35 results about "Photostimulation" patented technology

The invention discloses a photostimulation response material which is characterized in that a < 7 > H-benzo [c] carbazole group or a < 7 > H-dibenzo [c, g] carbazole group is connected to the site 2 of 9-thioxanthone to construct a thioxanthone derivative, and the thioxanthone derivative is doped in a polymethyl methacrylate matrix to form a composite film, so that the photostimulation response material has a remarkable photostimulation response characteristic; the light color of the film is changed after the film is subjected to ultraviolet radiation for 10 seconds, afterglow emission of s level appears, and the film can be applied to the technical field of information encryption and security anti-counterfeiting.

This invention discloses a method and system for evaluating the effectiveness of photostimulation based on multimodal feature fusion, belonging to the field of big data analysis technology. The method and system include the following steps: S1, acquiring raw observation data and performing time axis relocation, dynamic denoising, normalization, and sliding time window segmentation; S2, evaluating the state of the stimulation process and selecting effective windows; S3, extracting neural activity response features and hemodynamic response features, and performing physiological response reliability assessment; S4, performing consistency fusion to evaluate the effectiveness of photostimulation. This invention effectively improves the stability and reliability of effectiveness evaluation during head-mounted photostimulation, solving the problems of difficulty in distinguishing between abnormal stimulation pathways and true brain tissue responses, as well as insufficient consistency of results across batches of experiments.

A magnetic resonance-compatible programmable synchronized photostimulation system includes a main control unit and a stimulation execution unit. The main control unit is located outside the magnetic resonance scanning room, while the stimulation execution unit is located inside the scanning room and consists only of an LED light panel shielded by a magnetic field. The main control unit is configured to: receive photostimulation sequence parameters configured by the user in a modular manner through a graphical interface; receive a scan trigger signal from the magnetic resonance equipment, and automatically control the start and stop of the photostimulation sequence based on the trigger signal using hardware triggering; thereby achieving high-precision time synchronization between photostimulation and magnetic resonance scanning while maintaining magnetic resonance compatibility. This invention solves electromagnetic compatibility issues through a split architecture, achieves millisecond-level synchronization accuracy through hardware TTL triggering, and enhances experimental paradigm flexibility through modular programmable sequences, making it suitable for neuroscience research fields such as functional magnetic resonance imaging.

The present disclosure relates to optoelectronic devices and methods for optical epicardial pacing and endoscopic delivery devices and methods for translational photostimulation.

This application relates to the field of medical device technology, and in particular to a control system, control method, and storage medium for a transcranial photostimulator. The control system of the transcranial photostimulator includes: a microcontroller module; and at least two stimulation modules uniformly controlled by the microcontroller module, each stimulation module comprising a first stimulation module and a second stimulation module, wherein the first stimulation module is a photostimulation module and the second stimulation module is an electrical stimulation module. The microcontroller module independently controls the output parameters of the at least two stimulation modules through different digital communication protocols. The control method of the transcranial photostimulator is applied in the control system. A computer program is stored on a readable storage medium, and when executed by a processor, the computer program performs the steps according to the control method.

Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s).

The invention provides an assembling mode of RNA liquid drops deformed through photostimulation and application of the RNA liquid drops, and belongs to the technical field of preparation of nucleic acid for analysis. The method comprises the following steps: mixing an RNA single strand with a buffer solution through structural design to obtain a mixed system with a specific concentration; after the mixed system is subjected to heat shock to complete base pairing and assembling, sealing and packaging are performed, the RNA liquid drops deformed through photostimulation are obtained, and the diameter of the liquid drops is 7.0-13.0 microns. The RNA liquid drop obtained in the embodiment can deform under light stimulation, behavior regulation and control can be achieved through group modification, and feasibility is provided for construction and functional expression of artificial cells.

