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41 results about "Difficult swallowing" patented technology

Difficulty with swallowing is the feeling that food or liquid is stuck in the throat or at any point before the food enters the stomach. This problem is also called dysphagia.

Beta-lactam antibiotic-containing tablet and production thereof

This invention provides beta-lactam antibiotic-containing tablets capable of being orally taken either as such owing to their being small-sized, hence still easily swallowable, or, in the case of administration to the aged encountering some difficulty in swallowing, in the form of dispersions resulting from easy self-disintegration upon being dropped into water in a glass as well as a method of producing the same. The tablets of this invention comprise, on the per-tablet basis, 60-85% by weight of a beta-lactam antibiotic, 1-10% by weight of low-substituted hydroxypropylcellulose and / or crosslinked polyvinylpyrrolidone as a disintegrator, and 0.5-2% by weight of a binder. Granules to be compressed for tableting are prepared using water or an aqueous solution of ethanol or the like.
Owner:ASTELLAS PHARMA INC

Oral instant membrane of risperidone and preparation method thereof

The invention relates to an oral instant membrane of risperidone and a preparation method thereof, thereby being used for improving the using performance of the risperidone. The technical scheme is as follows: the instant membrane comprises 2-60 parts by weight of risperidone, 25-98 parts by weight of water-soluble pharmaceutical polymer excipients, additives and 0.1-25 parts by weight of water. The oral instant membrane solves the problems that the existing risperidone is clinically difficult to swallow, is not applicable to children and elderly patients for administration and can not be conveniently taken under the situation of having no water. The oral instant membrane can be dissolved on the tongue, the hidden trouble of choking can not be happened no matter how young a baby is, the active ingredients can be absorbed sublingually and absorbed by buccal mucosa, and the onset of action is more rapid in comparison with orally disintegrating tablets. In addition, the oral instant membrane has good compliance, thereby being particularly suitable for elderly people, children and patients with difficult swallowing.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY

Beta-lactam antibiotic-containing tablet and production thereof

This invention provides beta-lactam antibiotic-containing tablets capable of being orally taken either as such owing to their being small-sized, hence still easily swallowable, or, in the case of administration to the aged encountering some difficulty in swallowing, in the form of dispersions resulting from easy self-disintegration upon being dropped into water in a glass as well as a method of producing the same. The tablets of this invention comprise, on the per-tablet basis, 60-85% by weight of a beta-lactam antibiotic, 1-10% by weight of low-substituted hydroxypropylcellulose and / or crosslinked polyvinylpyrrolidone as a disintegrator, and 0.5-2% by weight of a binder. Granules to be compressed for tableting are prepared using water or an aqueous solution of ethanol or the like.
Owner:ASTELLAS PHARMA INC

Thickening composition improved in viscosity development

A thickening composition characterized by containing xanthan gum having per 100 parts by weight thereof, 0.5 part by weight or more of metal salt bound on the surface of xanthan gum powder. This thickening composition is capable of convenient viscosity development by addition to water-containing objects. Thus, the thickening composition is suitable for use in, for example, food application for convenient thickening of soft drink, basting, sauce, dressing, soup, mousse, jelly, etc., or application for viscosity development by addition of a small amount thereof to meals for patients having difficulty in mastication / swallowing due to eating disorder, etc.
Owner:TAIYO KAGAKU CO LTD

Pramipexole oral liquid and preparation method thereof

The present invention belongs to the technical field of medicine, and provides a pramipexole oral liquid and a preparation method thereof. Pramipexole is a dopamine D2 receptor agonist for treatment of Parkinson's disease; early symptoms of the Parkinson's disease comprise static tremor, myotonia, bradykinesia, and abnormal posture and gait; and moderate and advanced symptoms of the Parkinson's disease patients often comprise difficult chewing and swallowing. With the pramipexole oral liquid of the present invention, medication compliance of patients is easily improved, and a therapeutic effect is improved.
Owner:BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD

