118 results about "Micromanipulator" patented technology

An apparatus and method for safely cannulating a blood vessels, including but not limited retinal blood vessels, is described. In one embodiment, the apparatus can consist of a micropipette/microcannula, micromanipulator and positioner mounted to a base, which is attached to a wrist rest commonly used in eye surgery. The micropipette/microcannula is connected to tubing such that a medication may be injected through the micropipette/microcannula into the blood vessel or conversely, a small quantity of material may be removed from a blood vessel. Alternatively, a catheter, wire or stent may be placed through the micropipette/microcannula to treat or diagnose an area remote from the insertion site. The ability to cannulate a retinal blood vessel should be efficacious in the treatment of vein and artery occlusion, ocular tumors and other retinal, vascular and optic nerve disorders that would benefit from diagnosis and/or treatment. In another embodiment, a self-sealing needle is provided which allows the perforation of a blood vessel or other structure and the minimization of hemorrhaging when the needle is withdrawn from the blood vessel/structure. Another embodiment discloses an ocular implant needle.

A micromanipulator comprising a tubular structure and a structural compliance mechanism that are formed from a tube made of an elastic and/or superelastic material. The micromanipulator is useful for intravascular interventional applications and particularly ultrasonic imaging when coupled with an ultrasound transducer. Also disclosed are medical devices for crossing vascular occlusions using radio-frequency energy or rotary cutting, preferably under the guidance of real-time imaging of the occlusion, as well as accompanying methods.

A micromanipulation system includes a micromanipulator that includes a handpiece, and a micromanipulation tool that includes a tool shaft and is operatively connected to the handpiece. The micromanipulator further includes an actuator assembly connected to the micromanipulation tool to provide manual control of the micromanipulation tool, and a force sensing system comprising a force sensor attached to the tool shaft. The force sensing system is configured to provide an output signal that indicates a force imposed on the tool shaft. The micromanipulation system also includes a processor that is in communication with the force sensing system, and is configured to receive the output signal and compensate for forces due to actuation of the micromanipulation tool to determine a force due to interaction of the micromanipulation tool with a region of interest. The processor outputs an indication of at least one of a magnitude and a direction of the determined force.

The invention discloses a micromanipulator for enterocoelia minimally invasive surgery, relating to a micromanipulator for minimally invasive surgery. The invention solves the problem of the shortage of micromanipulators in surgical equipment of existing enterocoelia minimally invasive surgery. In the invention, a lower clutch dial is installed on the upper end face of a tooth-form central spindle of a driving box, an upper-finger upper clutch dial of a traction mechanism of the upper finger at the tail end of the surgical equipment is contacted with a corresponding lower clutch dial of the driving box; a lower-finger upper clutch dial of the traction mechanism of the upper finger at the tail end of the surgical equipment is contacted with the corresponding lower clutch dial of the driving box; a wrist upper clutch dial of the traction mechanism of the wrist at the tail end of the surgical equipment is contacted with the corresponding lower clutch dial of the driving box; and an autorotation upper clutch dial of an autorotation mechanism at the tail end of the surgical equipment is contacted with the corresponding lower clutch dial of the driving box. The micromanipulator of the invention is convenient for rapidly exchanging surgery tools, thereby increasing the nimbleness of surgery action, and meeting the requirements in various aspects such as size, function and clamping force an the like on the micromanipulator, thus being applicable to enterocoelia minimally invasive surgery.

A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipulator or similar holding devices. The microcatheter system is particularly suitable for the treatment of retinal venous occlusive disease.

The invention relates to a method for permeabilization of a cell structure consisting of a single cell, an intracellular structure or an organelle comprising the following steps: (a) microelectrodes, preferably two carbon fiber electrodes or hollow fiber electrodes, are provided, (b) the microelectrodes are connected to a power supply, (c) the electrodes, individually controlled by high-graduation micromanipulators, are placed close to the cell structure at an appropriate inter-electrode distance, and (d) a highly focused electric field of a strength sufficient to obtain electroporation is applied between the electrodes. The method may be used in order to transfer cell impermeant solutes, such as drugs or genes, into the cell structure or out of the cell structure, in biosensors, in the treatment of tumours and neurodegenerative diseases and in the study of biophysical processes.

A piezoelectric clamping micromanipulator with flexible drive and amplification and adjustable range is composed of microactuator, flexible multiplying mechanism, size pre-regulator, and clamping micromanipulator. Its advantages are compact structure, high reliability, and low non-linear error.

A hydraulically-operated micromanipulator apparatus is disclosed. The micromanipulator apparatus comprises: a micromanipulator fine control unit including an operating-side piston finely movable with respect to an operating-side hydraulic cylinder and fine control means, either the operating-side piston or the operating-side hydraulic cylinder being stationarily retained, while the rest being finely operable by the fine control means; a hydraulically-operated micromanipulator including an actuating-side piston finely movable with respect to an actuating-side hydraulic cylinder and a fine displacement member, the actuating-side hydraulic cylinder being connected to said operating-side hydraulic cylinder through a hose, either the actuating-side piston or the actuating-side hydraulic cylinder being stationarily retained, while the rest being attached to the fine displacement member; and compensating means for compensating a pressure change of the hydraulic fluid between said operating-side hydraulic cylinder and said actuating-side hydraulic cylinder when ambient temperature changes.