This invention discloses a multi-stimulus-responsive upconversion luminescent nanocrystalline magnetic microsphere and its preparation method, belonging to the field of biomedical polymer materials and nanobiotechnology. The microsphere's main body is a porous copolymer matrix, encapsulating a core of magnetite (Fe3O4) magnetic nanocrystals. Rare-earth-doped fluoride upconversion luminescent nanocrystals are coupled to the surface and pores. The copolymer side chains of the microsphere incorporate azide groups, acidic stimulus-responsive groups, and photostimulation-responsive groups, constructing an independent and non-interfering triple orthogonal logic gating system on the surface. The preparation method includes preparing an oil phase containing copolymers, magnetic nanoparticles, and a volatile porogen; pre-emulsifying and homogenizing the oil phase in an acidic aqueous phase using an SPG membrane; inducing phase separation by controlled solvent evaporation to form porous microspheres; and finally coupling the upconversion nanocrystals via a click chemistry reaction. The magnetic microspheres of this invention eliminate background fluorescence interference from complex samples from a physical perspective. Their porous structure endows the microspheres with excellent quasi-levitation properties and magnetic responsiveness, effectively solving problems such as single surface function and signal crosstalk of microspheres. They are suitable for in vitro clinical diagnosis and complex analysis of multiple targets.

The invention relates to the technical field of molecular switches, and discloses an optical switch molecule and a preparation method and application thereof. The structural general formula of the optical switch molecule is as follows: R1 is a hydrogen bond acceptor group, R2 is an electron donating group or an electron withdrawing group, and R3 and R4 are spatial substituent groups. According to the invention, sp3 hybrid carbon atoms are used as bridging units, and a series of space folding type ESIPT optical switch molecules are constructed for the first time and are applied to the aspects of chemical sensing, information encryption, data storage and the like. According to the method, light is used as an external stimulation condition to induce the photoswitch molecules to generate a rapid six-level photophysical-chemical process and generate a cis-trans isomerization process in an excited state, so that the photoswitch molecules are macroscopically represented as high-contrast color change before and after photostimulation.

The invention belongs to the field of cell culture automation and intelligent regulation and control, and discloses an optogenetics-based adherent cell culture optimization method and system. The method comprises the following steps: inputting an adherent cell type and a culture target, and calling an adherent cell-optical genetic parameter joint database; performing targeted pretreatment on the target adherent cells; processing through a multi-parameter optimization algorithm hardware platform to generate an executable customized photostimulation scheme; performing accurate light stimulation on the positive adherent cells; comparing the obtained detection data with normal adherent cell parameters in a joint database, and evaluating the influence of a photostimulation scheme on the cells; updating the parameters of the multi-parameter optimization algorithm and the prediction model; and inputting the adherent cell type and the culture target to the updated prediction model, and outputting an optimal light stimulation scheme. The core problems of low photostimulation accuracy and poor targeting in the prior art are solved, and high-activity and high-consistency light-sensitive adherent cells are stably produced.

According to the animal airway response induction real-time detection system and detection method provided by the invention, the photogenetic stimulation unit irradiates the photosensitive protein of the experimental subject by using the light source with the preset wavelength, and performs photostimulation on neurons in a specific brain region of the experimental subject; receiving an airway hyperresponse signal generated by the experimental subject after receiving the photostimulation in real time through a signal acquisition unit, and acquiring lung function data of the experimental subject; the collected data is subjected to fitting calculation through the processing unit, the lung function and capacity indexes are obtained, real-time detection of animal airway hyperresponse is achieved, activation of vagus nerves is allowed to be accurately controlled in time and space by adopting the photogenetic technology, real-time detection of animal airway response is achieved, and the accuracy of animal airway hyperresponse detection is improved. The accuracy and the reliability of an experiment result are improved; the repeatability of an experimental result is ensured by standardizing an experimental process and setting light source parameters; a local minimally invasive invasive photostimulation mode reduces trauma and stress response to an experimental subject.

This invention discloses a solar photoresponsive metal coordination polymer, its preparation method, and its applications, belonging to the field of coordination polymer technology. This invention synthesizes four structurally similar coordination polymers by reacting the ligand (E)-4-(4-(pyridin-4-yl)styryl)pyridine with isophthalic acid derivatives and CdSO4·8 / 3H2O via a solvothermal reaction. These four coordination polymers undergo a [2+2] cycloaddition reaction under solar irradiation. The resulting series of single crystals exhibit photoresponsive behavior under sunlight, with crystals of different sizes and shapes producing different mechanical movements. The composite film prepared by combining this coordination polymer with PVA exhibits mechanical movement under ultraviolet light, displaying mechanical behaviors not found in single crystals, and holds promise for applications in photo-actuators. Furthermore, this invention also extracts cyclobutane products based on the photoreaction of this series of coordination polymers, a simple and environmentally friendly process.