Balsam pear nutrient effervescence tablet and manufacture method thereof

InactiveCN101455337AChange hard to swallowPromote absorptionFood preparationDifficult swallowingVitamin C
The present invention relates to a bitter melon product, as well as a manufacturing technique of bitter melon nourishing effervescence tablet. The bitter melon nourishing effervescence tablet takes the bitter melon extract as its main components, and the effervescing agent is formed by mixing alkaline granules and acidic granules, wherein, the alkaline granules are produced by bitter melon extract, sodium carbonate, lactose, glucose, and sweeteners; and the acidic particles granules are produced by bitter melon extract, vitamin C, citric acid, and glucose. The inventive bitter melon nourishing effervescence tablet adopts acid-base reaction to rapidly disintegrate tablets into aqueous solution, so that it not only changes the difficult swallowing in the taking process, but also improves the taste, thereby enhancing the absorption of nutrients in the process of enjoying the drinks.
Owner:刘洪生 +1

Voriconazole dried suspension and preparation method thereof

The invention relates to a Voriconazole dried suspension, comprising 5-15wt% of Voriconazole, 3-20wt% of suspending agent, 30-60wt% of filling agent, 20-50wt% of sweetening agent, 0.1-10wt% of PH regulator, 0.2-2wt% of lubricant, 0.1-2wt% of flavoring agent and 1-5wt% of opacifier. The Voriconazole dried suspension is a fine particle dosage form with more advantages than tablet and other solid dosage forms, has the advantages of large distribution area in gastrointestinal tract, fast absorption and high bioavailability, and can avoid the disadvantage of difficult swallowing of the tablet. Dried suspension is stored as solid, and is given through the mouth in suspension state, so as to be suitable for drugs with low water stability, and for children, the old and the patients who has difficult in swallowing.
Owner:HANGZHOU SHARPLY PHARM R&D INSTIT +2

Orally disintegrating tablet of 5-HT receptor agonist and preparation method thereof

An orally disintegrating tablet of 5-HT receptor agonist and a preparation method thereof are disclosed. The invention relates to an orally disintegrating tablet of 5-HT receptor agonist as well as a prescription and a process for preparing the orally disintegrating tablet of 5-HT receptor agonist by a freeze-drying method. The orally disintegrating tablet of 5-HT receptor agonist disclosed by the invention is prepared from main medicines and pharmaceutical excipients, without the need of water while administration, capable of being rapidly disintegrated in mouth, and suitable for the administration of patients with difficulty in swallowing, such as the old and children; simultaneously, the orally disintegrating tablet of 5-HT receptor agonist is suitable for administration in a condition that water is not easy to obtain during travelling; and the orally disintegrating tablet of 5-HT receptor agonist has the advantages of being convenient to take, fast in absorption, small in first pass effect, small in irritation on digestive tract mucosa and the like, as well as has wide market application prospect. Moreover, the orally disintegrating tablet of 5-HT receptor agonist disclosed by the invention can obviously reduce the side effects of 5-HT receptor agonist. Additionally, the invention further relates to a preparation method for the orally disintegrating tablet of 5-HT receptor agonist.
Owner:BEIJING QUANTUM HI TECH PHARMA TECHCO

Preparation for treating sore throat and preparation method thereof

The invention relates to a preparation for treating sore throat and a preparation method thereof, in particular to a Chinese patent medicine prepared from Chinese herbal medicines serving as raw materials, which belongs to the technical field of medicaments. The effective components of the preparation comprise the following raw materials: honeysuckle, scaphium scaphigerum, eolite, rhizoma pleionis, subprostrate sophora, dandelion, platycodon grandiflorus, bulbus fritilariae, houttuynia cordata, dwarf lilyturf root and the like. The preparation is prepared by preparing the raw materials in different proportions according to different characteristics of the Chinese herbal medicines. The preparation has the beneficial effects that: symptoms, such as difficult swallow, cough, dryness of the throat, thirst, astriction, red tongue, yellow moss, cold and heat, headache and the like caused by the sore throat can be eliminated, quick effect is achieved after the preparation is orally taken, the preparation has no toxic and side effects, both the symptoms and root causes are addressed, the preparation is convenient to realize, and good social benefit and economic benefit are obtained if the preparation is widely popularized.
Owner:杨杰

