The invention discloses a nano imprint demoulding structure based on air driving, wherein a polymer clamping casing is arranged on a work bench, a mould plate is arranged at the lower end of the clamping casing, a plunger is arranged on the upper end surface of the mould plate, a sleeve is fixedly connected with the clamping casing, the sleeve and the plunger move from up to down, thereby the mould plate can move from up to down in the clamping casing, a sliding passage arranged on the lower end surface of the mould plate is provided with a spring and a slide block, a mould clamping air passage connected to the clamping casing is led into the slide passage via the mould plate, thereby the slide block can slide in the slide passage on the lower end surface of the mould plate, a demoulding air passage is switched in from the clamping casing and passes through the mould plate, and a sealing ring is arranged on the lower end surface of the clamping casing. The nano imprint demoulding structure is capable of demoulding smoothly, and stress of the polymer and the mould is uniform, further damages of the microstructure imprinted can be reduced to the minimum, the mould can be protested, and the cost of imprinting can be reduced.