393 results about "Acid catalysis" patented technology

The invention relates to the field of caprolactam production, and discloses a green and efficient production process and device. The process comprises the following steps: continuously oximating cyclohexanone and hydroxylamine in a microreactor under the catalysis of mesoporous silica solid acid; carrying out gas phase rearrangement on cyclohexanone-oxime in the presence of a ZSM-5 molecular sieve under the assistance of microwaves; coupling, rectifying and purifying the crude product through a four-stage molecular sieve membrane; and performing catalytic cracking on the by-product to obtain N2 / H2O and recycling. The device comprises a micro-reaction unit, a microwave-radial reactor, a membrane coupling rectifying tower group and a tail gas cracking unit. Zero emission of ammonium sulfate is achieved, the product purity is larger than or equal to 99.95%, and energy consumption is reduced by 45%.

The invention discloses a method for preparing 12-mercaptan through solid organic acid catalysis, belongs to the technical field of 12-mercaptan preparation, and aims to solve the problems of low catalyst activity, harsh reaction conditions, serious pollution, high cost and dependence on import in the prior art. N-dodecanol and hydrogen sulfide are used as raw materials and are mixed according to the molar ratio of 1: 1.2-1: 1.3; the method comprises the following steps: gasifying n-dodecanol, mixing with purified hydrogen sulfide, preheating to 210-240 DEG C, introducing into a fixed bed reactor filled with a solid organic acid catalyst, and reacting at-0.08-3.0 MPa for 3.5-4 hours; and cooling and condensing the reaction product, carrying out gas-liquid separation, rectifying and purifying the liquid product to obtain 12-mercaptan with the purity of more than or equal to 99.5%, and recycling unreacted hydrogen sulfide. The solid organic acid can be a catalyst of p-toluenesulfonic acid and the like or mesoporous silica loaded nickel, cobalt and molybdenum metal oxides. The method has the advantages of high catalytic activity, mild reaction conditions, high product yield (the conversion rate of n-dodecanol is greater than or equal to 94.5%), environmental protection and low cost, can realize the domestic mass production of 12-mercaptan, and meets the market demand.

The invention discloses a phenanthridine-6-formaldehyde derivative and a preparation method and application thereof.The preparation method comprises the steps that 2, 4, 5, 6-tetra (9-carbazolyl)-isophthalonitrile serves as a photocatalyst, 1-azabicyclo [2.2. 2] octane serves as a hydrogen atom transfer catalyst, a biphenyl isocyanide compound, the photocatalyst, the hydrogen atom transfer catalyst and an alkali additive are jointly dissolved in 1, 3-dioxolane, the mixture is stirred to be uniform, and the phenanthridine-6-formaldehyde derivative is obtained. And carrying out free radical tandem cyclization and acid-catalyzed hydrolysis reaction to obtain the phenanthridine-6-formaldehyde derivative. The invention also provides a specific reaction equation. According to the developed synthesis method of the phenanthridine-6-formaldehyde derivative, the compound can be efficiently and conveniently prepared, the technical bottlenecks of harsh reaction conditions and tedious steps in a traditional process are successfully overcome, raw materials which are low in price and easy to obtain are adopted, operation is carried out under mild conditions, the synthesis method has the outstanding advantages of being high in yield, safe and simple to operate, environmentally friendly and the like, and the method is suitable for industrial production. Good industrial application potential is shown.

The present invention relates to a fluxapyroxad intermediate trifluoronitrobiphenyl synthesis method, and belongs to the technical field of organic synthesis, the method comprises the following steps: Step 1: under nitrogen protection, adding 3, 4, 5-bromotrifluorobenzene, o-nitrophenylboronic acid, a catalyst, a promoter, an alkali and a solvent into a reaction flask, and after addition, carrying out a heat preservation reaction; and Step 2: after the reaction is finished, carrying out phase splitting and organic phase concentration to obtain the 3 ', 4', 5 '-trifluoro-2-nitrobiphenyl. Compared with a traditional synthetic method of the trifluoro-nitrobiphenyl, the synthetic method of the trifluoro-nitrobiphenyl has the advantages that the 3, 4, 5-trifluoro-bromobenzene and the o-nitrophenylboronic acid are directly used as raw materials, the production step of preparing the 3, 4, 5-trifluoro-phenylboronic acid from the 3, 4, 5-trifluoro-bromobenzene through a multi-step reaction is avoided, the yield can be effectively improved, the utilization rate of the raw materials is high, and the method is suitable for industrial production. And the o-nitrophenylboronic acid preparation method is simple, the reaction cost can be effectively reduced, the reaction route is shorter, simpler and more efficient, the reaction conditions are mild, and the method has higher industrial application value.

