The invention belongs to the field of medical instruments, particularly relates to a self-exhaust and bubble-proof transfusion apparatus, and comprises a bottle plug puncture outfit, a transfusion pipeline, a dripping bucket, a flow regulator, a medicine liquid filter, a water stopping clamp, a conical connector and a venous transfusion needle. An exhaust device is arranged in the dripping bucketand comprises an exhaust seat, an exhaust core and a cover cap. The bottom of the exhaust seat is fixed at the position of a liquid dripping opening at the bottom end of the dripping bucket and tightly matched with the liquid dripping opening, the hollow exhaust core communicated with the dripping opening is arranged in the exhaust seat, a liquid inlet gap is arranged between the exhaust core andthe exhaust seat, a liquid inlet groove is respectively arranged on the lateral walls of the exhaust core and the exhaust seat, the top of the exhaust seat is provided with the cover cap clamped withthe exhaust seat, and the lateral wall of the cover cap is provided with at least one exhaust groove. The transfusion apparatus is simple and reasonable in structure and convenient to operate, and the exhaust device in the dripping bucket can exhaust gas entering a gas-liquid mixture in the dripping bucket and prevent bubbles from being generated. The exhaust groove of the cover cap can avoid retention of the gas. The self-exhaust and bubble-proof transfusion apparatus is convenient and safe to use, fast and reliable.