The invention discloses a production method of enteric-coated 
kitasamycin for feed, which comprises the following process steps: step one, the preparation of 
drug-loaded 
pellets; step two, inner layer sustained-release 
coating of the 
drug-loaded 
pellets, which prolongs the release and acting time of 
kitasamycin; and steps three, outer layer 
enteric coating of the 
drug-loaded 
pellets, which ensures the release in 
succus entericus and small or 
no release in gastric juice. The method has the advantages that the 
kitasamycin is subjected to pellets 
pelletizing and 99 percent of the prepared granulums can pass through 24 meshes, so the dust is greatly reduced and the fluidity is increased; the 
coating of the inner layer sustained-
release agent (HPMC) prolongs the release and acting time of the kitasamycin, reduces medication times and reduces the 
medication cost; and a layer of enteric substance, namely 
acrylic resin-III is sprayed and coated on the outer layer of particles. The substance protects the kitasamycin which is a weakly alkaline antibiotic from being damaged by gastroc acid in 
stomach, quickly disintegrates after entering enteric canal and releases the kitasamycin; and then the kitasamycin is absorbed by 
gastrointestinal mucosa into 
blood drug to play a role of restraining the 
reproduction of 
pathogenic microorganism and preventing 
diarrhea. Insoluble in the 
stomach, kitasamycin 
coating formulations have no pessimal stimulation on the 
stomach, and cannot result in regurgitation and 
vomiting. In addition, the sustained-release formulation, namely the kitasamycin prolongs the acting time so the medication times is reduced, the 
medication cost of farmers is reduced, and the economic benefit is improved.