119 results about "Micromanipulator" patented technology

An apparatus and method for safely cannulating a blood vessels, including but not limited retinal blood vessels, is described. In one embodiment, the apparatus can consist of a micropipette / microcannula, micromanipulator and positioner mounted to a base, which is attached to a wrist rest commonly used in eye surgery. The micropipette / microcannula is connected to tubing such that a medication may be injected through the micropipette / microcannula into the blood vessel or conversely, a small quantity of material may be removed from a blood vessel. Alternatively, a catheter, wire or stent may be placed through the micropipette / microcannula to treat or diagnose an area remote from the insertion site. The ability to cannulate a retinal blood vessel should be efficacious in the treatment of vein and artery occlusion, ocular tumors and other retinal, vascular and optic nerve disorders that would benefit from diagnosis and / or treatment. In another embodiment, a self-sealing needle is provided which allows the perforation of a blood vessel or other structure and the minimization of hemorrhaging when the needle is withdrawn from the blood vessel / structure. Another embodiment discloses an ocular implant needle.

A micromanipulator comprising a tubular structure and a structural compliance mechanism that are formed from a tube made of an elastic and / or superelastic material. The micromanipulator is useful for intravascular interventional applications and particularly ultrasonic imaging when coupled with an ultrasound transducer. Also disclosed are medical devices for crossing vascular occlusions using radio-frequency energy or rotary cutting, preferably under the guidance of real-time imaging of the occlusion, as well as accompanying methods.

A micromanipulator comprising a tubular structure and a structural compliance mechanism that are formed from a tube made of an elastic and / or superelastic material. Fabricated with laser machining and has no mechanical joints, the micromanipulator can be manipulated in various motions and degree-of-freedoms without permanent deformation. Shape Memory Alloys (SMAs) in one embodiment are implemented as main actuators of the micromanipulator. The micromanipulator can be implemented with multiple SMAs to manipulate the mechanism with multiple degree-of-freedom. In another implementation, multiple segments of the mechanisms are formed and arranged in various configurations, including a “double-helix”-like configuration, for enabling intricate motions of the micromanipulator. The micromanipulator is useful for intravascular interventional applications and particularly ultrasonic imaging when coupled with an ultrasound transducer.

A micromanipulation system includes a micromanipulator that includes a handpiece, and a micromanipulation tool that includes a tool shaft and is operatively connected to the handpiece. The micromanipulator further includes an actuator assembly connected to the micromanipulation tool to provide manual control of the micromanipulation tool, and a force sensing system comprising a force sensor attached to the tool shaft. The force sensing system is configured to provide an output signal that indicates a force imposed on the tool shaft. The micromanipulation system also includes a processor that is in communication with the force sensing system, and is configured to receive the output signal and compensate for forces due to actuation of the micromanipulation tool to determine a force due to interaction of the micromanipulation tool with a region of interest. The processor outputs an indication of at least one of a magnitude and a direction of the determined force.

The invention discloses a micromanipulator for enterocoelia minimally invasive surgery, relating to a micromanipulator for minimally invasive surgery. The invention solves the problem of the shortage of micromanipulators in surgical equipment of existing enterocoelia minimally invasive surgery. In the invention, a lower clutch dial is installed on the upper end face of a tooth-form central spindle of a driving box, an upper-finger upper clutch dial of a traction mechanism of the upper finger at the tail end of the surgical equipment is contacted with a corresponding lower clutch dial of the driving box; a lower-finger upper clutch dial of the traction mechanism of the upper finger at the tail end of the surgical equipment is contacted with the corresponding lower clutch dial of the driving box; a wrist upper clutch dial of the traction mechanism of the wrist at the tail end of the surgical equipment is contacted with the corresponding lower clutch dial of the driving box; and an autorotation upper clutch dial of an autorotation mechanism at the tail end of the surgical equipment is contacted with the corresponding lower clutch dial of the driving box. The micromanipulator of the invention is convenient for rapidly exchanging surgery tools, thereby increasing the nimbleness of surgery action, and meeting the requirements in various aspects such as size, function and clamping force an the like on the micromanipulator, thus being applicable to enterocoelia minimally invasive surgery.

