40 results about "Difficult swallowing" patented technology

The invention relates to an oral instant membrane of risperidone and a preparation method thereof, thereby being used for improving the using performance of the risperidone. The technical scheme is as follows: the instant membrane comprises 2-60 parts by weight of risperidone, 25-98 parts by weight of water-soluble pharmaceutical polymer excipients, additives and 0.1-25 parts by weight of water. The oral instant membrane solves the problems that the existing risperidone is clinically difficult to swallow, is not applicable to children and elderly patients for administration and can not be conveniently taken under the situation of having no water. The oral instant membrane can be dissolved on the tongue, the hidden trouble of choking can not be happened no matter how young a baby is, the active ingredients can be absorbed sublingually and absorbed by buccal mucosa, and the onset of action is more rapid in comparison with orally disintegrating tablets. In addition, the oral instant membrane has good compliance, thereby being particularly suitable for elderly people, children and patients with difficult swallowing.

This invention provides beta-lactam antibiotic-containing tablets capable of being orally taken either as such owing to their being small-sized, hence still easily swallowable, or, in the case of administration to the aged encountering some difficulty in swallowing, in the form of dispersions resulting from easy self-disintegration upon being dropped into water in a glass as well as a method of producing the same. The tablets of this invention comprise, on the per-tablet basis, 60-85% by weight of a beta-lactam antibiotic, 1-10% by weight of low-substituted hydroxypropylcellulose and/or crosslinked polyvinylpyrrolidone as a disintegrator, and 0.5-2% by weight of a binder. Granules to be compressed for tableting are prepared using water or an aqueous solution of ethanol or the like.

The present invention belongs to the technical field of medicine, and provides a pramipexole oral liquid and a preparation method thereof. Pramipexole is a dopamine D2 receptor agonist for treatment of Parkinson's disease; early symptoms of the Parkinson's disease comprise static tremor, myotonia, bradykinesia, and abnormal posture and gait; and moderate and advanced symptoms of the Parkinson's disease patients often comprise difficult chewing and swallowing. With the pramipexole oral liquid of the present invention, medication compliance of patients is easily improved, and a therapeutic effect is improved.

The present invention relates to a bitter melon product, as well as a manufacturing technique of bitter melon nourishing effervescence tablet. The bitter melon nourishing effervescence tablet takes the bitter melon extract as its main components, and the effervescing agent is formed by mixing alkaline granules and acidic granules, wherein, the alkaline granules are produced by bitter melon extract, sodium carbonate, lactose, glucose, and sweeteners; and the acidic particles granules are produced by bitter melon extract, vitamin C, citric acid, and glucose. The inventive bitter melon nourishing effervescence tablet adopts acid-base reaction to rapidly disintegrate tablets into aqueous solution, so that it not only changes the difficult swallowing in the taking process, but also improves the taste, thereby enhancing the absorption of nutrients in the process of enjoying the drinks.

An orally disintegrating tablet of 5-HT receptor agonist and a preparation method thereof are disclosed. The invention relates to an orally disintegrating tablet of 5-HT receptor agonist as well as a prescription and a process for preparing the orally disintegrating tablet of 5-HT receptor agonist by a freeze-drying method. The orally disintegrating tablet of 5-HT receptor agonist disclosed by the invention is prepared from main medicines and pharmaceutical excipients, without the need of water while administration, capable of being rapidly disintegrated in mouth, and suitable for the administration of patients with difficulty in swallowing, such as the old and children; simultaneously, the orally disintegrating tablet of 5-HT receptor agonist is suitable for administration in a condition that water is not easy to obtain during travelling; and the orally disintegrating tablet of 5-HT receptor agonist has the advantages of being convenient to take, fast in absorption, small in first pass effect, small in irritation on digestive tract mucosa and the like, as well as has wide market application prospect. Moreover, the orally disintegrating tablet of 5-HT receptor agonist disclosed by the invention can obviously reduce the side effects of 5-HT receptor agonist. Additionally, the invention further relates to a preparation method for the orally disintegrating tablet of 5-HT receptor agonist.

The invention relates to a preparation for treating sore throat and a preparation method thereof, in particular to a Chinese patent medicine prepared from Chinese herbal medicines serving as raw materials, which belongs to the technical field of medicaments. The effective components of the preparation comprise the following raw materials: honeysuckle, scaphium scaphigerum, eolite, rhizoma pleionis, subprostrate sophora, dandelion, platycodon grandiflorus, bulbus fritilariae, houttuynia cordata, dwarf lilyturf root and the like. The preparation is prepared by preparing the raw materials in different proportions according to different characteristics of the Chinese herbal medicines. The preparation has the beneficial effects that: symptoms, such as difficult swallow, cough, dryness of the throat, thirst, astriction, red tongue, yellow moss, cold and heat, headache and the like caused by the sore throat can be eliminated, quick effect is achieved after the preparation is orally taken, the preparation has no toxic and side effects, both the symptoms and root causes are addressed, the preparation is convenient to realize, and good social benefit and economic benefit are obtained if the preparation is widely popularized.

