28 results about "Micromanipulator" patented technology

A micromanipulator comprising: a first frame portion defining an axial direction extending from a first proximal end to a first distal end; a second frame portion; a tool holder coupled to the second frame portion; a first connecting portion coupling the second frame portion and the first frame portion at the first distal end in resilient pivotable coupling; and a second connecting portion coupling the second frame portion and the first frame portion at the first proximal end in resilient pivotable coupling. The first frame portion, the second frame portion, the first connecting portion, and a second connecting portion form a flexural frame. The flexural frame is resiliently biased to a first frame state in which the tool holder is in a retracted position.

An automatic end effector tip position initialization mechanism for a micromanipulation system is provided. The method includes: S1, positioning a macro end effector tip, calculating a camera pose by using ArUco Tag, and realizing a three-dimensional positioning of the end effector tip by using a triangulation method, and moving the end effector to a area near a center of a focal plane based on a visual servo; S2, positioning a micro end effector tip; S3, acquiring calibration data based on a visual servo, calibrating the end effector tip and the petri dish, and obtaining a left calibration matrix and a right calibration matrix reflecting the transformation relationship between left and right micromanipulator coordinates and image coordinates; generating an intuitive human-computer interaction interface based on a mouse and a keyboard according to acquired position information. The method has obvious advantages in terms of operation accuracy, operation efficiency and repeatability.

1. Name of the product in this design: Micromanipulator. 2. Purpose of this design: Micromanipulator. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The design for which protection is sought includes color.

Micromanipulator for manipulating a laser beam of a laser surgery device, comprising a scanner for generating at least one scan figure and at least one control element for controlling the scanner, characterized in that the control element comprises a rotary element, wherein a rotation of the rotary element causes a rotation of the scan figure, which depends on the size and / or speed of the rotation of the rotary element.

A micromanipulator (1) for manipulating a laser beam (L in , L scan ) of a laser surgery device, comprising a scanner (10) for generating at least one scan figure (60) and at least one control element for controlling the scanner (10), wherein the control element comprises a rotating element (51), wherein a rotation (D d) of the rotating element (51) causes a rotation (D s) of the scan figure (60), which depends on the size and / or speed of the rotation (D d) of the rotating element (51), wherein the rotating element (51) can rotate freely without limiting the angle of rotation and the scan figure (60) follows this free rotation without restrictions, and a laser surgery device with said micromanipulator (1).

The invention relates to the field of nanotechnology, more particularly to exerting an utralocalized thermal effect on an object under examination, and even more particularly to controlled heating using a nanodiamond heater. The present ultralocalized optical heating method is based on exposing to laser radiation nanoparticles fixed in the end of a glass capillary that is placed in a medium under examination. An ultralocalized optical heating device for carrying out this method comprises a nanoparticle disposed in a glass capillary that is mounted in a micromanipulator, wherein the nanoparticle is disposed in the end of the glass capillary and is a polycrystalline diamond particle containing amorphous carbon at its grain boundaries, which is optically coupled to a source of laser radiation and to a luminescence recording unit, wherein the diamond particle contains at least one luminescent impurity centre and the glass capillary is placed in a medium under examination.

To control a rotation operation of an end effector smoothly and reliably.SOLUTION: A parallel link mechanism causes one end of a link 13 to make a linear movement by a plurality of linear actuators 14 supported by a base for each link, and moves an end effector 12 connected to the other end of each ink 13. The parallel link mechanism includes a rotation support part 17 provided between the end effector 12 and the parallel link mechanism and supporting the end effector 12 rotatably around a predetermined rotation axis, and a hydraulic drive mechanism for generating rotation force around the rotation axis for the end effector 12. The movement to rotate the end effector 12 is generated by giving liquid pressure variation of working fluid to the hydraulic drive mechanism from outside.SELECTED DRAWING: Figure 5

The present invention relates to an axial movement mechanism of a biological micromanipulator with an adjustable oblique movement angle, which comprises an angle adjustment component, an axial movement module and an operator arranged in sequence from top to bottom; the angle adjustment component includes a horizontally arranged reference plate, an adjustment shaft which is horizontally and rotatably connected to the bottom of the reference plate and extends in the front-rear direction, an adjustment plate arranged horizontally below the adjustment shaft, a worm gear sleeved and fixed outside the adjustment shaft, a first servo motor fixed to the bottom of the reference plate, and a worm concentrically fixed on the rotating shaft of the first servo motor and meshing with the worm gear; both ends of the adjustment shaft are fixed to the adjustment plate, and the rotating shaft of the first servo motor is arranged horizontally to the left or right; the present invention can significantly improve the accuracy of puncture or injection operations to ensure the experimental effect and avoid experimental failures; it also greatly speeds up the operation speed to achieve the effect of saving time and effort and greatly facilitates the use.

