release speed of the composite bone repair scaffold is increased, the anti-inflammatory effect is achieved, and the magnesium ions which are continuously released can promote bone tissue repair.

An osteoinductive and osteoconductive composition including DBM fibers having multiple geometries, as well as a method of producing the same are disclose. For example, such a method may include: obtaining bone tissue; cleaning the bone tissue obtained with a plurality of washes; milling the cleaned bone tissue into a plurality of fibers of two or more geometries including a long wide fiber, a long narrow fiber, a short wide fiber, and a short narrow fiber; demineralizing the plurality of fibers of two or more geometries to expose one or more biologically active components; and neutralizing the plurality of demineralized fibers of two or more geometries resulting in demineralized bone matrix.

A method for constructing a microfluidic bone organoid-on-chip can continuously observe the impacts of different external factors on a bone tissue structure based on the “ternary regulation theory” of bone angiogenesis-bone resorption-osteogenesis coupling. The method includes: (1) building a visual three-dimensional cell cultivation platform to continuously observe impacts of different external factors on a ternary regulation theory based on angiogenesis of osteoclast precursors, osteoblasts and osteoclasts, such that a user is allowed to directly observe interactions among various kinds of cells; (2) designing microfluidic channels in a chip to allow a reagent involved to present a concentration gradient distribution in the chip; and (3) adding three bioinks including osteoblasts, osteoclasts and vascular endothelial cells respectively, so as to reflect the three cell components individually, in pairs, and as a whole in the chip. An apparatus for constructing a microfluidic bone organoid-on-chip is further provided.

The invention provides an interface-enhanced regenerated bone scaffold for sustained-release medicines as well as a preparation method and application of the interface-enhanced regenerated bone scaffold, and belongs to the technical field of bone tissue engineering. According to the invention, polycaprolactone and hydroxyapatite are taken as matrix components of the regenerated bone scaffold, so that the regenerated bone scaffold has mechanical strength matched with a host bone and good biocompatibility; the polydopamine coating is loaded on the surface and internal pores of the regenerated bone scaffold matrix, surface functional modification is easy to perform, and a catechol structure in the polydopamine coating can perform coordination binding with metal ions in MOFs, so that the falling rate of MOFs particles is reduced, and the MOFs particles are uniformly and stably distributed; the MOFs particles are used for loading the eucommia ulmoides extract, safety and non-toxicity are achieved, the eucommia ulmoides extract is encapsulated in the MOFs particles, the stability of the eucommia ulmoides extract can be improved, and a better drug release effect and a better bone regeneration promoting effect are achieved.

The invention provides a multi-parameter feature fused vertebral CT image standardization preprocessing method and system. The method comprises the following steps: carrying out initial segmentation on an input original vertebral CT image; carrying out enhancement processing on the image by adopting an anisotropic diffusion filtering algorithm of multi-scale structure perception; establishing a tissue specificity density mapping model of multi-parameter fusion; adopting a self-adaptive segmentation histogram mapping method to map gray distribution of an original image to a standard template; and constructing a rigid-elastic mixed registration model. According to the invention, a complete quality evaluation system is established, the processing quality can be automatically detected and reported, and the reliability of an output result is ensured. By introducing a patient individualized correction mechanism, individual difference information is fully reserved while the standardization effect is ensured, and diagnosis information loss caused by excessive standardization is avoided. The multi-parameter fusion strategy ensures complete reservation of bone tissue density, texture and structure information.

The invention provides a preparation method of a mineralized collagen scaffold material with a bionic structure, and belongs to the field of biomedical engineering.The preparation method comprises the steps that an amorphous calcium phosphate solution stabilized by polyacrylic acid is prepared, and the molar ratio of Ca to P in the amorphous calcium phosphate solution is 1.67: 1; preparing a collagen solution containing noradrenaline; carrying out isoelectric focusing treatment on the collagen solution under a constant voltage to form a dense membrane, and stretching the dense membrane to generate 120-200% deformation, so as to obtain a collagen membrane with a bionic structure; and soaking the collagen membrane in the amorphous calcium phosphate solution, and then performing freeze drying to obtain the noradrenaline-mineralized collagen scaffold material. The mineralized collagen scaffold material prepared by the method has excellent biocompatibility, osteogenesis inductivity and sufficient mechanical strength, can effectively promote bone tissue defect repair, and has a good application prospect in the field of bone tissue engineering. The invention further provides the mineralized collagen scaffold material with the bionic structure and application of the mineralized collagen scaffold material.