The invention relates to analcime with an ANA structure and a preparation method of the analcime, the chemical molecular formula of a unit cell of the analcime with the ANA structure is Na < x > [SiyAlzO96], x is equal to 6-15, y is equal to 30-37, and z is equal to 10-16; the analcime with the ANA structure has a spherical crystal morphology. The analcime with the ANA structure disclosed by the invention has a spherical crystal morphology, shows excellent molecular diffusion performance, and has a good application prospect in the fields of small molecular acid catalytic reaction, small molecular gas adsorption separation, ion adsorption purification and the like.

The invention discloses a method for preparing an EGFR inhibitor through catalysis of lewis acid. The invention provides a novel preparation method of the compound as shown in the formula (I), and the method is high in yield, high in purity of the obtained product, stable in reaction on a large scale and more suitable for industrial production. # imgabs0 #

The invention discloses an anti-fatigue detection method for a structural member made of a high polymer material, and belongs to the field of material detection.The anti-fatigue detection method comprises the following steps that S1, a thermoplastic high polymer raw material for preparing the structural member is heated to be in a molten state, and a first intermediate is formed; s2, preparing a shell layer by taking polylactic acid, Y-type polyethylene glycol succinic acid, acetylsalicylic acid and a DCP catalyst as raw materials, and preparing fluorescent color developing agent microspheres by taking a high-temperature-resistant liquid fluorescent color developing agent as a core material; s3, adding fluorescent color developing agent microspheres into the first intermediate, uniformly stirring, heating, continuously stirring, uniformly mixing the color developing agent with the first intermediate after the color developing agent is released to obtain a second intermediate, and performing injection molding, molding, curing and cooling on the second intermediate to obtain a structural part sample; and S4, carrying out fatigue detection on the structural member sample by adopting a fatigue testing machine. The method solves the problems that closed cracks or internal defects are difficult to directly recognize from the inside and the initiation and expansion process of the internal cracks of the component cannot be captured at present.

The invention relates to the field of ion separation, and particularly discloses a crown ether-based monovalent / divalent selective cation exchange membrane preparation method, which comprises: carrying out super acid catalysis copolymerization on dibenzo crown ether and a pre-sulfonated monomer to obtain a precursor, and carrying out graft modification on a main chain by using a side chain on the basis to obtain the crown ether-based monovalent / divalent selective cation exchange membrane. The separation performance of monovalent / divalent cations is optimized, and the side chain type cation exchange membrane is prepared. The ion exchange membrane provided by the invention can be used for screening various monovalent / divalent ion systems, the number of # imgabs 0 can reach 370, the number of # imgabs 1 can reach 207, and the number of # imgabs 2 can reach 11125.

The invention provides a functional nanofiber material as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) adding raw materials into water to form an electrostatic spinning solution; performing electrostatic spinning to obtain a nanofiber membrane; (2) cross-linking the nanofiber membrane in an organic solvent under the catalysis of acid to obtain a cross-linked nanofiber membrane; and (3) carrying out grafting reaction on the cross-linked nanofiber membrane in a polyamine cross-linking agent, and then reacting with a sulfur-containing reagent to obtain the functional nanofiber material, the functionalized nanofiber material prepared by the preparation method disclosed by the invention combines good biocompatibility of polyvinyl alcohol, high specific surface area and high porosity of nanofiber and a synergistic adsorption effect of the polyamine cross-linking agent and cysteine, and has the advantages of large adsorption capacity, high adsorption rate, strong selectivity, good biocompatibility, stable structure and the like; the heavy metal ions in the plasma can be efficiently and safely removed, and a plurality of defects of the existing adsorption material are overcome.

The invention discloses an application of an ionic liquid in extraction of trioxymethylene, in the process of generating trioxymethylene by acid-catalyzed condensation of a formaldehyde aqueous solution, the ionic liquid is added as an extraction agent to extract and separate the trioxymethylene generated by reaction, and the ionic liquid is methyl tributyl phosphonium bis (trifluoromethanesulfonyl) imide salt; when the ionic liquid is used for extracting trioxymethylene, a ternary azeotropic system of trioxymethylene, water and methylene glycol can be broken, the ionic liquid and trioxymethylene are subjected to nonpolar Van der Waals' force interaction so as to realize extraction, and methylene glycol and water are left in a water phase through hydrogen-bond interaction, so that high-purity trioxymethylene with the purity of more than or equal to 99.5 wt.% is obtained.

