29 results about "Difficult swallowing" patented technology

1. Name of the design product: Spoon. 2. Use of the design product: As a spoon for feeding patients with swallowing difficulties. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view 1.

An oral formulation of granules of an active ingredient such as gepotidacin or a pharmaceutically acceptable salt thereof that rapidly disperses in water, or an oral formulation comprising such granules. Such granules provide an oral suspension with good mouthfeel and palatability. This oral suspension is particularly useful for pediatric patient populations or patient populations with difficulty swallowing.

A drug delivery platform is disclosed for sensitive patient populations, notably paediatric and geriatric population groups, subjects with swallowing difficulties and low treatment compliance groups.

The present invention addresses the problem of providing a food which is a high-energy-density food in which fat and oil are blended in a large amount, which can be directly eaten, has stable physical properties without being affected by temperature, and which is easily ingested by persons having difficulty in chewing and / or swallowing. Provided is an oily food for persons with difficulty in chewing and / or swallowing, which contains 30-80% by mass of a fat or oil that is liquid at 20 DEG C and 20-70% by mass of a non-oil-soluble powder that contains a saccharide, and which has a hardness at 20 DEG C of 50000 N / m2 or less and adhesiveness at 20 DEG C of 5000 J / m3 or less.

A protein-containing food is provided that contains a high-quality protein at a high concentration, is excellent in taste and flavor, and is also suitable as a food for people with swallowing difficulties, who tend to eat very little. The protein-containing food according to the present embodiment contains a collagen peptide, one or more essential amino acids selected from histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine, and water. In the protein-containing food, the content of the water is 35% by mass or less, and the content of the collagen peptide is 30% by mass or more.

To provide a jelly drink for rehydration for people who have difficulty chewing and swallowing, which has properties superior to those of conventional products in terms of cohesiveness, adhesion in the oral cavity, and adhesion in the pharynx. [Solution] By incorporating 1.0 to 1.5 mass% of low-methoxyl pectin relative to the total amount of the jelly beverage and 3.2 to 4.1 mass% of free calcium ions relative to the low-methoxyl pectin, a jelly beverage can be provided that has excellent properties in both adhesiveness in the oral cavity and adhesiveness in the pharynx.

This invention relates to a low-GI nutritionally regulated gel-type swallowing aid product and its preparation method. The gel-type swallowing aid product comprises a low-GI gel matrix, popping beads, and a complex additive. The low-GI gel matrix is ​​prepared from konjac flour, resistant starch, erythritol, oat fiber, a complex prebiotic, and water. The popping beads consist of an outer shell and a prebiotic filling encapsulated within the outer shell. The prebiotic filling comprises probiotic powder, chitosan oligosaccharide, chitin oligosaccharide, vitamin complex, trace elements, anthocyanins, and MCT oil. Compared with existing technologies, this invention, based on the use of low-GI ingredients and combined with popping beads containing a prebiotic filling, enhances the patient's chewing and swallowing ability, improves the product's nutritional value, and provides a novel nutritional functional gel option for swallowing aids for diabetic patients and those with swallowing difficulties.

The invention provides a bitter quenching quick-setting microcapsule, which is formed by using a bitter drug containing-OH as a capsule core, using a thin oil layer in the middle and using micro-kappa-Car as a quick-setting microcapsule wall material for coating. The invention also provides a preparation method of the bitter quenching rapid-hardening microcapsule. According to the invention, a bitter drug with PNS as a capsule core, OLI as a middle thin oil layer and micro-kappa-Car as a rapid-hardening microcapsule wall material are coated with a gel powder coating material on the surface of drug powder through a powder modification technology and a particle design technology to construct a PNS-OLI-kappa-Car rapid-hardening microcapsule, so that the bitter taste of PNS in water-mouth is covered, the medication compliance of a patient is improved, and the drug effect is improved. Through the rapid-hardening microcapsule which is a new bitterness-inhibiting and taste-masking preparation, the defects of a traditional solid preparation in the aspects of taste and swallowing are overcome, and the common problem that children, old people and other groups with sensitive taste and swallowing difficulty face medicine taking difficulty is solved.

The invention provides a stomach-strengthening and digestion-promoting oral gel and a preparation method thereof, and relates to the field of medical technology. The stomach-strengthening and digestion-promoting oral gel of the invention comprises components by weight fraction: 0.5-2% compound glue, 0.05-0.2% potassium chloride, 5-20% sucrose, 0.05-0.25% citric acid, 0.025-0.075% antibacterial agent, 2.5-4% fruit powder and 73.475-91.875% liquid; in the liquid, the concentration of the Chinese medicine extract is 0.19-0.51g crude drug / mL; in the compound glue, the mass ratio of carrageenan, locust bean gum and xanthan gum is 1-5:0.3-3:0.5-2.5; the prepared stomach-strengthening and digestion-promoting oral gel has moderate elasticity and hardness, is convenient to chew, has a good taste, can meet the needs of different groups of people, improve the compliance of people with chewing and swallowing difficulties, can also significantly reduce the relative residual rate of pigment in the stomach, and significantly accelerate the pigment propulsion movement in the small intestine.