A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipulator or similar holding devices. The microcatheter system is particularly suitable for the treatment of retinal venous occlusive disease.

The invention relates to a method for permeabilization of a cell structure consisting of a single cell, an intracellular structure or an organelle comprising the following steps: (a) microelectrodes, preferably two carbon fiber electrodes or hollow fiber electrodes, are provided, (b) the microelectrodes are connected to a power supply, (c) the electrodes, individually controlled by high-graduation micromanipulators, are placed close to the cell structure at an appropriate inter-electrode distance, and (d) a highly focused electric field of a strength sufficient to obtain electroporation is applied between the electrodes. The method may be used in order to transfer cell impermeant solutes, such as drugs or genes, into the cell structure or out of the cell structure, in biosensors, in the treatment of tumours and neurodegenerative diseases and in the study of biophysical processes.

A central nervous system (CNS) catheter assembly adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body defining at least one lumen therethrough having a drug delivery branch and a monitoring / sensing branch. The drug delivery branch and the monitoring / sensing second branch are in fluid communication with the lumen. Openings are disposed in fluid communication with the lumen and being located at proximal ends of the drug delivery branch and the monitoring / sensing branch. Another opening is disposed at a distal end of the main body. The assembly further includes a component such as an intracranial pressure / osmotic pressure monitoring system, a fluid drainage system, an attachable introduction aid, a patient surface attachment aid, a micromanipulator and a comprehensive intracranial pressure evaluation and relief system. The assembly optionally includes a filter assembly containing a proton exchange membrane.

A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

A hydraulically-operated micromanipulator apparatus is disclosed. The micromanipulator apparatus comprises: a micromanipulator fine control unit including an operating-side piston finely movable with respect to an operating-side hydraulic cylinder and fine control means, either the operating-side piston or the operating-side hydraulic cylinder being stationarily retained, while the rest being finely operable by the fine control means; a hydraulically-operated micromanipulator including an actuating-side piston finely movable with respect to an actuating-side hydraulic cylinder and a fine displacement member, the actuating-side hydraulic cylinder being connected to said operating-side hydraulic cylinder through a hose, either the actuating-side piston or the actuating-side hydraulic cylinder being stationarily retained, while the rest being attached to the fine displacement member; and compensating means for compensating a pressure change of the hydraulic fluid between said operating-side hydraulic cylinder and said actuating-side hydraulic cylinder when ambient temperature changes.

An improved method and apparatus for extracting and handling samples for S / TEM analysis. Preferred embodiments of the present invention make use of a micromanipulator and a hollow microprobe probe using vacuum pressure to adhere the microprobe tip to the sample. By applying a small vacuum pressure to the lamella through the microprobe tip, the lamella can be held more securely and its placement controlled more accurately than by using electrostatic force alone. By using a probe having a beveled tip and which can also be rotated around its long axis, the extracted sample can be placed down flat on a sample holder. This allows sample placement and orientation to be precisely controlled, thus greatly increasing predictability of analysis and throughput

A piezoelectric clamping micromanipulator with flexible drive and amplification and adjustable range is composed of microactuator, flexible multiplying mechanism, size pre-regulator, and clamping micromanipulator. Its advantages are compact structure, high reliability, and low non-linear error.

A microtome system has a cryomicrotome with a sectioning device in which is provided a preparation holder and a knife edge that are guided past one another inside a working space during a sectioning operation, in order to produce thin sections of a preparation retained in the preparation holder. A micromanipulator is operable outside the working space. With the micromanipulator, a tool for retention of a specimen support is positioned proximate the knife edge during a sectioning operation in order to receive the sections that are produced, preferably for substantially stationary retention of the specimen support.

A hydraulically-operated micromanipulator apparatus is disclosed. The micromanipulator apparatus comprises: a micromanipulator fine control unit including an operating-side piston finely movable with respect to an operating-side hydraulic cylinder and fine control means, either the operating-side piston or the operating-side hydraulic cylinder being stationarily retained, while the rest being finely operable by the fine control means; a hydraulically-operated micromanipulator including an actuating-side piston finely movable with respect to an actuating-side hydraulic cylinder and a fine displacement member, the actuating-side hydraulic cylinder being connected to said operating-side hydraulic cylinder through a hose, either the actuating-side piston or the actuating-side hydraulic cylinder being stationarily retained, while the rest being attached to the fine displacement member; and compensating means for compensating a pressure change of the hydraulic fluid between said operating-side hydraulic cylinder and said actuating-side hydraulic cylinder when ambient temperature changes.