The preparation method comprises the following steps: carrying out acid-catalyzed polymerization on p-terphenyl and a ketone monomer under the action of a first organic solvent and trifluoromethanesulfonic acid, and precipitating, filtering, washing and drying a reaction product to obtain a first polymer; carrying out quaternization reaction on the first polymer and quaternary ammonium salt under the action of a second organic solvent, cooling to room temperature, and adding 1, 6-hexamethylenediamine to obtain a second polymer solution; and coating a substrate with the second polymer solution, and carrying out drying membrane formation, heat treatment and hydroxyl anion exchange to obtain the cross-linked hydroxyl ion exchange membrane. The preparation method disclosed by the invention is simple and suitable for large-scale production, and the prepared anion exchange membrane has high ionic conductivity, excellent dimensional stability and mechanical property and relatively good machinability and application potential, and has a good application prospect in a water electrolysis hydrogen production technology.

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and discloses a total synthesis method of rhododendron heteroterpenin Rhododaurines A-C. The total synthesis method comprises the following steps: carrying out allyl stereoselective addition on a compound 3 and a compound 5 in a toluene solvent under the conditions of catalysis of n-butyllithium and low temperature of-78 DEG C, and constructing a chiral center to obtain a compound 6; removing a methoxy methyl (MOM) protecting group from the compound 6 under an acidic condition, cyclizing, and reacting to generate rhododaurine C (7); the rhododaurine C (7) is subjected to intramolecular [4 + 2] cycloaddition and oxidation reaction in the illumination and oxygen atmosphere of 300-385 nm, and rhododaurine B (8) and an epoxy epimer epinedodaurine B (9) are obtained; and carrying out protonation and rearrangement on the epidodaurine B (9) by virtue of acid catalysis cyclic ether, so as to generate the rhododaurine A (10). The method can overcome the defects that the content of rhododendron miscellaneous terpenoids Rhododaurines A-C in nature is extremely low, and large-scale extraction is difficult.

The invention discloses a crown ether cation selective separation membrane and a preparation method thereof. The preparation method comprises the following steps: carrying out super acid catalysis on dibenzo-18-crown-6, terphenyl and isatin in dichloromethane to synthesize a precursor; carrying out affinity substitution reaction on the precursor and a flexible side chain with an ion exchange group through a pre-modification method to obtain a functional precursor; dissolving the functionalized precursor in an organic solvent to form a film casting solution, coating on a glass plate, and heating to volatilize the solvent so as to form a film through curing; and taking down the membrane from the glass plate, acidifying in an acidic aqueous solution, washing with deionized water, and extracting with deionized water to obtain the crown ether cation selective separation membrane. The crown ether cation selective separation membrane has the advantages of relatively high mechanical strength, physical and chemical stability and the like. Meanwhile, the crown ether cation selective separation membrane shows performance superior to that of a commercial membrane in the field of monovalent cation separation, and has wide application prospects in the fields of TMAH purification, salt lake lithium extraction, seawater salt extraction and the like.

The invention relates to a synthetic method of a finelrenone racemate, which comprises the following steps: carrying out Knoevenagel condensation, Hantzsch dihydropyridine synthesis, O-ethylation and deprotection four-step reaction, selecting a compound shown as a formula (2) and a compound shown as a formula (3) as initial raw materials, and carrying out Knoevenagel condensation reaction under the combined action of organic alkali and organic acid to synthesize a compound shown as a formula (4); carrying out Hantzsch reaction on the compound in the formula (4) and a compound in a formula (5) to synthesize a compound in a formula (6); carrying out O-ethylation reaction on the compound shown in the formula (6) and an ethylation reagent under the catalysis of acid to synthesize a compound shown in a formula (7); finally, 2, 4-dimethoxybenzyl is removed from the compound shown in the formula (7) under the promotion of acid to synthesize the finerenone racemate, the method is high in selectivity and simple in post-treatment, the yield and purity of the product are high, the HPLC purity can reach 99% or above, a new synthesis route and method are developed for synthesizing the finerenone racemate, and the method has good application potential and research value.

