8 results about "Photostimulation" patented technology

This invention discloses a method and system for evaluating the effectiveness of photostimulation based on multimodal feature fusion, belonging to the field of big data analysis technology. The method and system include the following steps: S1, acquiring raw observation data and performing time axis relocation, dynamic denoising, normalization, and sliding time window segmentation; S2, evaluating the state of the stimulation process and selecting effective windows; S3, extracting neural activity response features and hemodynamic response features, and performing physiological response reliability assessment; S4, performing consistency fusion to evaluate the effectiveness of photostimulation. This invention effectively improves the stability and reliability of effectiveness evaluation during head-mounted photostimulation, solving the problems of difficulty in distinguishing between abnormal stimulation pathways and true brain tissue responses, as well as insufficient consistency of results across batches of experiments.

A magnetic resonance-compatible programmable synchronized photostimulation system includes a main control unit and a stimulation execution unit. The main control unit is located outside the magnetic resonance scanning room, while the stimulation execution unit is located inside the scanning room and consists only of an LED light panel shielded by a magnetic field. The main control unit is configured to: receive photostimulation sequence parameters configured by the user in a modular manner through a graphical interface; receive a scan trigger signal from the magnetic resonance equipment, and automatically control the start and stop of the photostimulation sequence based on the trigger signal using hardware triggering; thereby achieving high-precision time synchronization between photostimulation and magnetic resonance scanning while maintaining magnetic resonance compatibility. This invention solves electromagnetic compatibility issues through a split architecture, achieves millisecond-level synchronization accuracy through hardware TTL triggering, and enhances experimental paradigm flexibility through modular programmable sequences, making it suitable for neuroscience research fields such as functional magnetic resonance imaging.

This application relates to the field of medical device technology, and in particular to a control system, control method, and storage medium for a transcranial photostimulator. The control system of the transcranial photostimulator includes: a microcontroller module; and at least two stimulation modules uniformly controlled by the microcontroller module, each stimulation module comprising a first stimulation module and a second stimulation module, wherein the first stimulation module is a photostimulation module and the second stimulation module is an electrical stimulation module. The microcontroller module independently controls the output parameters of the at least two stimulation modules through different digital communication protocols. The control method of the transcranial photostimulator is applied in the control system. A computer program is stored on a readable storage medium, and when executed by a processor, the computer program performs the steps according to the control method.

This invention discloses a multi-stimulus-responsive upconversion luminescent nanocrystalline magnetic microsphere and its preparation method, belonging to the field of biomedical polymer materials and nanobiotechnology. The microsphere's main body is a porous copolymer matrix, encapsulating a core of magnetite (Fe3O4) magnetic nanocrystals. Rare-earth-doped fluoride upconversion luminescent nanocrystals are coupled to the surface and pores. The copolymer side chains of the microsphere incorporate azide groups, acidic stimulus-responsive groups, and photostimulation-responsive groups, constructing an independent and non-interfering triple orthogonal logic gating system on the surface. The preparation method includes preparing an oil phase containing copolymers, magnetic nanoparticles, and a volatile porogen; pre-emulsifying and homogenizing the oil phase in an acidic aqueous phase using an SPG membrane; inducing phase separation by controlled solvent evaporation to form porous microspheres; and finally coupling the upconversion nanocrystals via a click chemistry reaction. The magnetic microspheres of this invention eliminate background fluorescence interference from complex samples from a physical perspective. Their porous structure endows the microspheres with excellent quasi-levitation properties and magnetic responsiveness, effectively solving problems such as single surface function and signal crosstalk of microspheres. They are suitable for in vitro clinical diagnosis and complex analysis of multiple targets.

This invention discloses an integrated light source biological cell culture sensing device. The device comprises a Micro-LED array and a biosensor array, which are bonded together. A DGHFET device and the Micro-LED device form a field-effect biosensor, with the DGHFET device located within the light spot coverage area of ​​the Micro-LED device within the same field-effect biosensor. This integrated light source biological cell culture sensing device successfully integrates efficient photostimulation, high-sensitivity biosensing, and high-reliability anti-interference capabilities onto a single platform, providing a powerful, reliable, and flexible integrated solution for optogenetic research. This invention has wide applications in the semiconductor technology field.

This invention relates to the field of intelligent organic optoelectronic materials technology, specifically disclosing a photostimulation-responsive organic long-afterglow material and its preparation method. This invention is based on benzo[a]carbazole or naphthylamine derivatives with excellent long-afterglow performance, and by introducing diphenylphosphoxy groups to form a resonance system, it endows the material with excellent stimulus-response characteristics. Furthermore, using polymethyl methacrylate (PMMA) as the main component significantly avoids the quenching effect caused by self-aggregation. It also protects triplet excitons from quenching by triplet oxygen molecules, thereby enabling room-temperature phosphorescence. This material system exhibits significant photoactivation performance under photostimulation, with a visible afterglow exceeding 8 s, and possesses the characteristic that steady-state luminescence and afterglow luminescence can be co-activated. The material system provided by this invention has the following advantages: simple preparation process, low cost, and easy product purification; the obtained composite film exhibits long-lifetime and highly stable organic afterglow; its unique steady-state and afterglow synergistic photostimulation response characteristics provide a new solution for dynamic information encryption and afterglow imaging.

This invention relates to the field of ocular visual function rehabilitation and neuroelectrophysiological regulation technology. The invention discloses an ocular photostimulation matrix device, comprising: a housing; a display screen, power socket, power switch, and output socket disposed on the housing; a circuit board, a specific medical transformer, and a card reader chip assembly disposed inside the housing; and an output component connected to the output socket. This device is a non-invasive ocular rehabilitation device, breaking through the limitations of traditional vision correction and nerve repair technologies. Using 8-14Hz alpha waves as its core, it directly targets the core link of the visual nerve-central nervous system, fundamentally repairing visual conduction pathway disorders. It is non-invasive, has no usage restrictions, and is suitable for various visually impaired individuals. The device is easy to operate and can be used daily. It can induce endogenous light for preliminary fundus screening and can also address vision repair and brain nerve regulation. Supporting accessories further enhance the conditioning effect and device stability.

This invention relates to the field of brain function monitoring and discloses a closed-loop transcranial photostimulation (tPBM) modulation method and system based on near-infrared brain response characteristics. First, fNIRS signals of the target brain region of the subject are acquired. After the fNIRS signals pass through the data pathway, preprocessing and windowing calculations are performed to extract dynamic response characteristics. By setting the difference detection between the baseline and stimulation periods, blood oxygen response indicators are calculated, and based on these indicators, the current brain region is identified as having enhanced, sluggish, inhibited, or fatigued responses, yielding the change in HbO. Through the real-time acquisition of HbO changes, features such as the instantaneous rate of change and peak response of indicators like Δ[HbO] and Δ[HbR] are extracted to construct an individual's "baseline-response" curve model for parameter optimization and control, completing the tPBM stimulation modulation. This invention solves the problems of equipment redundancy, spatial interference, poor synchronization, difficulty in achieving real-time coordination between intervention and imaging, and poor measurement stability and accuracy in existing technologies.