Ephedra and apricot cough relieving traditional Chinese medicine dispersible tablet and preparation method thereof

The invention discloses an ephedra and apricot cough relieving traditional Chinese medicine dispersible tablet and a preparation method thereof. The tablet is prepared from a traditional Chinese medicine extract, a filler, an internal disintegrating agent, an external disintegrating agent, a corrigent, a wetting agent and a lubricant. The ephedra and apricot cough relieving dispersible tablet has effects of relieving a cough, eliminating phlegm and relieving asthma and is used for patients with acute and chronic bronchitis and gasp. The tablet is good in solubility and dispersity, high in dissolubility, good in bioavailability, rapid in in-vivo distribution, stable in quality, good in taste and convenient to take, can be swallowed and chewed, is sucked in a mouth or taken after dispersed by water, is more suitable for old people and the patients with difficult swallow, and has the advantages of good medicine stability, convenience in packaging, transportation and storage and the like, and the preparation method of the tablet is simple and practicable and applicable to industrial production.
Owner:HEILONGJIANG ZHICHENG MEDICAL TECH

Vilazodone orally disintegrating tablet and preparation method thereof

The invention discloses a vilazodone orally disintegrating tablet which has good taste, does not need water for administration, is capable of quickly disintegrating after entering the mouth, suitable for patients, having trouble in swallowing, like old people and psychiatric patients to take and also suitable for administration under conditions that water is difficult to get during travelling and wartime. an indication of the vilazodone orally disintegrating tablet is major depression disorder of adults, and administration compliance of the patients can be improved due to good taste and a simple and quick administration mode. In addition, the invention further discloses a preparation method of the vilazodone orally disintegrating tablet. The preparation method is simple in process and low in cost. The orally disintegrating tablet prepared by the method is quick to disintegrate and act, so that administration discomfort of the patients is reduced.
Owner:AVENTIS PHARMA HAINAN

Methylsulfonic acid pridinol oral disintegrating tablet and preparation method thereof

The invention discloses a methylsulfonic acid pridinol oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet comprises the following components by mass percentage: 2 to 8 percent of methylsulfonic acid pridinol, 40 to 80 percent of filler, 5 to 20 percent of disintegrant, 5 to 30 percent of effervescent agent, 1 to 5 percent of lubricant and 0.5 to 5 percent of flavoring agent. The methylsulfonic acid pridinol oral disintegrating tablet can be quickly disintegrated in mouth cavity and quickly absorbed, and takes effect quickly, has small first-passeffect on liver, high bioavailability, low acrimony to gastrointestinal tract, convenient taking and good taste, and is particularly suitable for the old, children and patients with difficult swallowing or inconvenient drinking of water, or in operation or coma; and the oral disintegrating tablet is prepared by adopting a method of wet granulation and compression or a method of direct compressionof powder, has simple production technique, low cost, easily-controlled quality, and stability, safety and effectiveness of the preparation, is suitable for large-scale industrial production and haswide market prospect.
Owner:SOUTHWEST UNIVERSITY

Enteric dry suspension of rabeprazole and dextroisomer thereof, and preparation method thereof

