49 results about "Photostimulation" patented technology

The invention discloses a photostimulation response material which is characterized in that a < 7 > H-benzo [c] carbazole group or a < 7 > H-dibenzo [c, g] carbazole group is connected to the site 2 of 9-thioxanthone to construct a thioxanthone derivative, and the thioxanthone derivative is doped in a polymethyl methacrylate matrix to form a composite film, so that the photostimulation response material has a remarkable photostimulation response characteristic; the light color of the film is changed after the film is subjected to ultraviolet radiation for 10 seconds, afterglow emission of s level appears, and the film can be applied to the technical field of information encryption and security anti-counterfeiting.

The invention provides a halogenated polysulfide aromatic hydrocarbon compound as well as a preparation method and application thereof. The structural formula of the halogenated polysulfide aromatic hydrocarbon compound is as shown in formula (I). Wherein X is one of F, Cl and Br. The halogenated polysulfide aromatic hydrocarbon compound disclosed by the invention can be used as a photoluminescent material and is a photostimulation response type luminescent material. The molecular structural formula of the photoluminescent material is as shown in a formula (1), and in the molecular structural formula of the photoluminescent material, based on a hexasulfobenzene unit as a core skeleton, the material is endowed with a unique photostimulation response characteristic through specific chemical group modification. The innovative material not only shows excellent light response capability, but also has the characteristic of aggregation-induced emission enhancement, so that the material has potential application value in the fields of biological imaging technology, organic light-emitting material application and the like.

This invention discloses a method and system for evaluating the effectiveness of photostimulation based on multimodal feature fusion, belonging to the field of big data analysis technology. The method and system include the following steps: S1, acquiring raw observation data and performing time axis relocation, dynamic denoising, normalization, and sliding time window segmentation; S2, evaluating the state of the stimulation process and selecting effective windows; S3, extracting neural activity response features and hemodynamic response features, and performing physiological response reliability assessment; S4, performing consistency fusion to evaluate the effectiveness of photostimulation. This invention effectively improves the stability and reliability of effectiveness evaluation during head-mounted photostimulation, solving the problems of difficulty in distinguishing between abnormal stimulation pathways and true brain tissue responses, as well as insufficient consistency of results across batches of experiments.

A magnetic resonance-compatible programmable synchronized photostimulation system includes a main control unit and a stimulation execution unit. The main control unit is located outside the magnetic resonance scanning room, while the stimulation execution unit is located inside the scanning room and consists only of an LED light panel shielded by a magnetic field. The main control unit is configured to: receive photostimulation sequence parameters configured by the user in a modular manner through a graphical interface; receive a scan trigger signal from the magnetic resonance equipment, and automatically control the start and stop of the photostimulation sequence based on the trigger signal using hardware triggering; thereby achieving high-precision time synchronization between photostimulation and magnetic resonance scanning while maintaining magnetic resonance compatibility. This invention solves electromagnetic compatibility issues through a split architecture, achieves millisecond-level synchronization accuracy through hardware TTL triggering, and enhances experimental paradigm flexibility through modular programmable sequences, making it suitable for neuroscience research fields such as functional magnetic resonance imaging.

Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s).

The present disclosure relates to optoelectronic devices and methods for optical epicardial pacing and endoscopic delivery devices and methods for translational photostimulation.

The invention provides a flexible miniature LED device and a preparation method thereof, and relates to the field of miniature LEDs. The device comprises an energy supply driving unit which is used for providing an electric signal and sending a control signal; a flexible substrate; the micro LED array is arranged on the surface of the flexible substrate and connected with the energy supply driving unit, and the micro LED array is used for converting the electric signal into an optical signal and controlling the light emitting parameter of the optical signal according to the control signal; wherein the energy supply driving unit is connected with the micro LED array through a flexible wire. According to the invention, the micro LED array is connected with the energy supply driving unit through the flexible wire, so that the energy supply driving unit is utilized to regulate and control the micro LED array. The problems that an existing optogenetics device is difficult to emit controllable photostimulation and is inconvenient to control are solved.