An inspection system for inspecting a surface includes a macromanipulator including an inspection end configured to be disposed proximal to the surface. The inspection system further includes a micromanipulator coupled to the inspection end. The. micromanipulator includes a housing, a pair of guide rails at least partially disposed within and fixedly coupled to the housing, a probe support slidably coupled to the pair of guide rails, an actuating arm disposed within the housing and coupled to the probe support via a scotch yoke mechanism, and an actuating mechanism configured to rotate the actuating arm relative to the housing. The inspection system further includes a probe coupled to the probe support for inspecting the surface.

Two or more micropipettes are used to increase a microinjection throughput in an automated system for microinjecting adherent cells on a Petri dish. In the system, a motorized stage carrying the Petri dish sequentially visits the cells according to an optimized injection sequence. The sequence is selected by minimizing a total distance traveled by the motorized stage such that each cell is visited once by one of the micropipettes. Using multiple micropipettes advantageously reduces the minimized total distance over using a single micropipette to thereby increase the throughput. The optimized injection sequence is obtained by solving an equality-generalized traveling salesman problem. Each micropipette is mounted on a motorized micromanipulator. The motorized stage and motorized micromanipulators operate coordinately that each micromanipulator goes down or up during movement of the motorized stage to compensate for unevenness between a focus plane and a moving trajectory of the motorized stage.

The invention discloses an application of EAG in measuring the retinal potential of insects, which is characterized in that core components of the EAG, namely an IDAC-2 controller and a Combi probe, are utilized to extend the functions of the EAG, special retinal potential measuring equipment does not need to be purchased, and the hardware cost is reduced by about 70%. An original electrode is improved, an original antenna locator is replaced with an eye electrode support, a smell stimulation device is removed and replaced with a built light stimulation device, and cross-function application of the EAG from'antenna potential measurement 'to'retina potential measurement' is achieved. The EgPro software synchronously triggers the photostimulation device and data acquisition, and the problem of phase error caused by desynchrony of photostimulation and potential recording in a traditional method is solved. An electrolytic sharpening tungsten filament electrode is combined with a micromanipulator for positioning, so that compound eye single-cell-level precise puncture is realized.

Micromanipulator (1) for manipulating a laser beam (Lin, Lscan) of a laser surgery device, comprising a scanner (10) for generating at least one scan figure (60) and at least one control element for controlling the scanner (10), wherein the control element comprises a rotary element (51), wherein a rotation (Dd) of the rotary element (51) causes a rotation (Ds) of the scan figure (60), which depends on the size and / or speed of the rotation (Dd) of the rotary element (51), wherein the rotary element (51) is freely rotatable without limiting the angle of rotation and the scan figure (60) follows this free rotation without restrictions, and laser surgery device with such a micromanipulator (1).

The application belongs to the technical field of integrated circuit preparation, and particularly discloses a micro-motion stage and a motion device. The micro-motion stage comprises a mounting base, a vertical driving device installed on the mounting base, a vertical base sleeved on the outside of the vertical driving device, a driving end of the vertical driving device driving the vertical base to move along the Z direction relative to the mounting base, a rotating seat rotatably sleeved on the vertical base along the Z direction and having an unchanged position relative to the vertical base along the Z direction, and a rotating driving motor sleeved on the side surface of the rotating seat and used for driving the rotating seat to rotate along the Z direction, wherein the rotating driving motor comprises a rotating motor rotor and a rotating motor stator which are coaxially and spacedly sleeved, the rotating motor rotor is fixed relative to the rotating seat, and the rotating motor stator is fixed relative to the mounting base. The motion device comprises the above micro-motion stage. The micro-motion stage and the motion device disclosed by the application are beneficial to the lightweight and flat design of the micro-motion stage and the motion device.

Reproductions correspond to multiple views of a single design for a micromanipulator; the broken lines show portions of the design and form no part of the claimed design.

This invention discloses an automated cell manipulation method and system guided by artificial intelligence, comprising: identifying and locating the biological target object to be manipulated based on real-time images acquired by a microscopic imaging system to obtain target position information; calibrating and tracking the end-effector position of a micromanipulator based on the real-time images to obtain the real-time end-effector position; planning and dynamically correcting the motion trajectory of the micromanipulator based on the target position information and the real-time end-effector position until the end-effector reaches the preset target operation position, and controlling the micromanipulator to execute a preset interactive operation; verifying the operation result based on the real-time image after the operation to obtain the verification result, and controlling subsequent processes based on the verification result. This invention overcomes the inherent defects of traditional manual operation and semi-automated solutions in microscale cell manipulation through an end-to-end intelligent process, achieving high-precision, high-throughput, high-success-rate, and highly standardized cell manipulation.