The invention discloses an enteric dry suspension of rabeprazole and dextroisomer thereof, and a preparation method thereof, and belongs to the technical field of medicines. The enteric dry suspension is composed of 30-59% by weight of rabeprazole enteric microspheres, 40-69% by weight of a corrective agent and 1-30% by weight of a suspending aid. Sustained-release microspheres A are prepared by a rabeprazole salt and a sustained-release skeleton material through a hot-melt spray method; the sustained-release microspheres A are coated by an isolation coating layer and an enteric coating layer in sequence; and then the sustained-release microspheres A are mixed with the corrective agent and the suspending aid. The prepared enteric dry suspension of rabeprazole and dextroisomer thereof is dispersed uniformly in intestinal tracts, and does not produce burst release. Compared with tablets or capsules, the enteric dry suspension has good stability, is convenient to separate dosage, is taken by adding water to form a solution, is good in absorptive capacity, fast in efficacy and good in bioavailability, has a good taste, is particularly suitable for patients suffering from difficult swallowing, especially for infant patients, and increases compliance of the patients. Besides, the preparation method is simple and is suitable for large-scale production and application.
Owner:河南省健康伟业生物医药研究股份有限公司

Oral instant membrane of risperidone and preparation method thereof

The invention relates to an oral instant membrane of risperidone and a preparation method thereof, thereby being used for improving the using performance of the risperidone. The technical scheme is as follows: the instant membrane comprises 2-60 parts by weight of risperidone, 25-98 parts by weight of water-soluble pharmaceutical polymer excipients, additives and 0.1-25 parts by weight of water. The oral instant membrane solves the problems that the existing risperidone is clinically difficult to swallow, is not applicable to children and elderly patients for administration and can not be conveniently taken under the situation of having no water. The oral instant membrane can be dissolved on the tongue, the hidden trouble of choking can not be happened no matter how young a baby is, the active ingredients can be absorbed sublingually and absorbed by buccal mucosa, and the onset of action is more rapid in comparison with orally disintegrating tablets. In addition, the oral instant membrane has good compliance, thereby being particularly suitable for elderly people, children and patients with difficult swallowing.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY

Suppository for treating constipation caused by dyspepsia and preparation method of suppository

The invention discloses a suppository for treating constipation caused by dyspepsia. The suppository comprises active pharmaceutical ingredients and a matrix. The active pharmaceutical ingredients are prepared by, by weight, 10-30 parts of malt, 15-25 parts of hawthorn, 15-25 parts of radix pseudostellariae, 5-15 parts of fructus amomi, 8-16 parts of oolong, 5-15 parts of cistanche, 5-15 parts of peach kernel, 4-12 parts of pine nut kernel, 20-40 parts of banana, 2-8 parts of semen cassiae and 10-15 parts of black sesame. The suppository for treating the constipation caused by the dyspepsia has the advantages that the suppository based on the principle of traditional Chinese medicine symptom differentiation prevention and treatment is scientific in prescription, capable of treating both root causes and symptoms, free of side effect, safe and effective, convenient in administration and capable of effectively treating the constipation caused by the dyspepsia, and defects that orally-taken traditional Chinese medicine and western medicine are difficult in swallowing and children are reluctant to cooperate are overcome.
Owner:刘东兴

Irbesartan self-emulsifying soft capsule and preparation method thereof

The invention belongs to the technical field of medicinal preparations, and concretely relates to an irbesartan self-emulsifying solution. The irbesartan self-emulsifying solution comprises 20-40 wt% of irbesartan, 25-50 wt% of an oil phase, 10-50 wt% of an emulsifier and 5-20 wt% of a co-emulsifier. The invention also discloses a preparation method of an irbesartan self-emulsifying soft capsule. The preparation method comprises the following steps: synthesizing the irbesartan self-emulsifying solution from the irbesartan, the emulsifier, the co-emulsifier and the oil phase according to a certain ratio, and processing the self-emulsifying solution through a device to prepare the soft capsule. The above medicine is dissolved in the oil phase, the obtained solution is orally taken and then self-emulsifies in bodies to form a micro-emulsion with the particle size of about 200 nm, so the in-vitro dissolubility and the in-vivo absorption of the irbesartan are remarkably improved, and the in-vivo bioavailability is improved. The medicine can be taken at an integral grain after being processed to prepare the soft capsule, and the content of the soft capsule also can be taken out and is diluted with water to form a solution to be sent in order to improve the medicine taking compliance of old people and difficult swallowing patients.
Owner:ZHENGZHOU TAIFENG PHARMA CO LTD

