The invention discloses a methylsulfonic acid pridinol oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet comprises the following components by
mass percentage: 2 to 8 percent of methylsulfonic acid pridinol, 40 to 80 percent of filler, 5 to 20 percent of disintegrant, 5 to 30 percent of effervescent agent, 1 to 5 percent of
lubricant and 0.5 to 5 percent of flavoring agent. The methylsulfonic acid pridinol oral disintegrating tablet can be quickly disintegrated in mouth cavity and quickly absorbed, and takes effect quickly, has small first-passeffect on liver, high
bioavailability, low acrimony to
gastrointestinal tract, convenient taking and good taste, and is particularly suitable for the old, children and patients with
difficult swallowing or inconvenient drinking of water, or in operation or
coma; and the oral disintegrating tablet is prepared by adopting a method of wet
granulation and compression or a method of direct compressionof
powder, has simple production technique, low cost, easily-controlled quality, and stability, safety and effectiveness of the preparation, is suitable for large-scale industrial production and haswide market prospect.