4 results about "Ezetimibe" patented technology

This invention relates to a modified ezetimibe having the structure of Formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of cancer by oral administration through inhibition of HDM2 / HDM4-mediated suppression of p53, wherein the binding affinity and oral bioavailability of the modified ezetimibe for targeting of HDM2, HDM4 (also known as HDMX) and more particularly, both HDM2 and HDM4 is enhanced compared with unmodified ezetimibe.

The present disclosure relates to combinations of obicetrapib and ezetimibe, or their salts, solvates or derivatives thereof. The disclosure further describes the use of ezetimibe and obicetrapib, e.g. in the form of a fixed dose combination product, for preparation of medicaments and method of treatment of subjects requiring reduction in LDL-cholesterol or those suffering from hyperlipidemia or mixed dyslipidemia.

This invention relates to a modified ezetimibe having the structure of Formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of cancer by oral administration through inhibition of HDM2 / HDM4-mediated suppression of p53, wherein the binding affinity and oral bioavailability of the modified ezetimibe for targeting of HDM2, HDM4 (also known as HDMX) and more particularly, both HDM2 and HDM4 is enhanced compared with unmodified ezetimibe. (I)

This invention relates to the field of pharmaceutical analysis technology and discloses a method for detecting the content of ezetimibe and rosuvastatin calcium tablets using a reversed-phase chromatography system. The method employs high-performance liquid chromatography (HPLC) with 0.1% trifluoroacetic acid solution as mobile phase A, acetonitrile as mobile phase B, and methanol as mobile phase C. Gradient elution is performed using an octadecylsilane-bonded silica column. The detection wavelength is 242 nm, and the injection volume is 10 μL. The content of ezetimibe and rosuvastatin calcium is calculated using the external standard method. This method can effectively separate the two main components from various degradation impurities, exhibiting good peak shape and excellent resolution. It meets the requirements for pharmaceutical quality control in terms of specificity, limit of quantitation, limit of detection, linear range, precision, accuracy, repeatability, and robustness. The system is stable and provides a reliable technical solution for the quality detection of ezetimibe and rosuvastatin calcium tablets.