The invention belongs to the technical field of biomedical materials, and particularly relates to a gradient bionic wood-based collagen bone-cartilage repair scaffold and a preparation method and application thereof.The scaffold comprises a surface layer, a middle layer and a bottom layer, the surface layer is composed of collagen, the middle layer is composed of collagen and nano-hydroxyapatite, and the bottom layer is composed of collagen and nano-hydroxyapatite; the bottom layer is composed of wood, collagen and nano-hydroxyapatite, the scaffold is obtained by stacking the surface layer, the middle layer and the bottom layer and then conducting freeze-drying, the structure of the scaffold is similar to that of natural osteochondral cartilage, the surface layer is of a porous structure communicated with one another, and the bottom layer is of a directionally-arranged pore channel structure; the main composition of a natural bone cartilage tissue can be highly simulated, and the gradient is presented; the bone marrow mesenchymal stem cell prepared by the method has the advantages of high mechanical performance, gradient enhancement from the surface layer to the bottom layer, excellent biocompatibility and biological activity, capability of remarkably promoting cell proliferation and gradient differentiation of bone marrow mesenchymal stem cells, and application to osteochondral tissue regeneration and clinical treatment of osteoarthritis.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention relates to the field of application of medicines for treating rheumatoid arthritis, and discloses an application method of targeted MTHFD2 in preparation of medicines for treating bone destruction of rheumatoid arthritis, (1) the level of MTHFD2 in knee joints of rheumatoid arthritis patients and mice is increased; (2) the expression of MTHFD2 is up-regulated in the process of differentiating osteoclast precursor cells from mice and humans into osteoclasts; (3) the MTHFD2 inhibitor can significantly inhibit differentiation of osteoclasts from mice and humans; (4) MTHFD2 gene silencing can inhibit differentiation of mouse-derived osteoclasts, MTHFD2 gene overexpression can promote differentiation of osteoclasts, and reliability of MTHFD2 as a therapeutic target is verified; and (5) the MTHFD2 inhibitor can improve the bone destruction of arthritis mice and increase the bone tissue density, which prompts that the targeted MTHFD2 is useful for the treatment or prevention of rheumatoid arthritis and other diseases.

The invention discloses a bone scaffold fusion design and preparation method based on mirror image registration, and the method comprises the steps: firstly, based on a three-dimensional medical image of a femoral defect region of a patient, combining an opposite-side complete femoral CT image, and achieving the automatic recognition and complementation of the defect region through the mirror image transformation and ICP registration technology; after defect boundary extraction is completed, three-dimensional reconstruction is carried out on the individualized outer contour of the left bone tissue, and an STL format model is exported. According to the femur functional partition characteristics, a Diamond structure is adopted in a cortical bone area to enhance mechanical support, and a Gyandroid structure is selected in a cancellous bone area to achieve porosity gradient filling, so that the permeability is optimized, and cell proliferation is promoted. Continuous transition among the structures is realized through a Sigmoid function, and the stability and the biological adaptability of the whole structure are improved. And finally, the stent model is subjected to selective laser melting, and a Zn-3Mg alloy material is utilized to complete printing manufacturing.

The invention provides application of polylactic acid and a copolymer thereof or microspheres thereof in preparation of medicines for promoting growth of bone tissues and cartilage tissues. The molecular weight of the polylactic acid and the copolymer thereof is 400 Da to 300 kDa. The invention firstly discovers that the polylactic acid and the copolymer thereof or the microspheres thereof have the effect of promoting the growth of the bone tissue and the cartilage tissue, and provides a new way for promoting the growth of the bone tissue and the cartilage tissue.