The present invention relates to a tool for use as a micromanipulator and a method for manufacturing the same. The tool comprises a plurality of parts in the form of: a frame (1) oriented along a longitudinal axis (L) and arranged as a hollow body around the interior; at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1); and at least one actuating element (3) arranged on a second end face (1.2) opposite the first end face (1.1) and mounted slidably and axially movable within the frame (1). These parts are movably connected to one another by the necessary connecting and bearing elements, and the tool is produced entirely by additive manufacturing, including all the necessary gaps between the movably connected parts. According to this method, the tool with all parts and gaps between the movable parts is produced entirely by additive manufacturing in a single processing operation.

The present invention discloses an automatic initialization positioning device and method for an end effector tip of a micromanipulation system, which relates to the field of automated micromanipulation. The method comprises: S1, performing macroscopic end effector tip positioning, calculating camera posture using ArUco Tag, and realizing three-dimensional positioning of the end effector tip by triangulation, and moving the end effector to an area close to the center of a focal plane based on visual servo; S2, performing microscopic end effector tip positioning; S3, collecting calibration data based on visual servo, calibrating the end effector tip and a culture dish, and obtaining a left calibration matrix and a right calibration matrix reflecting the conversion relationship between left and right micromanipulator coordinates and image coordinates; and generating an intuitive interactive microscope interface based on a mouse and a keyboard according to the position information collected by S1-S3. The method mentioned in the present application has obvious advantages in terms of operation accuracy, operation efficiency and repeatability, is easy to deploy, has strong compatibility, and is adapted to various magnifications of microscopes.

The invention discloses a double-layer MXene film multi-stimulation response actuator and a preparation method and application thereof, the double-layer MXene film multi-stimulation response actuator is composed of an active layer of an MXene / bacterial cellulose BC composite film and an inert layer with a large thermal expansion coefficient, so that the double-layer MXene film multi-stimulation response actuator is bent and deformed when subjected to humidity and photo-thermal stimulation. The deformation degree of the actuator can be changed by changing the content of Mxene, and the application effect of the actuator is enriched. The multi-stimulation response actuator can generate quick response under stimulation of light, heat and humidity, shows a good actuating effect, can avoid the problem of falling off, can adapt to complex environments, and has huge application potential in the fields of multi-stimulation response robots, artificial muscles, cell scaffolds, micromanipulators and the like.

The invention relates to the field of nanotechnology, more particularly to exerting an ultralocalized thermal effect on an object under examination, and even more particularly to controlled heating using a nanodiamond heater. The present ultralocalized optical heating method is based on exposing to laser radiation nanoparticles fixed in the end of a glass capillary that is placed in a medium under examination. An ultralocalized optical heating device for carrying out this method comprises a nanoparticle disposed in a glass capillary that is mounted in a micromanipulator, wherein the nanoparticle is disposed in the end of the glass capillary and is a polycrystalline diamond particle containing amorphous carbon at its grain boundaries, which is optically coupled to a source of laser radiation and to a luminescence recording unit, wherein the diamond particle contains at least one luminescent impurity centre and the glass capillary is placed in a medium under examination.

There is provided a microscope comprising a micromanipulator, comprising a first electromagnet comprising a first magnetic core; a second electromagnet comprising a second magnetic core, wherein the first magnetic core and the second magnetic core are configured to generate a magnetic force on magnetic probes arranged within a biological matrix arranged in between the first magnetic core and the second magnetic core; and wherein the microscope comprises imaging means configured to capture images of the biological matrix comprising the magnetic probes for detection of displacements of the magnetic probes caused by the magnetic force.

The invention relates to the technical field of oil and gas pipeline flow guarantee, in particular to a spraying system for testing the growth microstructure of hydrates in inhibitor-containing liquid drops and application of the spraying system. The spraying system comprises a microsyringe, an automatic micromanipulator and a small sprinkling can; the small spray contains a solution containing 0.5 wt% of an inhibitor, and the small sprinkling can is used for spraying small liquid drops; the output end of the microsyringe is fixedly connected with a transparent adhesive tape, the lens adhesive tape and the automatic micromanipulator are each connected with a glass fiber, and dispersed small liquid drops are hung on the glass fibers connected with the transparent adhesive tape. The data acquisition system and the image processing system can visually observe the influence of the inhibitor on the dynamic growth morphology of the hydrate, so that the problem that the influence of the inhibitor in the oil phase on the generation of the hydrate in water drops is difficult to measure due to the fact that the hydrate kinetic inhibitor is insoluble in the oil phase is solved.

