348results about How to "Suppress drug resistance" patented technology

The invention belongs to the biotechnology field, and in particular relates to escherichia coli TolC antigen and antibody. The antibody has the specificity aiming to a sequence shown by SEQ ID NO:1. The invention also provides a gene sequence for encoding the escherichia coli TolC antigen and application of the antibody to preparing a drug for inhibiting the bacterial resistance. The anti-TolC fragment SNGYRDANGI antibody enhances the sensitivity of bacteria to antibiotic and can specifically and efficiently inhibit the functions of drug resistance outer membrane protein of escherichia coli, thereby solving the problem of the bacterial resistance. Compared with the traditional antibody, the antibody has higher safety and operability on the application of the bacterial resistance drug.

The invention discloses a sterilization composition containing isopyrazam and carbendazim and application of the sterilization composition. The sterilization composition comprises isopyrazam and carbendazim as main effective components, wherein the mass ratio of isopyrazam to carbendazim is (1-70):(1-50). The sterilization composition can be used for preventing and treating diseases of cereals, fruit trees and vegetables, has a relatively good synergistic effect, overcomes and retards drug resistance of bacteria and is high in sterilization speed and long in lasting period, the application cost is lowered, and the prevention and treatment effect of the sterilization composition is remarkably superior to that of a single reagent. The sterilization composition can be used for preventing and treating fungous diseases of crops, particularly fungous diseases such as rice sheath blight diseases, rice blast and pepper phytophthora blight, and the effect of the sterilization composition is remarkably superior to that of the single reagent.

The invention relates to a core-shell type nano medical granule targeting to tumor cells. The core-shell type nano medical granule comprises an inner hydrophobic polymer with chemotherapeutics medicines and epigenetics medicines in an adsorbing manner, a single-layer lipid molecule layer wrapping the inner hydrophobic core, and an hydrophilic outer shell targeting to the tumor cells. The invention further relates to a preparation method of the core-shell type nano medical granule and the application of the core-shell type nano medical granule to preparing anti-tumor medicines. The core-shell type nano medical granule combines the nano wrapping, the chemotherapeutics medicines and the epigenetics medicines, thereby having the advantages of improving the medicine delivery targeting, improving the sensitivity of the tumor cells to the chemotherapeutics medicines, suppressing the medicine resistance of the tumor cells, and the like.

The invention discloses a bactericidal composition containing pyraclostrobin and prothioconazole and application thereof. The bactericidal composition uses the pyraclostrobin and prothioconazole as main effective components, wherein the weight ratio of the pyraclostrobin to the prothioconazole is (1-70):(1-50). The bactericidal composition can be used for preventing and treating diseases on cereals, melons and fruits, or vegetable crops, has higher synergic effect, overcomes and postpones the drug resistance of pathogenic bacteria, has the advantages of high bactericidal speed and long duration time, lowers the use cost, and has obviously better preventing and treating effects than a single agent. The bactericidal composition can be used for preventing and treating fungus diseases on the crops, especially can be used for preventing and treating leaf blight, rust disease, powdery mildew, downy mildew, epidemic disease, anthracnose, scab, brown spot, seedling blight, gray mold, banana freckle, penicilliosis and other fungus diseases, and has better effect than a single agent.

The invention discloses a compound pesticidal composition containing cyfluthrin and thiamethoxam and application thereof. The pesticidal composition adopts cyfluthrin and thiamethoxam as pesticidal active ingredients, wherein the weight ratio of cyfluthrin to thiamethoxam is 1 to 60:1 to 60. The pesticidal composition can generate a high synergistic effect, and can overcome and retard the pesticide resistance of pests, the pesticidal speed is high, the persistence is long, the application cost is reduced, and the control effect of the compound pesticidal composition is far better than the control effect of single agents. The compound pesticidal composition can control resistant insect pests of hemiptera on crops, and particularly can be used for controlling mealy aphids, leafhoppers and whiteflies, and the effect of the compound pesticidal composition is far better than the effect of single agents.

A feeding method for regulating and controlling the metabolic block of carbonhydrate in the rumen of ox or sheep features that beside the mixture of coarse feed and fine feed is used as daily feed, the extract of the plant containing alkaloid is proportionally fed to ox or sheep for increasing the pH value in rumen.

