The invention belongs to the technical field of intelligent
medical treatment, and particularly relates to a personalized
drug recommendation method and
system fusing adverse
drug reactions, and the method comprises the following steps: inputting longitudinal electronic health
record multi-
source data of a patient, extracting and fusing
time sequence features and
drug similarity features, and generating comprehensive
information representation of the patient. Local drug information representations and drug information representations are generated through a
drug molecule bipartite graph and a drug information cassette, respectively, based on the comprehensive
information representation of the patient. After external
adverse drug reaction information is introduced and processed by an
encoder, the comprehensive information of a patient is used for representing weighting, and
adverse drug reaction characteristics are obtained. And the local drug
information representation, the drug information representation and the
adverse drug reaction characteristics are spliced, and final drug combination recommendation is output through prediction scores. According to the method, various kinds of useful information are fully utilized, complementarity and correlation among different
medicine information sources are captured, the quality of multi-
source data fusion is improved, and the accuracy and safety of
medicine recommendation are optimized.