The present invention relates to a stable and palatable formulation containing a high content of meglustat, which can be used in particular by children or persons with dysphagia. This highly concentrated formulation contains at least 150 mg / mL of megranurite, and as excipients sodium benzoate, tartaric acid, a sweetener, and optionally an acidic flavoring. This formulation can advantageously be administered with a therapeutic bienzyme activator to alleviate the intestinal side effects of Magrude.

This application relates to the field of physiological function assessment technology, and in particular to a method and system for assessing swallowing function in psychiatric patients based on multidimensional physiological signals. The method includes: S1, acquiring basic information and medication information of the psychiatric patient to be assessed, and collecting multidimensional physiological signals; S2, extracting swallowing feature vectors based on these signals; S3, identifying behavioral risks in psychiatry based on swallowing event sequences and inertial measurement signals, obtaining behavioral risk labels and their confidence levels; S4, extracting extrapyramidal response representation vectors based on multidimensional physiological signals, and outputting the probability of swallowing difficulties related to extrapyramidal responses through a pre-set classification model; S5, mapping different abnormal indicators to item scores for nursing risk assessment items, obtaining a total score; S6, generating an assessment report containing item scores, total score, risk level, and key physiological evidence. This application solves the problem that existing assessments rely on subjective observation and lack objective evidence support.

The invention provides a temperature-sensitive whey protein sol and a preparation method thereof, the temperature-sensitive whey protein sol comprises iota-carrageenan, xanthan gum, whey protein powder, a potassium ion source, a calcium ion source, resistant dextrin and water; in the temperature-sensitive whey protein sol, the mass ratio of iota-carrageenan is 0.6%-0.8%, the mass ratio of xanthan gum is 0.05%-0.3%, the mass ratio of whey protein powder is 3.0%-4.5%, the mass ratio of potassium ions is 0.05%-0.1%, the mass ratio of calcium ions is 0.02%-0.04%, and the mass ratio of resistant dextrin is 1%-2%. Gel-sol reversible transformation can be achieved within the physiological temperature range (30-37 DEG C), stable gel is formed under refrigeration (4 DEG C), the gel is transformed into flowable sol under the oral cavity or the body temperature, swallowing safety and taste are both considered, and the gel is suitable for people with swallowing difficulty to eat.

A prednisone enteric-coated preparation and a preparation method and use thereof are provided. The prednisone enteric-coated preparation includes: 5% to 35% of an active prednisone micro-enteric-coated preparation unit, such as an enteric-coated microsphere; and an inactive pharmaceutical adjuvant. The enteric-coated microsphere has an average particle size of 100 μm to 1,000 μm, and a dissolution behavior of the enteric-coated microsphere conforms to the provisions for enteric-coated preparations. The enteric-coated microsphere characteristic not only avoids the stimulation of prednisone to a gastric mucosa, but also makes the active ingredient quickly released and absorbed in an intestinal tract to prevent the active ingredient from being destroyed by intestinal floras. The prednisone enteric-coated preparation can be any dosage form such as a suspension or a capsule suitable for patients with difficult swallowing or normal patients.

The present application discloses methods and uses for preparation of a dry solid composition as a precursor for a stable gel body formation upon addition of water. The invention also discloses the compositions obtained from said methods and uses. Said gel bodies can, for example, be used in pharmaceutical compositions to administer drug substances to patients with difficulties to swallow.

The utility model discloses a combined vacuum cup which comprises a cup body, a threaded ring is integrally formed on the top of the cup body, an inner cover is connected to the outer portion of the threaded ring through threads, a water outlet nozzle is integrally formed on the top of the inner cover, a water outlet is formed in the water outlet nozzle, a movable groove is formed in the water outlet nozzle, and a baffle is connected to the interior of the movable groove in a sliding mode. The baffle extends into the water outlet, a magnetic block is embedded in the outer wall of the top of the baffle, and a magnetic plate attracted to the magnetic block is embedded in the water outlet nozzle. According to the utility model, the water outlet in the water outlet nozzle is shielded through the movement of the baffle, so that the flow of water flowing out of the water outlet can be freely adjusted, and a patient with difficulty in swallowing is prevented from bucking when drinking water.