The invention discloses a bactericidal composition containing prothioconazole and validamycin and application thereof. The bactericidal composition uses the prothioconazole and validamycin as main effective components, wherein the weight ratio of the prothioconazole to the validamycin is (1-90):(1-90). The bactericidal composition can be used for preventing and treating diseases on cereals, fruit trees and vegetable crops, has higher synergic effect, overcomes and postpones the drug resistance of pathogenic bacteria, has the advantages of high bactericidal speed and long duration time, lowers the use cost, and has obviously better preventing and treating effects than a single agent. The bactericidal composition can be used for preventing and treating fungus diseases on crops, especially can be used for preventing and treating powdery mildew, rust, gray mold, black spot, brown spot, hollow stald rot, sheath blight and other fungus diseases, and has better effect than a single agent.

The invention discloses a bactericidal composition containing spiroxamine and zinc thiazole and an application of the bactericidal composition. The spiroxamine and the zinc thiazole are used as main effective constituents of the bactericidal composition, and the mass ratio of the spiroxamine to the zinc thiazole is 1-90:1-90. The bactericidal composition can be used for preventing and treating diseases of cereals, fruit trees and vegetables, has high synergism, overcomes and delays pesticide resistance of germs, and is high in bactericidal speed and long in lasting period; application cost is reduced; and the preventing and treating effect is obviously higher than that of a single agent. The bactericidal composition can be used for preventing and treating fungal diseases and bacterial diseases of crops, and can be particularly used for preventing and treating fungal diseases and bacterial diseases such as powdery mildew, rust disease, stripe disease, rice bacterial leaf blight, bacterial stripe and anthracnose, and the effect of the bactericidal composition is greater than that of the single agent.

The present invention discloses one kind of pesticide composition for preventing and killing plant hopper. The pesticide composition consists of pymetrozine 0.5-25 wt%, buprofezin 0.5-25 wt%, assistant 5-25 wt%, and stuffing 25- 94 wt%. The stuffing may be bentonite, fine particle calcium carbonate, kaolin, silica white or water; and the assistant may be starch, PVA, lignin sulfonate, etc. The pesticide composition of the present invention has the advantages of fast acting, lasting action, less influence on environment and low cost.

The invention discloses a postoperative low-specific-gravity seawater recuperation method for pinctada martensii after nucleus implantation, and belongs to the technical field of aquaculture. The method comprises the basic steps of preparation of a postoperative recuperation pond of pinctada martensii, preparation of recuperation water, selection and nucleus implantation of pearl breeding shellfishes and recuperation management of the pearl breeding shellfishes, wherein in the nucleus implantation and pearl breeding processes of pinctada martensii, healthy pinctada martensii is selected for nucleus implantation and pearl breeding and transferred into the indoor or outdoor pond for low-specific-gravity seawater recuperation after an operation, and after the recuperation is finished, pinctada martensii is transferred to a sea area for breeding of the pearl breeding shellfishes according to a conventional method. By means of the method, pinctada martensii is subjected to postoperative recuperation, the nucleus maintaining rate of the operative shellfishes is high, the rate of high-quality pearl is high, the pearl quality and economic benefit of the pearl breeding shellfishes can be improved, and the method is suitable for postoperative recuperation of the pearl breeding shellfishes of pinctada martensii, is easily applied and popularized in production enterprises and has significant economic and social benefits.

The invention relates to a long-chain non-coding RNA PRALR, and an expression plasmid and a use thereof. Starting from TCONS-00013523 sequence, a complete gene sequence is discovered by 5'-RACE and 3'-RACE technologies and is named as PRALR (paclitaxel resistance-associated lncRNA, paclitaxel resistance-associated long-chain non-coding RNA). Then, the PRALR expression plasmid and siRNA are constructed, and the PRALR is further confirmed to be a novel ovarian cancer drug resistance-associated lncRNA; the constructed PRALR expression plasmid can significantly increase the expression quantity ofthe PRALR, and the designed siRNA can significantly reverse drug resistance of paclitaxel-resistant ovarian carcinoma cells. A powerful tool is provided for study of the mechanism of paclitaxel resistance and other chemotherapeutic drug resistance, and a reference is provided for clinical development of drugs to reverse the drug resistance of tumor to paclitaxel.