Bread equivalents and methods of making the same

InactiveUS20030228408A1Easily incorporated into diet of dysphagic patientSufficient mechanical integrityDough treatmentLeguminous plant bakery productsDifficult swallowingGluten
A bread equivalent suitable for patients suffering from difficult in chewing or swallowing includes a starch-base and a gelling agent blended to form a dry mix and mixed with a liquid vehicle, such as water. The bread equivalent has properties that are similar to real bread. For example, the bread can be sliced and topped with spreadable foods like butter, margarine and the like. The bread equivalent lacks the glutenous nature of bread making it amenable for ingestion by patients having dysphagia.
Owner:MEISTER JEFF

Medicinal composition containing mycophonolate mofetil and its preparation method

The invention relates to a medicinal composition containing mycophenolate mofetil, which can be prepared into dispersible tablets, thereby overcoming the shortcomings of difficult swallowing and weak medicine compliance existed in the conventional dose forms, as a result, the patients can administrate the medicament more easily. The invention relates to the process for preparing compositions containing mycophenolate mofetil.
Owner:HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST

Easy-to-administrate oxiracetam granular formulation and preparation method

The invention relates to an easy-to-take oxiracetam particle preparation and a preparation method, which pertains to the technical field of medicine and is used for solving the problems of stability and inconvenient administration. The preparation comprises oxiracetam nano-particles and pharmaceutical excipients, the mix ratio by weight units of the main drug oxiracetam and the pharmaceutical excipients after the improvement is 1.195: 1, the pharmaceutical excipients are composed of mannitol, asipatan, sunset yellow and powdered fragrances, and the mix ratio by weight units of the ingredientsof the pharmaceutical excipients is 440: 5: 0.2: 1. The selection of the excipients in a formula of the preparation of the invention, the mix ratio of the main drug and the excipients and the mix ratio relationship among the excipients are accurate and reasonable, thus being characterized by easy water solubility, better smell and convenient administration, more particularly, the administration by the patients with difficult swallow of other oral preparations or the patients with senile dementia who are not cooperative for injection drug delivery. The preparation has stable quality and easy preservation, thus being applicable to the patients for long-term administration. The oxiracetam particle preparation of the invention has simple preparation process, lower production cost and easy implementation.
Owner:CSPC OUYI PHARM CO LTD

Composition as well as preparation method and application thereof

The invention provides a dextromethorphan quinidine composition as well as a preparation method and application of the dextromethorphan quinidine composition. According to the dextromethorphan and quinidine composition provided by the invention, the bitter taste and the numb taste of dextromethorphan and quinidine are improved by adding cyclodextrin, meanwhile, the dextromethorphan and quinidine composition provided by the invention is easily prepared into various oral preparations easy to swallow, the problem that patients with nervous system diseases are difficult to swallow is solved, and the medication experience can be greatly improved.
Owner:北京剂泰医药科技有限公司 +1

Resin compound composition as well as preparation method and application thereof

The invention provides a dextromethorphan quinidine resin compound composition as well as a preparation method and application of the dextromethorphan quinidine resin compound composition. The proper ion exchange resin is added, so that the technical effect that the taste correction effect of dextromethorphan and quinidine is good while medicine dissolution is met is achieved. The dextromethorquinine resin compound composition disclosed by the invention has a dissolution effect similar to that of an original compound, can be easily prepared into various oral preparations easy to swallow, solves the problem that patients suffering from nervous system diseases are difficult to swallow, and can greatly improve the medication experience of the patients.
Owner:BEIJING JITAI PHARM TECH CO LTD +1

Aniseed and pogostemon compound anti-viral influenza capsule as well as preparation method thereof