To provide an oily food product that can be easily consumed by persons with chewing and swallowing difficulties.SOLUTION: The present invention provides an oily food product for persons with chewing and swallowing difficulties, where the oily food product has a single continuous surface, part or all of the surface is curved, the maximum value of the linear distance connecting any two points on the surface is 5.0 mm or more and 50.0 mm or less, and the average thickness of the surface is 3.0 mm or less.SELECTED DRAWING: Figure 1

This invention relates to the field of pharmaceutical preparations, specifically providing anhydrous rimantadine hydrochloride granules and a method for preparing the same. The anhydrous rimantadine hydrochloride granules are a mixture of drug-containing taste-masked granules and flavor-correcting granules. The drug-containing taste-masked granules comprise rimantadine hydrochloride and a taste-masking material, wherein the taste-masking material is a lipid or waxy material. This invention, by selecting a lipid or waxy material as the taste-masking material and mixing it with rimantadine hydrochloride to prepare drug-containing taste-masked granules, and then mixing them with flavor-correcting granules, effectively masks the taste and allows for direct swallowing without water, greatly improving medication adherence, especially suitable for children, the elderly, and other individuals with swallowing difficulties. Furthermore, the preparation method of this invention is simple, requires minimal equipment, is low-cost, and suitable for large-scale production.

To provide a cooking auxiliary composition for imparting shape retention to liquid / pasty food and drink, and to provide mousse-like food using the cooking auxiliary composition, especially, mousse-like food of properties allowing a person having difficulty in chewing / swallowing to easily eat.SOLUTION: A food cooking auxiliary composition contains a sparingly cold water-soluble starch decomposition product (A pts.mass) and tapioca starch (B pts.mass) in A>B condition. Preferably, the sparingly cold water-soluble starch decomposition product (A pts.mass) and the tapioca starch (B pts.mass) are used in the following (1)-(4) conditions based on 100 pts.mass of a liquid or pasty food material: (1) A>B; (2) 0.5≤B≤4.0; (3) B≤8-0.5A; and (4) B≥6-A.SELECTED DRAWING: None

The invention belongs to the technical field of functional factor carrier preparation, and particularly relates to a double gel easy to swallow and capable of loading functional factors and a preparation method of the double gel. The double gel is composed of oleogel and hydrogel, and the mass ratio of the oleogel to the hydrogel is (3-5): (5-7). The double gel is not easy to soften and disintegrate at high temperature, has good stability, and effectively solves the problems of easy layering and low strength of the traditional gel; the gel is low in swelling rate and can avoid burst release of drugs; the lipid-soluble functional factor carrier has good water binding capacity and balanced oil binding capacity, is suitable for loading lipid-soluble functional factors, and can realize controllable slow release of the functional factors. After texture optimization, the product meets the IDDSI level 4 standard, and is suitable for people with dysphagia. Besides, the preparation process is simple, the prepared double gel can be applied to development of medicines, health care products and foods for special medical purposes for people with dysphagia, the application range is wide, and an efficient, safe and easy-to-industrialize scheme is provided for delivery of functional components.

The invention discloses a starch-hydrophilic colloid based easy-to-swallow food grading system utilizing concentration gradient and application thereof, and belongs to the technical field of food science and processing. According to the method disclosed by the invention, a set of accurate concentration grading system is established by measuring the characteristic parameter, namely entanglement concentration (Ce), of a starch-hydrophilic colloid composite system and taking the concentration as a benchmark. Specifically, the food concentration is divided into a plurality of intervals from 0.5 Ce to Ce, from Ce to 1.5 Ce, from 1.5 Ce to 2Ce and the like, and the intervals correspond to different easy swallowing grades respectively. By controlling the concentration of the food within the specific ranges, the easy swallowing grade of the food can be directly and accurately defined, and the food can be marked on the package. According to the method, conversion from subjective experience judgment to objective parameter control is achieved, the grading result consistency is good, and a scientific basis and industrial feasibility are provided for precise design, standardized production and quality control of food difficult to swallow.

To provide a container-packed rice porridge excellent in flavor and appearance for people with swallowing difficulties. [Solution] The present invention is a packaged rice porridge for people with dysphagia, which contains cooked rice, salt, an emulsifier, edible oil and fat, and water, The amount of salt equivalent in the rice porridge is 0.2% by mass or more and 2.0% by mass or less, The content of the edible oil and fat is 0.10 parts by mass or more and 1.35 parts by mass or less per 1 part by mass of the cooked rice converted into raw rice, The edible oil and fat in the rice porridge is present as emulsified particles in the form of oil-in-water droplets.

