14 results about "Boranes" patented technology

The invention belongs to the technical field of biological detection, and particularly relates to a bisulfite-free detection kit for specific site 5-methylcytosine and a detection method thereof. According to the method, a TAPbeta treatment method is adopted, 5hmC is sealed through beta-GT, 5mC oxidation is carried out through TET, and 5mC is reduced into dihydrouracil (DHU) through pyridine borane, so that the apparent difference between 5mC and C and 5hmC is converted into single nucleotide polymorphism difference. In addition, a flow microsphere technology based on PNA-assisted click chemical connection starting is established to detect DNA methylation specific sites. A PNA clip is innovatively introduced into click chemical connection, and non-specific connection is inhibited. Target sequence enrichment, signal amplification and signal acquisition are carried out through surface-functionalized magnetic nanoparticles, and the detection sensitivity is improved to fM. The invention provides a new tool for high-specificity and high-sensitivity epigenetic marker detection.

The present invention relates to the technical field of tumor therapeutic drugs, and in particular to a composition of albumin and mercaptododecaborane and its application in the preparation of tumor therapeutic drugs. Its technical solution includes albumin, which is covalently coupled with mercaptododecaborane through the cysteine thiol group at position 34 to construct a nucleation site, and further point-loaded with mercaptododecaborane on the protein through the nucleation effect; the thiol group of the mercaptododecaborane is bound to the thiol group at position 34 of albumin cysteine through a disulfide bond. The present invention forms a nucleus by covalently coupling the free thiol group of albumin with mercaptododecaborane, and utilizes the nucleation effect to point-coat mercaptododecaborane, thereby avoiding the toxicity risks brought by organic solvents or chemical modifications in traditional solubilization methods, and effectively preventing oxidative degradation and free boron ion release, achieving pH-responsive targeted release, and significantly increasing the boron accumulation in tumor tissues, with both high stability, precise drug release, and low systemic toxicity.

The present application relates to the chemical technology field, especially to a high calorific value self-ignition borane ion salt and its preparation method and application. The present application constructs borane cation skeleton and introduces carbon-carbon unsaturated bond by innovatively, uses the electron cloud delocalization effect of unsaturated bond to control the electronic structure of the molecule, reduces the activation energy of oxidation reaction, so as to give the borane ion salt high oxidation activity and self-ignition characteristics, so that it can contact with fuming nitric acid, hydrogen peroxide with a concentration greater than 90% or nitrogen tetraoxide and other strong oxidizing agents to ignite instantly without external ignition source, and still maintains the high calorific value advantage of borane molecule. The results of the examples show that the high calorific value self-ignition borane has a mass calorific value greater than 48.5 kJ / g, and after contacting with red fuming nitric acid, the self-ignition delay time is less than 70 ms; after contacting with 90% H2O2 solution, the self-ignition delay time is not more than 50 ms.

The invention discloses a sulfonium sulfonate photoacid generator containing a carborane structure and application of the sulfonium sulfonate photoacid generator, and particularly provides a compound which is composed of anions and cations, the structure of the anions is shown as a formula (I) or a formula (II), and the structure of the cations is shown as a formula (I) or a formula (II). The photoacid generator provided by the invention is novel in structure, high in exposure energy and good in application prospect.

The present application relates to a kind of multifunctional lithium battery additives containing fluorine and boron element substance and its application, the multifunctional lithium battery additives include: fluoroborate B a F b Or BF c X d , the complex of the fluoroborate, fluoroboric acid HBF4, inorganic fluoroborate M n (BF4) m , organic fluoroborate R-BF3M, polyfluoroaromatic boride F-R-BH y , fluorinated organoborane R-BF3, fluoroboric acid nitro BF4NO or BF4NO2 One or several kinds;Wherein, X includes one or several elements of Cl, Br, I;M includes one or several elements of aluminum, copper, lead, tin, nickel, zinc, cadmium, beryllium, magnesium, calcium, strontium, barium, cesium, rubidium, manganese, iron, cobalt, silver, indium, thallium;R includes one or several organic groups of hydrocarbon, alcohol, ether, ester, ketone, carboxylic acid, phenol;0.5≤a≤2, 1.5≤b≤3;0.5≤c≤3, 0.5≤d≤3;0.2≤n≤5, 0.2≤m≤8;0.5≤y≤3.