This invention relates to astrocyte-derived exosomes, their preparation method, and applications. Specifically, it involves using photostimulation with PBM to induce the generation of astrocyte-derived exosomes. The generated exosomes can protect neurons and improve cognitive impairment and mood disorders. The exosomes obtained by this invention can be used for the treatment and / or prevention of cognitive impairment and / or mood disorders, demonstrating excellent application prospects and research value.

The present disclosure is related to a method for improving physiological state by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency, and an apparatus used for the same. More specifically, improvement of physiological state such as, improvement or suppression of dermatitis, improvement or suppression of alopecia, improvement of hair condition, improvement or suppression of graying of hair, improvement or suppression of hearing loss, improvement or suppression of vision loss, improvement or enhancement of muscle strength, improvement or suppression of kyphosis, improvement or suppression of pain and / or feeling of discomfort, improvement of autonomic nerve abnormalities, improvement of healthy life expectancy, and obesity control is carried out by irradiating light of a specific wavelength such as violet light to a living body.

The invention discloses an in-vitro retina photostimulation device for retina patch clamp operation, and belongs to the field of optics and biomedical engineering. The device is mainly composed of four parts: a light source screen module can display a color programmable pattern; the screen mainboard is integrated with an accelerometer and a gyroscope, so that the screen posture can be measured; the convex lens is used for reducing a light source screen output pattern to a retina adaptive size; the dichroscope can reflect the shrunk pattern and transmit infrared light; the light path support is used for fixing the light source screen, the convex lens and the dichroscope, and enables the light source screen, the convex lens and the dichroscope to keep a preset distance so as to achieve an expected reduction magnification. Based on a convex lens imaging rule, the projection system can project a programmable image with 240 * 240 pixels and a single pixel side length of 10 microns on the retina, and can realize pattern correction according to a screen inclination angle.

The utility model provides a photostimulation assembly for treating brain function related diseases, which adopts a light transmission piece capable of circumferentially emitting near-infrared light, the light transmission piece is spirally arranged in an accommodating cavity of a bearing piece, and a light uniformizing layer is arranged on one side of a light transmission part of the bearing piece, so that the near-infrared light can be transmitted to the light transmission piece, and the light transmission piece can transmit near-infrared light to the bearing piece. The near-infrared light can be uniformly irradiated to the head of a patient, light spots with a certain area can be emitted to a head treatment area at a short distance, meanwhile, relatively uniform distribution of light power is guaranteed, and the treatment effect on patients with brain function related diseases in some special scenes is greatly improved. Meanwhile, the photostimulation assembly is not interfered by a high-intensity magnetic field in a treatment area of the head of the patient, and can be combined with magnetoencephalography, functional magnetic resonance imaging and other technologies, so that the change condition of the brain function state of the patient can be monitored in time while the brain function related diseases are treated by adopting photostimulation; the method can be used for evaluating the treatment effect of photostimulation, guiding the photostimulation treatment scheme and the like.

The invention discloses a neuromorphic photoelectric device, a preparation method and electronic equipment. The neuromorphic photoelectric device comprises a substrate, a bottom electrode, a first zinc oxide layer, a second zinc oxide layer and a top electrode which are stacked in sequence. As the oxygen concentration of the first zinc oxide layer is greater than that of the second zinc oxide layer, a heterojunction and an oxygen vacancy gradient are formed in the double-layer structure, so that the photoelectric device generates a response of a neuromorphic characteristic according to photostimulation. The oxygen vacancy of the first zinc oxide layer introduces an impurity energy level into a forbidden band, so that the impurity energy level generates an infrared signal according to the infrared ray. Due to the fact that the built-in electric field of the heterojunction enables carriers to be separated, the intensity of infrared signals is enhanced, and the infrared signals are easier to detect. And the second zinc oxide layer can directly absorb and generate an ultraviolet signal, so that the photoelectric device with the neuromorphic structure provided by the invention can simultaneously detect ultraviolet rays and infrared rays on the basis of simulating nerve synapse.

The application provides a novel light-sensitive channel protein VR2.0 and uses thereof. The light-sensitive channel protein VR2.0 series provided in this application demonstrates profound therapeutic effects in the treatment of retinal photoreceptor cell degenerative diseases. This novel light-sensitive channel protein exhibits enhanced photosensitivity, fast kinetics, and reduced side effects. Under identical photostimulation conditions, VR2.0 demonstrates faster response frequencies while maintaining stable photocurrent signals even during high-frequency stimulation. This application provides a better optogenetic therapeutic option for retinal photoreceptor cell degenerative diseases, and has significant application and promotion value.

