The invention discloses a freeze-dried
voriconazole micelle preparation and a preparation method thereof. The freeze-dried
voriconazole micelle preparation consists of the following components in part by weight: 1 part of
voriconazole, 2 to 10 parts of cholate, 1.5 to 5 parts of
phospholipid, and 1 to 10 parts of freeze-
drying supporting agent. According to the preparation, the dissolubility of the voriconazole is increased, and the
dissolution degree of the voriconazole in water is improved; and the preparation can be diluted into intravenous injection by using injection water for clinical use. The particle
diameter of the prepared voriconazole micelles is between 10 and 100 nanometers, the particle
diameter of most micelles is about 20 nanometers, the particle size is uniform, the frozen and dried voriconazole micelles are high in re-
dissolution speed, a transparent and colorless solution is formed after the voriconazole micelles are re-dissolved, and the particle
diameter has no obvious change, so the safety of clinical application is enhanced. According to the prepared freeze-dried voriconazole
micelle preparation, because the voriconazole is wrapped inside by the mixed micelles, influence of light, heat and
moisture is avoided, and the stability of the voriconazole in a long-term storage process is improved.