The invention discloses an anise-and-patchouli compound antiviral cold capsule and a preparation method thereof. Anise, patchouli, and thyme are used as monarch medicines, and supplemented with skullcap, honeysuckle, forsythia, licorice, folium Banlangen, almond, ephedra, bupleurum, tangerine peel, mulberry leaf, windproof, and fresh chrysanthemum root are 13 traditional Chinese medicine raw materials. The active ingredients are extracted by CO2 supercritical, which has high extraction rate, no damage to the active ingredients of traditional Chinese medicine, no organic solvent residue and advanced technology. The advantages of simplicity; the capsule seals the strong and peculiar smell of traditional Chinese medicines such as anise, and solves the problem that such traditional Chinese medicines are difficult to swallow; the invention strengthens the anti-influenza virus, anti-inflammatory and antipyretic effects, improves immunity, and can be cured quickly And significantly improve the symptoms of headache, fever, cough, sore throat, body pain and fatigue, nasal congestion and runny nose caused by viral influenza, without side effects.
Owner:闫战军

Tripterygium wilfordii soft-shelled turtle soup for treatment of rheumatoid arthritis

The invention relates to the pharmaceutical formulation field, in particular to a tripterygium wilfordii soft-shelled turtle soup for treatment of rheumatoid arthritis. The soup adopts the following raw materials by weight: 60%-73% of soft-shelled turtle, 3%-5% of tripterygium wilfordii, 3%-4% of Poria cocos, 1%-2% of radix paeoniae alba, 3%-5% of Rehmannia glutinosa, 6%-8% of Angelica sinensis, 3%-4% of willow branch, 3%-5% of Atractylodes lancea, and 5%-7% of Japanese Honeysuckle Stem. The tripterygium wilfordii soft-shelled turtle soup provided by the invention has the characteristics of simple preparation method, suitable taste, no difficult swallow problem in traditional Chinese medicines, high curative effect on rheumatoid arthritis, and has the functions of dispelling wind and eliminating dampness, activating blood and dredging collaterals, relieving swelling and pain, reinforcing nutrition and health care, nourishing and strengthening body, and resisting cancer and aging.
Owner:陈慧

A kind of enteric-coated dry suspension of rabeprazole and its dextrorotatory isomer and preparation method thereof

The invention discloses an enteric dry suspension of rabeprazole and dextroisomer thereof, and a preparation method thereof, and belongs to the technical field of medicines. The enteric dry suspension is composed of 30-59% by weight of rabeprazole enteric microspheres, 40-69% by weight of a corrective agent and 1-30% by weight of a suspending aid. Sustained-release microspheres A are prepared by a rabeprazole salt and a sustained-release skeleton material through a hot-melt spray method; the sustained-release microspheres A are coated by an isolation coating layer and an enteric coating layer in sequence; and then the sustained-release microspheres A are mixed with the corrective agent and the suspending aid. The prepared enteric dry suspension of rabeprazole and dextroisomer thereof is dispersed uniformly in intestinal tracts, and does not produce burst release. Compared with tablets or capsules, the enteric dry suspension has good stability, is convenient to separate dosage, is taken by adding water to form a solution, is good in absorptive capacity, fast in efficacy and good in bioavailability, has a good taste, is particularly suitable for patients suffering from difficult swallowing, especially for infant patients, and increases compliance of the patients. Besides, the preparation method is simple and is suitable for large-scale production and application.
Owner:河南省健康伟业生物医药研究股份有限公司

Flurarizine dropping pill and preparing method thereof

The invention is a Flunarizine drop pill and preparing method. It is prepared by micronization and drop-pill producing technique. It can enhance disintegrating and dissolving speed, stripping rate and degree, stability, and largely reduce the dosage of assistant material, convenient to carry and take. It can be sucked and also swallowed, adapted to children, older folks, and difficult-swallowing patients, especially the patients suffering from cranial vascular disease.
Owner:HONGYI SCI & TECH CO LTD NANCHANG
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