This application relates to the field of medical device technology, and in particular to a control system, control method, and storage medium for a transcranial photostimulator. The control system of the transcranial photostimulator includes: a microcontroller module; and at least two stimulation modules uniformly controlled by the microcontroller module, each stimulation module comprising a first stimulation module and a second stimulation module, wherein the first stimulation module is a photostimulation module and the second stimulation module is an electrical stimulation module. The microcontroller module independently controls the output parameters of the at least two stimulation modules through different digital communication protocols. The control method of the transcranial photostimulator is applied in the control system. A computer program is stored on a readable storage medium, and when executed by a processor, the computer program performs the steps according to the control method.

Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s).

The invention provides an assembling mode of RNA liquid drops deformed through photostimulation and application of the RNA liquid drops, and belongs to the technical field of preparation of nucleic acid for analysis. The method comprises the following steps: mixing an RNA single strand with a buffer solution through structural design to obtain a mixed system with a specific concentration; after the mixed system is subjected to heat shock to complete base pairing and assembling, sealing and packaging are performed, the RNA liquid drops deformed through photostimulation are obtained, and the diameter of the liquid drops is 7.0-13.0 microns. The RNA liquid drop obtained in the embodiment can deform under light stimulation, behavior regulation and control can be achieved through group modification, and feasibility is provided for construction and functional expression of artificial cells.

This invention discloses a multi-stimulus-responsive upconversion luminescent nanocrystalline magnetic microsphere and its preparation method, belonging to the field of biomedical polymer materials and nanobiotechnology. The microsphere's main body is a porous copolymer matrix, encapsulating a core of magnetite (Fe3O4) magnetic nanocrystals. Rare-earth-doped fluoride upconversion luminescent nanocrystals are coupled to the surface and pores. The copolymer side chains of the microsphere incorporate azide groups, acidic stimulus-responsive groups, and photostimulation-responsive groups, constructing an independent and non-interfering triple orthogonal logic gating system on the surface. The preparation method includes preparing an oil phase containing copolymers, magnetic nanoparticles, and a volatile porogen; pre-emulsifying and homogenizing the oil phase in an acidic aqueous phase using an SPG membrane; inducing phase separation by controlled solvent evaporation to form porous microspheres; and finally coupling the upconversion nanocrystals via a click chemistry reaction. The magnetic microspheres of this invention eliminate background fluorescence interference from complex samples from a physical perspective. Their porous structure endows the microspheres with excellent quasi-levitation properties and magnetic responsiveness, effectively solving problems such as single surface function and signal crosstalk of microspheres. They are suitable for in vitro clinical diagnosis and complex analysis of multiple targets.

The invention relates to the technical field of molecular switches, and discloses an optical switch molecule and a preparation method and application thereof. The structural general formula of the optical switch molecule is as follows: R1 is a hydrogen bond acceptor group, R2 is an electron donating group or an electron withdrawing group, and R3 and R4 are spatial substituent groups. According to the invention, sp3 hybrid carbon atoms are used as bridging units, and a series of space folding type ESIPT optical switch molecules are constructed for the first time and are applied to the aspects of chemical sensing, information encryption, data storage and the like. According to the method, light is used as an external stimulation condition to induce the photoswitch molecules to generate a rapid six-level photophysical-chemical process and generate a cis-trans isomerization process in an excited state, so that the photoswitch molecules are macroscopically represented as high-contrast color change before and after photostimulation.

The invention belongs to the field of cell culture automation and intelligent regulation and control, and discloses an optogenetics-based adherent cell culture optimization method and system. The method comprises the following steps: inputting an adherent cell type and a culture target, and calling an adherent cell-optical genetic parameter joint database; performing targeted pretreatment on the target adherent cells; processing through a multi-parameter optimization algorithm hardware platform to generate an executable customized photostimulation scheme; performing accurate light stimulation on the positive adherent cells; comparing the obtained detection data with normal adherent cell parameters in a joint database, and evaluating the influence of a photostimulation scheme on the cells; updating the parameters of the multi-parameter optimization algorithm and the prediction model; and inputting the adherent cell type and the culture target to the updated prediction model, and outputting an optimal light stimulation scheme. The core problems of low photostimulation accuracy and poor targeting in the prior art are solved, and high-activity and high-consistency light-sensitive adherent cells are stably produced.

In one aspect, apparatus for ophthalmic photostimulation is presented. An apparatus may include a light emitter, A light emitter may emit at least a first wavelength of light substantially within a wavelength range of about 420 nm to about 580 nm of a light spectrum. An apparatus may include a power connector that connects a light emitter to a power source. An apparatus may include a switch in electrical communication with the light emitter and the power connector, the switch operable to activate or deactivate the light emitter, wherein the light when shone in at least one eye of a user is effective in inducing tear production.