The invention belongs to the technical field of membranes, and discloses a monovalent / divalent cation selective separation membrane based on an intrinsic microporous polymer, and the preparation route of the membrane is as follows: taking an ether-free polymer synthesized by super acid catalysis as a precursor, introducing an ion exchange site into the polymer by utilizing grafting of a sulfonated monomer, and preparing the monovalent / divalent cation selective separation membrane based on the intrinsic microporous polymer. And improving the separation performance of monovalent ions / divalent ions by using an alkoxy chain graft with specific interaction on the monovalent ions, and greatly improving the mechanical strength of the membrane by using the interaction of hydrogen bonds between main and side chains, thereby finally obtaining the monovalent / divalent cation selective separation membrane. According to the present invention, the industrial production difficulty is significantly reduced by the full solvation reaction membrane synthesis route, the selectivity of the prepared membrane material is superior to the selectivity of the commercial membrane of the same type, the extremely high mechanical strength is maintained, and the large-scale production and application potential is provided.

The embodiment of the invention provides a preparation method of methylene-bridged substituted phenol substituted by hydroxyl ortho-hydroxymethyl, and the preparation method comprises the following steps: A1, reacting substituted phenol with formaldehyde in the presence of a Lewis acid catalyst to prepare a substituted salicylaldehyde compound (2); a2, carrying out condensation reaction on the substituted salicylaldehyde compound (2) in a system containing formaldehyde and a Bronsted acid catalyst to prepare a methylene-bridged substituted salicylaldehyde compound (3); and A3, reducing the methylene-bridged substituted salicylaldehyde compound (3) to prepare methylene-bridged substituted phenol (4) with hydroxyl ortho-hydroxymethyl substituted. According to the embodiment of the invention, the yield and the chemical purity of the prepared methylene-bridged substituted phenol substituted by hydroxyl ortho-hydroxymethyl can be improved. According to other embodiments of the invention, the invention also provides a preparation method of the polyphenol compound containing multiple phenol units.

The invention discloses a method for catalyzing melamino-formaldehyde resin methylation reaction by solid acid. According to the invention, epoxy silane coupling agent grafted modified nanocellulose is introduced into sulfonated styrene-divinyl benzene cross-linked copolymer microspheres for in-situ crystal cross-linking, so that the problems that the traditional sulfonated polystyrene resin is poor in mechanical strength and solution solubility resistance, low in cycle index, easy to swell and fall off and the like are effectively solved; the prepared solid acid resin has the characteristics of high reaction activity, high proton transfer rate, high mechanical strength, high cyclicity and easiness in solid-liquid separation, and by utilizing the solid acid resin to catalyze the etherification reaction of the melamino-formaldehyde resin, the reaction temperature and the production energy consumption are reduced, the reaction time is shortened, the product quality and the production efficiency are improved, and the production cost is reduced. The problems of environmental protection and energy consumption caused by the generation of a large amount of VOCs in the etherification reaction of the traditional liquid catalyst for synthesizing the high-etherified melamine formaldehyde resin and the by-product inorganic salt in the subsequent process are solved.

The invention discloses a preparation method of 20 (E)-ginsenoside F4 and application of the 20 (E)-ginsenoside F4 in preparation of anti-liver injury medicines, and relates to the technical field of biological medicines. The rare ginsenoside 20 (E)-ginsenoside F4 is prepared and purified from ginsenoside Re through an acid catalytic conversion method, and the rare ginsenoside 20 (E)-ginsenoside F4 shows remarkable advantages and wide prospects in research and development of liver protection drugs. The monomer has strong liver protection activity, complies with the development trend of monomeric compound preparations, and provides efficient active ingredients for liver protection drugs. The 20 (E)-ginsenoside F4 with efficient activity, excellent safety and environment-friendly preparation characteristics can be widely applied to preparation of liver protection drugs or pharmaceutical compositions, especially drugs or pharmaceutical compositions for treating liver injury caused by chemotherapeutic drugs.

The invention relates to a side chain type polyaryl anion-exchange membrane, a preparation method and application thereof and an anion-exchange membrane electrolytic bath, and belongs to the technical field of hydrogen energy. The preparation method of the side chain type polyaryl anion exchange membrane comprises the following steps: reacting a side chain type polyaryl skeleton polymer with a quaternization reagent to obtain a side chain type polyaryl anion polymer; the side-chain type polyaryl anion polymer is subjected to membrane forming, and the side-chain type polyaryl anion exchange membrane is obtained. According to the invention, a heteroatom-free polyaryl structure is selected as a main chain, and a super-acid-catalyzed Friedel-Crafts reaction is adopted for polymerization, so that the high-molecular polymer is obtained; the cationic functional group is a piperidine cationic functional group with excellent alkali stability; the piperidine cation functional group is connected with the polyaryl main chain through a long alkyl chain. According to the invention, a long alkyl chain is adopted to combine a polyaryl skeleton with a piperidine cation functional group, and a hydrophilic / hydrophobic microphase separation structure is constructed in the membrane, so that the conductivity of hydroxyl ions is remarkably improved while the alkali stability and the size stability are improved.

