This invention discloses a double-crosslinked hydrophobic fluid
gelatin hemostatic material and its preparation method, belonging to the field of biomedical materials technology. The material is composed of type A
gelatin, transglutaminase,
glycerol, and deionized water. It undergoes biological crosslinking via transglutaminase and vacuum high-temperature physical crosslinking, combined with a porous structure design, to prepare a ready-to-use shear-
thinning fluid
gelatin. This invention employs a biological
enzyme and physical double crosslinking
system, avoiding the toxic residues of chemical crosslinking agents and ensuring high
biosafety. The material is directly aseptically filled in a ready-to-use fluid form, requiring no preoperative preparation or
dilution; it is
ready to use immediately upon opening, significantly simplifying clinical procedures. Through the biological-physical double crosslinking network design, its
mechanical strength and
structural stability are greatly improved. It is heat-resistant, deformation-resistant, and does not disintegrate or collapse with long-term use. It can effectively adhere to irregular wound surfaces and is suitable for wound
hemostasis and repair in minimally invasive surgeries such as
neurosurgery and
spinal surgery.