This invention relates to measuring stiffness of a biological sample Specifically, the invention relates to a milliprobe indentation device that comprises a force probe and a micromanipulator and uses thereof for measuring stiffness of biological samples

The invention discloses a multi-degree-of-freedom micromanipulator which is driven by a multi-polarization mode piezoelectric actuator. The micromanipulator comprises a substrate, a nested x and y axis translation micromotion mechanism, a Z axis translation micromotion mechanism, a Z axis turning micromotion mechanism and an end executive mechanism, wherein three-dimensional translation is realized by using a piezoelectric pile actuator with a piezoelectric strain constant d33 driving a flexure hinge; Z axis turning is realized by using a piezoelectric turning actuator with a piezoelectric strain constant d15 driving a reverse arm; and the end executive mechanism is a micro clamp holder consisting of a piezoelectric double-chip cantilever beam based on a piezoelectric strain constant d31 or a micro injection probe. High accurate micromotions such as the three-dimensional translation, turning around with a Z axis and swing around with an X axis are realized by the drive of the piezoelectric actuator in different polarization modes, and operations such as clamping, transport, probing, injection and the like are realized by different end executive arms. The micromanipulator has the advantages of freedom decoupling, compact structure, flexible operation, convenient control, high motion precision and the like, and the micromanipulator can be applied in the fields of biomedicine, micro electro mechanical engineering and the like.

The present invention provides a microinjection assembly including a microscope, a microinjection system comprising a micromanipulator, a micropipette and a piezo-electric oscillator, and an obliquely angled macro monitoring unit. The present invention also provides methods of microinjecting the germinal disk of an avian egg, thereby delivering a transgenic nucleus, spermatozoon or isolated nucleic acid to the avian embryo. The avian ovum may be returned to a female bird for hard-shell deposit and laying of the egg for hatching as a transfected bird.

The invention relates to a micro-vision servo-control micromanipulation robot system which comprises a left and a right operation tools respectively mounted on a left and a right micromanipulators; the left and the right micromanipulators are controlled by a left and a right servo controller, and are connected with a computer so as to form a micromanipulation robot; a camera is mounted on a microscope, is connected with the computer through an image processing card, and inputs operation site image information to the computer; the computer calculates relative position relation between the left and the right operation tools and an operation object according to the inputted image information, resolves control instructions of the left and the right micromanipulators, and performs motion planning and real-time control of the left and the right micromanipulators through the servo controller respectively. The characteristic of the invention is that the automation and intelligentization of microscopic operation are realized in biomedical engineering. The system has the characteristics of automatic obstacle avoidance, high positioning precision, large work space, high operation efficiency, friendly man-machine interface, and the like.

An improved method for extracting and handling multiple samples for S / TEM analysis is disclosed. Preferred embodiments of the present invention make use of a micromanipulator that attaches multiple samples at one time in a stacked formation and a method of placing each of the samples onto a TEM grid. By using a method that allows for the processing of multiple samples, the throughput of sample prep in increased significantly.

A micromanipulator for positioning / localization of an operating instrument coupled therewith. The micromanipulator controls movement of the operating instrument in a single- or multi-axial system of coordinates with one or more electrical actuators. The electrical actuators are especially for providing a substantially elongated structure for the micromanipulator. The one or more actuators including a piezoelectric bender enable the positioning / localization of the operating instrument for providing at least one desired direction of motion.

The detection device includes slide glass with transparent film attached on surface, reactor, separation capillary (SC), reaction capillary with detection window (DW), luminescence detection part located at DW, and micromanipulator. Being positioned between the slide glass and the reactor, the micromanipulator is in use for grasping SC. Cell suspension pool and dissolve film pool are setup on the transparent film. Being setup on the slide glass, buffer solution pool is connected to high-voltage end. The reactor includes reaction continuous groove (RCG), and inlet connected to RCG for adding chemiluminescence reagent. RCG is connected to ground. RCG is connected to the reaction capillary. SC is setup in RCG. One end of SC is on the transparent film, and the other end is positioned at DW. Features are: easy of preparation, and operation, small size, low cost, and high detection sensitivity. The detection device is suitable for simple cell analysis, and research in area of life sciences.