The invention provides an antibacterial high-barrier starch-based plastic bottle and a preparation method thereof.The preparation method comprises the steps that firstly, titanate generates nano titanium dioxide in situ in starch through acid catalysis, starch is subjected to in-situ hybridization modification, and nano titanium dioxide in-situ hybridization starch is prepared; then adding nano inorganic barrier powder, and then adding a long-chain silane coupling agent to modify the nano titanium dioxide in-situ hybridized starch and the nano inorganic barrier powder to obtain a modified starch compound; performing vacuum kneading and drying until the water content is lower than 0.5%, and adding an antibacterial lubricant for plasticizing to obtain a plasticized material; and finally, carrying out melt blending and granulation with polyolefin resin, and carrying out extrusion blow molding. The environment-friendly and low-cost starch-based material is kept, meanwhile, the comprehensive performance of the product is remarkably improved, the surface contact angle of the product is 110 degrees or above, the antibacterial rate is 97% or above, and the oxygen permeation amount and the water vapor permeation amount are 100 cm / (m.24h. Atm) and 4 g / (m.24h) or below respectively.

The invention belongs to the technical field of biology, and discloses a transaminase GabT1 mutant S106I, a construction method thereof and application of the transaminase GabT1 mutant S106I in biosynthesis of 1-deoxynojirimycin. According to the invention, the 106th serine near the molecular catalytic domain of the transaminase GabT1 derived from bacillus amyloliquefaciens is mutated into isoleucine in a site-directed mutagenesis manner, so that the catalytic efficiency of the transaminase GabT1 is remarkably improved, the problem that the catalytic efficiency of the transaminase GabT1 on fructose-6-phosphoric acid is not high at present is solved, and the application of the transaminase GabT1 to the fructose-6-phosphoric acid is promoted. The yield of 1-deoxynojirimycin synthesized by the mutant GabTS106I is increased by 43.87% compared with that of a wild type. The 1-deoxynojirimycin fermentation production capability of the transaminase GabT1 mutant and the engineering strain obtained by the invention is greatly improved, and the transaminase GabT1 mutant and the engineering strain have a good industrial application prospect.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 1, 1-cyclohexyl diacetic acid. The preparation method comprises the following steps: taking cyclohexanone and ethyl cyanoacetate as raw materials to react and dehydrate to prepare a product 1, then reacting cyanoacetamide, sodium methoxide and the product 1 at low temperature to obtain a product 2, and then hydrolyzing the product 2 under the catalysis of a magnetic solid double-acid catalyst to obtain the 1, 1-cyclohexyl diacetic acid. The used magnetic solid double-acid catalyst is prepared by loading a metal active layer and a sulfonic acid group on a magnetic mesoporous silicon dioxide carrier step by step, and has Lewis acid and Bronsted acid sites, and the catalyst is separated by an external magnetic field after the reaction. The method is short in reaction time and high in catalytic efficiency, the catalyst can be recycled, the separation problem of traditional homogeneous acid catalysis is avoided, and the method has the advantages of being mild in reaction condition, high in yield, environmentally friendly and the like and is suitable for industrial production of 1, 1-cyclohexyl diacetic acid.

Anion exchange polymers comprise a plurality of repeating units of formula (I). The polymer may be synthesized from a super acid catalyzed polyhydroxyalkylation reaction of monomers Ar1′, Ar2′, and X1′ to form a neutral precursor polymer followed by a Menshutkin reaction to convert the neutral precursor polymer to the anion exchange polymer.Anion exchange membranes and membrane electrode assemblies incorporating the anion exchange polymers are also described.