According to the animal airway response induction real-time detection system and detection method provided by the invention, the photogenetic stimulation unit irradiates the photosensitive protein of the experimental subject by using the light source with the preset wavelength, and performs photostimulation on neurons in a specific brain region of the experimental subject; receiving an airway hyperresponse signal generated by the experimental subject after receiving the photostimulation in real time through a signal acquisition unit, and acquiring lung function data of the experimental subject; the collected data is subjected to fitting calculation through the processing unit, the lung function and capacity indexes are obtained, real-time detection of animal airway hyperresponse is achieved, activation of vagus nerves is allowed to be accurately controlled in time and space by adopting the photogenetic technology, real-time detection of animal airway response is achieved, and the accuracy of animal airway hyperresponse detection is improved. The accuracy and the reliability of an experiment result are improved; the repeatability of an experimental result is ensured by standardizing an experimental process and setting light source parameters; a local minimally invasive invasive photostimulation mode reduces trauma and stress response to an experimental subject.

This invention discloses a solar photoresponsive metal coordination polymer, its preparation method, and its applications, belonging to the field of coordination polymer technology. This invention synthesizes four structurally similar coordination polymers by reacting the ligand (E)-4-(4-(pyridin-4-yl)styryl)pyridine with isophthalic acid derivatives and CdSO4·8 / 3H2O via a solvothermal reaction. These four coordination polymers undergo a [2+2] cycloaddition reaction under solar irradiation. The resulting series of single crystals exhibit photoresponsive behavior under sunlight, with crystals of different sizes and shapes producing different mechanical movements. The composite film prepared by combining this coordination polymer with PVA exhibits mechanical movement under ultraviolet light, displaying mechanical behaviors not found in single crystals, and holds promise for applications in photo-actuators. Furthermore, this invention also extracts cyclobutane products based on the photoreaction of this series of coordination polymers, a simple and environmentally friendly process.

This invention relates to astrocyte-derived exosomes, their preparation method, and applications. Specifically, it involves using photostimulation with PBM to induce the generation of astrocyte-derived exosomes. The generated exosomes can protect neurons and improve cognitive impairment and mood disorders. The exosomes obtained by this invention can be used for the treatment and / or prevention of cognitive impairment and / or mood disorders, demonstrating excellent application prospects and research value.

The present disclosure is related to a method for improving physiological state by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency, and an apparatus used for the same. More specifically, improvement of physiological state such as, improvement or suppression of dermatitis, improvement or suppression of alopecia, improvement of hair condition, improvement or suppression of graying of hair, improvement or suppression of hearing loss, improvement or suppression of vision loss, improvement or enhancement of muscle strength, improvement or suppression of kyphosis, improvement or suppression of pain and / or feeling of discomfort, improvement of autonomic nerve abnormalities, improvement of healthy life expectancy, and obesity control is carried out by irradiating light of a specific wavelength such as violet light to a living body.

The invention discloses an in-vitro retina photostimulation device for retina patch clamp operation, and belongs to the field of optics and biomedical engineering. The device is mainly composed of four parts: a light source screen module can display a color programmable pattern; the screen mainboard is integrated with an accelerometer and a gyroscope, so that the screen posture can be measured; the convex lens is used for reducing a light source screen output pattern to a retina adaptive size; the dichroscope can reflect the shrunk pattern and transmit infrared light; the light path support is used for fixing the light source screen, the convex lens and the dichroscope, and enables the light source screen, the convex lens and the dichroscope to keep a preset distance so as to achieve an expected reduction magnification. Based on a convex lens imaging rule, the projection system can project a programmable image with 240 * 240 pixels and a single pixel side length of 10 microns on the retina, and can realize pattern correction according to a screen inclination angle.

The invention relates to a preparation method of a diarylethene-based triplet-state biradical molecule with short wavelength emission, and belongs to the field of organic light-emitting free radical materials. According to the invention, on the basis of the existing photochromic skeleton-diarylethene, the diarylethene-based triplet-state biradical molecule which not only has photochromic property but also has luminous free radical property and has short-wavelength emission is designed and synthesized, and the diarylethene-based triplet-state biradical molecule has photochromic property and luminous free radical property; free radicals are generated in situ through photostimulation. The invention develops a technology for preparing stable light-emitting free radicals by a method for generating free radicals in situ through photostimulation, and the method is novel.