The invention discloses an ephedra and apricot cough relieving traditional Chinese medicine dispersible tablet and a preparation method thereof. The tablet is prepared from a traditional Chinese medicine extract, a filler, an internal disintegrating agent, an external disintegrating agent, a corrigent, a wetting agent and a lubricant. The ephedra and apricot cough relieving dispersible tablet has effects of relieving a cough, eliminating phlegm and relieving asthma and is used for patients with acute and chronic bronchitis and gasp. The tablet is good in solubility and dispersity, high in dissolubility, good in bioavailability, rapid in in-vivo distribution, stable in quality, good in taste and convenient to take, can be swallowed and chewed, is sucked in a mouth or taken after dispersed by water, is more suitable for old people and the patients with difficult swallow, and has the advantages of good medicine stability, convenience in packaging, transportation and storage and the like, and the preparation method of the tablet is simple and practicable and applicable to industrial production.

The invention discloses a methylsulfonic acid pridinol oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet comprises the following components by mass percentage: 2 to 8 percent of methylsulfonic acid pridinol, 40 to 80 percent of filler, 5 to 20 percent of disintegrant, 5 to 30 percent of effervescent agent, 1 to 5 percent of lubricant and 0.5 to 5 percent of flavoring agent. The methylsulfonic acid pridinol oral disintegrating tablet can be quickly disintegrated in mouth cavity and quickly absorbed, and takes effect quickly, has small first-passeffect on liver, high bioavailability, low acrimony to gastrointestinal tract, convenient taking and good taste, and is particularly suitable for the old, children and patients with difficult swallowing or inconvenient drinking of water, or in operation or coma; and the oral disintegrating tablet is prepared by adopting a method of wet granulation and compression or a method of direct compressionof powder, has simple production technique, low cost, easily-controlled quality, and stability, safety and effectiveness of the preparation, is suitable for large-scale industrial production and haswide market prospect.

The invention belongs to the technical field of medicinal preparations, and concretely relates to an irbesartan self-emulsifying solution. The irbesartan self-emulsifying solution comprises 20-40 wt% of irbesartan, 25-50 wt% of an oil phase, 10-50 wt% of an emulsifier and 5-20 wt% of a co-emulsifier. The invention also discloses a preparation method of an irbesartan self-emulsifying soft capsule. The preparation method comprises the following steps: synthesizing the irbesartan self-emulsifying solution from the irbesartan, the emulsifier, the co-emulsifier and the oil phase according to a certain ratio, and processing the self-emulsifying solution through a device to prepare the soft capsule. The above medicine is dissolved in the oil phase, the obtained solution is orally taken and then self-emulsifies in bodies to form a micro-emulsion with the particle size of about 200 nm, so the in-vitro dissolubility and the in-vivo absorption of the irbesartan are remarkably improved, and the in-vivo bioavailability is improved. The medicine can be taken at an integral grain after being processed to prepare the soft capsule, and the content of the soft capsule also can be taken out and is diluted with water to form a solution to be sent in order to improve the medicine taking compliance of old people and difficult swallowing patients.

A bread equivalent suitable for patients suffering from difficult in chewing or swallowing includes a starch-base and a gelling agent blended to form a dry mix and mixed with a liquid vehicle, such as water. The bread equivalent has properties that are similar to real bread. For example, the bread can be sliced and topped with spreadable foods like butter, margarine and the like. The bread equivalent lacks the glutenous nature of bread making it amenable for ingestion by patients having dysphagia.

The invention relates to a medicinal composition containing mycophenolate mofetil, which can be prepared into dispersible tablets, thereby overcoming the shortcomings of difficult swallowing and weak medicine compliance existed in the conventional dose forms, as a result, the patients can administrate the medicament more easily. The invention relates to the process for preparing compositions containing mycophenolate mofetil.

The invention provides a dextromethorphan quinidine composition as well as a preparation method and application of the dextromethorphan quinidine composition. According to the dextromethorphan and quinidine composition provided by the invention, the bitter taste and the numb taste of dextromethorphan and quinidine are improved by adding cyclodextrin, meanwhile, the dextromethorphan and quinidine composition provided by the invention is easily prepared into various oral preparations easy to swallow, the problem that patients with nervous system diseases are difficult to swallow is solved, and the medication experience can be greatly improved.

The invention provides a dextromethorphan quinidine resin compound composition as well as a preparation method and application of the dextromethorphan quinidine resin compound composition. The proper ion exchange resin is added, so that the technical effect that the taste correction effect of dextromethorphan and quinidine is good while medicine dissolution is met is achieved. The dextromethorquinine resin compound composition disclosed by the invention has a dissolution effect similar to that of an original compound, can be easily prepared into various oral preparations easy to swallow, solves the problem that patients suffering from nervous system diseases are difficult to swallow, and can greatly improve the medication experience of the patients.