The invention relates to a high-effect and low-toxicity composite farm pesticide, which includes ether chrysanthemic ester, for preventing and controlling the pest of rice ash fly cootie, rice leaf folder, rice stem borer and yellow rice borer. The pesticide contains 0.5-20 wt.% of active components ether chrysanthemic ester, 2-30 wt.% of active components triazophos, 2-50 wt.% of chlorpyrifos, 2-50 wt.% of fenitrothion, 2-50 wt.% of diazinon, 10-60 wt.% of acephate, 20-60 wt.% of thrichlorfon, 5-50 wt.% of monosultap, 5-15 wt.% of emulsification, and the rest is solvent. The advantage of the composite farm pesticide is: 1) The effect is improved highly for controlling the pest of rice ash fly cootie and rice leaf folder; 2) One kind of agricultural chemicals can controlling various pests, and can prevent and control various pests at the same time. Agricultural chemicals' cost and work time being reduced. 3) High poisonous such as phosphorus methylamine insecticide can be replaced and the dosage of agricultural chemicals can also be reduced. Environment pollution and the rudimental pesticide of rice and marine lives can be reduced efficaciously. 4) The singular drug-fast capability of the pests such as rice leaf folder and rice ash fly cootie is restrained.

The invention relates to a short peptide therapy agent and a medicine composition comprising same. The short peptide therapy agent comprises at least one short peptide represented by the amino acid sequences SEQ ID No.1 and SEQ ID No.2; any one of the short peptides includes not more than forty amino acid residues. The therapy agent can inhibit activities, such as proliferation, cancer stemness, migration, invasion, metastasis or drug resistance, etc., of the cancer cells.

The invention relates to application of a miR-193a-5p antagonist or a medicine composition of the miR-193a-5p antagonist to preparation of medicine for treating prostate cancer, and belongs to the technical field of medicine. The medicine composition is the miR-193a-5p antagonist and docetaxel. According to the application, the miR-193a-5p antagonist can enhance the curative effect of the docetaxel or can inhibit the drug tolerance of the tumor on the docetaxel, so that the cell apoptosis sensitization effect induced by prostate cancer cells on the docetaxel is greatly improved. The miR-193a-5p antagonist and the docetaxel are combined for medication, so that an effective path is provided for the prostate cancer treatment.

The invention discloses a bactericidal composition containing boscalid and azoxystrobin and application thereof. The bactericidal composition uses boscalid and azoxystrobin as main active ingredients, wherein the mass ratio of boscalid to azoxystrobin is 1:50-70:1. The bactericidal composition can be applied to the prevention and treatment of cereals, fruit trees, and vegetable diseases, has a high synergistic effect, overcomes and delays the drug resistance of pathogens, has fast sterilization speed, long-lasting effect, reduces application costs, and has good control effect. Significantly better than its single dose use. The present invention can be used to control fungal diseases on crops, especially can be used to control fungi such as powdery mildew, gray mold, sclerotinia, rot, rust, glume blight, net spot, downy mildew, and rice blast disease, the effect is better than a single dose.

The present invention discloses a sterilization composition adopting fluxapyroxad and difenoconazole as main active components, and an application thereof, and belongs to the technical field of compounded pesticides. According to the present invention, the sterilization composition adopts fluxapyroxad and difenoconazole as main active components, wherein a weight ratio of the fluxapyroxad to the difenoconazole is 1-90:1-90, and the total amount of the fluxapyroxad and the difenoconazole is 2-90% of the mass of the sterilization composition; and the sterilization composition provides significant effects for preparation of drugs for prevention and control of crop resistance plant fungous diseases of cereals, fruits and vegetables, and specifically for preparation of sterilization drugs for prevention and control of powdery mildew, botrytis cinerea, sclerotinia rot, rot disease, rust disease, glume spot of rice, web blotch, downy mildew, rice blast, seedling blight and scab of cucurbits, especially sterilization drugs for prevention and control of pear scab of cucurbits and cucumber powdery mildew. In addition, compared with the single-agent substance, the composition has characteristics of prevention and control spectrum expanding, production and use cost reducing, and drug resistance overcome and delaying.