The utility model provides a photostimulation assembly for treating brain function related diseases, which adopts a light transmission piece capable of circumferentially emitting near-infrared light, the light transmission piece is spirally arranged in an accommodating cavity of a bearing piece, and a light uniformizing layer is arranged on one side of a light transmission part of the bearing piece, so that the near-infrared light can be transmitted to the light transmission piece, and the light transmission piece can transmit near-infrared light to the bearing piece. The near-infrared light can be uniformly irradiated to the head of a patient, light spots with a certain area can be emitted to a head treatment area at a short distance, meanwhile, relatively uniform distribution of light power is guaranteed, and the treatment effect on patients with brain function related diseases in some special scenes is greatly improved. Meanwhile, the photostimulation assembly is not interfered by a high-intensity magnetic field in a treatment area of the head of the patient, and can be combined with magnetoencephalography, functional magnetic resonance imaging and other technologies, so that the change condition of the brain function state of the patient can be monitored in time while the brain function related diseases are treated by adopting photostimulation; the method can be used for evaluating the treatment effect of photostimulation, guiding the photostimulation treatment scheme and the like.

The invention discloses a neuromorphic photoelectric device, a preparation method and electronic equipment. The neuromorphic photoelectric device comprises a substrate, a bottom electrode, a first zinc oxide layer, a second zinc oxide layer and a top electrode which are stacked in sequence. As the oxygen concentration of the first zinc oxide layer is greater than that of the second zinc oxide layer, a heterojunction and an oxygen vacancy gradient are formed in the double-layer structure, so that the photoelectric device generates a response of a neuromorphic characteristic according to photostimulation. The oxygen vacancy of the first zinc oxide layer introduces an impurity energy level into a forbidden band, so that the impurity energy level generates an infrared signal according to the infrared ray. Due to the fact that the built-in electric field of the heterojunction enables carriers to be separated, the intensity of infrared signals is enhanced, and the infrared signals are easier to detect. And the second zinc oxide layer can directly absorb and generate an ultraviolet signal, so that the photoelectric device with the neuromorphic structure provided by the invention can simultaneously detect ultraviolet rays and infrared rays on the basis of simulating nerve synapse.

The invention relates to a combined regulation and control method based on PV neurons, and the method comprises the following steps: building a thalamic cortical neuron group dynamic model, the thalamic cortical neuron group comprises a cortical main neuron, an inhibitory intermediate neuron, a specific relay nucleus and a thalamic reticulate nucleus; constructing a four-state photogenetic channel model, calibrating photogenetic channel parameters, and performing targeted photostimulation on PV neurons; and performing single-parameter scanning and parameter combination optimization on the parameters of the optical genetic channel, and realizing the parameter optimization of the optical genetic channel on the basis of the neuron activity state simulated by the thalamic cortex neuron group dynamic model. Compared with the prior art, the method has the advantages that accurate neuron regulation and control based on a targeted target can be realized, and the like.

The application provides a novel light-sensitive channel protein VR2.0 and uses thereof. The light-sensitive channel protein VR2.0 series provided in this application demonstrates profound therapeutic effects in the treatment of retinal photoreceptor cell degenerative diseases. This novel light-sensitive channel protein exhibits enhanced photosensitivity, fast kinetics, and reduced side effects. Under identical photostimulation conditions, VR2.0 demonstrates faster response frequencies while maintaining stable photocurrent signals even during high-frequency stimulation. This application provides a better optogenetic therapeutic option for retinal photoreceptor cell degenerative diseases, and has significant application and promotion value.

The present invention provides a method of treating Parkinson's disease by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency. The present invention, by irradiating light of a specific wavelength such as violet light to a living body, carries out treatment and / or prophylaxis of Parkinson's disease by improving or suppressing at least one symptom selected from a group of symptoms consisting of cognitive memory disorder, working memory disorder, dysphoria, anxiety, apathy, psychological symptoms (hallucination, visual hallucination, and auditory hallucination), impulse control disorder, orthostatic hypotension, urinary disorder, sexual dysfunction, digestive symptoms (drooling, swallowing, nausea, constipation), sleep disorder, pain, weight loss, olfactory abnormality, fatigue, and diaphoresis.