The present invention provides a method of treating Parkinson's disease by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency. The present invention, by irradiating light of a specific wavelength such as violet light to a living body, carries out treatment and / or prophylaxis of Parkinson's disease by improving or suppressing at least one symptom selected from a group of symptoms consisting of cognitive memory disorder, working memory disorder, dysphoria, anxiety, apathy, psychological symptoms (hallucination, visual hallucination, and auditory hallucination), impulse control disorder, orthostatic hypotension, urinary disorder, sexual dysfunction, digestive symptoms (drooling, swallowing, nausea, constipation), sleep disorder, pain, weight loss, olfactory abnormality, fatigue, and diaphoresis.

The invention discloses an NIR-IIb response type up-conversion nanometer material, a hydrogen production nanometer reactor prepared from the NIR-IIb response type up-conversion nanometer material and application of the NIR-IIb response type up-conversion nanometer material, and belongs to the technical field of nanometer biomedical materials. The controllable hydrogen production nanoreactor is obtained by using a bionic carrier formed by lipidosome, a photosensitizer, a catalyst and a proton donor which are jointly wrapped in the bionic carrier, and an up-conversion nanomaterial prepared by a chemical synthesis method, a hydrothermal method and the like, and can generate hydrogen under the stimulation of light with specific wavelength. According to the nano-reactor provided by the invention, a proton donor is efficiently catalyzed to generate hydrogen, on-demand and controllable release of hydrogen at a focus part is realized by utilizing high-tissue-penetrability NIR-IIb stimulation, and the nano-reactor provided by the invention can effectively remove active oxygen at the focus part and relieve oxidative stress by controllably releasing the generated hydrogen, so that pulmonary fibrosis is effectively relieved. The nanoreactor provided by the invention has the advantages of good biocompatibility, high hydrogen production efficiency, strong targeting property, small treatment side effect and the like, and has a wide market application prospect.

This application relates to an agricultural laser system intended to extend, supplement, or replace the functions performed by conventional tools for tasks such as pruning, weeding, cutting, drying, and photostimulation. The system employs one or more lasers and includes a power module (1-A), a control module (1-B), a compressed gas and / or ventilation module (1-C), a temperature control module (1-D), a power distribution module (1-E), a laser module (2-A), a constraint and laser beam guide module (2-B), and a positioning wheel (3). Advantages of this system include reduced size and weight, the ability to move at relatively high speeds, low fuel consumption and operating costs, the ability to operate in a positive pressure environment to prevent damage to optical components or along the laser beam path, or operation outside of a positive pressure environment, modularity, and adaptability to crops of various sizes.

This invention relates to the field of organoid preparation technology, and discloses a method for preparing retinal organoids by constructing pacemaker cells based on ChR2 and GCaMP5G double transfection of hESCs. The method includes the following steps: Step 1, Transfection: Transfecting hESCs with ChR2 and GCaMP5G; Step 2, Screening: Screening for ChR2 and GCaMP5G double-positive cells using FASC; Step 3, Differentiation Culture: Differentiating and culturing the two-dimensional ChR2 and GCaMP5G double-positive hESCs into three-dimensional retinal organoids; Step 4, Photostimulation: Activating ChR2 with 470nm blue light and observing calcium signals under a two-photon microscope. This method, by transfecting hESCs with ChR2 and GCaMP5G, screening for ChR2 and GCaMP5G double-positive cells, and culturing them into retinal organoids, effectively accelerates the differentiation and culture of hESCs into three-dimensional retinal organoids by specific blue light stimulation, thereby effectively improving the speed of retinal organoid preparation and shortening the cycle.

The purpose of the present invention is to provide: a method for suppressing neovascularization in a retinal surface layer; and a device therefor.　The present invention suppresses neovascularization in a retinal surface layer of a subject by, for example, blinking, at a specific blinking frequency, light with a specific wavelength such as violet light and irradiating the subject with the light by using a light irradiation device.

This invention relates to a simple method for preparing photochromic triphenylacrylonitrile compounds. The readily synthesizable 2-(4-bromophenyl)-3,3-diphenylacetonitrile acrylonitrile is reacted with diphenyl disulfide to obtain a sulfide fluorescent compound, which is then oxidized using different oxidants to obtain sulfoxide or sulfone fluorescent compounds. All synthesized fluorescent compounds exhibit photochromic properties in solution. The sulfoxide-containing triphenylacrylonitrile compounds can be recrystallized using different methods to obtain crystals with two conformations, only one of which exhibits photochromic properties. This method is simple to operate and has high yield. The crystal structure of the compounds prepared by this method is beneficial for studying the relationship between solid conformation and photostimulation, and can be applied to memory storage materials.

