Ezetimibe and atorvastatin calcium tablet and preparation method thereof
A technology of atorvastatin calcium and ezetimibe, applied in the field of medicine, can solve problems such as unfavorable industrial production, and achieve the effects of improving uniform distribution and hydrophilicity, increasing stability and reducing dosage
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Embodiment 1
[0028] Ezetimibe layer formulation and preparation
[0029] ingredient
Dosage (mg)
effect
Ezetimibe
10
Active ingredient
Povidone K30
120
Adhesive
Sodium dodecyl sulfate
8
Active agent
lactose
50
Water-soluble filler
Microcrystalline Cellulose 102
50
Water-insoluble filler
Croscarmellose Sodium
30
Disintegrant
Magnesium stearate
2
Lubricant
90% ethanol
0.06ml
lubricant
[0030] Mix the above-mentioned ezetimibe, sodium lauryl sulfate, lactose, microcrystalline cellulose 102, croscarmellose sodium, 3 / 4 amount of povidone K30 according to the prescription ratio, and use 20% The povidone K3090% ethanol solution is granulated with 40 meshes, dried, granulated, and magnesium stearate is added to prepare the ezetimibe layer.
[0031] Atorvastatin calcium layer prescription and preparation
[0032] ingredient
Dosage (mg)
effect
Atorvastatin calcium
11
Active ingredient
Microcrystalline Cellulose 102
100
Filler
Croscarmellose sodium
30
Disintegrant
Direct...
Embodiment 2
[0036] Ezetimibe layer formulation and preparation
[0037] In the top-drive granulator, ezetimibe and sodium lauryl sulfate were highly dispersed in a 20% povidone K30 90% ethanol solution according to the prescription ratio of Example 1, and then lactose was added. The crystalline cellulose 102 and the croscarmellose sodium are stirred evenly to form wet granules of 40-60 mesh, dried at 40 degrees, sizing, and adding an appropriate amount of lubricant to obtain.
[0038] Atorvastatin calcium layer prescription and preparation are the same as in Example 1
[0039] The two kinds of granules were respectively used in different feed hoppers, and pressed on a double-layer tablet press into upper and lower tablets, and then gastric-dissolved and coated to obtain double-layer tablets of Example 2.
Embodiment 3
[0041] Ezetimibe layer formulation and preparation
[0042] In the top drive granulator, ezetimibe and sodium lauryl sulfate were highly dispersed in a 20% povidone K30-90% ethanol solution according to the prescription ratio of Example 1, and then gradually added Stir the lactose evenly, add microcrystalline cellulose 102 and croscarmellose sodium to make wet granules of 40-60 mesh, dry at 40 degrees, sizing, and add appropriate amount of lubricant to get it.
[0043] Atorvastatin calcium layer prescription and preparation are the same as in Example 1
[0044] The two kinds of granules were respectively used in different feed hoppers, and pressed on a double-layer tablet press to form upper and lower tablets, and were gastric-dissolved and coated to obtain double-layer tablets of Example 3.
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