The present invention addresses the problem of providing a solvent-type base coating material composition that can achieve both reduction in energy load and storage stability during formation of a coating film while maintaining the appearance of the coating film.　This solvent-type base coating material composition comprises: (A) a pigment containing one or more kinds selected from the group consisting of coloring pigments and flake pigments; (B1) a specific hydroxy group-containing acrylic resin having a weight average molecular weight of 10,000-20,000; (B2) a hydroxy group-containing acrylic resin having a weight average molecular weight of 3,000-7,500; (C) a blocked isocyanate compound; (E) a melamine resin containing a fully alkylated melamine resin; (D) polymer crosslinked fine particles insoluble and stably dispersed in a solution of the hydroxy group-containing acrylic resin (B1); (F) an acid catalyst having no counterion; and (G) an amine compound containing a secondary amine compound. The solid content is 35% by mass or more. When a viscosity V1 is measured at 23°C under a shear rate of 0.1 / sec using a cone-plate viscometer, followed by 30 seconds of shearing with the shear rate changed from 0.1 / sec to 25,000 / sec and then one second of shearing with the shear rate returned to 0.1 / sec, and a viscosity V2 is subsequently measured, the viscosity recovery rate V2 / V1, which is the ratio of V2 to V1, is 90% or more.

The application relates to a method for hydrothermal acid-controlled degradation of mulberry leaf polysaccharide and antioxidant application thereof, and belongs to the technical field of extraction of active ingredients in natural products. The method comprises the following steps: pretreating raw materials, hydrothermally reacting and acid-catalytically treating mulberry leaves, and alcohol-sedimenting, separating and purifying mulberry leaf polysaccharide, so as to obtain mulberry leaf polysaccharide, finally, the antioxidant application of the mulberry leaf polysaccharide is explored, and a theoretical basis is provided for development of mulberry leaf resources. The method can not only obtain mulberry leaf polysaccharide, but also obtain high-value natural active ingredients such as rutin, astragalin, scopoletin and isoquercitrin in the mulberry leaves, is beneficial to development and utilization of the mulberry leaf resources, meets the needs of people's health, and has practical significance and economic value.

The invention provides an anti-interference control method for the concentration of a main reactant in a continuous stirring reaction kettle process, belongs to the technical field of chemical process control, and solves the problem that in the chemical process of producing cyclopentanol by catalyzing electrophilic water with cyclopentadienoic acid, the concentration of the main reactant is not influenced. The technical problem that the concentration of a main reactant is difficult to track a set value without steady-state errors under the conditions of fluctuation of feeding concentration, uncertainty and external disturbance of the continuous stirring reaction kettle is solved. According to the technical scheme, the method comprises the steps of constructing a model pre-estimation compensator and an anti-interference control structure, designing a four-dimensional decision model, carrying out parameter collaborative optimization by adopting a multi-target genetic optimization algorithm, and carrying out optimal solution selection based on a TOPSIS method. Under the condition of feed concentration fluctuation, the dynamic response speed and the anti-interference capability of the system can be remarkably improved, and faster adjustment time, smaller overshoot and stronger robustness can be realized in linear and nonlinear models.

The application discloses a cross-linked polyaryl piperidine anion exchange membrane and a preparation method and application thereof, and relates to the technical field of anion exchange membranes. The anion exchange membrane takes polyaryl piperidine as a skeleton, introduces crown ether structure and a cross-linked network, and solves the technical problem that the balance between the hydroxyl ion conductivity and the dimensional stability is difficult in the existing anion exchange membrane. The anion exchange membrane comprises a specific structure of a repeating unit, is prepared through Friedel-Crafts superacid catalytic polymerization, Menshutkin reaction functionalization and Michael addition reaction cross-linking, and has excellent hydroxyl ion conductivity, dimensional stability, chemical stability and mechanical strength. The preparation method is simple in operation, fast in polymerization rate, and high in conversion rate, does not need to strictly control the temperature and oxygen of a reaction environment, is suitable for the field of water electrolysis hydrogen production, especially suitable for an anion exchange membrane water electrolysis system, and has a wide industrial application prospect.

The invention belongs to the technical field of medicine synthesis, and discloses a preparation method of a sodium nitroprusside raw material medicine. According to the method, weak acid is adopted for catalysis, the effect of remarkably reducing generation of toxic substances such as cyanide and nitrogen dioxide is achieved by controlling the material dripping speed and the dripping pH, the reaction is mild, the technological operation is safe and controllable, and industrial production of the sodium nitroprusside raw material medicine is facilitated. According to the preparation method of some examples, silica gel filtration is used for post-treatment, the residual risk of impurities such as sodium ferricyanide, ferric ferrocyanide and ferric ferricyanide is reduced, and the purity of the raw material medicine is larger than or equal to 99.9% and is far superior to the requirements of pharmacopoeia of various countries.

The present application relates to a kind of preparation method of evocacet and its intermediate, it is the improvement of evocacet synthesis process, using cheap and readily available copper / amino acid catalyst combination, evocacet intermediate is obtained with high yield and high selectivity, compared with prior art reduces production cost.