Support or micromanipulator (100) for a surgical tool (20) comprising a complaint mechanism (1) providing direct support to the surgical tool (200), a positioning mechanism giving support to said complaint mechanism, and an attachment mechanism giving support to said positioning mechanism. The complaint mechanism (1) is made of a complaint material and allows three or four degrees of freedom to the movement of the tool (200). The positioning mechanism is located between the attachment mechanism and the complaint mechanism (1) and allows positioning of the same with six degrees of freedom. The attachment mechanism fastens the assembly to a surface of the surgical intervention region. The micromanipulator (100) is especially useful for practicing surgical interventions in the cochlea (performing cochlear implants, obtaining samples, etc), or other interventions for which high precision with the tool (200) is required.

The invention discloses a biological microscopic operating device based on visual feedback, and belongs to the technical field of biological operating instruments. The visual feedback based biological microscopic operating device comprises a microscopic image acquisition module, a micro-displacement platform, a micromanipulator module, a main controller and a computer. Different from the conventional operating mode, the main controller is introduced; in the whole operating process, after application of the visual-based biological microscopic operating device, all the operations can be completed on the computer side, so that the dependence degree on a professional operator is reduced, the operation is more simple, more convenient and faster, and the automation degree of microscopic operation is improved; in combination with an image processing technology, operated objects with different shapes can be matched with operating instruments, and a micro-suction pipe, a micro-injection needle and other tools can be recognized more effectively, so that the success rate of operation is improved.

The invention relates to a food processing machine which comprises a cup body (1), a cup cover (101), a handle (103), a rod linkage device and a machine body (2); wherein the cup cover (101) can be buckled on the cup body (1) in a rotating manner; the cup cover (101) at least comprises a first and a second trigger parts; at least a first and a second micromanipulators and an electric locking device are arranged in the machine body (2); and the electric locking device comprises a solenoid switch (204) and a top buckle (201). When the cup cover (101) is buckled on the cup body (1) in a rotatingmanner, the first trigger part of the cup cover (101) triggers the first micromanipulator and the second trigger part of the cup cover (101) triggers the second micromanipulator through the rod linkage device, therefore, the food processing machine can electrically run after the first and the second micromanipulators are switched on with electricity, and the top buckle (201) of the electric locking device locks the cup cover (101) in place during the electrical running process of the food processing machine.

A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

An easy and controllable method and system to attach a carbon nanotube to a scanning probe tip such as a scanning probe microscopy (SPM) tip using a focus ion beam (FIB) technique. The method and system includes selecting a carbon fiber by a Focus Ion Beam micromanipulator, picking up the carbon fiber with the nanotube tip, forming a slot on an SPM tip, and inserting the carbon fiber with the nanotube tip into the slot.

The invention belongs to sweet water breeding pure natural fresh-keeping type dull-tip spirulina and ultra-large spirulina which are alga for world wild production at present. Functional fresh-keeping new patern dull-tip spirulina and ultra-large spirulina variety which are emanated by cobalt (60)10 gray-25000 gray for 5 minutes to 10 hours, after controlling temperature, controlling light, controlling pH and conditioning all kinds of nutrition ingredient, single excellent mutagenesis variety screened by micromanipulator are purified and cultured are chosen. The functional fresh-keeping new patern dull-tip spirulina and ultra-large spirulina variety have stabilising germ line and higher nutrition ingredient than general dull-tip spirulina, ultra-large spirulina and other mutagenesis variety, especially some ingredients are more several times than present dull-tip spirulina and ultra-large spirulina. The alga wall of the new type spirulina is very thin, the width and length of alga body are larger than present dull-tip spirulina and ultra-large spirulina. We have breed five kinds of sweet water production alga variety whose functions are respectively fatigue protection, blood sugar dropping, beauty treatment, pruritus protection and hemostasia in indoor large scale clean environment deep layer (1 to 1.5meter).