The application discloses a synthesis method of a N,N-diphenyl-4-(pyridine-4-yl) aniline B-N coordination compound and application thereof. Under anhydrous and anaerobic conditions, (Me4N)B3H8 is reacted with I2 in THF to prepare an intermediate THF.B3H7, which is then reacted with a ligand N,N-diphenyl-4-(pyridine-4-yl) aniline to obtain a borane complex. Under anhydrous and anaerobic conditions, DMS.BH3 is reacted with the ligand N,N-diphenyl-4-(pyridine-4-yl) aniline in THF to obtain the borane complex. The synthesis method is simple, safe and high in yield, and is suitable for laboratory scale preparation. Optical property research shows that the prepared borane complexes all exhibit significant positive solvatochromic effect, aggregation-induced emission characteristics, mechanochromic performance and high quantum yield, and are ideal organic stimulus-responsive luminescent materials.

Provided herein are conjugated oligonucleotides including a linker with one or more hydrophobicity- or valency-modulating headgroups Zc having the structure of formula (II): (II) wherein: Y is selected from the group consisting of —[NR3]+, —[SR2]+,—NR2, and —CH(NH2)-CO2H, wherein each R is independently selected from the group consisting of hydrogen, and optionally substituted C1-C9 alkyl, C1-C9 heteroalkyl, C1-C9 alkenyl, C1-C9 heteroalkenyl, C1-C1 alkynyl, and C1-C9 heteroalkynyl groups; B is a bridge group selected from the group consisting of substituted or unsubstituted C2-C9 alkyl, C2-C9 heteroalkyl, C2-C9 alkenyl, C2-C9 heteroalkenyl, C2-C9 alkynyl, and C2-C9 heteroalkynyl groups; X1 is absent, an oxygen atom, or NH; X is oxygen, sulfur or borane; useful for RNA interference (RNAi).

The invention relates to the technical field of crystal materials, in particular to a bimetallic fluorescent nanocluster based on a sulfydryl carborane ligand and a preparation method and application of the bimetallic fluorescent nanocluster. The preparation method comprises the following steps: mixing a solution containing a carborane derivative ligand with two noble metal precursors or one noble metal precursor and one transition metal precursor to obtain a first mixed solution; stirring the first mixed solution and tetraphenylphosphine bromide in a dark place to obtain a second mixed solution; and stirring the second mixed solution and a reducing agent in a dark place to obtain the bimetallic fluorescent nanocluster. By introducing a carborane derivative ligand into a protection system of a noble metal bimetallic cluster, the ligand has strong metal binding capacity and electronegativity regulation and control characteristics of a carborane cage structure, and can control reduction kinetics under a low-temperature condition, so that synchronous nucleation and assembly of two noble metals or noble metals and transition metals are realized; therefore, the bimetallic cluster with a uniform structure and a clear atomic ratio is obtained.

This invention discloses a method for synthesizing and applying a nested carborane B-N coupling derivative with optical properties. The specific synthesis process is as follows: under anhydrous and oxygen-free conditions, nonborane (CH3)3N·B9H is synthesized... 13 Nested carboranes were prepared by reflux reaction of alkynes in toluene, followed by further reaction of the intermediate with alkali metal hydroxide (MOH) and purification. The nested carboranes were then subjected to a Brønsted-N coupling reaction with 8-aminoisoquinoline, and the crude product was purified to obtain the target product, the nested carborane Brønsted-N coupling derivative. This invention features a simple, safe, and high-yield synthetic process, avoiding the use of expensive ortho-carboranes as raw materials, thus significantly reducing the synthesis cost of nested carboranes. The synthesized nested carborane derivatives exhibit a significant positive solvation colorimetric effect, providing a new synthetic strategy for the design of boron cluster-based functional molecules and the development of luminescent materials.

Embodiments of the present invention generally relate to methods of epitaxially growing boron-containing structures. In an embodiment, a method of depositing a structure comprising boron and a Group IV element on a substrate is provided. The method includes heating the substrate at a temperature of about 300° C. or more within a chamber, the substrate having a dielectric material and a single crystal formed thereon. The method further includes flowing a first process gas and a second process gas into the chamber, wherein: the first process gas comprises at least one boron-containing gas comprising a haloborane; and the second process gas comprises at least one Group IV element-containing gas. The method further includes exposing the substrate to the first and second process gases to epitaxially and selectively deposit the structure comprising boron and the Group IV element on the single crystal.