The invention relates to a tool for use as a micromanipulator and a method for its production. The tool consists of several parts in the form - a frame (1) aligned along a longitudinal axis (L), which is arranged as a hollow body around an interior space, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuating element (3) arranged on a second end face (1.2) opposite the first end face (1.1), which actuating element is slide-mounted and axially movable in the interior of the frame (1), wherein the actuating elements are positively and movably connected to one another by means of the necessary connecting and bearing elements, and the tool is produced entirely by additive manufacturing, including all the necessary gaps between the movably connected parts. According to the method, the tool, with all its parts and the gaps between the movable parts, is manufactured entirely by additive manufacturing in a single machining operation.

A micromanipulator for mounting on the end of a macromanipulator, the micromanipulator comprising: a connection plate with a at least a first and second motor connected to a rigidly mounted base section, a first rotational section connected to the base section about a pivotable axis, the first rotational section being further connected to a slider rod which is connected to the first motor, and a second rotational section connected to the first rotational section about a pivotable axis, the second rotational section being further connected to a slider rod which is connected to the second motor and wherein the rotational joints between the base section and first joint section and the rotational joint between the first and second rotational sections are offset by 90°.

An automatic end effector tip position initialization mechanism for a micromanipulation system is provided. The method includes: S1, positioning a macro end effector tip, calculating a camera pose by using ArUco Tag, and realizing a three-dimensional positioning of the end effector tip by using a triangulation method, and moving the end effector to a area near a center of a focal plane based on a visual servo; S2, positioning a micro end effector tip; S3, acquiring calibration data based on a visual servo, calibrating the end effector tip and the petri dish, and obtaining a left calibration matrix and a right calibration matrix reflecting the transformation relationship between left and right micromanipulator coordinates and image coordinates; generating an intuitive human-computer interaction interface based on a mouse and a keyboard according to acquired position information. The method has obvious advantages in terms of operation accuracy, operation efficiency and repeatability.

To provide a micro manipulator using smectic liquid crystal that can strengthen interfacial force and be used for precise operation for a fine material.SOLUTION: A micro manipulator using smectic liquid crystal includes: smectic liquid crystal S; and interface generation means 2 for generating an interface F between an isotropic phase IP in a liquid state and a liquid crystal phase SP in a liquid crystal state in the smectic liquid crystal S. Generating an interface F between the isotropic phase IP and the liquid crystal phase SP in the smectic liquid crystal S can hold or move a substance with the interface F. Moreover, interfacial force can be strengthened, thereby enhancing capability of holding or moving a substance.SELECTED DRAWING: Figure 1

The invention discloses a measuring chip, an automatic measuring system and a measuring method for the elastic modulus of a flexible biological object, belongs to the field of measurement of mechanical properties of biological materials, and particularly relates to the measuring chip, the automatic measuring system and the measuring method for the elastic modulus of the flexible biological object. The measuring chip comprises a glass substrate, a patterned polydimethylsiloxane (PDMS) substrate and a thin film sensor, the automatic measuring system comprises a measuring chip, a three-axis micromanipulator, an electric oil pump, a focusing manual lifting table, an inclination angle adjusting table, an image acquisition module, an LED light source and an XY electric translation table. An agarose array-film sensor composite structure is used as a flexible plane, and the flexible plane and a solid glass rigid plane form a test system. Therefore, the upper surface is a hard surface, the lower film sensor gradually deforms, and the deformation of the film is far smaller than that of the flexible sample.

To provide a micromanipulator system and micromanipulator system control method that can efficiently make a position adjustment of a micro tool.SOLUTION: A micromanipulator system 1 is a micromanipulator system that is used together with a microscope 10 capable of observing an observation target object S, and that comprises: manipulators 40 that each include a micro tool 41, and that can move the micro tool 41; an acquisition unit 20 that can acquire a microscope photograph at the microscope 10; and a control unit 50 that can control the manipulators 40. The control unit 50 is configured to acquire a tool image being the microscope photograph of the one or more micro tools 41 the acquisition unit 20 acquires, and change a position of each micro tool 41 on the basis of the tool image.SELECTED DRAWING: Figure 1

The invention relates to the technical field of grinding of micromanipulation tubes, and discloses a glass micromanipulation tube numerical control needle grinding instrument which comprises a machine table, a mechanical arm, a grinding disc, a cleaning assembly and a loading / unloading assembly are arranged on the machine table, the end of the mechanical arm is connected with a needle holder through a connecting base, when the needle holder clamps a tube blank, gas can be introduced into the tube blank, and the tube blank is placed in the grinding disc. And the manipulator feeds the pipe blank into the millstone, the cleaning assembly and the loading / unloading assembly for treatment according to a set program. According to the numerical control needle grinding instrument for the glass micromanipulation tube, loading, grinding, cleaning, water supply, gas supply and unloading in the whole grinding process are completed at a time, the technical requirements for operators are reduced, the training cost of the operators is saved, the labor production efficiency is improved, and the grade difference precision of products is improved.