The goal of computer generated holography (CGH) is to synthesize custom illumination patterns by shaping the wavefront of a coherent light beam. Existing algorithms for CGH rely on iterative optimization with a fundamental trade-off between hologram fidelity and computation speed, making them inadequate for high-speed holography applications such as optogenetic photostimulation, optical trapping, or virtual reality displays. We propose a new algorithm, DeepCGH, that relies on a convolutional neural network to eliminate iterative exploration and rapidly synthesize high resolution holograms with fixed computational complexity. DeepCGH is an unsupervised model which can be tailored for specific tasks with customizable training data sets and an explicit cost function. Results show that our method computes 3D holograms at record speeds and with better accuracy than existing techniques.

The invention discloses an NIR-IIb response type up-conversion nanometer material, a hydrogen production nanometer reactor prepared from the NIR-IIb response type up-conversion nanometer material and application of the NIR-IIb response type up-conversion nanometer material, and belongs to the technical field of nanometer biomedical materials. The controllable hydrogen production nanoreactor is obtained by using a bionic carrier formed by lipidosome, a photosensitizer, a catalyst and a proton donor which are jointly wrapped in the bionic carrier, and an up-conversion nanomaterial prepared by a chemical synthesis method, a hydrothermal method and the like, and can generate hydrogen under the stimulation of light with specific wavelength. According to the nano-reactor provided by the invention, a proton donor is efficiently catalyzed to generate hydrogen, on-demand and controllable release of hydrogen at a focus part is realized by utilizing high-tissue-penetrability NIR-IIb stimulation, and the nano-reactor provided by the invention can effectively remove active oxygen at the focus part and relieve oxidative stress by controllably releasing the generated hydrogen, so that pulmonary fibrosis is effectively relieved. The nanoreactor provided by the invention has the advantages of good biocompatibility, high hydrogen production efficiency, strong targeting property, small treatment side effect and the like, and has a wide market application prospect.

This application relates to an agricultural laser system intended to extend, supplement, or replace the functions performed by conventional tools for tasks such as pruning, weeding, cutting, drying, and photostimulation. The system employs one or more lasers and includes a power module (1-A), a control module (1-B), a compressed gas and / or ventilation module (1-C), a temperature control module (1-D), a power distribution module (1-E), a laser module (2-A), a constraint and laser beam guide module (2-B), and a positioning wheel (3). Advantages of this system include reduced size and weight, the ability to move at relatively high speeds, low fuel consumption and operating costs, the ability to operate in a positive pressure environment to prevent damage to optical components or along the laser beam path, or operation outside of a positive pressure environment, modularity, and adaptability to crops of various sizes.

The invention discloses a visual light-induced full-field coherence tomography imaging device and a visual light-induced full-field coherence tomography imaging method. The device comprises an FFOCT unit, a photostimulation unit, a curvature matching unit, a synchronous control unit and a processor unit, wherein the FFOCT unit is used for illuminating three-dimensional tissues and acquiring signals; the photostimulation unit is used for activating target tissues; the curvature matching unit is used for curvature matching of the reference arm and the sample arm; the synchronous control unit is used for synchronously controlling the photostimulation unit and the FFOCT unit; and the processor unit is used for demodulating the collected signals and extracting the signals. The method comprises the following steps: activating a living body tissue by utilizing stimulation light, synchronously scanning and imaging a target tissue by virtue of FFOCT, acquiring three-dimensional information and a dynamic signal of the living body tissue, and extracting a functional signal of the target living body tissue based on analysis of relative change before and after the stimulation light is activated. According to the invention, optophoresis-induced imaging of submicron-dimension living tissues can be carried out, the imaging quality is high, the imaging field of view is wide, the function is convenient to transplant, and the experimental device is compact.

A miniature microscope that incorporates laser scanning optical microscopy and arbitrary spatially patterned photo stimulation typically at a different wavelength with two optical arms. The first optical arm both delivers patterned photostimulation and performs optical collection of fluorescence from a sample. The second arm provides scanned excitation pulses to cause the fluorescence. The light from the two optical arms can be combined with a dichroic mirror or polarizer to align the beams in the field of view of the microscope objective element.