The invention relates to the field of getter alloys, and discloses a low-temperature deposition method and a passive vacuum maintenance film getter, a deposition chamber is provided, a substrate is loaded on a sample table, and the sample table is sent into the deposition chamber; introducing a first reaction gas containing boron and a second reaction gas containing carbon into the deposition chamber; turning on an RF plasma source to perform low-temperature deposition, and enabling the first reaction gas and the second reaction gas to react with sputtered metal atoms or ions by controlling the power of the RF plasma source, the partial pressure of the trimethylborane gas and the partial pressure of the methane gas, and co-depositing on the substrate to form the amorphous alloy film. According to the invention, crystallization and grain growth of the amorphous film during long-term work or subsequent thermal process are inhibited through process regulation and control, so that the high-activity structure of the amorphous substrate is stabilized.

Embodiments of the present disclosure generally relate to the field of semiconductor manufacturing processes, more particularly, to precursor chemistries and methods of depositing silicon-containing films for forming semiconductor devices. In one or more embodiments, a method includes co-flowing a silicon-containing precursor with a dopant precursor into a processing chamber at a temperature of 600° C. or less to deposit an epitaxial layer over a substrate disposed within the processing chamber. The silicon-containing precursor is selected from a list consisting of silane (SiH4), disilane (Si2H6), trisilane(Si3H8), tetrasilane (Si4H10), monochlorotrisilane (Si3H7Cl), diiodosilane (SiH2I2), and dibromosilane (SiH2Br2). The dopant precursor selected from a list consisting of phosphine (PH3), phosphorus trichloride (PCl3), phosphorus tribromide (PBr3), tert-butylphosphine (TBP), tri-tert-butylborane ((tBu)3B), tert-butylarsine (TBAs), arsenic trichloride (AsCl3), trisilylphosphine (TSP), triisopropylborane (iPr)3B, tert-butylsilane ((tBu)SiH3), isopropylsilane ((iPr)SiH3), tetrakis(tert-butyl)tin ((tBu)4Sn), tetrakis(isopropyl)tin ((iPr)4Sn), tetrakis(tert-butyl)germane ((tBu)4Ge), tetrakis(isopropyl)germane ((iPr)4Ge), germanium tetrachloride (GeCl4), carbon tetrachloride (CCl4), and hexachlorodisilane (Si2Cl6).

The application discloses a kind of o-carborane-thioxanthene fluorescent compounds, fluorescent sensing film and its preparation method and the application of detecting terpene, belong to fluorescent sensing material technical field.The o-carborane of the present application is connected with thioxanthene by covalent bond, and a class of D-A type fluorescent compounds is constructed, wherein thioxanthene is used as electron donor to provide fluorescent emission capacity, and o-carborane is used as electron acceptor to give molecular three-dimensional cage-like stereostructure, which effectively inhibits the quenching effect caused by aggregation, so that the material keeps high fluorescence quantum yield in solid state.The fluorescent compound is loaded on the surface of matrix to prepare fluorescent sensing film, and the film has fluorescent response to a variety of terpene volatile organic compounds such as alpha-pinene, beta-pinene, limonene, 3-carene and camphene, wherein the response to alpha-pinene is the most sensitive, has the advantages of fast response speed, good reversibility, excellent cycle stability and the like, and is suitable for forest pest warning, ecological environment monitoring and volatile biomarker detection and other fields.

The invention relates to the technical field of fluorescent materials, and particularly discloses a fluorescent sensing material as well as a preparation method and application thereof. The fluorescent sensing material is a carborane-containing boron-oxygen multiple resonance fluorescent derivative, boron-oxygen multiple resonance molecules are combined with ortho-carborane, so that the fluorescent sensing material has a unique structure, and the structure can effectively capture BTEX gas molecules, so that the fluorescent sensing material is subjected to fluorescence quenching; therefore, efficient detection of the BTEX gas is realized. The boron-oxygen multi-resonance fluorescent sensing material containing carborane prepared by the invention can realize specific detection on BTEX steam, and shows excellent properties such as high response speed, short recovery time, low detection limit, recoverable utilization and large Stokes shift. By utilizing the method, the problems of expensive detection equipment, complicated operation and low detection sensitivity of the existing BTEX gas detection method are effectively solved.