This invention relates to measuring stiffness of a biological sample Specifically, the invention relates to a milliprobe indentation device that comprises a force probe and a micromanipulator and uses thereof for measuring stiffness of biological samples

The present invention provides a microinjection assembly including a microscope, a microinjection system comprising a micromanipulator, a micropipette and a piezo-electric oscillator, and an obliquely angled macro monitoring unit. The present invention also provides methods of microinjecting the germinal disk of an avian egg, thereby delivering a transgenic nucleus, spermatozoon or isolated nucleic acid to the avian embryo. The avian ovum may be returned to a female bird for hard-shell deposit and laying of the egg for hatching as a transfected bird.

An improved method for extracting and handling multiple samples for S/TEM analysis is disclosed. Preferred embodiments of the present invention make use of a micromanipulator that attaches multiple samples at one time in a stacked formation and a method of placing each of the samples onto a TEM grid. By using a method that allows for the processing of multiple samples, the throughput of sample prep in increased significantly.

The detection device includes slide glass with transparent film attached on surface, reactor, separation capillary (SC), reaction capillary with detection window (DW), luminescence detection part located at DW, and micromanipulator. Being positioned between the slide glass and the reactor, the micromanipulator is in use for grasping SC. Cell suspension pool and dissolve film pool are setup on the transparent film. Being setup on the slide glass, buffer solution pool is connected to high-voltage end. The reactor includes reaction continuous groove (RCG), and inlet connected to RCG for adding chemiluminescence reagent. RCG is connected to ground. RCG is connected to the reaction capillary. SC is setup in RCG. One end of SC is on the transparent film, and the other end is positioned at DW. Features are: easy of preparation, and operation, small size, low cost, and high detection sensitivity. The detection device is suitable for simple cell analysis, and research in area of life sciences.

Support or micromanipulator (100) for a surgical tool (20) comprising a complaint mechanism (1) providing direct support to the surgical tool (200), a positioning mechanism giving support to said complaint mechanism, and an attachment mechanism giving support to said positioning mechanism. The complaint mechanism (1) is made of a complaint material and allows three or four degrees of freedom to the movement of the tool (200). The positioning mechanism is located between the attachment mechanism and the complaint mechanism (1) and allows positioning of the same with six degrees of freedom. The attachment mechanism fastens the assembly to a surface of the surgical intervention region. The micromanipulator (100) is especially useful for practicing surgical interventions in the cochlea (performing cochlear implants, obtaining samples, etc), or other interventions for which high precision with the tool (200) is required.

The invention relates to a food processing machine which comprises a cup body (1), a cup cover (101), a handle (103), a rod linkage device and a machine body (2); wherein the cup cover (101) can be buckled on the cup body (1) in a rotating manner; the cup cover (101) at least comprises a first and a second trigger parts; at least a first and a second micromanipulators and an electric locking device are arranged in the machine body (2); and the electric locking device comprises a solenoid switch (204) and a top buckle (201). When the cup cover (101) is buckled on the cup body (1) in a rotatingmanner, the first trigger part of the cup cover (101) triggers the first micromanipulator and the second trigger part of the cup cover (101) triggers the second micromanipulator through the rod linkage device, therefore, the food processing machine can electrically run after the first and the second micromanipulators are switched on with electricity, and the top buckle (201) of the electric locking device locks the cup cover (101) in place during the electrical running process of the food processing machine.

The invention belongs to sweet water breeding pure natural fresh-keeping type dull-tip spirulina and ultra-large spirulina which are alga for world wild production at present. Functional fresh-keeping new patern dull-tip spirulina and ultra-large spirulina variety which are emanated by cobalt (60)10 gray-25000 gray for 5 minutes to 10 hours, after controlling temperature, controlling light, controlling pH and conditioning all kinds of nutrition ingredient, single excellent mutagenesis variety screened by micromanipulator are purified and cultured are chosen. The functional fresh-keeping new patern dull-tip spirulina and ultra-large spirulina variety have stabilising germ line and higher nutrition ingredient than general dull-tip spirulina, ultra-large spirulina and other mutagenesis variety, especially some ingredients are more several times than present dull-tip spirulina and ultra-large spirulina. The alga wall of the new type spirulina is very thin, the width and length of alga body are larger than present dull-tip spirulina and ultra-large spirulina. We have breed five kinds of sweet water production alga variety whose functions are respectively fatigue protection, blood sugar dropping, beauty treatment, pruritus protection and hemostasia in indoor large scale clean environment deep layer (1 to 1.5meter).