The invention discloses a sterilization composition containing fluoxastrobin and fludioxonil and application thereof. The sterilization composition is mainly prepared from fluoxastrobin and fludioxonil, wherein the weight ratio of fluoxastrobin to fludioxonil is (1-70):(1-50). The sterilization composition can be applied to preventing and treating of cereal, fruit tree and vegetable diseases, has the high synergistic interaction effect, overcomes and delays germ drug resistance, is high in sterilization speed and long in lasting period, reduces the application cost and has the better control effect than that of single dosages. The composition can be used for fungal diseases on crops, and can be particularly used for preventing rust diseases, glume blight, web blotch, powdery mildew, downy mildew, early blight, late blight, anthracnose, gray mold and other fungal diseases, and the effect is better than that of single dosages.

The invention discloses a synergistic pesticidal composition containing nitenpyram and ethofenprox and an application thereof. The synergistic pesticidal composition adopts the nitenpyram and the ethofenprox as the main active ingredients, wherein the weight ratio of the nitenpyram to the ethofenprox is (0.1-80): (0.1-60). The synergistic pesticidal composition containing the nitenpyram and the ethofenprox can be used for preventing and controlling resistant hemiptera injurious insects, and has obviously preventing and controlling effect on wheat aphids and rice planthopper. The pesticidal composition can generate higher synergy, overcomes and delays the drug resistance of the injurious insects, and has the advantages of fast insecticidal speed and long residual activity; and by using the synergistic pesticidal composition, the pesticide cost is reduced, and the prevention and control effect is obviously superior to that of the single dosage.

The invention belongs to the technical field of microbial insecticides and particularly relates to bacillus thuringiensis YN108 with high toxicity to lepidopteran pests, a culture method and application of the bacillus thuringiensis YN108. The bacillus thuringiensis YN108 is bacillus thuringiensis subsp.aizawai and has a preservation number of CGMCC No. 15140 in the China General Microbiological Culture Collection Center (CGMCC) on January 02, 2018. The bacillus thuringiensis YN108 dislcosed by the invention has high toxicity to the lepidopteran pests, and particularly has a median lethal concentration (LC500) of only 3.25*105 cfu/ml for the 3<rd> instar larva of spodoptera litura, which is smaller than a published YN1-1 bacterial strain and a published CAB109 bacterial strain. Meanwhile,the bacillus thuringiensis YN108 is also better than a commercial bacillus thuringiensis catfish subspecies I product, an SB product and a bacillus thuringiensis catfish subspecies SL product in indoor drug efficacy and field control effect and shows excellent insecticidal activity. In addition, the bacillus thuringiensis YN108 disclosed by the invention has no residue after use, avoids drug resistance and is green and environmentally-friendly.

The invention discloses a compound insecticidal composition containing dinotefuran and carbosulfan and a purpose thereof. The insecticidal composition treats dinotefuran and carbosulfan as main effective components, wherein the weight ratio of dinotefuran to carbosulfan is 1-70:1-70. The insecticidal composition of the invention, which can control homoptera pests and lepidoptera pests on crops, and can especially control rice hoppers, aphids, rice stem borers and cotton bollworms, can generate high synergy effects, and allows the pest drug resistance to be overcome and delayed, the insecticidal speed to be fast, the persistent period to be long, the drug consumption cost to be reduced, and the control effect to be obviously higher than the control effect one of dinotefuran and carbosulfan.

The invention discloses a pharmaceutical composition containing polymyxin and application thereof, and belongs to the field of biological medicine. The pharmaceutical composition comprises C507-0440 and polymyxin, the C507-0440 and the polymyxin are combined for use so that the activity of the polymyxin in gram-negative bacteria can be effectively improved, and the drug resistance of the polymyxinis inhibited; and meanwhile, the C507-0440 can significantly reduce the use dosage of the polymyxin, and is conductive to reducing side effects caused by drug use.

The invention discloses a compound insecticidal composition containing dinotefuran and fenobucarb and application thereof, and the insecticidal composition takes the dinotefuran and the fenobucarb as main active ingredients, wherein the weight ratio of the dinotefuran to the fenobucarb is (0.1-80):(0.5-80). The insecticidal composition can generate the higher synergy, overcome and stay the drug resistance of pests, realize long desinsection speed and long lasting period and reduce the medicament cost; and the control effect of the insecticidal composition is obviously higher than a single agent. The compound insecticidal composition can be used for controlling homoptera pests, in particular to rice plant hoppers and aphids on crops, and the effects of the compound insecticidal composition are obviously higher than the single agent.