This invention discloses an integrated light source biological cell culture sensing device. The device comprises a Micro-LED array and a biosensor array, which are bonded together. A DGHFET device and the Micro-LED device form a field-effect biosensor, with the DGHFET device located within the light spot coverage area of ​​the Micro-LED device within the same field-effect biosensor. This integrated light source biological cell culture sensing device successfully integrates efficient photostimulation, high-sensitivity biosensing, and high-reliability anti-interference capabilities onto a single platform, providing a powerful, reliable, and flexible integrated solution for optogenetic research. This invention has wide applications in the semiconductor technology field.

The invention provides a photoresponse reversible regulation molecule as well as a preparation method and application thereof, and belongs to the technical field of electrical elements. A main side chain of the azobenzene derivative has a D-A structure, and A is an azobenzene unit with photoresponse and is a side chain serving as an acceptor part; a is an azobenzene unit, D is an anchoring connection unit, imidazole with different anchoring connection sites is used as a molecular skeleton of a donor part, the azobenzene unit has response characteristics to photostimulation, and the structures of the D part and the A part realize charge transfer and reversible regulation during photostimulation.

This invention relates to the field of intelligent organic optoelectronic materials technology, specifically disclosing a photostimulation-responsive organic long-afterglow material and its preparation method. This invention is based on benzo[a]carbazole or naphthylamine derivatives with excellent long-afterglow performance, and by introducing diphenylphosphoxy groups to form a resonance system, it endows the material with excellent stimulus-response characteristics. Furthermore, using polymethyl methacrylate (PMMA) as the main component significantly avoids the quenching effect caused by self-aggregation. It also protects triplet excitons from quenching by triplet oxygen molecules, thereby enabling room-temperature phosphorescence. This material system exhibits significant photoactivation performance under photostimulation, with a visible afterglow exceeding 8 s, and possesses the characteristic that steady-state luminescence and afterglow luminescence can be co-activated. The material system provided by this invention has the following advantages: simple preparation process, low cost, and easy product purification; the obtained composite film exhibits long-lifetime and highly stable organic afterglow; its unique steady-state and afterglow synergistic photostimulation response characteristics provide a new solution for dynamic information encryption and afterglow imaging.

This application provides a human brain photostimulation device, comprising: a delivery mechanism including a piston rod, a push rod, and a guide; the output end of the piston rod is connected to the input end of the push rod, and the guide has a through hole in the middle, through which the output end of the push rod passes; and an implantation mechanism including a housing, a light source, a power supply, and a control module; the input end of the light source is connected to the output end of the control module, and the output end of the power supply is connected to the input end of the control module. The human brain photostimulation device provided by this application delivers the light source system in the implantation mechanism into the patient's sphenoid sinus cavity via the delivery mechanism. Then, the push rod in the delivery mechanism is removed from the implantation mechanism, causing the implantation mechanism to abut against the sphenoid sinus cavity. Subsequently, near-infrared light is continuously emitted deep into the brain, thereby stimulating and treating the brain. The entire process does not require craniotomy. This device is easy to operate and can reduce treatment costs for patients.

Multi-modal fiber optic probe devices and methods of making the same are described. In one example, a multi-modal fiber optic probe apparatus may include a flexible tapered fiber optic probe structure having a microscale tip region at a first end and a macroscale connector region at a second end opposite the first end. The multi-modal fiber optic probe device may also include an optical waveguide positioned in the flexible tapered fiber optic probe structure and extending through the flexible tapered fiber optic probe structure from the micro-scale tip region to the macro-scale connector region. The multi-modal fiber optic probe device may also include a microfluidic channel formed in the flexible tapered fiber optic probe structure and extending through the flexible tapered fiber optic probe structure from the micro-scale tip region to the macro-scale connector region.

A capsule comprising a polymeric shell surrounding a NIR absorber, the polymeric shell comprises a poly(amino acid) and is obtainable by interfacial polymerization of a N-carboxy-anhydride monomer according to general structure (I). The capsule is suitable for opto-medical applications such as phototherapies including photothermal therapy (PTT), photodynamic therapy (PDT), photo stimulated drug release and fluorescence medical imaging.