The invention relates to a preparation containing pravastatin sodium enteric-coated pellets as well as a preparation method and application thereof, and relates to the technical field of biological medicines. According to the preparation disclosed by the invention, the unification of enteric protection and patient-friendly administration is realized, and the bioavailability of the medicine and the convenience and compliance of taking the medicine are remarkably improved; according to the preparation disclosed by the invention, the structure of the enteric-coated pellet is specially designed aiming at the processing and using characteristics of the dry suspension and the orally disintegrating tablet, so that the obtained enteric-coated pellet can be stably applied to the dry suspension or the orally disintegrating tablet while being not released in the stomach, and the medicine taking convenience and compliance of old people and patients with dysphagia are remarkably improved. According to the invention, the technical contradiction that an enteric preparation is difficult to be compatible with a patient-friendly dosage form in the prior art is solved, and a pravastatin administration scheme which gives consideration to enteric protection, bioavailability improvement and ease of administration is provided for old people or patients with dysphagia.

The invention discloses a phenobarbital orally disintegrating micro-tablet based on 3D printing. The phenobarbital orally disintegrating micro-tablet is mainly prepared from, by mass, 15%-70% of phenobarbital, 10%-60% of filler, 0%-50% of disintegrating agent, 0.1%-2% of flavoring agent and 0%-15% of adhesive through the 3D printing technology. The invention also discloses a preparation method of the phenobarbital orally disintegrating micro-tablet. The phenobarbital orally disintegrating micro-tablet is high in drug release speed, can improve the drug taking compliance of patients, and is particularly convenient for infants and other persons with dysphagia to take.

A swallowing disorder management method by which a device manages a swallowing disorder on the basis of voice analysis, according to one embodiment of the present invention, comprises the steps of: (a) receiving a voice obtained using a first aspiration test of a subject; (b) inputting the voice into a voice analysis model so as to perform a first aspiration analysis for analyzing whether aspiration of the subject has occurred; and (c) guiding a swallowing-assisted electrical stimulation meal or a free meal by using an electrical stimulation module according to the result of the first aspiration analysis performed using the voice analysis model, wherein the voice obtained by the first aspiration test includes voices before and after the subject ingests a first type of food, and the step of performing the first aspiration analysis determines whether aspiration occurs on the basis of characteristic information of the voices before and after ingestion of the food.

To provide a containerized jelly porridge for people with swallowing difficulties, which has excellent flavor and appearance. The present invention provides a packaged jelly porridge for people with dysphagia, which contains cooked rice, salt, a gelling agent, an emulsifier, edible oil and fat, and water, The salt equivalent amount in the jelly porridge is 0.2% by mass or more and 2.0% by mass or less, the gelling agent comprises deacylated gellan gum; The content of the edible oil and fat is 1.5% by mass or more and 13% by mass or less based on the total amount of the jelly porridge, The content of the edible oil and fat is 0.10 parts by mass or more and 0.80 parts by mass or less per 1 part by mass of the cooked rice converted into raw rice, The edible oil and fat in the jelly gruel is characterized in that it exists as emulsified particles emulsified in the form of oil-in-water droplets.

The preparation method of the compound liver-tonifying oral liquid comprises the following steps: S1, extracting a sedum sarmentosum concentrated solution; s2, extracting a silymarin concentrated solution; s3, extracting a fructus schizandrae concentrated solution; s4, mixing the ingredients; and S5, filtering. Compared with tablets, the compound Yiganling oral liquid disclosed by the invention is better in absorption and quick in drug effect development, and solves the problem that some patients are difficult to swallow.

This invention discloses a pharmaceutical composition and its preparation method, specifically an injectable formulation. The injectable formulation exhibits controllable particle size, narrow particle size distribution, good reproducibility, good long-term drug stability, and a gradual and stable blood drug concentration upon release. It overcomes the disadvantages of tablets, such as the need for frequent administration and the risk of swallowing difficulties, and avoids the occurrence of neuroleptic malignancy syndrome. This significantly improves medication safety and patient compliance, and has important clinical significance.

The embodiments of the present invention relate to a stable liquid vigabatrin pharmaceutical compositions in the liquid form of a solution. Particularly, the stable vigabatrin liquid pharmaceutical composition is manufactured as a ready-to-use industrialized premixture that does not require reconstitution or dilution prior to administration to a patient. The vigabatrin liquid pharmaceutical composition is stable six months or longer at room temperature and has levels of total impurities and Vigabatrin-related compound A that are both not more than 0.04% at, or prior to, six months. In some embodiments, the composition has improved stability and patient compliance. In some embodiments, the compositions may be advantageous for the patients having swallowing difficulties or when the patients are unable to take solid oral dosage forms. In some embodiments, the composition improves compliance with ketogenic diet.